Abstract：
INTRODUCTION:An indication of the adequacy of the intra-vascular volume is of importance in critically ill patients. The status of the intravascular volume can be determined from a fluid challenge test. Most tests involve invasive monitoring. An exception is the capnographic measurement of changes in end-tidal (ET) CO2 after a fluid challenge. The method is appealing as it rests on solid physiological ground - the Fick principle and the Frank-Starling mechanism. Furthermore, it is non-invasive and convenient. We report the results of a systematic review of the merits of this method. METHODS:After a registration with PROSPERO, we searched MEDLINE, EMBASE, the Cochrane Library database and trial registers for studies on the diagnostic accuracy of changes in ET-CO2 in fluid responsiveness testing. Test sensitivity, specificity and area under the receiver operating charac-teristics curve (AUROC) were the primary outcome meas-ures. RESULTS:Seven papers met the inclusion criteria. The test was found to have a median sensitivity of 0.75 (range: 0.60-0.91) and a median specificity of 0.94 (range: 0.70-1.00). The median AUROC was 0.82 (range: 0.67-0.94); the diagnostic threshold was an increase in ET-CO2 of 2 mmHg/5%. CONCLUSIONS:Monitoring of ET-CO2 during fluid responsiveness testing provides good diagnostic value with few false negative tests and fewer false positive tests. The included studies have important methodological flaws. It must therefore be acknowledged that the diagnostic value of ET-CO2 monitoring found in the review is overrated and overrated to an unknown degree. Therefore, at the present state of affairs, implementation of the test cannot be considered evidence-based.
journal_name
Dan Med Jjournal_title
Danish medical journalauthors
Øberg EB,Jørgensen BG,Berthelsen PGsubject
Has Abstractpub_date
2019-09-01 00:00:00issue
9issn
2245-1919pii
A5560journal_volume
66pub_type
杂志文章abstract：INTRODUCTION:Transferring a patient from one health-care sector to another implies a risk of medication errors. It is of interest to evaluate whether a specialist in clinical pharmacy is beneficial for the patients in the emergency departments (ED). The aim of the present study was to report the incidence, categories a...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-11-01 00:00:00
abstract：INTRODUCTION:Difficult airway management is associated with an increased risk of morbidity and mortality. Several preoperative risk factors associated with airway management difficulties have been proposed; however, no clear guideline for airway assessments exists. We therefore hypothesised that Danish airway assessmen...
journal_title：Danish medical journal
pub_type： 杂志文章,多中心研究
doi：
更新日期：2016-10-01 00:00:00
abstract：:Sudden Cardiac Death (SCD) in the young (aged 1-35 years), although presumably rare, is always a tragic and devastating event often occurring in apparently healthy persons. Through the last decades, research have been undertaken to estimate the incidence rate and underlying causes of these deaths. However, because aut...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-02-01 00:00:00
abstract：:The overall aim of this thesis was to validate the new concept of the Fertility Assessment and Counselling (FAC) Clinic at Rigshospitalet. The intention was to: explore the prognostic value of fertility risk factors by a risk score and provide an estimate of female fecundity, to quantify the impact of oral contracepti...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2016-10-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章,多中心研究
doi：
更新日期：2016-09-01 00:00:00
abstract：INTRODUCTION:This article presents the treatment results of 320 consecutive patients with malignant haematological diagnoses admitted to a tertiary intensive care unit at a Danish University hospital over a six-year period (2005-2010). With reference to international publications, we describe the development in treatme...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-03-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2016-08-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2016-07-01 00:00:00
abstract：INTRODUCTION:Pain and distress during minor hospital-related procedures is a familiar problem in many children. Inadequate relief of children's procedural pain and distress not only affects the experience of the children and their parents, but also adversely impacts procedural success. We aimed to review the safety and...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2013-06-01 00:00:00
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journal_title：Danish medical journal
pub_type： 临床试验,杂志文章
doi：
更新日期：2014-07-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2016-11-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-04-01 00:00:00
abstract：:Fertility treatment has been associated with obstetrical and perinatal complications. It is, however, uncertain whether fertility treatment or parental subfertility is associated with long-term development of the children. We aimed to assess the growth and mental health of children and adolescents conceived after fert...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-10-01 00:00:00
abstract：INTRODUCTION:The aim of the study is to identify how disease management programmes for patients with a chronic disease work. This issue is explored from the patients' perspective. Specifically, we study how transition and coordination are related to the patient's perception of quality of care, with a particular focus o...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2016-03-01 00:00:00
abstract：INTRODUCTION:The widespread use of computed tomography (CT) improves detection of pulmonary lesions, which are not only detected at an increased rate but also at a smaller size. CT-guided lung biopsies are now more frequently used than fluoroscopy-guided lung biopsies. The main aim of the present paper was to investiga...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2016-06-01 00:00:00
abstract：INTRODUCTION:Knowledge of trauma patients is often based on US studies. However, these may not be representative of the Scandinavian population. Knowing which trauma patients are at risk of dying might help us target and optimise their treatment. The purpose of this study was to examine the epidemiological characterist...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-10-01 00:00:00
abstract：INTRODUCTION:Patient blood management strategies for total hip and knee arthroplasty are controversial. They range from pre-operative haemoglobin optimisation to intra- and post-operative interventions. The aim of this study was to assess the various treatment modalities with respect to blood loss, haemoglobin levels a...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2015-12-01 00:00:00
abstract：INTRODUCTION:Psychiatric disorders are common among patients with irritable bowel syndrome (IBS) which may make a psychiatric evaluation appropriate. The Hospital Anxiety and Depression Scale (HADS) has been recommended internationally for screening. The Common Mental Disorder Questionnaire (CMDQ) is a novel Danish ins...
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pub_type： 杂志文章,随机对照试验
doi：
更新日期：2014-02-01 00:00:00
abstract：INTRODUCTION:Marfan syndrome is an autosomal, dominantly inherited disorder of the connective tissue. We report the clinical data and results of a genetic analysis of a large Danish Marfan family. METHODS:Sanger sequencing of FBN1 was initially performed on genomic DNA from the index patient. Subsequently, four affect...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-11-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-08-01 00:00:00
abstract：INTRODUCTION:The primary purpose of reconstructive and cosmetic breast surgery is to improve patients' quality of life, and patient-reported outcome measurements are important in outcome assessment of breast surgery. The BREAST-Q questionnaire measures changes in quality of life and patient satisfaction in patients und...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2020-05-01 00:00:00
abstract：INTRODUCTION:The Danish Adult Diabetes Database (DADD) annually reports a quality indicator for lipid-lowering treatment of type 2 diabetes mellitus (T2DM) patients. This retrospective cohort study aims to A) investigate the reasons for inadequate or lacking lipid-lowering treatment and to B) assess the validity of the...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2018-09-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-07-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2014-04-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-12-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2018-03-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-05-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2018-10-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2020-08-07 00:00:00
abstract：INTRODUCTION:(99m)Tc-pertechnetate scintigraphy is much used in the evaluation of patients with nodular goitre. We investigated the ability of experienced observers to estimate the thyroid 24-h (131)I uptake (RAIU) and the thyroid volume by visual evaluation of the scintigram. MATERIAL AND METHODS:Two endocrinologists...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-02-01 00:00:00
