Characterisation of a rat model of mechanical low back pain at an advanced stage using immunohistochemical methods.

abstract：:1. The use of the isolated lung strip and single open tracheal ring for studying Schultz Dale anaphylactic contractions in both the peripheral and central airways is described. 2. This method is particularly relevant to studies of anaphylaxis because many preparations may be obtained from a single sensitized animal. 3...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lulich KM,Papadimitriou JM,Paterson JW

更新日期：1979-11-01 00:00:00

abstract：:1. The aim of the present study was to examine the role of dopaminergic and glutamatergic receptors on different stages of the amphetamine (AMPH) sensitized effect in schedule-induced polydipsia (SIP) in rats. 2. Three experiments were designed to evaluate the roles of DAD2 receptor antagonist haloperidol (HAL) and gl...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu YP,Tung CS,Lin PJ,Wan FJ

更新日期：2010-09-01 00:00:00

abstract：:The aim of the present study was to determine the effects of increased cAMP levels in response to pituitary adenylate cyclase-activating polypeptide 27 (PACAP27) on atrial atrial natriuretic peptide (ANP) secretion in rabbit atria. A perfused beating atrial model was used in the present study and cAMP efflux and ANP l...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang Y,Liu LP,Liang ZL,Li XL,Jin YZ,Cui X

更新日期：2008-10-01 00:00:00

abstract：:1. Muscle injury (rhabdomyolysis) is one of the causes of acute renal failure (ARF). Iron, free radicals and nitric oxide (NO) play a critical role in the pathogenesis of glycerol-induced myoglobinuric ARF. L-Carnitine is an anti-oxidant and prevents the accumulation of end-products of lipid peroxidation. Therefore, t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Aydogdu N,Atmaca G,Yalcin O,Taskiran R,Tastekin E,Kaymak K

更新日期：2006-01-01 00:00:00

abstract：:1. In coronary artery disease, the typical atheromatous plaque consists of a lipid core containing various inflammatory cells and a fibrous cap composed mostly of extracellular matrix. Both matrix metalloproteinases (MMPs) and inflammation are involved in the initiation of atherosclerotic plaques and plaque instabilit...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang W,Wang CH,Li F,Zhu WZ

更新日期：2008-03-01 00:00:00

abstract：:1. The reproducibility of blood volume measurements, using [51Cr]-labelled red blood cells (RBC) was tested in three lambs, 79-89 days of age, and the accuracy was tested in eight lambs, 83 +/- 0.4 days of age, in which blood volume was measured simultaneously by [51Cr]-RBC and [125I]-gamma globulin plus haematocrit (...

journal_title：Clinical and experimental pharmacology & physiology

authors： Moritz KM,Potocnik SJ,Tangalakis K,Wintour EM

更新日期：1994-07-01 00:00:00

abstract：:1. Prenatal dexamethasone leads to low birth weight and compromises organogenesis, but its effects on nephrogenesis in male and female rats have not yet been investigated extensively. Reduced renal mass may be responsible for hypertension and renal haemodynamic and morphological adjustments to maintain the glomerular ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Martins JP,Monteiro JC,Paixão AD

更新日期：2003-01-01 00:00:00

abstract：:1. The Type 2C protein phosphatases (PP2C) represent a highly conserved gene family in the mammalian genome. Recent studies have revealed that PP2C isoforms possess unique patterns of tissue and subcellular distribution associated with diverse functionalities. 2. The functional importance of PP2C isoforms has been sho...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lu G,Wang Y

更新日期：2008-02-01 00:00:00

abstract：:1. There has been considerable recent interest in the possibility that increased intake of dietary anti-oxidants may protect against cardiovascular disease. This is partly due to the knowledge that oxidative events in vivo may play a role in the pathogenesis of atherosclerosis. 2. While dietary anti-oxidants, such as ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morton LW,Abu-Amsha Caccetta R,Puddey IB,Croft KD

更新日期：2000-03-01 00:00:00

abstract：:1. The chronotropic and inotropic effects of the anti-anginal agent SG-75 (2-nicotinamidoethyl nitrate) and 1-verapamil were investigated in isolated blood-perfused canine atrial preparations. The compounds were administered via the cannulated sinus node artery. 2. SG-75 induced a selective negative inotropic as oppos...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chiba S,Furukawa Y,Kobayashi M

