Abstract：
:Both non-pathological psychological stress states and mental disorders are associated with molecular, cellular and epidemiological signs of accelerated aging. Oxidative stress on nucleic acids is a critical component of cellular and organismal aging, and a suggested pathogenic mechanism in several age-related somatic disorders. The overall aim of the PhD project was to investigate the relation between psychopathology, psychological stress, stress hormone secretion and oxidatively generated DNA and RNA damage, as measured by the urinary excretion of markers of whole-body DNA/RNA oxidation (8-oxodG and 8-oxoGuo, respectively). The main hypothesis was that psychological stress states are associated with increased DNA/RNA damage from oxidation. In a study of 40 schizophrenia patients and 40 healthy controls matched for age and gender, we found that 8-oxodG/8-oxoGuo excretion was increased in schizophrenia patients, providing a possible molecular link between schizophrenia and its associated signs of accelerated aging. We found no association between psychopathology, perceived stress or cortisol secretion and 8-oxodG/8-oxoGuo excretion in the patients. In the controls, there were positive correlations between 8-oxodG/8-ocoGuo excretion and 9AM plasma cortisol, but no associations to perceived stress. In an animal study of experimentally induced chronic stress performed in metabolism cages, we found no increase in urinary 8-oxodG/8-oxoGuo or cerebral (hippocampal and frontal cortex) levels of oxidatively generated nucleic acid damage. However, there was a trend towards an increased expression of genes involved in DNA repair, possibly reflecting a compensatory mechanism. In a study of 220 elderly, mostly healthy individuals from the Italian InChianti cohort, we found a significant association between the 24 h urinary cortisol excretion and the excretion of 8-oxodG/8-oxoGuo, determined in the same samples. Collectively, the studies could not confirm an association between psychological stress and oxidative stress on nucleic acids. Systemic oxidatively generated DNA/RNA damage was increased in schizophrenia, and linked to cortisol levels in healthy humans. Finally, the cerebral repair of DNA may be an aspect of the adaptation that, to our knowledge, has not previously been addressed.
journal_name
Dan Med Jjournal_title
Danish medical journalauthors
Jørgensen Asubject
Has Abstractpub_date
2013-07-01 00:00:00pages
B4685issue
7issn
2245-1919pii
B4685journal_volume
60pub_type
杂志文章abstract：INTRODUCTION:Neoadjuvant chemotherapy (NACT) has been found useful in downstaging tumours in women with primary operable breast cancer without increasing mortality. As a result of several studies supporting this, the Danish Breast Cancer Cooperative Group implemented new guidelines for the treatment of primary operable...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2020-11-04 00:00:00
abstract：INTRODUCTION:An indication of the adequacy of the intra-vascular volume is of importance in critically ill patients. The status of the intravascular volume can be determined from a fluid challenge test. Most tests involve invasive monitoring. An exception is the capnographic measurement of changes in end-tidal (ET) CO2...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2019-09-01 00:00:00
abstract：INTRODUCTION:Abdominal auscultation is a part of the clinical examination of patients, but the determining factors in bowel sound evaluation are poorly described. The aim of this study was to assess inter- and intra-observer agreement in physicians' evaluation of pitch, intensity and quantity in abdominal auscultation....
