当前位置： SCI文献检索 > Pediatric Rheumatology期刊下所有文献 > Tuberculin skin test and ELISPOT/T. SPOT.TB in children and adolescents with juvenile idiopathic arthritis.

Tuberculin skin test and ELISPOT/T. SPOT.TB in children and adolescents with juvenile idiopathic arthritis.

Abstract：

BACKGROUND:There are controversies regarding the accuracy of the tuberculin skin test (TST) and methods based on the production of interferon gamma by sensitized T cells for the diagnosis of latent tuberculosis infection (LTBI) in pediatrics and immunosuppressed patients. Our objectives are to study TST and ELISPOT/T. SPOT.TB in the diagnosis of LTBI in children and adolescents with JIA undergoing methotrexate, the correlation between both and the sensitivity and specificity of T. SPOT.TB. METHODS:This is an observational prospective longitudinal study in which children and adolescents with JIA undergoing methotrexate therapy were assessed for clinical and epidemiological data for LTBI, in addition to performing TST and T. SPOT.TB at baseline and after 3 and 12months. RESULTS:There were 24 patients. The prevalence of LTBI at inclusion was 20.8%, the incidence after initiation of immunosuppressions 26.3% and the prevalence at the end of the study 41.6%. Epidemiological history positive for TB showed a relative risk of 2.0 for the development of LTBI. Only 2 patients had positive T. SPOT.TB but only in one it was useful for detecting early LTBI. T. SPOT.TB presented a sensitivity of 10%, specificity of 92.8%, and low correlation with TST. No patient developed TB disease at a mean follow-up of 47months. CONCLUSIONS:We found a high prevalence of ILTB that doubled with immunosuppression and that epidemiological history was an important relative risk. T. SPOT.TB showed low sensitivity and high specificity, and no superiority over TST. There was low agreement and little influence of immunosuppression on the results of both tests.

journal_name

Pediatr Rheumatol Online J

journal_title

Pediatric rheumatology online journal

authors

Sztajnbok F,Boechat NL,Ribeiro SB,Oliveira SK,Sztajnbok DC,Sant'Anna CC

doi

10.1186/1546-0096-12-17

subject

Has Abstract

pub_date

2014-05-22 00:00:00

pages

17

issn

1546-0096

pii

1546-0096-12-17

journal_volume

12

pub_type

杂志文章

相关文献

Pediatric Rheumatology文献大全
  • Efficacy and safety of intraarticular corticosteroid injections in adolescents with juvenile idiopathic arthritis in the temporomandibular joint: a Norwegian 2-year prospective multicenter pilot study.

    abstract：BACKGROUND:Intraarticular corticosteroids (IACs) have been used to treat temporomandibular joint (TMJ) arthritis. However, prospective clinical studies with magnetic resonance imaging (MRI) scoring are lacking. The aim of this study was to examine efficacy and safety of a single IAC in the TMJ in adolescents with juven...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/s12969-020-00464-3

    authors： Frid P,Augdal TA,Larheim TA,Halbig J,Rypdal V,Songstad NT,Rosén A,Tylleskär KB,Berstad JR,Flatø B,Stoustrup P,Rosendahl K,Kirkhus E,Nordal E

    更新日期：2020-10-01 00:00:00

  • Prosthetic temporomandibular joint reconstruction in a cohort of adolescent females with juvenile idiopathic arthritis.

    abstract：BACKGROUND:Temporomandibular joint (TMJ) arthritis and involvement is commonly seen in Juvenile Idiopathic Arthritis (JIA). Therapy includes conservative measures, but also includes intraarticular corticosteroid injections (IASI) and systemic immunosuppressive therapy. Despite aggressive medical therapy, some patients ...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/s12969-020-00453-6

    authors： Lypka M,Shah K,Jones J

    更新日期：2020-09-04 00:00:00

  • Development and pilot testing of the treatment and education approach for childhood-onset lupus (TEACH): a cognitive behavioral treatment.

    abstract：BACKGROUND:To develop and test the feasibility and initial effectiveness of the Treatment and Education Approach for Childhood-onset Lupus (TEACH) protocol, a 6-session cognitive behavioral therapy (CBT) intervention for adolescents and young adults (AYA) with childhood-onset systemic lupus erythematosus (cSLE). METHO...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/s12969-019-0307-8

    authors： Cunningham NR,Fussner LM,Moorman E,Avar Aydin PO,Brunner HI,Kashikar-Zuck S

