Effects of adenosine administration on spike-wave discharge frequency in genetically epileptic rats.

abstract：:1. Ambulatory monitoring provides a unique opportunity for studying the temporal relationships between lifestyle factors and blood pressure (BP). These include physical activity, mental activity, environmental stressors, substances ingested for pleasure such as smoking, alcohol and caffeine, and nutrition. 2. Changes ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pickering TG,Schwartz JE,James GD

更新日期：1995-03-01 00:00:00

abstract：:1. The role of cardiac reflexes in baroreflex control mechanisms and the changes that occur in chronic hypertension is reviewed. The rapid resetting properties of the arterial baroreceptors ensures its role in short-term rather than long-term control of blood pressure. 2. In hypertensive humans and animals, the barore...

journal_title：Clinical and experimental pharmacology & physiology

authors： Head GA

更新日期：1994-10-01 00:00:00

abstract：:The resistance of breast cancer cells to drugs is a major obstacle to effective cancer chemotherapy. Here, we study the function mechanisms of long non-coding RNA XIST in chemoresistance of breast cancer to doxorubicin. We examined the 50% inhibitive concentration of doxorubicin to MDA-MB-231 and MDA-MB-231/ADM cells,...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang M,Wang F,Xiang Z,Huang T,Zhou WB

更新日期：2020-08-01 00:00:00

abstract：:1. There is controversy regarding plasma catecholamine levels in patients with hypertrophic cardiomyopathy (HCM) and few data exist on serial plasma catecholamine measurements during exercise. The present study determined whether cardiovascular and plasma catecholamine responses to exercise were altered in patients wi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Omodani H,Kinugawa T,Ogino K,Furuse Y,Yamaguchi M,Mori M,Endo A,Kato M,Kato T,Osaki S,Miyakoda H,Igawa O,Hisatome I,Shigemasa C

更新日期：1998-12-01 00:00:00

abstract：:1. The development of microneurography, in which an insulated tungsten microelectrode is inserted into an accessible peripheral or cranial nerve in awake human subjects, has allowed detailed analyses of the signalling capacities of single mechanoreceptive afferents from the skin, muscles and joints. For example, we kn...

journal_title：Clinical and experimental pharmacology & physiology

authors： Macefield VG

更新日期：2005-01-01 00:00:00

abstract：:This study evaluates the association between the long noncoding RNA GAS5 levels and the anti-proliferative effect of the glucocorticoid (GC) methylprednisolone (MP) alone and in combination with rapamycin in peripheral blood mononuclear cells (PBMCs) obtained from healthy donors. The effect of MP, rapamycin, and MP pl...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lucafò M,Bravin V,Tommasini A,Martelossi S,Rabach I,Ventura A,Decorti G,De Iudicibus S

更新日期：2016-06-01 00:00:00

abstract：:1. The transport of taurocholic acid from portal blood to bile was studied in the anaesthetized rat by injecting a radiolabelled pulse of bile acid. 2. The transport process was very rapid, 50% of the dose being secreted within 5 min, and the total dose within 15 min. 3. The transport process had a large capacity. The...

journal_title：Clinical and experimental pharmacology & physiology

authors： Iser JH,Packer JS,Smallwood RA,Hoffman NE

更新日期：1976-01-01 00:00:00

abstract：:1. Taurine and homocysteine are metabolites of methionine. Hyperhomocysteinaemia is one of the risk factors for cardiovascular disease. Although taurine may be a cardiovascular cytoprotective substance, we hypothesized that it may antagonize the effects of homocysteine on myocardial mitochondrial function. 2. We studi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chang L,Zhao J,Xu J,Jiang W,Tang CS,Qi YF

更新日期：2004-04-01 00:00:00

abstract：:1. Neutrophil function was studied in 10 males presenting with acute myocardial infarction (MI) within 6 h of onset and in 10 normal males. Neutrophil production of platelet-activating factor (PAF), determined by bioassay, that of leukotriene B4 by HPLC, and the activity of an enzyme involved in the synthesis of PAF, ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Strahan ME,Graham RM,Eccleston DS,Sturm MJ,Taylor RR

更新日期：1995-02-01 00:00:00

abstract：:1. The present study was designed to compare and contrast the effects of 1 year's treatment with angiotensin-converting enzyme inhibition (captopril 25-100 mg daily) and beta-blockade (atenolol 50-100 mg daily) on hypertensive cardiac structure and function as well as the other established cardiovascular risk factors ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Laufer E,Reid C,Qi XL,Jennings GL

