Transplantation of human umbilical mesenchymal stem cells attenuates dextran sulfate sodium-induced colitis in mice.

abstract：:1. The effects of volume depletion and NaHCO(3) loading on the expression of Na(+)/H(+) exchanger isoform 3 (NHE3), Na(+) : HCO(3)(-) cotransporter type 1 (NBC1) and neuronal (n) and inducible (i) isoforms of nitric oxide synthase (NOS) were determined in rat kidney. 2. Adult male Sprague-Dawley rats were used. Rats w...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ma SK,Kang JS,Bae EH,Choi C,Lee J,Kim SH,Choi KC,Kim SW

更新日期：2008-03-01 00:00:00

abstract：:1. The present review focuses on the cytotoxic effects of iodinated contrast media (CM) that are shared by all types of CM. 2. Although the clinical nephrotoxicity of CM has been progressively improved, all currently available CM still possess a level of cytotoxicity, which is probably caused by iodine. 3. The toxicit...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sendeski MM

更新日期：2011-05-01 00:00:00

abstract：:1. The effects of endogenous and exogenous acetylcholine (ACh) on nitrergic relaxations elicited by electrical field stimulation (EFS) were studied in guinea-pig endothelium-denuded basilar artery preparations precontracted with 1 mumol/L prostaglandin F2 alpha and a possible role of K+ channels in mediating the effec...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jiang F,Li CG,Rand MJ

更新日期：1999-04-01 00:00:00

abstract：:1. Infusion of increasing doses of angiotensin II (AII) in normal subjects sequentially increased blood pressure, aldosterone and atrial natriuretic peptide (ANP) levels. 2. The slope of ANP response to AII was positively correlated with basal ANP and with the slope of blood pressure response to AII (pressor slope) bu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Finn WL,Tunny TJ,Klemm SA,Ryan SJ,Gordon RD

更新日期：1993-05-01 00:00:00

abstract：:1. The objectives of the study were to establish that inhibition of neuronal differentiation in culture (assessed by neurite outgrowth) can be used as a broad spectrum in vitro measure of neurotoxicity. 2. To establish whether a rapid measure of neurite outgrowth could be used. Thus the study examined the relationship...

journal_title：Clinical and experimental pharmacology & physiology

authors： Abdulla EM,Calaminici M,Campbell IC

更新日期：1995-05-01 00:00:00

abstract：:1. This study aimed to investigate the protective effects of isosteviol against myocardial ischaemia-reperfusion (IR) injury and its effects on mitochondrial adenosine triphosphate (ATP)-sensitive potassium channel (mitoK(ATP)) activity in vitro. 2. Groups of eight guinea pigs were treated as follows: constant perfusi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Xu D,Zhang S,Foster DJ,Wang J

更新日期：2007-05-01 00:00:00

abstract：:The aim of this study was to investigate whether enoxaparin (ENX) administration would increase seroma risk and worsen mesh tissue recovery in an experimental rat hernia repair model. Fifty-six adult male Wistar-Albino rats were included in the study. Rats were equally and randomly separated into seven groups: Group 1...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ozkececi ZT,Gonul Y,Karavelioglu A,Bozkurt MF,Kacar E,Bal A,Ozsoy M,Turamanlar O,Celep B

更新日期：2016-07-01 00:00:00

abstract：:1. Adult soft-shelled turtles were exposed to hyperosmotic and dehydration stresses. 2. Acute treatment for 0.5, 1 or 2 h with sodium chloride (3.6%, single intramuscular injection, 2 mL volume) caused depletion of pineal serotonin contents followed by elevation of norepinephrine and epinephrine levels. In addition, i...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mahapatra MS,Mahata SK,Maiti B

更新日期：1991-10-01 00:00:00

abstract：:The effect of pancuronium in the rabbit ear artery was investigated in order to measure the inhibition it produces at the prejunctional muscarinic receptor on sympathetic nerve endings in this tissue. Pancuronium (0.1-0.2 mmol/l) produced an enhancement of responses to transmural electrical stimulation but this effect...

journal_title：Clinical and experimental pharmacology & physiology

authors： Leung E,Mitchelson F

更新日期：1983-11-01 00:00:00

abstract：:1. Amino acid neurotransmitters are critical for controlling the activity of most central neurons, including sympathetic preganglionic neurons (SPN), the spinal cord neurons involved in controlling blood pressure and other autonomic functions. 2. In studies reviewed here, SPN were identified either by retrograde traci...