    更新日期：2019-02-18 00:00:00

  • Development of practice and consensus-based strategies including a treat-to-target approach for the management of moderate and severe juvenile dermatomyositis in Germany and Austria.

    abstract：BACKGROUND:Juvenile dermatomyositis (JDM) is the most common inflammatory myopathy in childhood and a major cause of morbidity among children with pediatric rheumatic diseases. The management of JDM is very heterogeneous. The JDM working group of the Society for Pediatric Rheumatology (GKJR) aims to define consensus- a...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/s12969-018-0257-6

    authors： Hinze CH,Oommen PT,Dressler F,Urban A,Weller-Heinemann F,Speth F,Lainka E,Brunner J,Fesq H,Foell D,Müller-Felber W,Neudorf U,Rietschel C,Schwarz T,Schara U,Haas JP

    更新日期：2018-06-25 00:00:00

  • Agreement between physicians and parents in rating functional ability of children with juvenile idiopathic arthritis.

    abstract：OBJECTIVE:To investigate concordance between physicians and parents in rating the degree of functional ability of children with juvenile idiopathic arthritis (JIA). METHODS:The attending physician and a parent were asked to rate independently the level of physical functioning of 155 patients with disease duration >/= ...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/1546-0096-5-23

    authors： Palmisani E,Solari N,Pistorio A,Ruperto N,Malattia C,Viola S,Buoncompagni A,Loy A,Martini A,Ravelli A

    更新日期：2007-12-11 00:00:00

  • The pediatric rheumatology objective structured clinical examination: progressing from a homegrown effort toward a reliable and valid national formative assessment.

    abstract：BACKGROUND:Of 37 pediatric rheumatology fellowship training programs in the United States, many have three or fewer fellows at a given time, making large-scale assessment of fellow performance difficult. An objective structured clinical examination (OSCE) is a scenario-based simulation method that assesses individual p...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/s12969-019-0308-7

    authors： Curran ML,Martin EE,Thomas EC,Singh R,Armana S,Kauser A,Zaheer EA,Sherry DD

    更新日期：2019-02-08 00:00:00

  • The safety of live-attenuated vaccines in patients using IL-1 or IL-6 blockade: an international survey.

    abstract：BACKGROUND:Withholding live-attenuated vaccines in patients using interleukin (IL)-1 or IL-6 blocking agents is recommended by guidelines for both pediatric and adult rheumatic diseases, since there is a risk of infection in an immune suppressed host. However, this has never been studied. This retrospective, multicente...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章,多中心研究

    doi：10.1186/s12969-018-0235-z

    authors： Jeyaratnam J,Ter Haar NM,Lachmann HJ,Kasapcopur O,Ombrello AK,Rigante D,Dedeoglu F,Baris EH,Vastert SJ,Wulffraat NM,Frenkel J

    更新日期：2018-03-21 00:00:00

  • Towards a new set of classification criteria for PFAPA syndrome.

    abstract：BACKGROUND:Diagnosis of Periodic Fever, Aphthous stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) syndrome is currently based on the modified Marshall's criteria, but no validated evidence based classification criteria for PFAPA has been established so far. METHODS:A multistep process, based on the Delphi and Nom...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/s12969-018-0277-2

    authors： Vanoni F,Caorsi R,Aeby S,Cochard M,Antón J,Berg S,Brik R,Dolezalova P,Koné-Paut I,Neven B,Ozen S,Pillet P,Stojanov S,Wouters C,Gattorno M,Hofer M

    更新日期：2018-09-21 00:00:00

  • Disease course and treatment effects of a JAK inhibitor in a patient with CANDLE syndrome.

    abstract：BACKGROUND:CANDLE syndrome (an acronym for Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature) is a recently described rare autosomal recessive disorder charaterized by systemic autoinflammation. Clinical manifestations include presentation in the first year of life, episodes of fever ...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/s12969-019-0322-9

    authors： Boyadzhiev M,Marinov L,Boyadzhiev V,Iotova V,Aksentijevich I,Hambleton S

    更新日期：2019-05-02 00:00:00

  • Damage index in childhood-onset systemic lupus erythematosus in Egypt.

