Vitamin D deficiency is unrelated to type of atrial fibrillation and its complications.

Abstract:

INTRODUCTION:Vitamin D plays an important role in a broad range of organ functions, including the cardiovascular system. Only one study has tested the association between vitamin D deficiency and arrhythmia and it found no association. The aim of the present study was to evaluate the association between vitamin D deficiency and the type of atrial fibrillation (AF) and complications to AF. MATERIAL AND METHODS:In total, 258 patients were consecutively included from March 2009 to February 2011. All in- and out-patients in the Department of Cardiology at Hvidovre Hospital were invited to participate, provided they had electrocardiographically documented AF. Patients with dementia or terminal illness were excluded. 25 hydroxyvitamin D (25 OHD) was measured with a chemiluminescence assay (Liaison from DiaSorin, Stillwater, Minnesota, USA). RESULTS:No association between vitamin D level and type of AF was found. Furthermore, no association between vitamin D deficiency and ischaemic heart disease, stroke or acute myocardial infarction was found. Vitamin D deficiency was significantly associated with low age (p = 0.02) and gender with a higher proportion of females having the optimal level of 25 OHD (p = 0.0005). CONCLUSION:Other studies have found a beneficial effect of vitamin D on cardiovascular diseases, but we found no association between vitamin D deficiency and the type of AF or complications to AF. Further investigation is necessary to determine whether vitamin D supplementation improves cardiovascular outcomes in patients with AF. FUNDING:The study has received financial support from several private and one public fund. TRIAL REGISTRATION:The study was approved by the National Ethics Committee (Project-ID: H-C-2009-014).

journal_name

Dan Med J

journal_title

Danish medical journal

authors

Qayyum F,Landex NL,Agner BR,Rasmussen M,Jøns C,Dixen U

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

A4505

issue

9

issn

2245-1919

pii

A4505

journal_volume

59

pub_type

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