Abstract：
INTRODUCTION:Spontaneous reporting of adverse drug reactions (ADRs) is used for continuous risk-benefit evaluation of marketed pharmaceutical products and for signal detection. The Adverse Drug Event Manager (ADEM) is a service offered to clinicians employed at hospitals in the Capital Region of Denmark. The ADEM assists healthcare professionals in reporting suspected ADRs to the Danish Health Authority. The aim of this retrospective observational study was to quantify and describe ADRs reported via the ADEM in 2014. METHODS:All ADR reports handled by the ADEM in 2014 were recorded anonymously and analysed descriptively. RESULTS:A total of 484 ADRs were reported through the ADEM in 2014 (the median number of reports per month was 37; range: 17-78). The majority of the reports came from departments of internal medicine (61%), psychiatry (14%) and dermatology, ophthalmology or otorhinolaryngology (11%). The drugs most frequently reported were lisdexamphetamine (n = 40), rivaroxaban (n = 16) and warfarin (n = 15) (vaccines excluded). In 13 out of 484 reports, the ADR was associated with a fatal outcome. CONCLUSION:The findings of this study indicate that an ADEM promotes and facilitates spontaneous ADR reporting and helps raise awareness about ADRs, including how and why they should be reported. Hopefully, this will assist national and European spontaneous reporting systems in their work to increase patient safety nationally and abroad. FUNDING:none. TRIAL REGISTRATION:not relevant. .
journal_name
Dan Med Jjournal_title
Danish medical journalauthors
Vinther S,Klarskov P,Borgeskov H,Darsø P,Christophersen AK,Borck B,Christensen C,Hansen MV,Halladin NM,Christensen MB,Harboe KM,Lund M,Jimenez-Solem Esubject
Has Abstractpub_date
2017-01-01 00:00:00issue
1issn
2245-1919pii
A5315journal_volume
64pub_type
杂志文章abstract：:Surgeons are increasingly using ultrasonography (US) in their clinical management of patients. However, US is a very user-dependent imaging modality and proper skills of the US operator are needed to ensure quality in patient care. This thesis explores the validity evidence for assessment of competence in abdominal an...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-11-01 00:00:00
abstract：INTRODUCTION:The aim of the study is to identify how disease management programmes for patients with a chronic disease work. This issue is explored from the patients' perspective. Specifically, we study how transition and coordination are related to the patient's perception of quality of care, with a particular focus o...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2016-03-01 00:00:00
abstract：INTRODUCTION:The primary purpose of reconstructive and cosmetic breast surgery is to improve patients' quality of life, and patient-reported outcome measurements are important in outcome assessment of breast surgery. The BREAST-Q questionnaire measures changes in quality of life and patient satisfaction in patients und...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2020-05-01 00:00:00
abstract：:End-stage liver diseases represent major health problems that are currently treated by liver transplantation. However, given the world-wide shortage of donor livers novel strategies are needed for therapeutic treatment. Adult stem cells have the ability to self-renew and differentiate into the more specialized cell ty...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2013-05-01 00:00:00
abstract：INTRODUCTION:Total mesorectal excision (TME) is the standard surgical treatment for mid and low rectal cancer. The procedure is performed by open, laparoscopic or robotic approaches. Transanal TME (TaTME) is a new procedure that potentially solves some difficulties in the pelvic part of the dissection. We aimed to eval...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2015-07-01 00:00:00
abstract：INTRODUCTION:Patients with diabetes suffering from hypoglycaemia may be treated by a Mobile Emergency Care Unit (MECU) and are often released at the scene following treatment. Some of these patients experience secondary hypoglycaemia and require renewed treatment or admission to hospital. The present study was initiate...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2015-04-01 00:00:00
abstract：INTRODUCTION:Patient blood management strategies for total hip and knee arthroplasty are controversial. They range from pre-operative haemoglobin optimisation to intra- and post-operative interventions. The aim of this study was to assess the various treatment modalities with respect to blood loss, haemoglobin levels a...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2015-12-01 00:00:00
abstract：INTRODUCTION:The treatment strategy for appendiceal mass is controversial, ranging from operation or image-guided drainage to conservative treatment with or without antibiotics. The aim of this study was to assess the various treatment modalities with respect to complications and treatment failure. METHODS:The analysi...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2014-08-01 00:00:00
abstract：INTRODUCTION:This study explored whether health-related quality of life (HRQOL) changes following Roux-en-Y gastric bypass surgery were associated with identifiable socio-demographic or clinical characteristics, and it examined the impact on health outcomes of changes in the Danish criteria for bariatric surgery. MATE...
journal_title：Danish medical journal
pub_type： 临床试验,杂志文章
doi：
更新日期：2014-07-01 00:00:00
abstract：INTRODUCTION:From the clinical forensic examination reports made at the Department of Forensic Medicine, the University of Copenhagen, in 2007 concerning rape, attempted rape and sexual assault (RAS), information about the assault, including both violence and the perpetrator's line of sexual action was extracted, analy...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-09-01 00:00:00
abstract：:The epidemiology and prognosis of ''fainting'' or syncope has puzzled physicians over the years. Is fainting dangerous? This is a question often asked by the patient--and the answer is ''it depends on a lot of things''. The diverse pathophysiology of syncope and the underlying comorbidites of the patients play an esse...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2013-09-01 00:00:00
abstract：INTRODUCTION:Abdominal auscultation is a part of the clinical examination of patients, but the determining factors in bowel sound evaluation are poorly described. The aim of this study was to assess inter- and intra-observer agreement in physicians' evaluation of pitch, intensity and quantity in abdominal auscultation....