    abstract：BACKGROUND:To investigate the prevalence of cumulative organ damage among Egyptian children with juvenile-onset systemic lupus erythematosus (jSLE) and the relationships between the organ damage and the demographic data, clinical variables, and disease activity. METHODS:A total of 148 patients with jSLE have been foll...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/1546-0096-9-36

    authors： Salah S,Lotfy HM,Mokbel AN,Kaddah AM,Fahmy N

    更新日期：2011-12-09 00:00:00

  • Health-related quality of life during early aggressive treatment in patients with polyarticular juvenile idiopathic arthritis: results from randomized controlled trial.

    abstract：BACKGROUND:Juvenile Idiopathic Arthritis (JIA) may cause significant impairment in health-related quality of life (HrQoL), despite effective therapies. The aim of this study was to assess HrQoL during first-year treatment in patients with new-onset polyarticular JIA, and to compare treatment strategies. METHODS:In ACU...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/s12969-019-0370-1

    authors： Tarkiainen M,Tynjälä P,Vähäsalo P,Kröger L,Aalto K,Lahdenne P

    更新日期：2019-12-16 00:00:00

  • Early combination therapy with etanercept and methotrexate in JIA patients shortens the time to reach an inactive disease state and remission: results of a double-blind placebo-controlled trial.

    abstract：BACKGROUND:Remission is the primary objective of treating juvenile idiopathic arthritis (JIA). It is still debatable whether early intensive treatment is superior in terms of earlier achievement of remission. The aim of this study was to evaluate the effectiveness of early etanercept+methotrexate (ETA+MTX) combination ...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/s12969-020-00488-9

    authors： Alexeeva E,Horneff G,Dvoryakovskaya T,Denisova R,Nikishina I,Zholobova E,Malievskiy V,Santalova G,Stadler E,Balykova L,Spivakovskiy Y,Kriulin I,Alshevskaya A,Moskalev A

    更新日期：2021-01-06 00:00:00

  • Familial Takayasu arteritis - a pediatric case and a review of the literature.

    abstract：: Takayasu arteritis (TA) is a rare chronic inflammatory disease of the aorta and its major branches. It is seen predominantly in females during the second and third decades of life, although it can occur in childhood. The aetiology of TA remains unknown. To date, familial cases of TA have been considered rare; however...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/1546-0096-9-6

    authors： Morishita KA,Rosendahl K,Brogan PA

    更新日期：2011-02-02 00:00:00

  • Development of neoplasms in pediatric patients with rheumatic disease exposed to anti-tumor necrosis factor therapies: a single Centre retrospective study.

    abstract：BACKGROUND:Anti-TNF (Tumor necrosis factor) therapy is effective in treating pediatric patients with refractory rheumatic disease. There is however a concern that anti-TNF usage may increase the risk of malignancy. Reports on specific types of malignancy in this patient population have been emerging over the past decad...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/s12969-018-0233-1

    authors： Okihiro A,Hasija R,Fung L,Cameron B,Feldman BM,Laxer R,Schneider R,Silverman E,Spiegel L,Yeung RSM,Tse SML

    更新日期：2018-03-14 00:00:00

  • Bacterial infections in a pediatric cohort of primary and acquired complement deficiencies.

    abstract：BACKGROUND:Acquired complement deficiency can occur in the setting of autoimmune syndromes, such as systemic lupus erythematosus (SLE), with very low or, occasionally, undetectable C3 levels. Based on inherited complement defects, patients with transiently low complement may be at similar risk for serious bacterial inf...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/s12969-020-00467-0

    authors： Al-Shaikhly T,Hayward K,Basiaga ML,Allenspach EJ

    更新日期：2020-09-24 00:00:00

  • Association of juvenile idiopathic arthritis with PTPN22 rs2476601 is specific to females in a Greek population.

    abstract：BACKGROUND:Juvenile idiopathic arthritis (JIA) is an autoimmune disease characterized by persistent chronic arthritis. Disease risk is believed to be influenced by both genetic and environmental factors. It is well established that the PTPN22 single nucleotide polymorphism (SNP) rs2476601 is associated with JIA suscept...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章,多中心研究

    doi：10.1186/s12969-016-0087-3

    authors： Goulielmos GN,Chiaroni-Clarke RC,Dimopoulou DG,Zervou MI,Trachana M,Pratsidou-Gertsi P,Garyfallos A,Ellis JA

