Tight glycemic control in the ICU - is the earth flat?

abstract：INTRODUCTION:Although effective strategies are available for the management of chronic hypertension, less is known about treating patients with acute, severe elevations in blood pressure. Using data from the European registry for Studying the Treatment of Acute hyperTension (Euro-STAT), we sought to evaluate 'real-life...

journal_title：Critical care (London, England)

authors： Vuylsteke A,Vincent JL,de La Garanderie DP,Anderson FA,Emery L,Wyman A,Rushton-Smith S,Gore JM,Euro-STAT Investigators.

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Ventilation according to the open lung concept (OLC) consists of recruitment maneuvers, followed by low tidal volume and high positive end-expiratory pressure, aiming at minimizing atelectasis. The minimization of atelectasis reduces the right ventricular (RV) afterload, but the increased intrathoracic pre...

journal_title：Critical care (London, England)

authors： Miranda DR,Klompe L,Cademartiri F,Haitsma JJ,Palumbo A,Takkenberg JJ,Lachmann B,Bogers AJ,Gommers D

更新日期：2006-01-01 00:00:00

abstract：:Sepsis and septic shock are the leading causes of acute renal failure, multiple organ system dysfunction, and death in the intensive care unit. The pathogenesis of sepsis is complex and comprises a mosaic of interconnected pathways. Several attempts to improve patient outcomes by targeting specific components of this ...

journal_title：Critical care (London, England)

authors： Venkataraman R,Subramanian S,Kellum JA

更新日期：2003-04-01 00:00:00

abstract：INTRODUCTION:Identification of bacterial infections is crucial if treatment is to be initiated early and antibiotics used rationally. The primary objective of this study was to test the efficiency of procalcitonin (PCT) in identifying bacterial/parasitic episodes among febrile adult patients presenting to an emergency ...

journal_title：Critical care (London, England)

authors： Hausfater P,Juillien G,Madonna-Py B,Haroche J,Bernard M,Riou B

更新日期：2007-01-01 00:00:00

abstract：:The present review introduces the notion of statistical power and the hazard of under-powered studies. The problem of how to calculate an ideal sample size is also discussed within the context of factors that affect power, and specific methods for the calculation of sample size are presented for two common scenarios, ...

journal_title：Critical care (London, England)

authors： Whitley E,Ball J

更新日期：2002-08-01 00:00:00

abstract：:Until relatively recently, critical illness was considered as a separate entity and the intensive care unit (ICU), often a little cut-off from other areas of the hospital, was in many cases used as a last resort for patients so severely ill that it was no longer possible to care for them on the general ward. However, ...

journal_title：Critical care (London, England)

authors： Vincent JL

更新日期：2019-06-14 00:00:00

abstract：:Novel insights into the metabolic alterations of critical illness were published in Critical Care in 2009. The association between early hypoglycaemia/high glycemic variability and poor outcome was confirmed. Improvements in the understanding of the pathophysiological mechanisms of stress hyperglycemia and potential p...

journal_title：Critical care (London, England)

authors： Huberlant V,Preiser JC

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Dehydroepiandrosterone (DHEA) improves survival after trauma and sepsis, while mechanisms of action are not yet fully understood. Therefore, we investigated the influence of DHEA on local cytokine expression in a two-hit model. METHODS:Male NMRI mice were subjected to femur fracture/hemorrhagic shock and ...

journal_title：Critical care (London, England)

authors： Barkhausen T,Hildebrand F,Krettek C,van Griensven M

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation occurs frequently in patients following cardiac surgery and can be a cause of increased morbidity and mortality. The use of dexmedetomidine to prevent atrial fibrillation is unclear. The present study was designed to evaluate the effect of dexmedetomidine sedation on the incidence of atri...

journal_title：Critical care (London, England)

authors： Liu X,Zhang K,Wang W,Xie G,Fang X

更新日期：2016-09-21 00:00:00

abstract：BACKGROUND:Accurate prediction of delirium in the intensive care unit (ICU) may facilitate efficient use of early preventive strategies and stratification of ICU patients by delirium risk in clinical research, but the optimal delirium prediction model to use is unclear. We compared the predictive performance and user c...

journal_title：Critical care (London, England)

authors： Wassenaar A,Schoonhoven L,Devlin JW,van Haren FMP,Slooter AJC,Jorens PG,van der Jagt M,Simons KS,Egerod I,Burry LD,Beishuizen A,Matos J,Donders ART,Pickkers P,van den Boogaard M

