The role of benign joint hypermobility in the pain experience in Juvenile Fibromyalgia: an observational study.

Abstract:

BACKGROUND:Juvenile Fibromyalgia (JFM) is characterized by chronic widespread musculoskeletal pain and approximately 40% of children and adolescents with JFM also suffer from benign joint hypermobility (HM). It is not currently known if the presence of HM affects the pain experience of adolescents with JFM. The objective of this study was to examine whether there were any differences in self-reported pain intensity and physiologic pain sensitivity between JFM patients with and without joint HM. METHODS:One hundred thirty-one adolescent patients with JFM recruited from four pediatric rheumatology clinics completed a daily visual analogue scale (VAS) pain rating for one week and underwent a standardized 18-count tender point (TP) dolorimeter assessment. Medical records were reviewed for the presence of joint HM. Average pain VAS ratings, tender point count and tender point sensitivity were compared between JFM patients with and without hypermobility (HM+ and HM-). RESULTS:Nearly half (48%) the sample of JFM patients were found to be HM+. HM+ and HM- patients did not differ in their self-reported pain intensity. However, HM + patients had significantly greater pain sensitivity, with lower TP thresholds (p = 0.002) and a greater number of painful TPs (p = 0.003) compared to HM- patients. CONCLUSION:The presence of HM among adolescent patients with JFM appears to be associated with enhanced physiologic pain sensitivity, but not self-report of clinical pain. Further examination of the mechanisms for increased pain sensitivity associated with HM, especially in adolescents with widespread pain conditions such as JFM is warranted.

authors

Ting TV,Hashkes PJ,Schikler K,Desai AM,Spalding S,Kashikar-Zuck S

doi

10.1186/1546-0096-10-16

subject

Has Abstract

pub_date

2012-06-15 00:00:00

pages

16

issue

1

issn

1546-0096

pii

1546-0096-10-16

journal_volume

10

pub_type

杂志文章
  • Disease course and treatment effects of a JAK inhibitor in a patient with CANDLE syndrome.

    abstract:BACKGROUND:CANDLE syndrome (an acronym for Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature) is a recently described rare autosomal recessive disorder charaterized by systemic autoinflammation. Clinical manifestations include presentation in the first year of life, episodes of fever ...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/s12969-019-0322-9

    authors: Boyadzhiev M,Marinov L,Boyadzhiev V,Iotova V,Aksentijevich I,Hambleton S

    更新日期:2019-05-02 00:00:00

  • Endothelial function in children with a history of henoch schonlein purpura.

    abstract:BACKGROUND:Although Henoch-Schonlein purpura (HSP) is the most common form of systemic vasculitis in children, the long term effect of HSP on endothelial function is still not clear. The aim of our study was to evaluate the long term effect of HSP on endothelial function in children and adolescents. METHODS:This resea...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/s12969-016-0135-z

    authors: Butbul Aviel Y,Dafna L,Pilar G,Brik R

    更新日期:2017-01-14 00:00:00

  • Musculoskeletal ultrasound in pediatric rheumatology.

    abstract:: Although musculoskeletal ultrasound (MSUS) has emerged as an indispensible tool among physicians involved in musculoskeletal medicine in the last two decades, only recently has it become more attractive to pediatric rheumatologists. Thereafter, the use of MSUS in pediatric rheumatology has started to increase. Yet, a...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/1546-0096-9-25

    authors: Tok F,Demirkaya E,Ozçakar L

    更新日期:2011-09-12 00:00:00

  • Autoimmune thyroiditis in antinuclear antibody positive children without rheumatologic disease.

    abstract:BACKGROUND:Children are commonly referred to a pediatric rheumatology center for the laboratory finding of an Anti-nuclear antibody (ANA) of undetermined significance. Previous studies regarding adult rheumatology patients have supported an association between ANA and anti-thyroid antibodies, with the prevalence of thy...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/1546-0096-8-15

    authors: Torok KS,Arkachaisri T

    更新日期:2010-05-05 00:00:00

  • Early combination therapy with etanercept and methotrexate in JIA patients shortens the time to reach an inactive disease state and remission: results of a double-blind placebo-controlled trial.

