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abstract：BACKGROUND:Withholding live-attenuated vaccines in patients using interleukin (IL)-1 or IL-6 blocking agents is recommended by guidelines for both pediatric and adult rheumatic diseases, since there is a risk of infection in an immune suppressed host. However, this has never been studied. This retrospective, multicente...

journal_title：Pediatric rheumatology online journal

authors： Jeyaratnam J,Ter Haar NM,Lachmann HJ,Kasapcopur O,Ombrello AK,Rigante D,Dedeoglu F,Baris EH,Vastert SJ,Wulffraat NM,Frenkel J

更新日期：2018-03-21 00:00:00

abstract：BACKGROUND:Bisphosphonates are recommended for use as first-line therapy for the prevention and treatment of glucocorticoid-induced osteoporosis in adults. However, the appropriate usage of bisphosphonates for the prevention or treatment of glucocorticoid-induced osteoporosis in children remains unclear. METHODS:We pe...

journal_title：Pediatric rheumatology online journal

authors： Inoue Y,Mitsunaga K,Yamamoto T,Chiba K,Yamaide F,Nakano T,Morita Y,Yamaide A,Suzuki S,Arima T,Yamaguchi KI,Tomiita M,Shimojo N,Kohno Y

更新日期：2018-06-18 00:00:00

abstract：BACKGROUND:There is a critical shortage of pediatric rheumatologists in the US. Substantial travel to clinics can impose time and monetary burdens on families. The aim of this study was to evaluate the cost of in-person pediatric rheumatology visits for families and determine if telemedicine clinics resulted in time an...

journal_title：Pediatric rheumatology online journal

authors： Kessler EA,Sherman AK,Becker ML

更新日期：2016-09-20 00:00:00

abstract：:Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease in Canada and is characterized by a clinical syndrome of episodic inflammatory symptoms. Traditionally, the disease is defined by autosomal recessive inheritance of MEFV gene variants, yet FMF also not uncommonly manifests in indi...

journal_title：Pediatric rheumatology online journal

authors： Westwell-Roper C,Niemietz I,Tucker LB,Brown KL

更新日期：2019-05-14 00:00:00

abstract：: Bullous systemic lupus erythematosus is a rare blistering condition with a distinctive combination of clinical, histological and immunopathologic features that together constitute a unique bullous disease phenotype. It is often associated with autoimmunity to type VII collagen. Here we report a child who presented wi...

journal_title：Pediatric rheumatology online journal

authors： Kumar S,Agarwal I

更新日期：2007-11-21 00:00:00

abstract：BACKGROUND:Juvenile Idiopathic Arthritis (JIA) is the most common cause of non-infectious joint inflammation in children. Synovial inflammation results in pain, swelling and stiffness. Animal and adult human studies indicate that localized joint-associated inflammation may produce generalized changes in pain sensitivit...

journal_title：Pediatric rheumatology online journal

authors： Cornelissen L,Donado C,Kim J,Chiel L,Zurakowski D,Logan DE,Meier P,Sethna NF,Blankenburg M,Zernikow B,Sundel RP,Berde CB

更新日期：2014-09-06 00:00:00

abstract：BACKGROUND:Anti-TNF (Tumor necrosis factor) therapy is effective in treating pediatric patients with refractory rheumatic disease. There is however a concern that anti-TNF usage may increase the risk of malignancy. Reports on specific types of malignancy in this patient population have been emerging over the past decad...

journal_title：Pediatric rheumatology online journal

authors： Okihiro A,Hasija R,Fung L,Cameron B,Feldman BM,Laxer R,Schneider R,Silverman E,Spiegel L,Yeung RSM,Tse SML

更新日期：2018-03-14 00:00:00

abstract：: Xanthomatous skin lesions and arthritis in children are not a common association. We present the case of a 3 year old girl who presented with xanthomatous lesions in the periungual region of both hands, around the nares and on her forehead, associated with significant arthritis that was clinically compatible with mul...

journal_title：Pediatric rheumatology online journal

authors： Matiz C,Ferguson PJ,Zaenglein A,Groh B,Bingham CA

更新日期：2009-10-08 00:00:00

abstract：BACKGROUND:Intraarticular corticosteroids (IACs) have been used to treat temporomandibular joint (TMJ) arthritis. However, prospective clinical studies with magnetic resonance imaging (MRI) scoring are lacking. The aim of this study was to examine efficacy and safety of a single IAC in the TMJ in adolescents with juven...

journal_title：Pediatric rheumatology online journal

authors： Frid P,Augdal TA,Larheim TA,Halbig J,Rypdal V,Songstad NT,Rosén A,Tylleskär KB,Berstad JR,Flatø B,Stoustrup P,Rosendahl K,Kirkhus E,Nordal E

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) were historically thought to be distinct entities, often managed in isolation. In fact, these conditions are closely related. A collaborative approach, which incorporates expertise from subspecialties that previously treated HL...