更新日期：2018-05-05 00:00:00

abstract：INTRODUCTION:Severe acute pancreatitis (SAP) requiring admission to a critical care unit is associated with high mortality and long lengths of stay. We describe the case mix, outcome, and activity of admissions with SAP who were identified from a high-quality clinical database. METHODS:We conducted a secondary analysi...

journal_title：Critical care (London, England)

authors： Harrison DA,D'Amico G,Singer M

更新日期：2007-01-01 00:00:00

abstract：:The European Society of Intensive Care Medicine Annual Congress offers the opportunity for basic scientists and clinicians to share recent findings. Apart from the large number of free communications, several sessions of the congress were dedicated to state-of-the-art tutorials given by established speakers. The areas...

journal_title：Critical care (London, England)

authors： Preiser JC

更新日期：2001-12-01 00:00:00

abstract：INTRODUCTION:Despite recent modifications, the clinical definition of the acute respiratory distress syndrome (ARDS) remains non-specific, leading to under-diagnosis and under-treatment. This study was designed to test the hypothesis that a biomarker panel would be useful for biologic confirmation of the clinical diagn...

journal_title：Critical care (London, England)

authors： Ware LB,Koyama T,Zhao Z,Janz DR,Wickersham N,Bernard GR,May AK,Calfee CS,Matthay MA

更新日期：2013-10-24 00:00:00

abstract：INTRODUCTION:Hypoxemia and high fractions of inspired oxygen (FiO2) are concerns in critically ill patients. An automated FiO2 controller based on continuous oxygen saturation (SpO2) measurement was tested. Two different SpO2-FiO2 feedback open loops, designed to react differently based on the level of hypoxemia, were ...

journal_title：Critical care (London, England)

authors： Saihi K,Richard JC,Gonin X,Krüger T,Dojat M,Brochard L

更新日期：2014-02-19 00:00:00

abstract：INTRODUCTION:This small observational study was motivated by our belief that scaling the tidal volume in mechanically ventilated patients to the size of the injured lung is safer and more 'physiologic' than scaling it to predicted body weight, i.e. its size before it was injured. We defined Total Lung Capacity (TLC) as...

journal_title：Critical care (London, England)

authors： Mattingley JS,Holets SR,Oeckler RA,Stroetz RW,Buck CF,Hubmayr RD

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Impaired skeletal muscle function has important clinical outcome implications for survivors of critical illness. Previous studies employing volitional manual muscle testing for diagnosing intensive care unit-acquired weakness (ICU-AW) during the early stages of critical illness have only provided limited d...

journal_title：Critical care (London, England)

authors： Connolly BA,Jones GD,Curtis AA,Murphy PB,Douiri A,Hopkinson NS,Polkey MI,Moxham J,Hart N

更新日期：2013-10-10 00:00:00

abstract：BACKGROUND:Burnout has gained increasing attention worldwide; however, there is a lack of relevant research in China. This study investigated the prevalence and factors associated with burnout in physicians of the intensive care unit (ICU) in mainland China. METHODS:This cross-sectional multicenter study included crit...

journal_title：Critical care (London, England)

authors： Wang J,Hu B,Peng Z,Song H,Cai S,Rao X,Li L,Li J

更新日期：2021-01-05 00:00:00

abstract：INTRODUCTION:Patients in intensive care units (ICUs) often receive sedation for prolonged periods. In order to better understand the impact of sub-optimal sedation practice on outcomes, we performed a systematic review, including observational studies and controlled trials which were conducted in sedated patients in th...

journal_title：Critical care (London, England)

authors： Jackson DL,Proudfoot CW,Cann KF,Walsh T

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Fluid responsiveness prediction is difficult in spontaneously breathing patients. Because the swings in intrathoracic pressure are minor during spontaneous breathing, dynamic parameters like pulse pressure variation (PPV) and systolic pressure variation (SPV) are usually small. We hypothesized that during ...

journal_title：Critical care (London, England)

authors： Dahl MK,Vistisen ST,Koefoed-Nielsen J,Larsson A

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:To investigate whether respiratory variation of inferior vena cava diameter (cIVC) predict fluid responsiveness in spontaneously breathing patients with acute circulatory failure (ACF). METHODS:Forty patients with ACF and spontaneous breathing were included. Response to fluid challenge was defined as a 15...

journal_title：Critical care (London, England)

authors： Muller L,Bobbia X,Toumi M,Louart G,Molinari N,Ragonnet B,Quintard H,Leone M,Zoric L,Lefrant JY,AzuRea group.

