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Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist.

Abstract：

BACKGROUND:The pathologic diagnosis of isolated myocarditis without pericardial involvement is uncommonly encountered in systemic onset Juvenile Idiopathic Arthritis (soJIA). CASE:An eleven year-old boy with soJIA died suddenly while being treated with the interleukin 1 (IL-1) receptor inhibitor, anakinra. His autopsy revealed an enlarged heart and microscopic findings were consistent with myocarditis, but not pericarditis. Viral PCR testing performed on his myocardial tissue was negative. CONCLUSION:This case illustrates myocarditis as a fatal complication of soJIA, potentially enabled by anakinra.

journal_name

Pediatr Rheumatol Online J

journal_title

Pediatric rheumatology online journal

authors

Zeft AS,Menon SC,Miller D

doi

10.1186/1546-0096-10-8

subject

Has Abstract

pub_date

2012-04-10 00:00:00

pages

8

issn

1546-0096

pii

1546-0096-10-8

journal_volume

10

pub_type

杂志文章

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