Abstract：
INTRODUCTION:Treatment of infections in neonates with gentamicin is a balance between optimising bactericidal effect and minimising adverse effects. Previously, at the Neonatal Intensive Care Unit (NICU) at Kolding Hospital, Denmark, neonates suspected of having infections were treated daily with gentamicin 5 mg/kg for the first three days, thus exposing the smallest neonates to double gentamicin amounts compared with those used in most Danish NICUs. We aimed to evaluate if this regimen increased the trough values and oto- and nephrotoxicity. METHODS:Neonates admitted to the NICU between 2008 and 2012 and treated with gentamicin were included retrospectively in the study. Neonates with trough serum (S)-gentamicin level ≥ 2.0 mg/l before the third dose were reviewed in detail. RESULTS:In total, S-gentamicin level was measured in 253 treated neonates of whom 7% displayed elevated trough values. Neonates < 32 weeks of age had a slightly higher incidence of S-gentamicin level ≥ 2.0 mg/l compared with less premature and mature infants (16%, 13%, and 2%, respectively). No oto- or nephrotoxicity was found despite the high-dose gentamicin regimen. CONCLUSIONS:The incidence of elevated S-gentamicin trough levels was increased among very premature neonates. However, no evidence of oto- or nephrotoxicity was observed. This simple regimen of gentamicin 5 mg/kg for the first three days should be considered for all neonates as it potentially minimises the risk of dosing errors and bacterial breakthrough infection. FUNDING:none. TRIAL REGISTRATION:Danish Data Protection Agency (2008-58-0035).
journal_name
Dan Med Jjournal_title
Danish medical journalauthors
Blaabjerg AS,Kofoed PE,Dalegaard MC,Fenger-Gron Jsubject
Has Abstractpub_date
2017-06-01 00:00:00issue
6issn
2245-1919pii
A5387journal_volume
64pub_type
杂志文章abstract：INTRODUCTION:Colorectal cancer is a common malignant disease, caused by different aetiologies and molecular pathways. Heterogeneous results have been published regarding the association of microsatellite instability and clinicopathological features. The aim of this study was to compare clinicopathological features of m...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2016-02-01 00:00:00
abstract：INTRODUCTION:Difficult airway management is associated with an increased risk of morbidity and mortality. Several preoperative risk factors associated with airway management difficulties have been proposed; however, no clear guideline for airway assessments exists. We therefore hypothesised that Danish airway assessmen...
journal_title：Danish medical journal
pub_type： 杂志文章,多中心研究
doi：
更新日期：2016-10-01 00:00:00
abstract：:Excessive health anxiety, still designated as hypochondriasis in ICD-10, refers to worries and anxiety about harbouring serious illness. It is common in both primary and secondary health care with prevalence rates up to 9% and causes great suffering for the individual as well as high health care costs when untreated. ...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-05-01 00:00:00
abstract：INTRODUCTION:In order to optimise the selection process for admission to specialist training in family medicine, we developed a new design for structured applications and selection interviews. The design contains semi-structured interviews, which combine individualised elements from the applications with standardised b...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-09-01 00:00:00
abstract：:Surgeons are increasingly using ultrasonography (US) in their clinical management of patients. However, US is a very user-dependent imaging modality and proper skills of the US operator are needed to ensure quality in patient care. This thesis explores the validity evidence for assessment of competence in abdominal an...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-11-01 00:00:00
abstract：INTRODUCTION:The incidence of cutaneous malignant melanoma is rapidly increasing in Denmark like in other Northern and Western European countries. Our objective was to investigate the characteristics of current patients suffering from cutaneous malignant melanoma. METHODS:We evaluated patient and tumour characteristic...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2015-10-01 00:00:00
abstract：:The overall aim of this thesis was to validate the new concept of the Fertility Assessment and Counselling (FAC) Clinic at Rigshospitalet. The intention was to: explore the prognostic value of fertility risk factors by a risk score and provide an estimate of female fecundity, to quantify the impact of oral contracepti...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2016-10-01 00:00:00
abstract：INTRODUCTION:Clinical practice does not reflect current clinical guidelines recommending an early multimodal non-surgical treatment for knee and hip osteoarthritis (OA). The purpose of this study was to examine the feasibility of such an initiative (Good Life with osteoArthritis in Denmark (GLA:D) in persons with mild ...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-12-01 00:00:00
abstract：INTRODUCTION:The aim of the study is to identify how disease management programmes for patients with a chronic disease work. This issue is explored from the patients' perspective. Specifically, we study how transition and coordination are related to the patient's perception of quality of care, with a particular focus o...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2016-03-01 00:00:00
abstract：INTRODUCTION:Patients living alone or having a low socioeconomic status are likely to quit cardiac rehabilitation. We aimed to compare patients being offered extended rehabilitation (ERP) with those being offered standard rehabilitation (SRP) as concerns 1) attendance rates and 2) achievement of treatment goals at 12 m...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by pain, swelling and progressive destruction of the joints leading to loss of function and invalidity. The bone destruction in RA is characterised by two distinct features: structural joint damage and hand bone loss, and their prevention is an im...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2018-03-01 00:00:00
abstract：:Heart failure is a complex clinical syndrome and one of the leading causes of morbidity and mortality with a prevalence of 1%-2% of the adult population. The prognosis is poor with a 5-year mortality rate of 50%, which partly can be attributed to the presence of concomitant comorbidity, including neurological and psyc...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2018-04-01 00:00:00