journal_title：Pediatric rheumatology online journal

authors： Halyabar O,Chang MH,Schoettler ML,Schwartz MA,Baris EH,Benson LA,Biggs CM,Gorman M,Lehmann L,Lo MS,Nigrovic PA,Platt CD,Priebe GP,Rowe J,Sundel RP,Surana NK,Weinacht KG,Mann A,Yuen JC,Meleedy-Rey P,Starmer A,Ban

更新日期：2019-02-14 00:00:00

abstract：PURPOSE:We investigated the etiology of acute hepatitis in three children with systemic Juvenile Idiopathic Arthritis (sJIA) taking Interleukin-1 receptor antagonist (IL1RA). METHODS:Laboratory and clinical data for three children with sJIA diagnosed at ages 13 months to 8 years who developed acute hepatitis during tr...

journal_title：Pediatric rheumatology online journal

authors： Canna S,Frankovich J,Higgins G,Narkewicz MR,Nash SR,Hollister JR,Soep JB,Dragone LL

更新日期：2009-12-22 00:00:00

abstract：BACKGROUND:Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease and a leading cause of childhood disability. The objective of this study was to characterize the PK, safety, and taste acceptability of tofacitinib in patients with JIA. METHODS:This Phase 1, open-label, multiple-dose (twice ...

journal_title：Pediatric rheumatology online journal

authors： Ruperto N,Brunner HI,Zuber Z,Tzaribachev N,Kingsbury DJ,Foeldvari I,Horneff G,Smolewska E,Vehe RK,Hazra A,Wang R,Mebus CA,Alvey C,Lamba M,Krishnaswami S,Stock TC,Wang M,Suehiro R,Martini A,Lovell DJ,Pediatric Rheu

更新日期：2017-12-28 00:00:00

abstract：BACKGROUND:Children are commonly referred to a pediatric rheumatology center for the laboratory finding of an Anti-nuclear antibody (ANA) of undetermined significance. Previous studies regarding adult rheumatology patients have supported an association between ANA and anti-thyroid antibodies, with the prevalence of thy...

journal_title：Pediatric rheumatology online journal

authors： Torok KS,Arkachaisri T

更新日期：2010-05-05 00:00:00

abstract：BACKGROUND:Kawasaki disease (KD) is an acute febrile systemic vasculitis that affects small and medium blood vessels. Intensified treatments for the most severely affected patients have been proposed recently, and the early identification of KD patients at high risk for coronary artery aneurysms (CAA) is crucial. Howev...

journal_title：Pediatric rheumatology online journal

authors： Chbeir D,Gaschignard J,Bonnefoy R,Beyler C,Melki I,Faye A,Meinzer U

更新日期：2018-07-18 00:00:00

abstract：BACKGROUND:Idiopathic juvenile osteoporosis (IJO) is a rare condition of poorly understood etiology and pathophysiology that affects otherwise healthy children. This condition is characterized clinically by bone pain and vertebral fractures; spontaneous recovery is observed after puberty in the majority of cases. Altho...

journal_title：Pediatric rheumatology online journal

authors： Bacchetta J,Wesseling-Perry K,Gilsanz V,Gales B,Pereira RC,Salusky IB

更新日期：2013-02-19 00:00:00

abstract：BACKGROUND:Familial chilblain lupus (FCL) is a rare, chronic form of cutaneous lupus erythematosus, which is characterized by painful bluish-red inflammatory cutaneous lesions in acral locations. Mutations in TREX1, SAMHD1 and STING have been described in FCL patients. Less than 10 TREX1 mutation positive FCL families ...

journal_title：Pediatric rheumatology online journal

authors： Yi C,Li Q,Xiao J

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Kawasaki Disease (KD), the leading cause of acquired heart disease in children in the developed world, is extremely rare in neonates. We present a case of incomplete KD in a neonate and a review of the literature on neonatal KD. CASE PRESENTATION:A previously healthy full term 15 day old Caucasian male with...

journal_title：Pediatric rheumatology online journal

authors： Altammar F,Lang B

更新日期：2018-07-03 00:00:00

abstract：BACKGROUND:The aim of the study was to determine whether polymorphisms in toll-like receptor 4 (TLR4) confer susceptibility to rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) in a central south Chinese Han population. METHODS:Genotyping for six well studied polymorphisms (rs4986790, rs4986791, rs1075...

journal_title：Pediatric rheumatology online journal

authors： Wang Y,Chen L,Li F,Bao M,Zeng J,Xiang J,Luo H,Li J,Tang L

更新日期：2017-02-21 00:00:00

abstract：BACKGROUND:Although Henoch-Schonlein purpura (HSP) is the most common form of systemic vasculitis in children, the long term effect of HSP on endothelial function is still not clear. The aim of our study was to evaluate the long term effect of HSP on endothelial function in children and adolescents. METHODS:This resea...

journal_title：Pediatric rheumatology online journal

authors： Butbul Aviel Y,Dafna L,Pilar G,Brik R

更新日期：2017-01-14 00:00:00

abstract：OBJECTIVES:To examine the prescribing habits of NSAIDs among pediatric medical and surgical practitioners, and to examine concerns and barriers to their use. METHODS:A sample of 1289 pediatricians, pediatric rheumatologists, sports medicine physicians, pediatric surgeons and pediatric orthopedic surgeons in the United...

