Heat-killed Salmonella typhimurium mitigated radiation-induced lung injury.

abstract：:Anaemia is an important issue in patients undergoing haemodialysis. We aimed to identify a better dosing schedule of a fixed monthly dose of continuous erythropoietin receptor activator (CERA) in patients with chronic kidney disease (CKD) on haemodialysis. The CERA dosing schedule included 100 μg once monthly for 2 mo...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu WS,Chu DC,Chan HL,Li SY,Liu CK,Yang CY,Chen YW,Lee PC,Lai YT,Lin CC

更新日期：2016-10-01 00:00:00

abstract：:The anti-acetylcholinesterase (AChEase) activity of 15 opioids, namely morphine, nalorphine, oxymorphone, naloxone, naltrexone, N-methylnaloxone, levorphanol, levallophan, dextrorphan, dextrallophan, levo-methadone, dextro-methadone, pethidine, leu-enkephalin and U-50,488H was investigated. Among the opioids, the morp...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sim MK,Chua ME

更新日期：1986-02-01 00:00:00

abstract：:1. The endothelin (ET) system and NADPH oxidase play important roles in the regulation of cardiovascular function, as well as in the pathogenesis of hypertension and other cardiovascular diseases. 2. Endothelins activate NADPH oxidases and thereby increase superoxide production, resulting in oxidative stress and cardi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Dammanahalli KJ,Sun Z

更新日期：2008-01-01 00:00:00

abstract：:1. Conscious experimental hypertensive rats injected intraventricularly with 5,6-dihydroxytryptamine (50 microgram) responded with a rapid and long-lasting (4 days) fall in blood pressure and this was accompanied by a bradycardia of similar duration. 2. The acute actions of 5,6-dihydroxytryptamine on the cardiovascula...

journal_title：Clinical and experimental pharmacology & physiology

authors： Finch L

更新日期：1975-11-01 00:00:00

abstract：:1. Renin gene expression was investigated in kidneys from 13 foetal and four adult sheep. 2. The levels of renal renin mRNA in foetuses were greater than those in adult sheep (P < 0.001). 3. There was no significant difference in renin mRNA levels between foetuses aged 91 and 134 days (term 150 days). 4. The levels of...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang DY,Lumbers ER,Simonetta G

更新日期：1996-08-01 00:00:00

abstract：:1. The choice of initial pharmacological therapy is one area where the different hypertension management guidelines vary in recommending either the use of diuretics and beta-blockers as preferred drugs or choosing from any of the five major classes of antihypertensives. 2. Improvement in cardiovascular morbidity and m...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tomlinson B

更新日期：1997-12-01 00:00:00

abstract：:1. It is a central thesis of this review that in clinical and experimental pharmacology and physiology the goal of statistical analysis should be to minimize the risk of making any false-positive inferences from the results of an experiment (experimentwise Type I error). 2. It is common in clinical and experimental ph...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ludbrook J

更新日期：1991-06-01 00:00:00

abstract：:1. In order to investigate further whether the increased sensitivity to inhibition by nifedipine of the responses to noradrenaline of aortae from spontaneously hypertensive stroke-prone (SHRSP) rats is related to the development of the hypertension, we have compared the sensitivity to noradrenaline, potassium chloride...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jiang GC,Iwanov V,Moulds RF

更新日期：1995-01-01 00:00:00

abstract：:Simultaneous measurements of smooth muscle membrane potential and tension were made from isolated pieces of rat tail artery. A single electrical stimulus to the perivascular nerves produced a transient contraction of the smooth muscle. The amplitude of the contraction was increased after removal of the endothelium. Th...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kotecha N,Neild TO

更新日期：1986-03-01 00:00:00

abstract：:1. Neutrophil function was studied in 10 males presenting with acute myocardial infarction (MI) within 6 h of onset and in 10 normal males. Neutrophil production of platelet-activating factor (PAF), determined by bioassay, that of leukotriene B4 by HPLC, and the activity of an enzyme involved in the synthesis of PAF, ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Strahan ME,Graham RM,Eccleston DS,Sturm MJ,Taylor RR