更新日期：1998-03-01 00:00:00

abstract：:We compared the intraocular pressure (IOP)-lowering effect and safety profile of latanoprost (Xalatan) with its generic variant, Glautan (Unipharm, Tel Aviv, Israel). After 1 and 4 weeks of treatment, a randomized, prospective, cross-over comparison was carried out that included patients with open-angle glaucoma or oc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Golan S,Rosenfeld E,Shemesh G,Kurtz S

更新日期：2015-02-01 00:00:00

abstract：:1. The present study investigated whether the somatostatin receptor (SSTR) agonist, octreotide, could inhibit the activation of dorsal skin afferent fibres induced by local injection of capsaicin in the rat. 2. Single unit activity from Aδ mechano-heat sensitive (AMH; n = 41) and C mechano-heat sensitive (CMH; n = 30)...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang J,Cao DY,Guo Y,Ma SJ,Luo R,Pickar JG,Zhao Y

更新日期：2011-08-01 00:00:00

abstract：:The circulating miRNAs are dysregulated in non-small cell lung cancer (NSCLC) and have great promise for clinical diagnosis. The aim of this study was to screen and evaluate the reliability and diagnostic efficiency of candidate serum miRNAs for NSCLC diagnosis. We found that miR-21 and let-7a were significantly dysre...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang X,Jia Z,Shi H,Pan C

更新日期：2018-10-01 00:00:00

abstract：:  NADPH oxidases (Nox) are reactive oxygen species (ROS)-generating enzymes that play important physiological roles in host defence and redox signalling. However, Nox activity is upregulated in the vascular wall during atherosclerosis and contributes to plaque formation by promoting oxidative stress and inflammation. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Rivera J,Walduck AK,Strugnell RA,Sobey CG,Drummond GR

更新日期：2012-03-01 00:00:00

abstract：:Radiation-induced lung injury (RILI) is a serious complication in thoracic tumour radiotherapy. It often occurs in clinical chest radiotherapy and acute whole-body irradiation (WBI) caused by nuclear accidents or nuclear weapon attack. Some radioprotective agents have been reported to exert protective effects when giv...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kun C,Tao L,Leiyuan H,Yunhao F,Ning W,Zhe L,Yuanyuan C,Xiao L,Hongran Q,Jianming C,Fu G,Yanyong Y

更新日期：2019-12-01 00:00:00

abstract：:Recent in vitro experiments have indicated that human resistin increases the number of lipoprotein particles secreted by the human hepatocytes and also influences their quality, in terms of generating more proatherogenic lipid particles. The aim of this study is to investigate associations of plasma resistin and perip...

journal_title：Clinical and experimental pharmacology & physiology

authors： Joksić J,Sopić M,Spasojević-Kalimanovska V,Gojković T,Zeljković A,Vekić J,Andjelkovic K,Kalimanovska-Oštrić D,Jelić-Ivanović Z

更新日期：2016-01-01 00:00:00

abstract：:1. Low-voltage electrical stimulation (LVES) in skeletal muscle at a level far below the threshold of muscle contraction has been reported to promote local angiogenesis. However, the mechanism underlying the promotion of local angiogenesis by LVES has not been fully elucidated. In the present study, we evaluated wheth...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nagasaka M,Kohzuki M,Fujii T,Kanno S,Kawamura T,Onodera H,Itoyama Y,Ichie M,Sato Y

更新日期：2006-07-01 00:00:00

abstract：:The aim of this study was to determine whether the kaliuresis associated with glucocorticoids is due to a direct tubular action or is secondary to effects of glucocorticoids on distal tubule flow. A whole kidney technique was used to avoid the problem, inherent in microperfusion and micropuncture studies, of deciding ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Adam WR,Adams BA,Ellis AG

更新日期：1987-01-01 00:00:00

abstract：:1. Ion gradients across the cell membrane are important for proper cellular communication and homeostasis. With the exception of erythrocytes, chloride (Cl), one of the most important free anions in animal cells, is not distributed at thermodynamic equilibrium across the plasma membrane. The K-Cl cotransporter (COT), ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gagnon KB,Fyffe RE,Adragna NC,Lauf PK

更新日期：2007-07-01 00:00:00

abstract：:1. Using the electromagnetic flow probe and the radioactive microsphere technique, systemic and regional haemodynamic variables were measured in conscious normotensive and hypertensive rabbits. The rabbits were made hypertensive by unilateral nephrectomy combined with cellophane-wrapping of the remaining kidney and sy...

