Determinants of smooth muscle sensitivity.

abstract：:The intrarenal renin-angiotensin system (RAS) plays a critical role in the pathogenesis and progression of hypertension and kidney disease. In angiotensin (Ang) II-dependent hypertension, collecting duct renin synthesis and secretion are stimulated despite suppression of juxtaglomerular (JG) renin. This effect is medi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gonzalez AA,Prieto MC

更新日期：2015-01-01 00:00:00

abstract：:1. Mast cells cultured from human peripheral blood have been used as a cell model for functional studies of human mast cells, particularly human lung mast cells. However, the beta-adrenoceptor subtype expressed by these cultured cells has not been identified. The aim of the present study was to characterize pharmacolo...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang XS,Lau HY

更新日期：2006-08-01 00:00:00

abstract：:1. Iron overload contributes to the pathogenesis of various diseases and directly induces tissue injury. In the present study, we investigated the relationship between heart and liver injury induced by iron overload and cellular endoplasmic reticulum (ER) stress to explore the molecular mechanism of iron overload-indu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lou LX,Geng B,Chen Y,Yu F,Zhao J,Tang CS

更新日期：2009-07-01 00:00:00

abstract：:1. Hyperhomocysteinaemia (HHcy) is associated with endothelial dysfunction and has been recognized as a risk factor of cardiovascular disease. The present study aimed to investigate the effect of homocysteine (Hcy) on endothelial function in vivo and in vitro, and the underlying signalling pathways. 2. The HHcy animal...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yan TT,Li Q,Zhang XH,Wu WK,Sun J,Li L,Zhang Q,Tan HM

更新日期：2010-11-01 00:00:00

abstract：:1. Angiotensin (Ang)II is involved in responses to hypovolaemia, such as sodium appetite and increase in blood pressure. Target areas subserving these responses for AngII include the cardiovascular system in the periphery and the circumventricular organs in the brain. 2. Conflicting data have been reported for the rol...

journal_title：Clinical and experimental pharmacology & physiology

authors： De Luca LA Jr,Sugawara AM,Menani JV

更新日期：2000-05-01 00:00:00

abstract：:1. Rapid ventricular rate (VR) and rhythm irregularity during atrial fibrillation (AF) impair cardiac performance. Although digoxin has been widely used in patients with AF, its efficacy for the control of VR and rhythm irregularity is unsatisfactory. Whether low-dose amiodarone is more effective remains unclear. 2. W...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tse HF,Lam YM,Lau CP,Cheung BM,Kumana CR

更新日期：2001-05-01 00:00:00

abstract：:Drug-induced phospholipidosis (DIPL) is characterized by phospholipid storage in the lysosomes of affected tissues. Many severe effects and toxicities have been linked to DIPL. The aim of this study was to determine whether the endogenous opioid system is involved in chloroquine-induced phospholipidosis. The effect of...

journal_title：Clinical and experimental pharmacology & physiology

authors： Malek MR,Ahmadian S,Dehpour AR,Ebrahim-Habibi A,Shafizadeh M,Kashani-Amin E

更新日期：2020-09-01 00:00:00

abstract：:Hepatic fibrosis is an outcome of chronic liver injury. Angiotensin II (ANG II) may play a role in the pathogenesis of hepatic fibrosis. Certain drugs such as ACE inhibitors, ANG II antagonists, and even statins could interfere with the renin angiotensin system and modulate its deleterious effects. This study was carr...

journal_title：Clinical and experimental pharmacology & physiology

authors： El-Ashmawy NE,El-Bahrawy HA,Shamloula MM,Ibrahim AO

更新日期：2015-09-01 00:00:00

abstract：:1. Intravenous endothelin-1 releases endothelium-derived relaxing factor (EDRF) and prostacyclin from the lungs, and substantial pulmonary clearance is claimed. Since these vaso-active substances could alter the haemodynamic effects of endothelin-1, the effects of boluses of endothelin-1 injected intravenously and int...

journal_title：Clinical and experimental pharmacology & physiology

authors： Roberts-Thomson P,McRitchie RJ,Cain MD,Chalmers JP

更新日期：1994-04-01 00:00:00

abstract：:1. Congenital long QT syndrome (LQTS) is a genetically heterogeneous disease. The aim of the present study was to identify the gene mutation in a Chinese family with LQTS and investigate the functional changes associated with the mutation. 2. Polymerase chain reaction and DNA sequencing were used to screen for the KCN...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang HT,Sun CF,Cui CC,Xue XL,Zhang AF,Li HB,Wang DQ,Shu J