    更新日期：2016-04-23 00:00:00

  • Choroidal vascularity index as a biomarker of systemic inflammation in childhood Polyarteritis Nodosa and adenosine deaminase-2 deficiency.

    abstract：BACKGROUND/PURPOSE:To assess EDI-OCT (enhanced depth imaging optical coherence tomography) of choroid for inflammatory signs in children with polyarteritis nodosa (PAN) and adenosine deaminase-2 deficiency (DADA-2). METHODS:In this cross-sectional study conducted between June 2017 and September 2018, we evaluated chil...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/s12969-020-0417-3

    authors： Baytaroğlu A,Kadayifçilar S,Ağin A,Deliktaş Ö,Demir S,Bilginer Y,Karakaya J,Özen S,Eldem B

    更新日期：2020-04-03 00:00:00

  • Kawasaki Disease in the neonate: case report and literature review.

    abstract：BACKGROUND:Kawasaki Disease (KD), the leading cause of acquired heart disease in children in the developed world, is extremely rare in neonates. We present a case of incomplete KD in a neonate and a review of the literature on neonatal KD. CASE PRESENTATION:A previously healthy full term 15 day old Caucasian male with...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章,评审

    doi：10.1186/s12969-018-0263-8

    authors： Altammar F,Lang B

    更新日期：2018-07-03 00:00:00

  • Predictors for intravenous immunoglobulin resistance and coronary artery lesions in Kawasaki disease.

    abstract：BACKGROUND:To assess the predictors for intravenous immunoglobulin (IVIG) resistance and coronary artery lesions (CALs) in Kawasaki disease (KD). METHODS:A total of 560 KD patients were reviewed retrospectively, including 410 complete KD (cKD) and 150 incomplete KD (iKD) patients. The laboratory data were compared bet...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/s12969-017-0149-1

    authors： Xie T,Wang Y,Fu S,Wang W,Xie C,Zhang Y,Gong F

    更新日期：2017-03-21 00:00:00

  • MRI thresholds for discrimination between normal and mild temporomandibular joint involvement in juvenile idiopathic arthritis.

    abstract：BACKGROUND:Currently there is no consensus agreement on the degree of enhancement in normal temporomandibular joints (TMJ) in children, which makes it difficult for clinicians to distinguish between the presence/absence of mild synovitis. Quantitative measurements of synovial and condylar enhancement may be useful addi...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/s12969-015-0051-7

    authors： Ma GM,Amirabadi A,Inarejos E,Tolend M,Stimec J,Moineddin R,Spiegel L,Doria AS

    更新日期：2015-12-01 00:00:00

  • Protective parents and permissive children: what qualitative interviews with parents and children can tell us about the feasibility of juvenile idiopathic arthritis trials.

    abstract：BACKGROUND:Patient recruitment can be very challenging in paediatric studies, especially in relatively uncommon conditions, such as juvenile idiopathic arthritis (JIA). However, involving children and young people (CYP) in the design of such trials could promise a more rapid trajectory towards making evidence-based tre...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/s12969-018-0293-2

    authors： Sherratt FC,Roper L,Stones SR,McErlane F,Peak M,Beresford MW,Foster H,Ramanan AV,Rooney M,Baildam E,Young B

    更新日期：2018-12-04 00:00:00

  • Establishing percentile charts for hip joint capsule and synovial cavity thickness in apparently healthy children.

    abstract：BACKGROUND:The usefulness of musculoskeletal ultrasonography (MSUS) in paediatric population is limited by lack of reference values. One of such parameters is hip joint capsule thickness, postulated as an early measure for synovitis. However, the joint capsule is hardly a distinguished structure from slit synovial cavi...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/s12969-017-0136-6

    authors： Żuber Z,Owczarek A,Sobczyk M,Migas-Majoch A,Turowska-Heydel D,Sternal A,Michalczak J,Chudek J

    更新日期：2017-01-31 00:00:00

  • Treating juvenile idiopathic arthritis to target: what is the optimal target definition to reach all goals?

    abstract：:In 2018, an international Task Force formulated recommendations for treating Juvenile Idiopathic Arthritis (JIA) to target. The Task Force has not yet resolved three issues. The first issue is the lack of a single "best" target. The Task Force decided not to recommend the use of a specific instrument to assess inactiv...