journal_title：Clinical and experimental pharmacology & physiology

authors： Llewellyn-Smith IJ

更新日期：2002-05-01 00:00:00

abstract：:1. Hepatic resection with concomitant periods of ischaemia and reperfusion (I/R) is required to perform reduced-size liver (RSL) transplantation procedures, such as living donor or split liver transplantation. Although a great deal of progress has been made using these types of surgical procedures, a significant numbe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Urakami H,Abe Y,Grisham MB

更新日期：2007-09-01 00:00:00

abstract：:1. The angiotensin type 1 (AT1) receptor antagonist, losartan (10 mg/kg) was infused intravenously into nine chronically catheterized fetal sheep (125-132 days gestation). Losartan reduced the fetal systolic (P <0.01) and diastolic (P <0.01) pressor response to 5 microg angiotensin II (AngII) i.v. from 27.4 +/- 1.5 to...

journal_title：Clinical and experimental pharmacology & physiology

authors： Stevenson KM,Gibson KJ,Lumbers ER

更新日期：1996-02-01 00:00:00

abstract：:1. Conscious experimental hypertensive rats injected intraventricularly with 5,6-dihydroxytryptamine (50 microgram) responded with a rapid and long-lasting (4 days) fall in blood pressure and this was accompanied by a bradycardia of similar duration. 2. The acute actions of 5,6-dihydroxytryptamine on the cardiovascula...

journal_title：Clinical and experimental pharmacology & physiology

authors： Finch L

更新日期：1975-11-01 00:00:00

abstract：:1. Deviation supersensitivity and post-junctional supersensitivity are important determinants in the control of the response of smooth muscle. 2. Post-junctional supersensitivity is a process whereby effector cells have augmented responsiveness as a consequence of an impaired physiological stimulus. Deviation supersen...

journal_title：Clinical and experimental pharmacology & physiology

authors： Head RJ

更新日期：1989-06-01 00:00:00

abstract：:1. Ionic channels appear to play an important role in contractile responses of the cerebral arteries and, thereby, contribute to the regulation of cerebral circulation. In the present study, we investigated the role of large-conductance Ca(2+)-activated K+ (BK(Ca)) channels in the regulation of cerebral arterial tone ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kamouchi M,Kitazono T,Nagao T,Fujishima M,Ibayashi S

更新日期：2002-07-01 00:00:00

abstract：:1. In order to investigate further whether the increased sensitivity to inhibition by nifedipine of the responses to noradrenaline of aortae from spontaneously hypertensive stroke-prone (SHRSP) rats is related to the development of the hypertension, we have compared the sensitivity to noradrenaline, potassium chloride...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jiang GC,Iwanov V,Moulds RF

更新日期：1995-01-01 00:00:00

abstract：:1. Oxidative stress (OS) is a biological entity indicated as being responsible for several pathologies, including diabetes. Diabetes can also be associated with human cirrhosis. Portal hypertension (PH), a major syndrome in cirrhosis, produces hyperdynamic splanchnic circulation and hyperaemia. The present study was d...

journal_title：Clinical and experimental pharmacology & physiology

authors： Evelson P,Llesuy S,Filinger E,Rodriguez RR,Lemberg A,Scorticati C,Susemihl M,Villareal I,Polo JM,Peredo H,Perazzo JC

更新日期：2004-03-01 00:00:00

abstract：:1. The present study evaluated changes in autonomic control of the cardiovascular system in conscious rats following blockade of endothelin (ET) receptors with bosentan. 2. Rats were treated with bosentan or vehicle (5% gum arabic) for 7 days by gavage. 3. Baseline heart rate (HR) was higher in the bosentan-treated gr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Souza HC,Terzini GC,da Silva VJ,Martins-Pinge MC,Salgado HC,Salgado MC

更新日期：2008-07-01 00:00:00

abstract：:1. Physical movement is accompanied by coordinated changes in respiratory and cardiovascular activity proportional to the metabolic demands of the locomotor task. Cardiorespiratory changes include increases in ventilation, blood pressure and heart rate, as well as altered regional sympathetic nerve activity and blood ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kramer JM,Beatty JA,Plowey ED,Waldrop TG

