Abstract：
INTRODUCTION:Pain and distress during minor hospital-related procedures is a familiar problem in many children. Inadequate relief of children's procedural pain and distress not only affects the experience of the children and their parents, but also adversely impacts procedural success. We aimed to review the safety and efficacy of nitrous oxide during brief, but painful paediatric procedures and to compare nitrous oxide with some of the commonly used pharmacological and non-pharmacological treatments for relieving anxiety and mild to moderate pain in Denmark. METHOD:We searched MEDLINE (PubMed) and the Cochrane Database of Systematic Reviews with the MeSH term nitrous oxide combined with midazolam, surgical procedures minor, analgesia or conscious sedation. The references in the articles acquired that were not found in the MEDLINE search were further investigated. Only articles written in English and published after 1980 were included to ensure optimal data collection. RESULTS:Nitrous oxide is an effective sedative/analgesic for mildly to moderately painful paediatric procedures. Furthermore, it is safely administrated, particularly for short procedures (< 15 min.). Serious and potentially serious adverse events are rare and occur in less than 0.5% of cases, while minor events typically occur amongst 4-8% of patients. CONCLUSION:Nitrous oxide is a safe and effective method to achieve analgesia and sedation during minor, but painful procedures. It can be safely administered by a dedicated staff member. This helpful method is still underused in Denmark, and we believe that it could be an alternative or the first choice of treatment in emergency and paediatric departments.
journal_name
Dan Med Jjournal_title
Danish medical journalauthors
Pedersen RS,Bayat A,Steen NP,Jacobsson MLsubject
Has Abstractpub_date
2013-06-01 00:00:00pages
A4627issue
6issn
2245-1919pii
A4627journal_volume
60pub_type
杂志文章,评审abstract：INTRODUCTION:Mechanical restraint and other forms of coercion may be used under certain circumstances at psych-iatric wards. The use of coercion receives considerable focus, yet little is known about its diurnal distribution. We examined the initiation of mechanical restraint, sedative drug administration, physical ret...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Active surveillance - an initial observational strategy - offers a tailored management of patients with localised prostate cancer. The aim of the strategy is to appoint patients with potentially lethal prostate cancer to curatively intended treatment, while patients with slowly evolving tumours are spared fr...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2015-02-01 00:00:00
abstract：:Ischemia-reperfusion injuries occur when the blood supply to an organ or tissue is temporarily cut-off and then restored. Even though the restoration of blood flow is absolutely essential in preventing tissue death, the reperfusion of oxygenated blood to the oxygen-deprived areas may in itself augment the tissue damag...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2015-04-01 00:00:00
abstract：INTRODUCTION:Patient blood management strategies for total hip and knee arthroplasty are controversial. They range from pre-operative haemoglobin optimisation to intra- and post-operative interventions. The aim of this study was to assess the various treatment modalities with respect to blood loss, haemoglobin levels a...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2015-12-01 00:00:00
abstract：INTRODUCTION:Adjuvant treatment of early-stage breast cancer has been associated with bone loss in randomised trials, but evidence from unselected populations is needed. In a single-center study, we assessed the annual percentage change in bone mineral density (∆BMDt) and risk of osteoporosis from two to five years aft...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2020-10-20 00:00:00
abstract：INTRODUCTION:The incidence of cutaneous malignant melanoma is rapidly increasing in Denmark like in other Northern and Western European countries. Our objective was to investigate the characteristics of current patients suffering from cutaneous malignant melanoma. METHODS:We evaluated patient and tumour characteristic...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2015-10-01 00:00:00
abstract：INTRODUCTION:An indication of the adequacy of the intra-vascular volume is of importance in critically ill patients. The status of the intravascular volume can be determined from a fluid challenge test. Most tests involve invasive monitoring. An exception is the capnographic measurement of changes in end-tidal (ET) CO2...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2019-09-01 00:00:00
abstract：INTRODUCTION:Surveying sexual behaviour of the general population serves to identify key points of preventive interventions, monitor the effect and interpret changes in patterns of disease. Validated questionnaires describing sexual behaviour can be adapted to some extent from other countries, but national adaption, re...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：:Surgeons are increasingly using ultrasonography (US) in their clinical management of patients. However, US is a very user-dependent imaging modality and proper skills of the US operator are needed to ensure quality in patient care. This thesis explores the validity evidence for assessment of competence in abdominal an...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-11-01 00:00:00
abstract：INTRODUCTION:Abdominal auscultation is a part of the clinical examination of patients, but the determining factors in bowel sound evaluation are poorly described. The aim of this study was to assess inter- and intra-observer agreement in physicians' evaluation of pitch, intensity and quantity in abdominal auscultation....