    abstract:BACKGROUND:Remission is the primary objective of treating juvenile idiopathic arthritis (JIA). It is still debatable whether early intensive treatment is superior in terms of earlier achievement of remission. The aim of this study was to evaluate the effectiveness of early etanercept+methotrexate (ETA+MTX) combination ...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/s12969-020-00488-9

    authors: Alexeeva E,Horneff G,Dvoryakovskaya T,Denisova R,Nikishina I,Zholobova E,Malievskiy V,Santalova G,Stadler E,Balykova L,Spivakovskiy Y,Kriulin I,Alshevskaya A,Moskalev A

    更新日期:2021-01-06 00:00:00

  • Burden of childhood-onset arthritis.

    abstract:: Juvenile arthritis comprises a variety of chronic inflammatory diseases causing erosive arthritis in children, often progressing to disability. These children experience functional impairment due to joint and back pain, heel pain, swelling of joints and morning stiffness, contractures, pain, and anterior uveitis lead...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/1546-0096-8-20

    authors: Moorthy LN,Peterson MG,Hassett AL,Lehman TJ

    更新日期:2010-07-08 00:00:00

  • The role of age-specific N-terminal pro-brain natriuretic peptide cutoff values in predicting intravenous immunoglobulin resistance in Kawasaki disease: a prospective cohort study.

    abstract:BACKGROUND:The prediction of resistance to intravenous immunoglobulins (IVIG) is currently still one of the main research areas in Kawasaki disease (KD). Several studies have reported on the use of N-terminal pro-brain natriuretic peptide (NT-ProBNP) to this end. However, considering the age-dependency of NT-ProBNP lev...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/s12969-019-0368-8

    authors: Shao S,Luo C,Zhou K,Hua Y,Wu M,Liu L,Liu X,Wang C

    更新日期:2019-09-18 00:00:00

  • Damage index in childhood-onset systemic lupus erythematosus in Egypt.

    abstract:BACKGROUND:To investigate the prevalence of cumulative organ damage among Egyptian children with juvenile-onset systemic lupus erythematosus (jSLE) and the relationships between the organ damage and the demographic data, clinical variables, and disease activity. METHODS:A total of 148 patients with jSLE have been foll...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/1546-0096-9-36

    authors: Salah S,Lotfy HM,Mokbel AN,Kaddah AM,Fahmy N

    更新日期:2011-12-09 00:00:00

  • Kawasaki disease: abnormal initial echocardiogram is associated with resistance to IV Ig and development of coronary artery lesions.

    abstract:BACKGROUND:Kawasaki disease (KD) is an acute febrile systemic vasculitis that affects small and medium blood vessels. Intensified treatments for the most severely affected patients have been proposed recently, and the early identification of KD patients at high risk for coronary artery aneurysms (CAA) is crucial. Howev...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/s12969-018-0264-7

    authors: Chbeir D,Gaschignard J,Bonnefoy R,Beyler C,Melki I,Faye A,Meinzer U

    更新日期:2018-07-18 00:00:00

  • Homocysteine and lipid profile in children with Juvenile Idiopathic Arthritis.

    abstract:BACKGROUND:An increased concentration of plasma homocysteine (Hcy) has toxic effects on vascular endothelium. This seems to be a risk factor of cardiovascular disease, premature stroke and venous thrombosis. The risk is higher in coincidence with other factors like chronic diseases and familiar hypercholesterolemia. Th...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/1546-0096-5-2

    authors: Gonçalves M,D'Almeida V,Guerra-Shinohara EM,Galdieri LC,Len CA,Hilário MO

    更新日期:2007-04-02 00:00:00

  • Clinical practice variation and need for pediatric-specific treatment guidelines among rheumatologists caring for children with ANCA-associated vasculitis: an international clinician survey.

    abstract:BACKGROUND:Because pediatric antineutrophil cytoplasmic antibody-associated vasculitis is rare, management generally relies on adult data. We assessed treatment practices, uptake of existing clinical assessment tools, and interest in pediatric treatment protocols among rheumatologists caring for children with granuloma...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12969-017-0191-z

    authors: Westwell-Roper C,Lubieniecka JM,Brown KL,Morishita KA,Mammen C,Wagner-Weiner L,Yen E,Li SC,O'Neil KM,Lapidus SK,Brogan P,Cimaz R,Cabral DA,for ARChiVe Investigators Network within the PedVas initiative.