abstract：INTRODUCTION:Tuberous sclerosis complex (TSC) is a rare autosomal dominant multi-organ disease. In TSC, epilepsy is frequent and often treatment refractory. Dysfunction of the tumour-suppressing hamartin/tuberin complex leads to an over-activated mammalian target of rapamycin (mTOR) signalling pathway and uncontrolled ...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2019-12-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to examine the use of quantitative fluorescein angiographic analysis as a means of estimating rates of perfusion of the retina in eyes with a circulatory deficit secondary to carotid artery stenosis. MATERIAL AND METHODS:The study included 21 eyes with ocular ischaemic syndrome (...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-10-01 00:00:00
abstract：:Kidney cancer (Renal Cell Carcinoma (RCC)) is one of the most deadly malignancies due to frequent late diagnosis and poor treatment options. Histologically, RCC embraces a wide variety of different subtypes with the clear cell variant (ccRCC) being the most common, accounting for 75-90% of all RCCs. At present, the su...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-10-01 00:00:00
abstract：INTRODUCTION:Due to the coronavirus disease 2019 (COVID-19) exposure in Denmark, first-line referral centres were established to handle all patients suspected of COVID-19 or other upper respiratory tract infection. Here we report the first experiences from a first-line referral centre from Amager-Hvidovre Hospital, sit...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2020-08-07 00:00:00
abstract：INTRODUCTION:The objective was to search the literature with a view to providing a general description of critical illness myopathy/polyneuropathy (CIM/CIP), including its genesis and prevention. Furthermore, it was our aim to determine whether new treatments have occurred in the past five years. MATERIAL AND METHODS:...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2012-10-01 00:00:00
abstract：INTRODUCTION:Brachial plexus injuries are usually a result of road traffic accidents and a cause of severe disability that typically affects young adult males. In 2010, a national centre was established for referral of these cases from Danish trauma centres. In this paper, we report on our surgical activity and reflect...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2015-03-01 00:00:00
abstract：INTRODUCTION:Vitamin D plays an important role in a broad range of organ functions, including the cardiovascular system. Only one study has tested the association between vitamin D deficiency and arrhythmia and it found no association. The aim of the present study was to evaluate the association between vitamin D defic...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-09-01 00:00:00
abstract：INTRODUCTION:The aim was to illustrate current use of temporary pacing (TP) in Denmark by replicating a questionnaire study from 1986 and to compare the results of the two studies. MATERIAL AND METHODS:The questionnaire was sent to Danish hospitals treating patients with acute myocardial infarction (AMI). To illustrat...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-02-01 00:00:00
abstract：:Sudden Cardiac Death (SCD) in the young (aged 1-35 years), although presumably rare, is always a tragic and devastating event often occurring in apparently healthy persons. Through the last decades, research have been undertaken to estimate the incidence rate and underlying causes of these deaths. However, because aut...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-02-01 00:00:00
abstract：:Hip dysplasia and hip joint deformities in general are recognized as possible precursors of osteoarthritic development. Early and correct identification of hip dysplasia is important in order to offer timely joint preserving treatment. In the contemporary literature, several controversies exist, and some of these were...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2012-06-01 00:00:00
abstract：INTRODUCTION:Spontaneous reporting of adverse drug reactions (ADRs) is used for continuous risk-benefit evaluation of marketed pharmaceutical products and for signal detection. The Adverse Drug Event Manager (ADEM) is a service offered to clinicians employed at hospitals in the Capital Region of Denmark. The ADEM assis...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:Tonsillectomy may be performed by several methods. It is continuously being discussed which method is preferable with regard to postoperative haemorrhage, pain, activity and nutrition. MATERIAL AND METHODS:The present study is a prospective non-randomized study of tonsillectomy. It included 198 patients a...
journal_title：Danish medical journal
pub_type： 临床试验,杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：INTRODUCTION:Pelvic sepsis after Hartmann's procedure for low rectal cancer is a frequent complication. It has been reported at a frequency of 12.2-17.2% and has even reached 33% when the transection level of the rectum is ≤ 2 cm from the anal verge. The aim of this study was to examine whether intersphincteric proctec...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-12-01 00:00:00
abstract：INTRODUCTION:Fine-needle aspiration biopsy (FNAB) is the cornerstone of thyroid nodule evaluation. In most cases, FNAB can discriminate between benign and malignant disease. In other cases, it is only indicative of malignancy and the results are considered "suspicious". In Denmark, thyroid FNAB results are categorised ...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-02-01 00:00:00
abstract：INTRODUCTION:Despite rehabilitation programmes offered to all patients with newly diagnosed type 2 diabetes in Denmark, a number of patients either never accomplish good diabetes regulation or the regulation deteriorates with time. Therefore, new approaches are needed. The aim of the present study is to examine whether...
journal_title：Danish medical journal
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2013-12-01 00:00:00
abstract：INTRODUCTION:When patients are transferred from intensive care units (ICUs) to general wards with a tracheostomy in situ, there is a risk of suboptimal care and increased morbidity. The aim of this study was to elucidate the management of patients with a tracheostomy in situ at discharge from the ICU to the ward. MATE...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
abstract：INTRODUCTION:Patient blood management strategies for total hip and knee arthroplasty are controversial. They range from pre-operative haemoglobin optimisation to intra- and post-operative interventions. The aim of this study was to assess the various treatment modalities with respect to blood loss, haemoglobin levels a...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2015-12-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to compare cancer mortality among migrant patients with cancer mortality in Danish-born patients. MATERIAL AND METHODS:This was a historical prospective cohort study. All non-Western migrants (n = 56,273) who were granted a right to residency in Denmark between 1 January 1993 and...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-06-01 00:00:00