journal_title：Clinical and experimental pharmacology & physiology

authors： van Boom M,Saxena PR

更新日期：1981-05-01 00:00:00

abstract：:1. This study investigated the effect of progesterone, which, under certain circumstances, can antagonize both the mineralocorticoid and glucocorticoid activities of steroid hormones, on the development and maintenance of adrenocorticotrophic hormone (ACTH)-induced hypertension in conscious sheep. 2. Progesterone (500...

journal_title：Clinical and experimental pharmacology & physiology

authors： Spence CD,Reid AF,Coghlan JP,Mills EH,Whitworth JA,Scoggins BA

更新日期：1989-08-01 00:00:00

abstract：:Hepatic fibrosis is an outcome of chronic liver injury. Angiotensin II (ANG II) may play a role in the pathogenesis of hepatic fibrosis. Certain drugs such as ACE inhibitors, ANG II antagonists, and even statins could interfere with the renin angiotensin system and modulate its deleterious effects. This study was carr...

journal_title：Clinical and experimental pharmacology & physiology

authors： El-Ashmawy NE,El-Bahrawy HA,Shamloula MM,Ibrahim AO

更新日期：2015-09-01 00:00:00

abstract：:1. The differential identification of the angiotensin AT1A and AT1B receptor subtypes is impaired by the existing>96% homology of both receptors. In the present study, we characterized two polyclonal rabbit peptide antibodies, namely alpha-AT1A and alpha-AT1B, that recognize the C-terminal region of mouse AT1A and AT1...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hoffmann A,Cool DR

更新日期：2005-11-01 00:00:00

abstract：:1. The field of extracellular nucleotides and purinoceptors has undergone a resurgence of interest and enthusiasm in the past decade. More and more investigators are probing the physiological and pathophysiological roles of P2 receptors in virtually every organ system, including the kidney. 2. With this renewed intere...

journal_title：Clinical and experimental pharmacology & physiology

authors： Inscho EW

更新日期：2001-04-01 00:00:00

abstract：:Urapidil had blocking activity on alpha 1-adrenoceptors in the rat isolated caudal artery (pA2 congruent to 7) and in the anaesthetized rat. Urapidil had no clonidine like agonistic activity on alpha 2-adrenoceptors in preparations of the guinea-pig ileum (prejunctional) or dog saphenous vein (post-junctional). Urapid...

journal_title：Clinical and experimental pharmacology & physiology

authors： Verberne AJ,Rand MJ

更新日期：1984-07-01 00:00:00

abstract：:1. NBPA is a derivative of 3-n-butylpathalide isolated from Apium granolens Linn. 2. At concentrations ranging from 6 x 10(-6) to 10(-6) mol/L, NBPA inhibited the L-type calcium current in guinea-pig myocardial cells and cultured human neuroblastoma cells. 3. At 10(-6) mol/L, NBPA markedly inhibited calcium-dependent ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang J,Peng X,Wei G,Su D

更新日期：1999-10-01 00:00:00

abstract：:1. Ischaemia-reperfusion (IR) injury is an important contributor to tissue damage and has been shown to be attenuated by preconditioning (PC) in some animal models. A recent report has suggested that the forearm can be used for the study of this phenomenon in humans. We aimed to reproduce and further characterize this...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kilian JG,Nakhla S,Griffith K,Harmer J,Skilton M,Celermajer DS

更新日期：2005-01-01 00:00:00

abstract：:According to Guyton's model, impaired renal sodium excretion plays a key role in the increased salt sensitivity of blood pressure (BP). Several factors contribute to impaired renal sodium excretion, including the sympathetic nervous system, the renin-angiotensin system and aldosterone. Accumulating evidence suggests t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kawarazaki W,Fujita T

更新日期：2013-12-01 00:00:00

abstract：:The antihypertensive agent rilmenidine has threefold higher affinity for I(1) imidazoline receptors compared with alpha(2)-adrenoceptors and acts on the central nervous system by reducing sympathetic activity and in the kidney by inhibiting Na(+)/H(+) exchange activity. In the present study, we examined: (i) the effec...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jovanovska V,Eitle E,Harris PJ

更新日期：2004-05-01 00:00:00

abstract：:1. The role of calcium-activated potassium (KCa) channels in bronchodilation produced by a direct adenylyl cyclase activator, forskolin, was investigated. The involvement of intracellular cyclic AMP (cAMP) in the process was also examined. 2. The isometric tension records from guinea-pig tracheal smooth muscles indica...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hiramatsu T,Kume H,Kotlikoff MI,Takagi K

更新日期：1994-05-01 00:00:00