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:Active surveillance - an initial observational strategy - offers a tailored management of patients with localised prostate cancer. The aim of the strategy is to appoint patients with potentially lethal prostate cancer to curatively intended treatment, while patients with slowly evolving tumours are spared fr...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2015-02-01 00:00:00
abstract：INTRODUCTION:The treatment strategy for appendiceal mass is controversial, ranging from operation or image-guided drainage to conservative treatment with or without antibiotics. The aim of this study was to assess the various treatment modalities with respect to complications and treatment failure. METHODS:The analysi...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2014-08-01 00:00:00
abstract：:Surgeons are increasingly using ultrasonography (US) in their clinical management of patients. However, US is a very user-dependent imaging modality and proper skills of the US operator are needed to ensure quality in patient care. This thesis explores the validity evidence for assessment of competence in abdominal an...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-11-01 00:00:00
abstract：:The epidemiology and prognosis of ''fainting'' or syncope has puzzled physicians over the years. Is fainting dangerous? This is a question often asked by the patient--and the answer is ''it depends on a lot of things''. The diverse pathophysiology of syncope and the underlying comorbidites of the patients play an esse...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2013-09-01 00:00:00
abstract：INTRODUCTION:Tonsillectomy may be performed by several methods. It is continuously being discussed which method is preferable with regard to postoperative haemorrhage, pain, activity and nutrition. MATERIAL AND METHODS:The present study is a prospective non-randomized study of tonsillectomy. It included 198 patients a...
journal_title：Danish medical journal
pub_type： 临床试验,杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：INTRODUCTION:The incidence of cutaneous melanoma is increasing in Denmark and worldwide. However, the prevalence of distant metastases at the time of diagnosis has decreased to 1%. We therefore questioned the value of routine preoperative chest X-ray (CXR) for staging asymptomatic melanoma patients and hypothesised tha...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2016-12-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by pain, swelling and progressive destruction of the joints leading to loss of function and invalidity. The bone destruction in RA is characterised by two distinct features: structural joint damage and hand bone loss, and their prevention is an im...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2018-03-01 00:00:00
abstract：INTRODUCTION:When patients are transferred from intensive care units (ICUs) to general wards with a tracheostomy in situ, there is a risk of suboptimal care and increased morbidity. The aim of this study was to elucidate the management of patients with a tracheostomy in situ at discharge from the ICU to the ward. MATE...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
abstract：INTRODUCTION:Patients' non-attendance is a significant problem in modern healthcare. Non-attendance delays treatment, reduces efficiency and increases healthcare costs. For several years, the introduction of financial incentives such as a non-attendance fee has been discussed in Denmark. Set in the context of a tax-fin...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2016-07-01 00:00:00
abstract：INTRODUCTION:Tuberous sclerosis complex (TSC) is a rare autosomal dominant multi-organ disease. In TSC, epilepsy is frequent and often treatment refractory. Dysfunction of the tumour-suppressing hamartin/tuberin complex leads to an over-activated mammalian target of rapamycin (mTOR) signalling pathway and uncontrolled ...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2019-12-01 00:00:00
abstract：INTRODUCTION:Mechanical restraint and other forms of coercion may be used under certain circumstances at psych-iatric wards. The use of coercion receives considerable focus, yet little is known about its diurnal distribution. We examined the initiation of mechanical restraint, sedative drug administration, physical ret...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-08-01 00:00:00
abstract：INTRODUCTION:The aim of the study is to identify how disease management programmes for patients with a chronic disease work. This issue is explored from the patients' perspective. Specifically, we study how transition and coordination are related to the patient's perception of quality of care, with a particular focus o...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2016-03-01 00:00:00
abstract：INTRODUCTION:Pelvic sepsis after Hartmann's procedure for low rectal cancer is a frequent complication. It has been reported at a frequency of 12.2-17.2% and has even reached 33% when the transection level of the rectum is ≤ 2 cm from the anal verge. The aim of this study was to examine whether intersphincteric proctec...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-12-01 00:00:00