更新日期：1995-02-01 00:00:00

abstract：:1. Nitric oxide (NO) is an important mediator of contractile function in the heart. However, isolated papillary muscle preparations appear to lack NO responsiveness in certain animal species. Although cat, guinea-pig and ferret models have been NO responsive, there have been mixed results in the rat papillary muscle. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Worthley MI,Horowitz JD,Zeitz CJ

更新日期：2005-07-01 00:00:00

abstract：:1. Tetramethylpyrazine (TMP) is one of the active principles contained in Ligusticum chuanxiong Hort. (Umbelliferae), a herb that has been used widely in China to treat vascular disorders. 2. In an attempt to elucidate the possible mechanisms of action of TMP, the effect of TMP on intracellular calcium concentrations ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wong KL,Chan P,Huang WC,Yang TL,Liu IM,Lai TY,Tsai CC,Cheng JT

更新日期：2003-10-01 00:00:00

abstract：:1. We set out to investigate whether the administration of naloxone alone, naloxone plus vasopressin (AVP) or naloxone plus alprazolam to patients with Cushing's syndrome would result in a blunted dynamic response of the pituitary-adrenal axis compared with normal volunteers. Cushing's syndrome is often difficult to d...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jackson RV,Hockings GI,Torpy DJ,Grice JE,Crosbie GV,Walters MM,Strakosch CR

更新日期：1996-06-01 00:00:00

abstract：:1. The maintenance of skeletal muscle mass is determined by a fine balance between protein synthesis and protein degradation. Skeletal mass is increased when there is a net gain in protein synthesis, which can occur following progressive exercise training. In contrast, skeletal muscle mass is lost when degradation occ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Russell AP

更新日期：2010-03-01 00:00:00

abstract：:1. Arterial baroreflexes are suppressed in stressful conditions. Intense visual stimuli can cause a threatening sensation and produce defensive reactions. 2. The present study was designed to determine whether and how electrical stimulation of the optic tract (OT) affects arterial baroreflexes, especially the heart ra...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cheng ZB,Kobayashi M,Nosaka S

更新日期：2001-09-01 00:00:00

abstract：:1. The concentrations of gamma-amino butyric acid (GABA) and glutamate were measured in the brains of chickens which were treated with furazolidone (FZ) or nitrofurazone (NF) at oral doses of 12.5, 25 or 50 mg/kg for 5 days. 2. At the end of the treatment, birds on the small dose of FZ or NF lost about 9% of their bod...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ali BH

更新日期：1988-12-01 00:00:00

abstract：:The combined administration of metronidazole and ampicillin increased faecal weights by 198% in normal male subjects on controlled diets with constant energy, protein and dietary fibre content. Intestinal transit times were unaltered despite marked increase in faecal weights. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kurpad AV,Shetty PS

更新日期：1984-09-01 00:00:00

abstract：:1. The effects of endogenous and exogenous acetylcholine (ACh) on nitrergic relaxations elicited by electrical field stimulation (EFS) were studied in guinea-pig endothelium-denuded basilar artery preparations precontracted with 1 mumol/L prostaglandin F2 alpha and a possible role of K+ channels in mediating the effec...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jiang F,Li CG,Rand MJ

更新日期：1999-04-01 00:00:00

abstract：:1. Inhibiting the renin-angiotensin-aldosterone system prevents left ventricular (LV) remodelling after myocardial infarction (MI). 2. The present study was designed to assess the effects of a combination of perindopril and losartan on LV remodelling, cardiac function and serum procollagen type III amino terminal pept...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li L,Liu RY,Zhao XY,Zhang JY,Jia M,Lu PQ

更新日期：2009-07-01 00:00:00

abstract：:1. A comparison has been made of the effects of three acetylcholine antagonists--hexamethonium, tubocurarine and pancuronium--on maximal tetani of limb muscles of cats under chloralose anaesthesia. In most experiments, the indirectly stimulated soleus muscle was studied, but observations were also made on the tibialis...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bowman WC,Webb SN

更新日期：1976-11-01 00:00:00

abstract：:1. Triiodothyronine (T3; 1.0 mg/kg per day subcutaneously) was administered to 10 dogs for 14 days; 10 saline-treated dogs served as controls. T3-treated dogs showed the expected physiological responses of hyperthyroidism; further, chronotropic responses to isoprenaline in vivo were significantly increased in T3-treat...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hoey A,Brown L,Marchant C,Atwell R,Sernia C