    更新日期:2017-08-07 00:00:00

  • MRI thresholds for discrimination between normal and mild temporomandibular joint involvement in juvenile idiopathic arthritis.

    abstract:BACKGROUND:Currently there is no consensus agreement on the degree of enhancement in normal temporomandibular joints (TMJ) in children, which makes it difficult for clinicians to distinguish between the presence/absence of mild synovitis. Quantitative measurements of synovial and condylar enhancement may be useful addi...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/s12969-015-0051-7

    authors: Ma GM,Amirabadi A,Inarejos E,Tolend M,Stimec J,Moineddin R,Spiegel L,Doria AS

    更新日期:2015-12-01 00:00:00

  • Pain hypersensitivity in juvenile idiopathic arthritis: a quantitative sensory testing study.

    abstract:BACKGROUND:Juvenile Idiopathic Arthritis (JIA) is the most common cause of non-infectious joint inflammation in children. Synovial inflammation results in pain, swelling and stiffness. Animal and adult human studies indicate that localized joint-associated inflammation may produce generalized changes in pain sensitivit...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1546-0096-12-39

    authors: Cornelissen L,Donado C,Kim J,Chiel L,Zurakowski D,Logan DE,Meier P,Sethna NF,Blankenburg M,Zernikow B,Sundel RP,Berde CB

    更新日期:2014-09-06 00:00:00

  • Tuberculin skin test and ELISPOT/T. SPOT.TB in children and adolescents with juvenile idiopathic arthritis.

    abstract:BACKGROUND:There are controversies regarding the accuracy of the tuberculin skin test (TST) and methods based on the production of interferon gamma by sensitized T cells for the diagnosis of latent tuberculosis infection (LTBI) in pediatrics and immunosuppressed patients. Our objectives are to study TST and ELISPOT/T. ...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/1546-0096-12-17

    authors: Sztajnbok F,Boechat NL,Ribeiro SB,Oliveira SK,Sztajnbok DC,Sant'Anna CC

    更新日期:2014-05-22 00:00:00

  • Familial Takayasu arteritis - a pediatric case and a review of the literature.

    abstract:: Takayasu arteritis (TA) is a rare chronic inflammatory disease of the aorta and its major branches. It is seen predominantly in females during the second and third decades of life, although it can occur in childhood. The aetiology of TA remains unknown. To date, familial cases of TA have been considered rare; however...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/1546-0096-9-6

    authors: Morishita KA,Rosendahl K,Brogan PA

    更新日期:2011-02-02 00:00:00

  • Spectrum of paediatric rheumatic diseases in Nigeria.

    abstract:BACKGROUND:Paediatric rheumatology service in Sub-Sahara African is virtually not available as there is a shortage of paediatric rheumatologists and other rheumatology health professionals. We aim to describe the clinical spectrum and the frequencies of paediatric rheumatic diseases (PRDs) in Lagos State University Tea...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/s12969-017-0139-3

    authors: Olaosebikan BH,Adelowo OO,Animashaun BA,Akintayo RO

    更新日期:2017-01-31 00:00:00

  • Bacterial infections in a pediatric cohort of primary and acquired complement deficiencies.

    abstract:BACKGROUND:Acquired complement deficiency can occur in the setting of autoimmune syndromes, such as systemic lupus erythematosus (SLE), with very low or, occasionally, undetectable C3 levels. Based on inherited complement defects, patients with transiently low complement may be at similar risk for serious bacterial inf...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/s12969-020-00467-0

    authors: Al-Shaikhly T,Hayward K,Basiaga ML,Allenspach EJ

    更新日期:2020-09-24 00:00:00

  • Treating juvenile idiopathic arthritis to target: what is the optimal target definition to reach all goals?