abstract：INTRODUCTION:From the clinical forensic examination reports made at the Department of Forensic Medicine, the University of Copenhagen, in 2007 concerning rape, attempted rape and sexual assault (RAS), information about the assault, including both violence and the perpetrator's line of sexual action was extracted, analy...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-09-01 00:00:00
abstract：INTRODUCTION:Microbiological documentation of one uropathogenic bacterium in significant numbers in urine from patients with typical symptoms is the gold standard for diagnosing urinary tract infection (UTI). Cleaning before collecting midstream urine (MSU) is reported not to reduce the risk of contaminating the sample...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-06-01 00:00:00
abstract：INTRODUCTION:The aim was to illustrate current use of temporary pacing (TP) in Denmark by replicating a questionnaire study from 1986 and to compare the results of the two studies. MATERIAL AND METHODS:The questionnaire was sent to Danish hospitals treating patients with acute myocardial infarction (AMI). To illustrat...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-02-01 00:00:00
abstract：:Fertility treatment has been associated with obstetrical and perinatal complications. It is, however, uncertain whether fertility treatment or parental subfertility is associated with long-term development of the children. We aimed to assess the growth and mental health of children and adolescents conceived after fert...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-10-01 00:00:00
abstract：INTRODUCTION:The objective was to search the literature with a view to providing a general description of critical illness myopathy/polyneuropathy (CIM/CIP), including its genesis and prevention. Furthermore, it was our aim to determine whether new treatments have occurred in the past five years. MATERIAL AND METHODS:...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2012-10-01 00:00:00
abstract：INTRODUCTION:The prevalence of sarcopenia varies extensively depending on the definitions and studied populations. The aim of this study was to assess the prevalence of sarcopenia in a Danish geriatric out-patient population using criteria from the European Working Group on Sarcopenia (EWGSOP). METHODS:Patients referr...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2018-06-01 00:00:00
abstract：INTRODUCTION:Atrial fibrillation (AF) is a cardiac epidemic. In this study, we aimed to describe the causes of hospital-isation in an AF population over time and to study how different AF treatment strategies affected hospitalization. MATERIAL AND METHODS:This was an observational study in which long-term follow-up da...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：INTRODUCTION:Surveying sexual behaviour of the general population serves to identify key points of preventive interventions, monitor the effect and interpret changes in patterns of disease. Validated questionnaires describing sexual behaviour can be adapted to some extent from other countries, but national adaption, re...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：INTRODUCTION:In Copenhagen, Denmark, patients in need of prehospital emergency assistance dial 112 and may then receive evaluation and treatment by physicians (from the Mobile Emergency Care Unit (MECU)). ST-elevation myocardial infarction (STEMI) is a severe condition leaving only a limited time frame to deliver optim...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-04-01 00:00:00
abstract：INTRODUCTION:Treatment of infections in neonates with gentamicin is a balance between optimising bactericidal effect and minimising adverse effects. Previously, at the Neonatal Intensive Care Unit (NICU) at Kolding Hospital, Denmark, neonates suspected of having infections were treated daily with gentamicin 5 mg/kg for...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-06-01 00:00:00
abstract：INTRODUCTION:This study reports our experience with microscopic phonosurgery (PS) of benign lesions of the vocal folds. MATERIAL AND METHODS:During the five-year period from 2003 to 2007, a total of 97 patients had PS for vocal fold polyps (n = 63), vocal fold cysts (n = 17), vocal fold nodules (n = 12) or vocal fold ...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-02-01 00:00:00
abstract：:Hip dysplasia and hip joint deformities in general are recognized as possible precursors of osteoarthritic development. Early and correct identification of hip dysplasia is important in order to offer timely joint preserving treatment. In the contemporary literature, several controversies exist, and some of these were...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2012-06-01 00:00:00
abstract：:Today, sentinel lymph node dissection (SLND) has replaced axillary lymph node dissection (ALND) as standard procedure for staging of the axilla in the treatment of breast cancer. SLND can accurately stage the axilla by removing on average only two lymph nodes. Only in case of metastatic spread to sentinel nodes an ALN...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2012-07-01 00:00:00
abstract：INTRODUCTION:Recently, we established that a group of obese children and adolescents had a higher blood pressure (BP) than a healthy control group. In the present study, we investigate whether the higher BP in the obese group was influenced by BP cuff sizes. METHODS:A total of 104 obese patients aged 10-18 years were ...
journal_title：Danish medical journal
pub_type： 临床试验,杂志文章
doi：
更新日期：2016-01-01 00:00:00