更新日期：1992-11-01 00:00:00

abstract：:1. We have studied the role of kallikrein (KK) in the maintenance of renal function in chronic hypoxic rats (high altitude; HA), compared with control rats kept at sea level (SL). Hypoxia was induced by placing female Wistar rats (198-290 g) in an altitude chamber (5500 m) 15 h/day for 4 weeks. Experiments were also c...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chen CF,Chen LW,Chien CT,Wu MS,Tsai TJ

更新日期：1996-09-01 00:00:00

abstract：:1. The present study examined the effects of an aqueous extract of Anoectochilus formosanus (AFE) on both hepatic fibrosis and regeneration in rats. 2. Fibrosis was induced by intraperitoneal injection of dimethylnitrosamine (DMN) for 3 consecutive days per week for 4 weeks. 3. In DMN-treated rats, liver cirrhosis-ass...

journal_title：Clinical and experimental pharmacology & physiology

authors： Shih CC,Wu YW,Hsieh CC,Lin WC

更新日期：2004-09-01 00:00:00

abstract：:1. Adult soft-shelled turtles were exposed to hyperosmotic and dehydration stresses. 2. Acute treatment for 0.5, 1 or 2 h with sodium chloride (3.6%, single intramuscular injection, 2 mL volume) caused depletion of pineal serotonin contents followed by elevation of norepinephrine and epinephrine levels. In addition, i...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mahapatra MS,Mahata SK,Maiti B

更新日期：1991-10-01 00:00:00

abstract：:1. Evidence gathered in recent years has revealed microRNAs (miRNAs) fine-tune gene expression and play an important role in various cellular processes, including cell growth, differentiation, proliferation and apoptosis. 2. The present review summarizes current knowledge of miRNA pathways in the pathogenesis of cance...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tsai LM,Yu D

更新日期：2010-01-01 00:00:00

abstract：:Following the potent efficacy of β-D-Mannuronic acid in a breast cancer murine model, we evaluated the efficacy of this novel non-steroidal anti-inflammatory drug in breast cancer patients in the present clinical trial. The study was an 8-week randomized, controlled, phase II clinical trial (IRCT: 2017012213739N7 (in ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kashefi S,Omranipour R,Mahmoodzadeh H,Ahmadi H,Alikhassi A,Hosseini M,Cuzzocrea S,Rehm BHA,Matsuo H,Mirshafiey A

更新日期：2019-06-01 00:00:00

abstract：:1. Medullary blood flow (MBF) is important in the long-term control of arterial pressure. However, it is unclear which vascular elements regulate MBF. 2. Exogenous endothelin (ET)-1 decreases cortical more than medullary blood flow. We hypothesized that ET-1 would therefore constrict afferent (AA) and efferent arterio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Denton KM,Shweta A,Finkelstein L,Flower RL,Evans RG

更新日期：2004-08-01 00:00:00

abstract：:Chemotherapy resistance is a major contributor to poor treatment responses and tumour relapse, the development of which has been strongly linked to the action of cancer stem cells (CSCs). Mounting evidence suggests that CSCs are reliant on low oxygen conditions and hypoxia-inducible factors 1α and 2α (HIF1α and HIF2α)...

journal_title：Clinical and experimental pharmacology & physiology

authors： Schöning JP,Monteiro M,Gu W

更新日期：2017-02-01 00:00:00

abstract：:1. Patients were grouped into categories of 'no airways disease', 'obstructive airways disease without response to bronchodilator' and 'obstructive airways disease with bronchodilator responsiveness'. 2. Cyclic nucleotides were assayed in specimens of lung tissue that were excised during surgery. 3. Reduced levels of ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Krzanowski JJ,Polson JB,Goldman AL,Ebel TA,Szentivanyi A

更新日期：1979-01-01 00:00:00

abstract：:This study investigated the effect of muscarinic M1 and M2 receptor antagonists on the rocuronium-induced train of four (TOF) fade and tetanic fade, respectively. Ex-vivo phrenic nerves and diaphragms were obtained from adult Sprague-Dawley rats and stabilized in Krebs buffer; the nerve-stimulated muscle TOF fade was ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kim YB,Lee S,Lee KC,Kim HJ,Ro YJ,Yang HS

更新日期：2017-07-01 00:00:00