    abstract::In 2018, an international Task Force formulated recommendations for treating Juvenile Idiopathic Arthritis (JIA) to target. The Task Force has not yet resolved three issues. The first issue is the lack of a single "best" target. The Task Force decided not to recommend the use of a specific instrument to assess inactiv...

    journal_title:Pediatric rheumatology online journal

    pub_type: 信件

    doi:10.1186/s12969-020-00428-7

    authors: Schoemaker CG,Swart JF,Wulffraat NM

    更新日期:2020-04-16 00:00:00

  • Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome.

    abstract:BACKGROUND:Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) were historically thought to be distinct entities, often managed in isolation. In fact, these conditions are closely related. A collaborative approach, which incorporates expertise from subspecialties that previously treated HL...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/s12969-019-0309-6

    authors: Halyabar O,Chang MH,Schoettler ML,Schwartz MA,Baris EH,Benson LA,Biggs CM,Gorman M,Lehmann L,Lo MS,Nigrovic PA,Platt CD,Priebe GP,Rowe J,Sundel RP,Surana NK,Weinacht KG,Mann A,Yuen JC,Meleedy-Rey P,Starmer A,Ban

    更新日期:2019-02-14 00:00:00

  • Amendment of the OMERACT ultrasound definitions of joints' features in healthy children when using the DOPPLER technique.

    abstract:BACKGROUND:Recently preliminary ultrasonography (US) definitions, in B mode, for normal components of pediatric joints have been developed by the OMERACT US group. The aim of the current study was to include Doppler findings in the evaluation and definition of normal joint features that can be visualized in healthy chi...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/s12969-018-0240-2

    authors: Collado P,Windschall D,Vojinovic J,Magni-Manzoni S,Balint P,Bruyn GAW,Hernandez-Diaz C,Nieto JC,Ravagnani V,Tzaribachev N,Iagnocco A,D'Agostino MA,Naredo E,OMERACT ultrasound subtask force on pediatric.

    更新日期:2018-04-10 00:00:00

  • The temporomandibular joint in juvenile idiopathic arthritis: frequently used and frequently arthritic.

    abstract:: Recent recognition of the markedly high prevalence of temporomandibular joint (TMJ) arthritis in children with juvenile idiopathic arthritis (JIA) coupled with the significant morbidity associated with TMJ damage has prompted increased interest in both the clinical and pathological aspects of TMJ arthritis. This revi...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/1546-0096-7-11

    authors: Ringold S,Cron RQ

    更新日期:2009-05-29 00:00:00

  • Correction to: Biomarkers associating endothelial dysregulation in pediatric-onset systemic lupus erythematous.

    abstract::Following publication of the original article [1], we have been notified that the colour representation of the graph is not correct in Figure 6 legend. ...

    journal_title:Pediatric rheumatology online journal

    pub_type: 已发布勘误

    doi:10.1186/s12969-020-0405-7

    authors: Lee WF,Wu CY,Yang HY,Lee WI,Chen LC,Ou LS,Huang JL

    更新日期:2020-02-18 00:00:00

  • Efficacy and safety of intraarticular corticosteroid injections in adolescents with juvenile idiopathic arthritis in the temporomandibular joint: a Norwegian 2-year prospective multicenter pilot study.

    abstract:BACKGROUND:Intraarticular corticosteroids (IACs) have been used to treat temporomandibular joint (TMJ) arthritis. However, prospective clinical studies with magnetic resonance imaging (MRI) scoring are lacking. The aim of this study was to examine efficacy and safety of a single IAC in the TMJ in adolescents with juven...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/s12969-020-00464-3

    authors: Frid P,Augdal TA,Larheim TA,Halbig J,Rypdal V,Songstad NT,Rosén A,Tylleskär KB,Berstad JR,Flatø B,Stoustrup P,Rosendahl K,Kirkhus E,Nordal E

    更新日期:2020-10-01 00:00:00

  • Kawasaki Disease in the neonate: case report and literature review.