更新日期：2002-01-01 00:00:00

abstract：:1. Congenital long QT syndrome (LQTS) is a genetically heterogeneous disease. The aim of the present study was to identify the gene mutation in a Chinese family with LQTS and investigate the functional changes associated with the mutation. 2. Polymerase chain reaction and DNA sequencing were used to screen for the KCN...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang HT,Sun CF,Cui CC,Xue XL,Zhang AF,Li HB,Wang DQ,Shu J

更新日期：2009-08-01 00:00:00

abstract：:Osteosarcoma is the most common non-hematological primary bony malignancy in children and young adults with tumor metastasis being a common event at diagnosis. Understanding the pathogenesis of metastatic osteosarcoma may help identify potential therapeutic targets. In this study, we found that the level of microRNA-6...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jiao GJ,Zhang SJ,Li Y,Wu WL,Liu HC

更新日期：2018-12-01 00:00:00

abstract：:Recently, the roles of gene polymorphisms in poor responsiveness to aspirin were extensively investigated, with conflicting results. Therefore, we performed this meta-analysis to better assess the relationship between candidate genetic variants and poor responsiveness to aspirin. Eligible articles were searched in Pub...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang J,Chen X,Zhou J,Hu S,Tang Y

更新日期：2018-05-21 00:00:00

abstract：:1. Endogenous polyamines play a key role in mediating cellular growth and differentiation. Hypertension is associated with structural modifications of the circulatory system, a process that may be facilitated by polyamines. In this study, we examined whether there are elevated polyamine concentrations in the cardiovas...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ibrahim J,Hughes AD,Schachter M,Sever PS

更新日期：1996-05-01 00:00:00

abstract：:Chronic low back pain (LBP) has high prevalence in the adult population which is associated with enormous disability. Hence, our aim was to further characterise our LBP rat model by using immunohistological and immunohistochemical methods at an advanced stage (day 49) of the model. Male Sprague-Dawley rats were anaest...

journal_title：Clinical and experimental pharmacology & physiology

authors： Park TSW,Khan N,Kuo A,Nicholson JR,Corradini L,Smith MT

更新日期：2020-09-05 00:00:00

abstract：:1. The serotonin transporter (SERT) is strongly implicated in the pathogenesis of pulmonary arterial hypertension (PAH) in patients and animal models. Inhibitors of SERT have been reported to attenuate or reverse experimental PAH, which makes them potential therapeutic options for the treatment of PAH in humans. Howev...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhu SP,Mao ZF,Huang J,Wang JY

更新日期：2009-08-01 00:00:00

abstract：:The aim of this study was to determine whether the kaliuresis associated with glucocorticoids is due to a direct tubular action or is secondary to effects of glucocorticoids on distal tubule flow. A whole kidney technique was used to avoid the problem, inherent in microperfusion and micropuncture studies, of deciding ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Adam WR,Adams BA,Ellis AG

更新日期：1987-01-01 00:00:00

abstract：:1. The common pathological alteration in virtually every progressive chronic kidney disease (CKD) is renal fibrosis. 2. This review focuses on some growth factors, which are particularly well-established in contributing to fibrosis, such as the profibrotic, transforming growth factor-β, and connective tissue growth fa...

journal_title：Clinical and experimental pharmacology & physiology

authors： Boor P,Floege J

更新日期：2011-07-01 00:00:00

abstract：:The therapeutic potential of the antimicrobial peptide cathelicidin (Camp) administration in sepsis has been widely investigated. However, little is known about the pathophysiological roles of cathelicidin in septic cardiomyopathy. In a lipopolysaccharide (LPS)-induced endotoxaemic model, we found that the mRNA and pr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhai T,Zhang J,Zhang Y,Wu Y

更新日期：2020-04-01 00:00:00

abstract：:Vancomycin is an antibiotic used in the treatment of infections caused by multidrug-resistant Gram-positive bacteria, especially methicillin-resistant Staphylococcus aureus. In the last decades, vancomycin has been widely used in hospital environments due to the increasing incidence of sepsis and septic shock. Sepsis ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zamoner W,Prado IRS,Balbi AL,Ponce D

更新日期：2019-04-01 00:00:00

abstract：:1. Recent reports have described the role of osteocalcin in glucose metabolism and glycaemic variability has been proven to be associated with an increased risk of diabetes complications. However, the relationship between osteocalcin and glycaemic variability remains unclear. The aim of the present study was to examin...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bao YQ,Zhou M,Zhou J,Lu W,Gao YC,Pan XP,Tang JL,Lu HJ,Jia WP

更新日期：2011-01-01 00:00:00