更新日期：1980-03-01 00:00:00

abstract：:1. In a controlled, randomized double-blind trial, 15 patients with essential hypertension were treated with enalapril 5-20 mg/day, or doxazosin 1-8 mg/day, during a 7 week dose titration phase. This was followed by 7 weeks of combined treatment with doxazosin and enalapril. 2. Blood was taken after a 2 week placebo r...

journal_title：Clinical and experimental pharmacology & physiology

authors： Stokes GS,Monaghan JC,Marwood JF,Okoro EO,Johnston H

更新日期：1992-05-01 00:00:00

abstract：:1. The aims of the present study were to investigate the pharmacological effects of quercetin on wild-type (WT) and mutant (I502A) human (h) Kv1.5 channel currents (I(kur)) and to identify whether mutation in the S6 segment is critical to activation of I(kur) by quercetin. 2. Experiments were performed on WT and site-...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang L,Ma JH,Zhang PH,Zou AR,Tu DN

更新日期：2009-02-01 00:00:00

abstract：:The efficacy of streptokinase as an intracoronary thrombolytic agent is well-recognized. The effect of streptokinase, distinct from its thrombolytic action, on ischaemic myocardium distal to an area of coronary artery occlusion when reperfusion occurs has not been well-defined. In order to do this, myocardial creatine...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mickelson JK,Carlson CJ,Margaretten W,Rapaport E

更新日期：1986-09-01 00:00:00

abstract：:1. In the present study we have examined the effects of angiotensin I converting enzyme (ACE) inhibition and nitric oxide (NO) synthesis inhibition on bradykinin (BK) depressor responses in pregnancy in both Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). 2. Ramipril (10 mg/kg, i.v.) significantly reduce...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chu ZM,Beilin LJ

更新日期：1995-06-01 00:00:00

abstract：:The chemosensitive cardiac vagal and sympathetic afferent reflexes are implicated in driving pathophysiological changes in sympathetic nerve activity (SNA) in cardiovascular disease states. This study investigated the impact of sex and ovarian hormones on the chemosensitive cardiac afferent reflex. Experiments were pe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pinkham MI,Barrett CJ

更新日期：2015-06-01 00:00:00

abstract：:1. Trophoblast invasion during embryo implantation in some aspects resembles tumour cell invasion but, unlike tumour cells, trophoblast cells are able to differentiate and establish a placenta. Because direct cell-cell communication is believed to be involved in growth control and differentiation, we have investigated...

journal_title：Clinical and experimental pharmacology & physiology

authors： Winterhager E,Reuss B,Hellmann P,Spray DC,Gruemmer R

更新日期：1996-12-01 00:00:00

abstract：:Sixteen stable asthmatics had the protective effects of inhaled fenoterol (200 micrograms) and inhaled ipratropium bromide (60 micrograms) against standardized histamine inhalation tests at 1 h examined in a randomized double blind fashion. There was no significant difference in the baseline forced expired volume in 1...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ruffin RE,Meki M,Alpers JH

更新日期：1987-02-01 00:00:00

abstract：:1. Subacute administration of dyflos to guinea-pigs (1.2 mg/kg, s.c., daily for 10 days) led to the development of subsensitivity to carbachol in the ileum but not in the electrically stimulated left atrium. 2. Atria from dyflos-pretreated animals became supersensitive to acetylcholine but the ileum became subsensitiv...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mitchelson F,O'Shea RA

更新日期：1977-11-01 00:00:00

abstract：:1. Structural changes in resistance vessels were studied sequentially (a) by hindquarter perfusion and (b) by planimetry of renal arterioles less than or equal to 20 micrometers radius, for 10 weeks during development of DOCA (deoxycorticosterone acetate)/salt hypertension in uninephrectomized rats and 5 weeks after c...

journal_title：Clinical and experimental pharmacology & physiology

authors： Vial JH,Yong AC,Boyd GW

更新日期：1982-05-01 00:00:00

abstract：:An efficient animal model is fundamental for studies on the underlying mechanisms of constrictive pericarditis (CP). A novel CP rat model was established by pericardial injection composing of lipopolysaccharides (LPS) and talcum powder without thoracotomy. Pathological changes were confirmed by histological staining. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Qiao W,Xiao YJ,Wang X,Sun LJ,Chen YX,Ren WD