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-05-01 00:00:00
abstract：INTRODUCTION:In order to optimise the selection process for admission to specialist training in family medicine, we developed a new design for structured applications and selection interviews. The design contains semi-structured interviews, which combine individualised elements from the applications with standardised b...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-09-01 00:00:00
abstract：INTRODUCTION:A routine follow-up urine sample (FUS) in the form of a midstream urine sample (MSU) is recommended after treatment for urinary tract infection (UTI) according to the Danish Paediatric Society (DPS) and "Lægehåndbogen" published by Danish Regions. We studied the effect of FUS with a focus on patients witho...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2015-01-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to examine the use of quantitative fluorescein angiographic analysis as a means of estimating rates of perfusion of the retina in eyes with a circulatory deficit secondary to carotid artery stenosis. MATERIAL AND METHODS:The study included 21 eyes with ocular ischaemic syndrome (...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-10-01 00:00:00
abstract：INTRODUCTION:When patients are transferred from intensive care units (ICUs) to general wards with a tracheostomy in situ, there is a risk of suboptimal care and increased morbidity. The aim of this study was to elucidate the management of patients with a tracheostomy in situ at discharge from the ICU to the ward. MATE...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
abstract：INTRODUCTION:Extant studies on arterial trauma originate from outside Denmark and their findings may therefore not apply to a Danish setting. The aim of the present study was to investigate the long-term mortality and clinical characteristics of patients with arterial trauma treated in Odense University Hospital (OUH)....
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2015-03-01 00:00:00
abstract：INTRODUCTION:This is a systematic review of existing literature on the diagnostic modalities and treatment of traumatic abdominal wall hernia caused by bicycle handlebar injury in children. METHODS: A systematic literature search was conducted covering incidents involving children below 17 years of age. Data were extr...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2018-01-01 00:00:00
abstract：INTRODUCTION:(99m)Tc-pertechnetate scintigraphy is much used in the evaluation of patients with nodular goitre. We investigated the ability of experienced observers to estimate the thyroid 24-h (131)I uptake (RAIU) and the thyroid volume by visual evaluation of the scintigram. MATERIAL AND METHODS:Two endocrinologists...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-02-01 00:00:00
abstract：INTRODUCTION:The health authorities have recommended that face-to-face consultations be substituted by telephone consultations to reduce the risk of virus transmission in out-patient clinics during the coronavirus disease 2019 (COVID-19) pandemic. The aim of the present study was to assess the frequency of such telepho...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2020-06-23 00:00:00
abstract：INTRODUCTION:Volvulus is an axial twist of any part of the gastrointestinal tract along its mesentery. If it goes unattended, it will cause bowel obstruction and bowel ischaemia with gangrene and perforation. The primary treatment is endoscopic desufflation, but the place for elective surgery is controversial. Volvulus...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-07-01 00:00:00
abstract：INTRODUCTION:This article presents the treatment results of 320 consecutive patients with malignant haematological diagnoses admitted to a tertiary intensive care unit at a Danish University hospital over a six-year period (2005-2010). With reference to international publications, we describe the development in treatme...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-03-01 00:00:00
abstract：INTRODUCTION:Clinical practice does not reflect current clinical guidelines recommending an early multimodal non-surgical treatment for knee and hip osteoarthritis (OA). The purpose of this study was to examine the feasibility of such an initiative (Good Life with osteoArthritis in Denmark (GLA:D) in persons with mild ...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-12-01 00:00:00
abstract：INTRODUCTION:Infants with bronchopulmonary dysplasia (BPD) are at high risk of developing cardiovascular sequelae in the form of pulmonary hypertension (PH) which significantly increases morbidity and mortality. The aim of this study was to evaluate the incidence of BPD, to identify characteristics associated with BPD ...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-08-01 00:00:00
abstract：INTRODUCTION:Tonsillectomy may be performed by several methods. It is continuously being discussed which method is preferable with regard to postoperative haemorrhage, pain, activity and nutrition. MATERIAL AND METHODS:The present study is a prospective non-randomized study of tonsillectomy. It included 198 patients a...
journal_title：Danish medical journal
pub_type： 临床试验,杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：INTRODUCTION:Brachial plexus injuries are usually a result of road traffic accidents and a cause of severe disability that typically affects young adult males. In 2010, a national centre was established for referral of these cases from Danish trauma centres. In this paper, we report on our surgical activity and reflect...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2015-03-01 00:00:00
abstract：INTRODUCTION:The widespread use of computed tomography (CT) improves detection of pulmonary lesions, which are not only detected at an increased rate but also at a smaller size. CT-guided lung biopsies are now more frequently used than fluoroscopy-guided lung biopsies. The main aim of the present paper was to investiga...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2016-06-01 00:00:00
abstract：INTRODUCTION:We investigated the frequency of con-sanguinity among the parents to newborns with inborn errors of metabolism (IEM) diagnosed by neonatal screening. METHODS:Data were obtained from 15 years of national newborn screening for selected IEM with autosomal recessive mode of inheritance. Among the 838,675 newb...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2018-10-01 00:00:00
abstract：:Both non-pathological psychological stress states and mental disorders are associated with molecular, cellular and epidemiological signs of accelerated aging. Oxidative stress on nucleic acids is a critical component of cellular and organismal aging, and a suggested pathogenic mechanism in several age-related somatic ...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-07-01 00:00:00
abstract：INTRODUCTION:The prevalence of sarcopenia varies extensively depending on the definitions and studied populations. The aim of this study was to assess the prevalence of sarcopenia in a Danish geriatric out-patient population using criteria from the European Working Group on Sarcopenia (EWGSOP). METHODS:Patients referr...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2018-06-01 00:00:00