journal_title：Pediatric rheumatology online journal

authors： Levy DM,Imundo LF

更新日期：2010-02-04 00:00:00

abstract：BACKGROUND:Temporomandibular joint (TMJ) arthritis and involvement is commonly seen in Juvenile Idiopathic Arthritis (JIA). Therapy includes conservative measures, but also includes intraarticular corticosteroid injections (IASI) and systemic immunosuppressive therapy. Despite aggressive medical therapy, some patients ...

journal_title：Pediatric rheumatology online journal

authors： Lypka M,Shah K,Jones J

更新日期：2020-09-04 00:00:00

abstract：BACKGROUND:JIA-associated uveitis (JIAU) is a serious, sight-threatening disease with significant long-term complications and risk of blindness, even with improved contemporary treatments. The MIWGUC was set up in order to propose specific JIAU activity and response items and to validate their applicability for clinica...

journal_title：Pediatric rheumatology online journal

authors： Foeldvari I,Klotsche J,Simonini G,Edelsten C,Angeles-Han ST,Bangsgaard R,de Boer J,Brumm G,Torrent RB,Constantin T,DeLibero C,Diaz J,Gerloni VM,Guedes M,Heiligenhaus A,Kotaniemi K,Leinonen S,Minden K,Miranda V,Miser

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Depression and anxiety adversely affects outcomes in systemic lupus erythematosus (SLE) and healthcare utilization is high for pediatric SLE. We aimed to characterize the prevalence of depression and anxiety in pediatric SLE, and their association with healthcare utilization. METHODS:We conducted a cross-se...

journal_title：Pediatric rheumatology online journal

authors： Knight A,Weiss P,Morales K,Gerdes M,Gutstein A,Vickery M,Keren R

更新日期：2014-09-10 00:00:00

abstract：: Takayasu arteritis (TA) is a rare chronic inflammatory disease of the aorta and its major branches. It is seen predominantly in females during the second and third decades of life, although it can occur in childhood. The aetiology of TA remains unknown. To date, familial cases of TA have been considered rare; however...

journal_title：Pediatric rheumatology online journal

authors： Morishita KA,Rosendahl K,Brogan PA

更新日期：2011-02-02 00:00:00

abstract：:Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood, with JIA-associated uveitis its most common extra-articular manifestation. JIA-associated uveitis is a potentially sight-threatening condition and thus carries a considerable risk of morbidity. The aetiology of the condition is auto...

journal_title：Pediatric rheumatology online journal

authors： Clarke SL,Sen ES,Ramanan AV

更新日期：2016-04-27 00:00:00

abstract：BACKGROUND:Periodic fever syndromes (PFS) are an emerging group of autoinflammatory disorders. Clinical overlap exists and multiple genetic analyses may be needed to assist diagnosis. We evaluated the diagnostic value of a 5-gene sequencing panel (5GP) in patients with undiagnosed PFS. METHODS:Simultaneous double stra...

journal_title：Pediatric rheumatology online journal

authors： De Pieri C,Vuch J,De Martino E,Bianco AM,Ronfani L,Athanasakis E,Bortot B,Crovella S,Taddio A,Severini GM,Tommasini A

更新日期：2015-04-10 00:00:00

abstract：BACKGROUND:To characterize suicidality among youth with juvenile fibromyalgia syndrome (JFMS) receiving treatment from pediatric rheumatologists at a tertiary care center in order to determine the prevalence of suicidality in JFMS and to explore risk factors for persistent suicidal ideation. METHODS:We performed a cro...

journal_title：Pediatric rheumatology online journal

authors： Gmuca S,Sonagra M,Xiao R,Miller KS,Thomas NH,Young JF,Weiss PF,Sherry DD,Gerber JS

更新日期：2021-01-06 00:00:00

abstract：OBJECTIVE:To follow up the refractory juvenile dermatomyositis (JDM) with autologous hematopoietic stem cell transplantation (AHSCT) in a long time and to investigate whether AHSCT is effective and safe to treat refractory JDM. METHODS:We collected the AHSCT and follow-up data of three patients with refractory JDM who...

journal_title：Pediatric rheumatology online journal

authors： Zhu J,Su G,Lai J,Dong B,Kang M,Li S,Zhou Z,Wu F

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:Relapsing periodic arthritis is a general term used for a group of diseases with recurring and periodic nature, in which the joints are intermittently involved. The aim of this study is to evaluation of the possible relationship between MEFV gene mutations in intermittent arthritis of children which has recu...

journal_title：Pediatric rheumatology online journal

authors： Salehzadeh F,Barak M,Nematdoust Haghi R

更新日期：2019-06-06 00:00:00

abstract：:Mevalonate kinase deficiency (MKD), a very rare autosomal recessive autoinflammatory disease with multiple organ involvement, presents clinically as hyperimmunoglobulinemia D syndrome (HIDS), a less severe phenotype and more common form, and mevalonic aciduria (MVA), a more severe phenotype and rare form. MKD is chara...

journal_title：Pediatric rheumatology online journal

authors： Zhang S

更新日期：2016-05-04 00:00:00