更新日期：2020-12-21 00:00:00

abstract：:1. In order to explore the mechanisms responsible for the hypernoradrenergic innervation of the vasculature in the spontaneously hypertensive rat (SHR) the tissue content of nerve growth factor messenger ribonucleic acid (NGFmRNA) was examined. 2. The concentration of NGFmRNA was markedly elevated in mesenteric veins ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Falckh PH,Harkin LA,Head RJ

更新日期：1992-08-01 00:00:00

abstract：:1. Endothelial dysfunction is seen in patients with essential hypertension or congestive heart failure (CHF). The present study aimed to evaluate the direct effect on endothelium- dependent vasodilation (EDV) of different pharmacological drugs commonly used in the treatment of these conditions. 2. Forearm blood flow (...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mühlen BV,Millgård J,Lind L

更新日期：2001-05-01 00:00:00

abstract：:1. Mechanisms involved in the plasma extravasation observed following thermal injury of rat dorsal skin were investigated. 2. Heat applied to the dorsal skin of anaesthetized rats by a temperature-controlled skin heater (1 cm diameter) for 5 min induced temperature-dependent plasma protein extravasation at 48-48.5 deg...

journal_title：Clinical and experimental pharmacology & physiology

authors： Waller J,Siney L,Hoult JR,Brain SD

更新日期：1997-11-01 00:00:00

abstract：:Malignant tumours are a major cause of mortality in humans. Currently used therapeutic regimens have not improved survival rates of patients suffering from malignant tumours much because of their limited efficacy and side-effects. A therapeutic approach that uses Newcastle disease virus (NDV) represents an attractive ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhao L,Liu H

更新日期：2012-08-01 00:00:00

abstract：:Simultaneous measurements of smooth muscle membrane potential and tension were made from isolated pieces of rat tail artery. A single electrical stimulus to the perivascular nerves produced a transient contraction of the smooth muscle. The amplitude of the contraction was increased after removal of the endothelium. Th...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kotecha N,Neild TO

更新日期：1986-03-01 00:00:00

abstract：:Hypoxia-inducible factor-1 alpha (HIF-1α) and nuclear receptor related-1 (Nurr1) play pivotal roles in the development and survival of dopaminergic neurons, and deficiencies in these genes may be involved in Parkinson's disease (PD) pathogenesis. Recently, anthelminthic benzimidazoles were shown to promote HIF-1α tran...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kandil EA,Sayed RH,Ahmed LA,Abd El Fattah MA,El-Sayeh BM

更新日期：2019-12-01 00:00:00

abstract：:1. The calcineurin inhibitor cyclosporine is widely used to prevent allograft rejection after solid organ transplantation. It has a narrow therapeutic index and shows considerable interindividual differences in its pharmacokinetics. Interindividual differences in the activity and expression of the metabolising enzymes...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hu YF,Qiu W,Liu ZQ,Zhu LJ,Liu ZQ,Tu JH,Wang D,Li Z,He J,Zhong GP,Zhou G,Zhou HH

更新日期：2006-11-01 00:00:00

abstract：:1. The intravenous administration of nicergoline (5 mg) was followed by a rapid and sustained lowering of blood pressure; less rapid effects were bradycardia and an elevation of cardiac output. These delayed effects are consistent with an indirect action on the alpha-adrenoreceptors of the central nervous system. 2. F...

journal_title：Clinical and experimental pharmacology & physiology

authors： Boismare F,Lefrançois J

更新日期：1980-03-01 00:00:00

abstract：:The beta-receptor stimulant effects of Sm220Cl, dl-N-(1,1-dimethyl-3-phenylpropyl)-2-hydroxy-2-(3,4-dihydroxy-2-methoxyphenyl)ethylamine, and (-)-isoprenaline have been compared in isolated atrial (beta1) and tracheal (beta2) preparations from guinea-pigs and cats. 2. The compounds were also tested for their ability t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bohmer K,Raper C

更新日期：1977-07-01 00:00:00

abstract：:A high-salt diet in rats has been shown to result in enhanced vasoconstrictor and/or reduced vasodilator responses of isolated arteries to agonists. The present experiments were designed to investigate the effects of dietary salt on the responses of the pressurized mesenteric resistance artery of the dog to constricto...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sofola O,Knill A,Myers D,Hainsworth R,Drinkhill M

更新日期：2004-10-01 00:00:00