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-05-01 00:00:00
abstract：INTRODUCTION:The health authorities have recommended that face-to-face consultations be substituted by telephone consultations to reduce the risk of virus transmission in out-patient clinics during the coronavirus disease 2019 (COVID-19) pandemic. The aim of the present study was to assess the frequency of such telepho...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2020-06-23 00:00:00
abstract：INTRODUCTION:Severely painful or dysfunctional destroyed wrists can be reconstructed by fusion, interposition of soft-tissue or by arthroplasty using artificial materials. Total and partial wrist arthroplasty (T/PWA) has been used on a regular basis since the 1960's. The objective of this study was to review the litera...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2014-05-01 00:00:00
abstract：:Bariatric surgery (e.g. Roux-en-Y gastric bypass (RYGB)) has proven the most effective way of achieving sustainable weight losses and remission of type 2 diabetes (T2D). Studies indicate that the effectiveness of RYGB is mediated by an altered gastrointestinal tract anatomy, which in particular favours release of the ...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2016-11-01 00:00:00
abstract：:Hip dysplasia and hip joint deformities in general are recognized as possible precursors of osteoarthritic development. Early and correct identification of hip dysplasia is important in order to offer timely joint preserving treatment. In the contemporary literature, several controversies exist, and some of these were...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2012-06-01 00:00:00
abstract：INTRODUCTION:Due to the coronavirus disease 2019 (COVID-19) exposure in Denmark, first-line referral centres were established to handle all patients suspected of COVID-19 or other upper respiratory tract infection. Here we report the first experiences from a first-line referral centre from Amager-Hvidovre Hospital, sit...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2020-08-07 00:00:00
abstract：INTRODUCTION:Vitamin D plays an important role in a broad range of organ functions, including the cardiovascular system. Only one study has tested the association between vitamin D deficiency and arrhythmia and it found no association. The aim of the present study was to evaluate the association between vitamin D defic...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-09-01 00:00:00
abstract：INTRODUCTION:This study explored whether health-related quality of life (HRQOL) changes following Roux-en-Y gastric bypass surgery were associated with identifiable socio-demographic or clinical characteristics, and it examined the impact on health outcomes of changes in the Danish criteria for bariatric surgery. MATE...
journal_title：Danish medical journal
pub_type： 临床试验,杂志文章
doi：
更新日期：2014-07-01 00:00:00
abstract：INTRODUCTION:The treatment strategy for appendiceal mass is controversial, ranging from operation or image-guided drainage to conservative treatment with or without antibiotics. The aim of this study was to assess the various treatment modalities with respect to complications and treatment failure. METHODS:The analysi...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2014-08-01 00:00:00
abstract：:Biological rhythms are essential for the regulation of many life processes. Disturbances of the circadian rhythm are known to affect human health, performance and well-being and the negative consequences are numerous and widespread. Cognitive dysfunction, fatigue, pain, sleep disturbances and mood disorders, such as a...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-09-01 00:00:00
abstract：:Asthma and allergies are today the most common chronic diseases in children and the leading causes of school absences, chronic medication usage, emergency department visits and hospitalizations, which affect all members of the family and represent a significant societal and scientific challenge. These highly prevalent...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2016-08-01 00:00:00
abstract：INTRODUCTION:The optimal treatment of acute, displaced midshaft clavicle fractures is controversial. Despite lack of compelling evidence towards superior results after primary surgery, it seems that more and more patients are treated surgically. The aim of this study was to investigate which treatment modality should b...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2012-07-01 00:00:00
abstract：INTRODUCTION:Colorectal cancer is a common malignant disease, caused by different aetiologies and molecular pathways. Heterogeneous results have been published regarding the association of microsatellite instability and clinicopathological features. The aim of this study was to compare clinicopathological features of m...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2016-02-01 00:00:00
abstract：:Strategies to reduce the burden of blood pressure attributable diseases require knowledge of secular trend in PBP and its determinants. The issues were investigated in the Copenhagen City Heart Study. The design of CCHS is a repeated measures study. Such designs are uniquely suited to studying changes of an outcome an...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-03-01 00:00:00
abstract：INTRODUCTION:Microbiological documentation of one uropathogenic bacterium in significant numbers in urine from patients with typical symptoms is the gold standard for diagnosing urinary tract infection (UTI). Cleaning before collecting midstream urine (MSU) is reported not to reduce the risk of contaminating the sample...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-06-01 00:00:00
abstract：INTRODUCTION:There is no consensus among hip surgeons in Denmark on how to follow up patients after total hip arthroplasty (THA). Agreement on the need for radiographic examinations is also lacking. The purpose of this study was to evaluate if routine outpatient post-operative radiographs, obtained three and 12 months ...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-04-01 00:00:00
abstract：INTRODUCTION:Marfan syndrome is an autosomal, dominantly inherited disorder of the connective tissue. We report the clinical data and results of a genetic analysis of a large Danish Marfan family. METHODS:Sanger sequencing of FBN1 was initially performed on genomic DNA from the index patient. Subsequently, four affect...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-11-01 00:00:00
abstract：INTRODUCTION:In order to optimise the selection process for admission to specialist training in family medicine, we developed a new design for structured applications and selection interviews. The design contains semi-structured interviews, which combine individualised elements from the applications with standardised b...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-09-01 00:00:00
abstract：INTRODUCTION:Due to disagreement on optimal timing of inguinal hernia repair in children, we explored how Danish surgeons plan repair in children at different ages and with different symptoms. METHODS:A validated questionnaire on timing of inguinal hernia repair in children was sent to all surgeons performing paediatr...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2020-12-22 00:00:00
abstract：INTRODUCTION:The aim of this study was to assess the complication rates of total thyroidectomy in a regional hospital setting in Denmark for permanent hypoparathyroidism, recurrent laryngeal nerve palsy and post-operative bleeding. Furthermore, the long-term outcomes in the management of hypoparathyroidism were investi...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2015-11-01 00:00:00
abstract：:Critically ill acute high-risk abdominal surgery patients represent a major challenge to health care providers, with the typical patient being elderly and frail, and with severe and multiple comorbidities. The mortality rate in this population is high, and the postoperative course is characterized by complications, pr...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2018-02-01 00:00:00