    journal_title：Pediatric rheumatology online journal

    pub_type： 信件

    doi：10.1186/s12969-020-00428-7

    authors： Schoemaker CG,Swart JF,Wulffraat NM

    更新日期：2020-04-16 00:00:00

  • Radiographic damage in hands and wrists of patients with juvenile idiopathic arthritis after 29 years of disease duration.

    abstract：BACKGROUND:There are few studies on radiographic outcome after long-term disease duration in juvenile idiopathic arthritis (JIA). We wanted to evaluate 29-year radiographic outcome in hands/wrists and predictors of damage in patients with long-term active JIA. METHODS:Patients diagnosed from 1980 to 1985, who had acti...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/s12969-017-0151-7

    authors： Selvaag AM,Kirkhus E,Törnqvist L,Lilleby V,Aulie HA,Flatø B

    更新日期：2017-04-11 00:00:00

  • Being on the juvenile dermatomyositis rollercoaster: a qualitative study.

    abstract：BACKGROUND:Juvenile Dermatomyositis is a rare, potentially life-threatening condition with no known cure. There is no published literature capturing how children and young people feel about their condition, from their perspective. This study was therefore unique in that it asked children and young people what is it lik...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/s12969-019-0332-7

    authors： Livermore P,Gray S,Mulligan K,Stinson JN,Wedderburn LR,Gibson F

    更新日期：2019-06-18 00:00:00

  • TLR4 rs41426344 increases susceptibility of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) in a central south Chinese Han population.

    abstract：BACKGROUND:The aim of the study was to determine whether polymorphisms in toll-like receptor 4 (TLR4) confer susceptibility to rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) in a central south Chinese Han population. METHODS:Genotyping for six well studied polymorphisms (rs4986790, rs4986791, rs1075...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/s12969-017-0137-5

    authors： Wang Y,Chen L,Li F,Bao M,Zeng J,Xiang J,Luo H,Li J,Tang L

    更新日期：2017-02-21 00:00:00

  • Monitoring change in volume of calcifications in juvenile idiopathic inflammatory myopathy: a pilot study using low dose computed tomography.

    abstract：BACKGROUND:Dystrophic calcifications may occur in patients with J uvenile Idiopathic Inflammatory Myopathy (JIIM) as well as other connective tissue and metabolic diseases, but a reliable method of measuring the volume of these calcifications has not been established. The purpose of this study is to determine the feasi...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/s12969-016-0123-3

    authors： Ibarra M,Rigsby C,Morgan GA,Sammet CL,Huang CC,Xu D,Targoff IN,Pachman LM

    更新日期：2016-11-29 00:00:00

  • The role of benign joint hypermobility in the pain experience in Juvenile Fibromyalgia: an observational study.

    abstract：BACKGROUND:Juvenile Fibromyalgia (JFM) is characterized by chronic widespread musculoskeletal pain and approximately 40% of children and adolescents with JFM also suffer from benign joint hypermobility (HM). It is not currently known if the presence of HM affects the pain experience of adolescents with JFM. The objecti...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/1546-0096-10-16

    authors： Ting TV,Hashkes PJ,Schikler K,Desai AM,Spalding S,Kashikar-Zuck S

    更新日期：2012-06-15 00:00:00

  • Childhood Cogan syndrome with aortitis and anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.

    abstract：:Cogan syndrome is a systemic disease manifesting interstitial keratitis, sensorineural hearing loss, tinnitus, and rotatory vertigo. Renal complications of this syndrome are very rare. We encountered an adolescent with Cogan syndrome complicated by aortitis and anti-neutrophil cytoplasmic antibody (ANCA)-associated gl...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/1546-0096-12-15

    authors： Sugimoto K,Miyazawa T,Nishi H,Izu A,Enya T,Okada M,Takemura T

    更新日期：2014-04-25 00:00:00

  • Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist.

    abstract：BACKGROUND:The pathologic diagnosis of isolated myocarditis without pericardial involvement is uncommonly encountered in systemic onset Juvenile Idiopathic Arthritis (soJIA). CASE:An eleven year-old boy with soJIA died suddenly while being treated with the interleukin 1 (IL-1) receptor inhibitor, anakinra. His autopsy...

    journal_title：Pediatric rheumatology online journal

    pub_type： 杂志文章

    doi：10.1186/1546-0096-10-8

    authors： Zeft AS,Menon SC,Miller D

    更新日期：2012-04-10 00:00:00