    abstract:BACKGROUND:Kawasaki Disease (KD), the leading cause of acquired heart disease in children in the developed world, is extremely rare in neonates. We present a case of incomplete KD in a neonate and a review of the literature on neonatal KD. CASE PRESENTATION:A previously healthy full term 15 day old Caucasian male with...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章,评审

    doi:10.1186/s12969-018-0263-8

    authors: Altammar F,Lang B

    更新日期:2018-07-03 00:00:00

  • Aerobic capacity and disease activity in children, adolescents and young adults with juvenile idiopathic arthritis (JIA).

    abstract:UNLABELLED: BACKGROUND:As patients with juvenile idiopathic arthritis (JIA) progress into adulthood, long-term outcome is determined by disease activity, physical and psychosocial development. Decreased aerobic capacity may play a critical role in health-related outcomes in JIA, since it has been linked with cardiovas...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/1546-0096-10-25

    authors: van Pelt PA,Takken T,van Brussel M,de Witte M,Kruize AA,Wulffraat NM

    更新日期:2012-08-20 00:00:00

  • Patient factors associated with waiting time to pediatric rheumatologist consultation for patients with juvenile idiopathic arthritis.

    abstract:BACKGROUND:Early diagnosis and treatment of Juvenile Idiopathic Arthritis (JIA) is essential to optimize outcomes. Wait times (WTs) to consultation with a pediatric rheumatologist consultation is a Canadian quality measure, with benchmarks set at 7 days for systemic JIA (sJIA) and 4 weeks for other JIA categories. In t...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/s12969-020-0413-7

    authors: Barber CEH,Barnabe C,Benseler S,Chin R,Johnson N,Luca N,Miettunen P,Twilt M,Veeramreddy D,Shiff NJ,Schmeling H

    更新日期:2020-03-06 00:00:00

  • Natural history of mevalonate kinase deficiency: a literature review.

    abstract::Mevalonate kinase deficiency (MKD), a very rare autosomal recessive autoinflammatory disease with multiple organ involvement, presents clinically as hyperimmunoglobulinemia D syndrome (HIDS), a less severe phenotype and more common form, and mevalonic aciduria (MVA), a more severe phenotype and rare form. MKD is chara...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章,评审

    doi:10.1186/s12969-016-0091-7

    authors: Zhang S

    更新日期:2016-05-04 00:00:00

  • Juvenile idiopathic arthritis-associated uveitis.

    abstract::Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood, with JIA-associated uveitis its most common extra-articular manifestation. JIA-associated uveitis is a potentially sight-threatening condition and thus carries a considerable risk of morbidity. The aetiology of the condition is auto...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章,评审

    doi:10.1186/s12969-016-0088-2

    authors: Clarke SL,Sen ES,Ramanan AV

    更新日期:2016-04-27 00:00:00

  • Relapsing periodic arthritis, palindromic rheumatism and MEFV gene-related variants alleles in children.

    abstract:BACKGROUND:Relapsing periodic arthritis is a general term used for a group of diseases with recurring and periodic nature, in which the joints are intermittently involved. The aim of this study is to evaluation of the possible relationship between MEFV gene mutations in intermittent arthritis of children which has recu...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/s12969-019-0329-2

    authors: Salehzadeh F,Barak M,Nematdoust Haghi R

    更新日期:2019-06-06 00:00:00

  • Nonsteroidal Anti-Inflammatory Drugs: A survey of practices and concerns of pediatric medical and surgical specialists and a summary of available safety data.

    abstract:OBJECTIVES:To examine the prescribing habits of NSAIDs among pediatric medical and surgical practitioners, and to examine concerns and barriers to their use. METHODS:A sample of 1289 pediatricians, pediatric rheumatologists, sports medicine physicians, pediatric surgeons and pediatric orthopedic surgeons in the United...

    journal_title:Pediatric rheumatology online journal

    pub_type: 杂志文章

    doi:10.1186/1546-0096-8-7

    authors: Levy DM,Imundo LF

    更新日期:2010-02-04 00:00:00