Abstract：
INTRODUCTION:Neoadjuvant chemotherapy (NACT) has been found useful in downstaging tumours in women with primary operable breast cancer without increasing mortality. As a result of several studies supporting this, the Danish Breast Cancer Cooperative Group implemented new guidelines for the treatment of primary operable T2 N0/N1 M0 ductal carcinomas in late 2016, treating patients with six cycles of NACT. This study aimed to conduct a quality assessment of the efficacy of the NACT regime based on real-time data from a single Danish hospital. METHODS:A retrospective observational study was conducted at Odense University Hospital, Denmark, from the introduction of the NACT regime to December 2018. Patients were identified using the surgical department's registry. Through medical chart review, predefined outcomes were collected on tumour characteristics, surgical outcomes, treatment response and type of NACT treatment. Descriptive statistics and Fisher's exact test were used on relevant data. RESULTS:Among the 64 patients, 67% completed a recommended NACT regime. A 55% majority underwent lumpectomy and 64% were spared axillary dissection. Complete pathological response was found in 28% of patients. After treatment, 38% of the pre-NACT N1 patients were downstaged to N0. CONCLUSIONS:This study indicated that the NACT regime was a favourable treatment strategy for these patients. Two-thirds of patients were able to undergo a recommended NACT regime. The majority of patients were both spared axillary dissection and mastectomy. FUNDING:none. TRIAL REGISTRATION:not relevant.
journal_name
Dan Med Jjournal_title
Danish medical journalauthors
Halberg AK,Gravesen CD,Cold S,Jensen JDsubject
Has Abstractpub_date
2020-11-04 00:00:00issue
12issn
2245-1919pii
A01200010journal_volume
67pub_type
杂志文章abstract：INTRODUCTION:The aim of the study is to identify how disease management programmes for patients with a chronic disease work. This issue is explored from the patients' perspective. Specifically, we study how transition and coordination are related to the patient's perception of quality of care, with a particular focus o...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2016-03-01 00:00:00
abstract：INTRODUCTION:Treatment of infections in neonates with gentamicin is a balance between optimising bactericidal effect and minimising adverse effects. Previously, at the Neonatal Intensive Care Unit (NICU) at Kolding Hospital, Denmark, neonates suspected of having infections were treated daily with gentamicin 5 mg/kg for...
journal_title：Danish medical journal
pub_type： 杂志文章
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更新日期：2017-06-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2015-11-01 00:00:00
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journal_title：Danish medical journal
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doi：
更新日期：2019-07-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章,多中心研究
doi：
更新日期：2016-10-01 00:00:00
abstract：INTRODUCTION:Marfan syndrome is an autosomal, dominantly inherited disorder of the connective tissue. We report the clinical data and results of a genetic analysis of a large Danish Marfan family. METHODS:Sanger sequencing of FBN1 was initially performed on genomic DNA from the index patient. Subsequently, four affect...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-11-01 00:00:00
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journal_title：Danish medical journal
pub_type： 临床试验,杂志文章
doi：
更新日期：2012-01-01 00:00:00
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journal_title：Danish medical journal
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更新日期：2012-07-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章
doi：
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journal_title：Danish medical journal
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journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2020-09-07 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2015-09-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2018-11-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2018-03-01 00:00:00
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journal_title：Danish medical journal
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doi：
更新日期：2016-04-01 00:00:00
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journal_title：Danish medical journal
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doi：
更新日期：2012-10-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2018-05-01 00:00:00
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journal_title：Danish medical journal
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doi：
更新日期：2015-04-01 00:00:00
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journal_title：Danish medical journal
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doi：
更新日期：2012-12-01 00:00:00
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journal_title：Danish medical journal
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doi：
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doi：
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更新日期：2019-12-01 00:00:00
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doi：
更新日期：2016-06-01 00:00:00
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doi：
更新日期：2018-10-01 00:00:00
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pub_type： 杂志文章
doi：
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journal_title：Danish medical journal
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doi：
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