更新日期：2009-08-01 00:00:00

abstract：:Both opiates and dopamine play important roles in learning and memory. Although synergistic action between these two neurotransmitters has been found, their functional roles remain unclear. Here, low dose morphine (2.5 mg/kg) and low dose dopamine receptor agonists (apomorphine 0.05 mg/kg; SKF38393 0.01 mg/kg; bromocr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chen Y,Fu Y,An Y,Cao J,Wang J,Zhang J

更新日期：2018-04-01 00:00:00

abstract：:1. Activation of bulbospinal neurons projecting from the C1 area of the rostral ventrolateral medulla evokes a pressor response. The nature of the neurotransmitters involved in mediating this response at spinal cord level has not been established. 2. Amino acid antagonists were introduced into the spinal subarachnoid ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mills EH,Minson JB,Pilowsky PM,Chalmers JP

更新日期：1988-02-01 00:00:00

abstract：:1. The most usual form of chronic hypoxia in humans is the intermittent hypoxia resulting from obstructive sleep apnoea (OSA). The OSA syndrome is a highly prevalent sleep breathing disorder that is considered an independent risk factor for hypertension and cardiovascular diseases. Endothelial dysfunction, oxidative s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Iturriaga R,Moya EA,Del Rio R

更新日期：2009-12-01 00:00:00

abstract：:1. Ion gradients across the cell membrane are important for proper cellular communication and homeostasis. With the exception of erythrocytes, chloride (Cl), one of the most important free anions in animal cells, is not distributed at thermodynamic equilibrium across the plasma membrane. The K-Cl cotransporter (COT), ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gagnon KB,Fyffe RE,Adragna NC,Lauf PK

更新日期：2007-07-01 00:00:00

abstract：:1. The effects of left ventricular repair (LVR) surgery for ischaemic or dilated cardiomyopathy are not fully understood. The development of a proper animal model will help to resolve this issue. 2. The ischaemic cardiomyopathy (ICM) model used was as follows. Twenty-six rats developed ICM with a large akinetic left v...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nishina T,Miwa S,Yuasa S,Nishimura K,Komeda M

更新日期：2002-08-01 00:00:00

abstract：:Cellular senescence is a state of irreversible cell growth arrest. Increasing evidence suggests that cellular senescence contribute to tumour suppression in vivo. However, only a few anti-cancer drugs have been discovered to induce cellular senescence. Searching for new compounds which can inhibit cancer cell growth b...

journal_title：Clinical and experimental pharmacology & physiology

authors： Shang D,Wu Y,Ding Y,Lu Z,Shen Y,Zhu F,Liu H,Zhu C,Tu Z

更新日期：2018-05-01 00:00:00

abstract：:Following the potent efficacy of β-D-Mannuronic acid in a breast cancer murine model, we evaluated the efficacy of this novel non-steroidal anti-inflammatory drug in breast cancer patients in the present clinical trial. The study was an 8-week randomized, controlled, phase II clinical trial (IRCT: 2017012213739N7 (in ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kashefi S,Omranipour R,Mahmoodzadeh H,Ahmadi H,Alikhassi A,Hosseini M,Cuzzocrea S,Rehm BHA,Matsuo H,Mirshafiey A

更新日期：2019-06-01 00:00:00

abstract：:1. In the mammalian central nervous system, GABA is the main inhibitory neurotransmitter. GABA is a highly flexible molecule and, thus, can exist in many low-energy conformations. Conformationally restricted analogues of GABA have been used to help identify three major GABA receptors, termed GABAA, GABAB and GABAC rec...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chebib M,Johnston GA

更新日期：1999-11-01 00:00:00

abstract：:The inhibitory effect of morphine on intestine was observed by following the intestinal transit of a charcoal meal. This inhibitory effect of morphine was antagonized by naloxone. In addition, the inhibitory effect of morphine was also suppressed by prior administration of yohimbine and phentolamine. However, prazosin...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wong CL

更新日期：1984-11-01 00:00:00

abstract：:In the present study, we investigated whether mood stabilizer lithium (Li) protects against d-amphetamine (AMP)-induced mania-like behaviours via modulating the novel proinflammatory potential. Repeated treatment with AMP resulted in significant increases in proinflammatory cyclooxygenase-2 (COX-2) and indolemaine-2,3...

journal_title：Clinical and experimental pharmacology & physiology

authors： Phan DH,Shin EJ,Jeong JH,Tran HQ,Sharma N,Nguyen BT,Jung TW,Nah SY,Saito K,Nabeshima T,Kim HC

