Abstract:
INTRODUCTION:The use of positron emission tomography with 2-deoxy-2-18F-fluoro-D-glucose integrated with CT (18F-FDG-PET/CT) in oncology is common. Unexpected incidental findings are occasionally recognised and can represent clinically relevant lesions or conditions. This study aims to assess the occurrence, clinical significance and economic impact of incidental 18F-FDG-PET/CT findings. METHODS:PET/CT of 670 cancer patients was evaluated in consensus by two experienced specialists within nuclear medicine and radiology. Foci with an abnormally increased 18F-FDG uptake and/or CT changes not related to the patients` disease were reported. Thirty-five foci in 29 patients were assessed and their cost and impact on patient management were analysed with up to 32 months of follow-up. A supplementary literature review was conducted using PubMed, Embase and Web of Science and the results were compared with ours. RESULTS:A total of 28 foci (80%) were clinically relevant and elicited management or follow-up including four malignancies and 18 premalignant and six benign lesions. Seven foci were without pathology. The estimated additional cost was 1,984 US$ per focus. In the literature review, 642 of 1,090 foci (59%) were relevant, distributed as 270 malignancies, 166 premalignant and 206 benign lesions, whereas 448 foci were without pathology. CONCLUSIONS:Incidental 18F-FDG-PET/CT findings should be investigated despite the occurrence of false-positive findings, additional time consumption and cost as they may represent obscure malignancies and premalignant or benign conditions needing treatment. FUNDING:none. TRIAL REGISTRATION:not relevant.
journal_name
Dan Med Jjournal_title
Danish medical journalauthors
Hadad ZSH,Afzelius P,Sørensen SM,Jurik AGsubject
Has Abstractpub_date
2020-09-07 00:00:00issue
10issn
2245-1919pii
A10190553journal_volume
67pub_type
杂志文章abstract:INTRODUCTION:Fine-needle aspiration biopsy (FNAB) is the cornerstone of thyroid nodule evaluation. In most cases, FNAB can discriminate between benign and malignant disease. In other cases, it is only indicative of malignancy and the results are considered "suspicious". In Denmark, thyroid FNAB results are categorised ...
journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2017-02-01 00:00:00
abstract:INTRODUCTION:The prevalence of sarcopenia varies extensively depending on the definitions and studied populations. The aim of this study was to assess the prevalence of sarcopenia in a Danish geriatric out-patient population using criteria from the European Working Group on Sarcopenia (EWGSOP). METHODS:Patients referr...
journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2018-06-01 00:00:00
abstract:INTRODUCTION:The incidence of cutaneous melanoma is increasing in Denmark and worldwide. However, the prevalence of distant metastases at the time of diagnosis has decreased to 1%. We therefore questioned the value of routine preoperative chest X-ray (CXR) for staging asymptomatic melanoma patients and hypothesised tha...
journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2016-12-01 00:00:00
abstract:INTRODUCTION:Tonsillectomy may be performed by several methods. It is continuously being discussed which method is preferable with regard to postoperative haemorrhage, pain, activity and nutrition. MATERIAL AND METHODS:The present study is a prospective non-randomized study of tonsillectomy. It included 198 patients a...
journal_title:Danish medical journal
pub_type: 临床试验,杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:The health authorities have recommended that face-to-face consultations be substituted by telephone consultations to reduce the risk of virus transmission in out-patient clinics during the coronavirus disease 2019 (COVID-19) pandemic. The aim of the present study was to assess the frequency of such telepho...
journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2020-06-23 00:00:00
abstract:INTRODUCTION:Marfan syndrome is an autosomal, dominantly inherited disorder of the connective tissue. We report the clinical data and results of a genetic analysis of a large Danish Marfan family. METHODS:Sanger sequencing of FBN1 was initially performed on genomic DNA from the index patient. Subsequently, four affect...
journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2014-11-01 00:00:00
abstract:INTRODUCTION:Mechanical restraint and other forms of coercion may be used under certain circumstances at psych-iatric wards. The use of coercion receives considerable focus, yet little is known about its diurnal distribution. We examined the initiation of mechanical restraint, sedative drug administration, physical ret...
journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2017-08-01 00:00:00
abstract:INTRODUCTION:An indication of the adequacy of the intra-vascular volume is of importance in critically ill patients. The status of the intravascular volume can be determined from a fluid challenge test. Most tests involve invasive monitoring. An exception is the capnographic measurement of changes in end-tidal (ET) CO2...
journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2019-09-01 00:00:00
abstract:INTRODUCTION:Vitamin D plays an important role in a broad range of organ functions, including the cardiovascular system. Only one study has tested the association between vitamin D deficiency and arrhythmia and it found no association. The aim of the present study was to evaluate the association between vitamin D defic...
journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2012-09-01 00:00:00
abstract::Surgeons are increasingly using ultrasonography (US) in their clinical management of patients. However, US is a very user-dependent imaging modality and proper skills of the US operator are needed to ensure quality in patient care. This thesis explores the validity evidence for assessment of competence in abdominal an...
journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2017-11-01 00:00:00
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journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2015-02-01 00:00:00
abstract:INTRODUCTION:Psychiatric disorders are common among patients with irritable bowel syndrome (IBS) which may make a psychiatric evaluation appropriate. The Hospital Anxiety and Depression Scale (HADS) has been recommended internationally for screening. The Common Mental Disorder Questionnaire (CMDQ) is a novel Danish ins...
journal_title:Danish medical journal
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2014-02-01 00:00:00
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journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2013-05-01 00:00:00
abstract:INTRODUCTION:Severely painful or dysfunctional destroyed wrists can be reconstructed by fusion, interposition of soft-tissue or by arthroplasty using artificial materials. Total and partial wrist arthroplasty (T/PWA) has been used on a regular basis since the 1960's. The objective of this study was to review the litera...
journal_title:Danish medical journal
pub_type: 杂志文章,评审
doi:
更新日期:2014-05-01 00:00:00
abstract:INTRODUCTION:Since the introduction of the quadrivalent human papillomavirus vaccine, young girls and women have reported a broad range of symptoms. These have been described as possible adverse effects of the vaccine. In this study, we describe demographic characteristics, symptomatology, clinical and laboratory test ...
journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2017-07-01 00:00:00
abstract:INTRODUCTION:Danish healthcare seeks to improve cancer survival through improved diagnostics, rapid treatment and increased focus on cancer prevention and early help-seeking. In neuro-oncology, this has resulted in the Integrated Brain Cancer Pathway (IBCP). The paper explores how the pathway works in the initial phase...
journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2012-05-01 00:00:00
abstract::Critically ill acute high-risk abdominal surgery patients represent a major challenge to health care providers, with the typical patient being elderly and frail, and with severe and multiple comorbidities. The mortality rate in this population is high, and the postoperative course is characterized by complications, pr...
journal_title:Danish medical journal
pub_type: 杂志文章,评审
doi:
更新日期:2018-02-01 00:00:00
abstract:INTRODUCTION:Cell-free DNA testing (cfDNA testing) in maternal plasma has recently been implemented in Danish healthcare. Prior to that we wanted to evaluate the preferences among pregnant women, partners and health professionals regarding cfDNA testing compared with invasive prenatal diagnostics. METHODS:Responders w...
journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2018-05-01 00:00:00
abstract:INTRODUCTION:Atrial fibrillation (AF) is a cardiac epidemic. In this study, we aimed to describe the causes of hospital-isation in an AF population over time and to study how different AF treatment strategies affected hospitalization. MATERIAL AND METHODS:This was an observational study in which long-term follow-up da...
journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:This article presents the treatment results of 320 consecutive patients with malignant haematological diagnoses admitted to a tertiary intensive care unit at a Danish University hospital over a six-year period (2005-2010). With reference to international publications, we describe the development in treatme...
journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2012-03-01 00:00:00
abstract:INTRODUCTION:Recent studies have reported an asso-ciation between the day of week of surgery and post-operative mortality, meaning that patients undergoing surgery at the end of the week or during weekends may be at higher risk. The aim of this study was to investigate the influence of the day of week of surgery on mor...
journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2019-07-01 00:00:00
abstract:INTRODUCTION:Spontaneous reporting of adverse drug reactions (ADRs) is used for continuous risk-benefit evaluation of marketed pharmaceutical products and for signal detection. The Adverse Drug Event Manager (ADEM) is a service offered to clinicians employed at hospitals in the Capital Region of Denmark. The ADEM assis...
journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:Surveying sexual behaviour of the general population serves to identify key points of preventive interventions, monitor the effect and interpret changes in patterns of disease. Validated questionnaires describing sexual behaviour can be adapted to some extent from other countries, but national adaption, re...
journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Pain and distress during minor hospital-related procedures is a familiar problem in many children. Inadequate relief of children's procedural pain and distress not only affects the experience of the children and their parents, but also adversely impacts procedural success. We aimed to review the safety and...
journal_title:Danish medical journal
pub_type: 杂志文章,评审
doi:
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:High levels of pro-inflammatory cytokines are present in the gut of patients with inflammatory bowel disease (IBD) and have a crucial role in the dysfunction of mucosal homeostasis. Caudal-related homeobox transcription factor 2 (CDX2) is an essential regulator of intestinal epithelium homeostasis. When expr...
journal_title:Danish medical journal
pub_type: 杂志文章,评审
doi:
更新日期:2014-03-01 00:00:00
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journal_title:Danish medical journal
pub_type: 临床试验,杂志文章
doi:
更新日期:2014-07-01 00:00:00
abstract::Hip dysplasia and hip joint deformities in general are recognized as possible precursors of osteoarthritic development. Early and correct identification of hip dysplasia is important in order to offer timely joint preserving treatment. In the contemporary literature, several controversies exist, and some of these were...
journal_title:Danish medical journal
pub_type: 杂志文章,评审
doi:
更新日期:2012-06-01 00:00:00
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journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2013-03-01 00:00:00
abstract::Fertility treatment has been associated with obstetrical and perinatal complications. It is, however, uncertain whether fertility treatment or parental subfertility is associated with long-term development of the children. We aimed to assess the growth and mental health of children and adolescents conceived after fert...
journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2014-10-01 00:00:00
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journal_title:Danish medical journal
pub_type: 杂志文章
doi:
更新日期:2012-02-01 00:00:00