更新日期：2012-10-08 00:00:00

abstract：BACKGROUND:Recurrent delivery of tidal mechanical energy (ME) inflicts ventilator-induced lung injury (VILI) when stress and strain exceed the limits of tissue tolerance. Mechanical power (MP) is the mathematical description of the ME delivered to the respiratory system over time. It is unknown how ME relates to underl...

journal_title：Critical care (London, England)

authors： Kneyber MCJ,Ilia S,Koopman AA,van Schelven P,van Dijk J,Burgerhof JGM,Markhorst DG,Blokpoel RGT

更新日期：2020-10-07 00:00:00

abstract：:Prediction of ventilation weaning outcome in children is important, as unsuccessful extubation increases both morbidity and mortality. Adult weaning criteria are poor predictors of weaning outcome in children for several possible reasons: the length of mechanical ventilation is generally much shorter, and the weaning ...

journal_title：Critical care (London, England)

authors： Schindler MB

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Calcium release-activated calcium (CRAC) channel inhibitors stabilize the pulmonary endothelium and block proinflammatory cytokine release, potentially mitigating respiratory complications observed in patients with COVID-19. This study aimed to investigate the safety and efficacy of Auxora, a novel, intraven...

journal_title：Critical care (London, England)

authors： Miller J,Bruen C,Schnaus M,Zhang J,Ali S,Lind A,Stoecker Z,Stauderman K,Hebbar S

更新日期：2020-08-14 00:00:00

abstract：INTRODUCTION:Functional assessment of arterial load by dynamic arterial elastance (Eadyn), defined as the ratio between pulse pressure variation (PPV) and stroke volume variation (SVV), has recently been shown to predict the arterial pressure response to volume expansion (VE) in hypotensive, preload-dependent patients....

journal_title：Critical care (London, England)

authors： García MI,Romero MG,Cano AG,Aya HD,Rhodes A,Grounds RM,Cecconi M

更新日期：2014-11-19 00:00:00

abstract：:The diagnosis of patients presenting to the emergency department with acute heart failure (AHF) is challenging due to the similarity of AHF symptoms to other conditions such as chronic obstructive pulmonary disease and pneumonia. Additionally, because AHF is most common in an older population, the presentation of coex...

journal_title：Critical care (London, England)

authors： Peacock WF,Cannon CM,Singer AJ,Hiestand BC

更新日期：2015-11-10 00:00:00

abstract：BACKGROUND:Intensive care units (ICUs) face financial, bed management, and staffing constraints. Detailed data covering all aspects of patients' journeys into and through intensive care are now collected and stored in electronic health records: machine learning has been used to analyse such data in order to provide dec...

journal_title：Critical care (London, England)

authors： Shillan D,Sterne JAC,Champneys A,Gibbison B

更新日期：2019-08-22 00:00:00

abstract：BACKGROUND:Prognostication in out-of-hospital cardiac arrest (OHCA) survivors is often difficult. Recent studies have shown the predictive ability of bispectral index (BIS) monitoring to assist with early neuroprognostication. The aim of this study was to investigate whether characteristics of BIS values equal to zero ...

journal_title：Critical care (London, England)

authors： Eertmans W,Genbrugge C,Haesevoets G,Dens J,Boer W,Jans F,De Deyne C

更新日期：2017-08-22 00:00:00

abstract：BACKGROUND:Frailty is a state of vulnerability to poor resolution of homeostasis after a stressor event and is strongly associated with adverse outcomes. Therefore, the assessment of frailty may be an essential part of evaluation in any healthcare encounter that might result in an escalation of care. The purpose of the...

journal_title：Critical care (London, England)

authors： So RKL,Bannard-Smith J,Subbe CP,Jones DA,van Rosmalen J,Lighthall GK,METHOD study investigators.

更新日期：2018-09-22 00:00:00

abstract：BACKGROUND:The plasma colloid osmotic pressure (COP) plays a major role in transcapillary fluid balance. There is no information on plasma COP of healthy infants beyond the first post-natal week. The normal COP in healthy adult subjects (25 mmHg) is currently also applied as a reference value for healthy infants. This ...

journal_title：Critical care (London, England)

authors： Sussmane JB,de Soto M,Torbati D

更新日期：2001-10-01 00:00:00

abstract：INTRODUCTION:Respiratory viruses are increasingly recognized as significant etiologies of pneumonia among hospitalized patients. Advanced technologies using multiplex molecular assays and polymerase-chain reaction increase the ability to identify viral pathogens and may ultimately impact antibacterial use. METHOD:This...

journal_title：Critical care (London, England)

authors： Crotty MP,Meyers S,Hampton N,Bledsoe S,Ritchie DJ,Buller RS,Storch GA,Kollef MH,Micek ST

更新日期：2015-11-18 00:00:00