更新日期：2020-05-01 00:00:00

abstract：:1. The intravenous administration of nicergoline (5 mg) was followed by a rapid and sustained lowering of blood pressure; less rapid effects were bradycardia and an elevation of cardiac output. These delayed effects are consistent with an indirect action on the alpha-adrenoreceptors of the central nervous system. 2. F...

journal_title：Clinical and experimental pharmacology & physiology

authors： Boismare F,Lefrançois J

更新日期：1980-03-01 00:00:00

abstract：:1. Reactive oxygen species (ROS) are a diverse family of molecules that are produced throughout the vascular wall. Many ROS, such as the superoxide anion (*O2-) and hydrogen peroxide (H2O2), are now known to act as cellular signalling molecules within blood vessels. In particular, these molecules can exert powerful ef...

journal_title：Clinical and experimental pharmacology & physiology

authors： Paravicini TM,Sobey CG

更新日期：2003-11-01 00:00:00

abstract：:The present study aimed to investigate the relationship between normal serum concentrations of thyrotropin (TSH) and urinary incontinence (IU), urinary infections, and quality of life in old women. Euthyroid post-menopausal women without sarcopenia, estrogen replacement, emotional illness, and/or cancer were enrolled ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cuevas-Romero E,Sánchez-Cardiel A,Zamora-Gallegos AM,Cruz-Lumbreras R,Corona-Quintanilla DL,Castelán F,Martínez-Gómez M

更新日期：2017-12-01 00:00:00

abstract：:1. Levodopa markedly reduces parkinsonism during the first years of treatment. However, with continued therapy the response to levodopa becomes erratic and is complicated by involuntary movements. To improve the therapy of parkinsonism, the challenge is to understand why fluctuations in response develop and, once deve...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nutt JG

更新日期：1995-11-01 00:00:00

abstract：:Hypoxia-inducible factor-1 alpha (HIF-1α) and nuclear receptor related-1 (Nurr1) play pivotal roles in the development and survival of dopaminergic neurons, and deficiencies in these genes may be involved in Parkinson's disease (PD) pathogenesis. Recently, anthelminthic benzimidazoles were shown to promote HIF-1α tran...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kandil EA,Sayed RH,Ahmed LA,Abd El Fattah MA,El-Sayeh BM

更新日期：2019-12-01 00:00:00

abstract：:1. Regulatory T cells (T(reg)) and cytotoxic T cells (CTL) are involved in various immune diseases. However, the prognostic impact of T(reg) and CTL in patients with myeroperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (MPO-ANCA-GN) is not well known. Therefore, in the present study, we e...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yoshimura J,Fukami K,Koike K,Nagano M,Matsumoto T,Iwatani R,Kusumoto T,Hazama T,Ueda S,Adachi H,Hirai Y,Takasu K,Ohshima K,Yamagishi S,Okuda S

更新日期：2010-09-01 00:00:00

abstract：:1. The present study examined whether or not cilostazol reduces the myocardial infarct size, and investigated its mechanism in a rabbit model of myocardial infarction. 2. Japanese white rabbits underwent 30 min of coronary occlusion, followed by 48 h of reperfusion. Cilostazol (1 and 5 mg/kg) or vehicle was given intr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bai Y,Muqier,Murakami H,Iwasa M,Sumi S,Yamada Y,Ushikoshi H,Aoyama T,Nishigaki K,Takemura G,Uno B,Minatoguchi S

更新日期：2011-10-01 00:00:00

abstract：:1. We have examined the question asked in the title by studying: the carotid baroreceptor reflex in man with a variable-pressure neck chamber; the carotid baroreceptor reflex in conscious rabbits with a variable-pressure capsule around the carotid bifurcation; and the barorecptor-heart rate reflex. 2. At rest, the ass...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ludbrook J,Mancia G,Zanchetti A

更新日期：1980-09-01 00:00:00

abstract：:1. Amino acid neurotransmitters are critical for controlling the activity of most central neurons, including sympathetic preganglionic neurons (SPN), the spinal cord neurons involved in controlling blood pressure and other autonomic functions. 2. In studies reviewed here, SPN were identified either by retrograde traci...

journal_title：Clinical and experimental pharmacology & physiology

authors： Llewellyn-Smith IJ

更新日期：2002-05-01 00:00:00

abstract：:1. The diffusional permeability of collecting ducts to 22Na+ and 36Cl- was measured in rat papillae in vitro. 2. The permeability of the collecting duct to 36Cl- was 0.72 (s.e.m. = 0.01; n = 356) microns/sec which was significantly higher than the value of 0.51 (s.e.m. = 0.01; n = 356) microns/sec measured for 22Na+. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morgan T,Ray C

更新日期：1982-11-01 00:00:00