Abstract：
INTRODUCTION:Adjuvant treatment of early-stage breast cancer has been associated with bone loss in randomised trials, but evidence from unselected populations is needed. In a single-center study, we assessed the annual percentage change in bone mineral density (∆BMDt) and risk of osteoporosis from two to five years after adjuvant chemotherapy in patients with oestrogen-receptor-positive and oestrogen-receptor-negative tumours. METHODS:Dual energy X-ray absorptiometry (DXA) was performed in 241 recurrence-free Danish breast cancer patients, among whom 157 had a prior DXA scan within two years of chemotherapy ("early"). Linear regression was used to assess ∆BMDt in spine and hip according to age, different health-related variables and time since early DXA. RESULTS:Based on 157 patients, we observed annual decreases in spine BMD of 1.73% (95% confidence interval (CI): -2.01--1.44, p less than 0.001) and hip BMD of 1.30% (95% CI: -1.51--1.09, p less than 0.001). Patients aged less than 50 years at diagnosis had a significant decrease in mean spine BMD of 2.23% (95% CI: -2.78--1.68), whereas the decline was more limited in patients aged 50-59 years and patients aged 60 years or older with a mean spine BMD of 1.70% (95% CI: -2.07--1.34) and 0.81% (95% CI: -1.42--0.20), respectively. The results persisted in multivariable analyses. Osteoporosis was diagnosed in 9% of patients, all postmenopausal. CONCLUSIONS:Adjuvant anthracycline-taxane-based chemotherapy followed by endocrine therapy caused bone loss, especially in younger compared with older patients with early-stage breast cancer, confirming the results from randomised trials. FUNDING:This work was supported by the Region of Southern Denmark (grant number 13/7078); the University of Southern Denmark (grant number 00-101-000); the Danish Cancer Society (grant number R90-A6210-14-52); the Department of Oncology and Department of Endocrinology, Odense University Hospital; and the Consultant Council Scholarship, Odense University Hospital. TRIAL REGISTRATION:The study was approved by the Ethics Committee in Region of Southern Denmark (Project ID S-20140142) and the Danish Data Protection Board (ID 2008-58-0035).
journal_name
Dan Med Jjournal_title
Danish medical journalauthors
Christensen CØ,Jensen MB,Hermann AP,Ewertz Msubject
Has Abstractpub_date
2020-10-20 00:00:00issue
11issn
2245-1919pii
A04200223journal_volume
67pub_type
杂志文章abstract：INTRODUCTION:The aim of this study was to examine the use of quantitative fluorescein angiographic analysis as a means of estimating rates of perfusion of the retina in eyes with a circulatory deficit secondary to carotid artery stenosis. MATERIAL AND METHODS:The study included 21 eyes with ocular ischaemic syndrome (...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-10-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by pain, swelling and progressive destruction of the joints leading to loss of function and invalidity. The bone destruction in RA is characterised by two distinct features: structural joint damage and hand bone loss, and their prevention is an im...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2018-03-01 00:00:00
abstract：INTRODUCTION:Brachial plexus injuries are usually a result of road traffic accidents and a cause of severe disability that typically affects young adult males. In 2010, a national centre was established for referral of these cases from Danish trauma centres. In this paper, we report on our surgical activity and reflect...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2015-03-01 00:00:00
abstract：:Today, sentinel lymph node dissection (SLND) has replaced axillary lymph node dissection (ALND) as standard procedure for staging of the axilla in the treatment of breast cancer. SLND can accurately stage the axilla by removing on average only two lymph nodes. Only in case of metastatic spread to sentinel nodes an ALN...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2012-07-01 00:00:00
abstract：INTRODUCTION:Due to the coronavirus disease 2019 (COVID-19) exposure in Denmark, first-line referral centres were established to handle all patients suspected of COVID-19 or other upper respiratory tract infection. Here we report the first experiences from a first-line referral centre from Amager-Hvidovre Hospital, sit...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2020-08-07 00:00:00
abstract：INTRODUCTION:This article presents the treatment results of 320 consecutive patients with malignant haematological diagnoses admitted to a tertiary intensive care unit at a Danish University hospital over a six-year period (2005-2010). With reference to international publications, we describe the development in treatme...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-03-01 00:00:00
abstract：INTRODUCTION:Psychiatric disorders are common among patients with irritable bowel syndrome (IBS) which may make a psychiatric evaluation appropriate. The Hospital Anxiety and Depression Scale (HADS) has been recommended internationally for screening. The Common Mental Disorder Questionnaire (CMDQ) is a novel Danish ins...
journal_title：Danish medical journal
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2014-02-01 00:00:00
abstract：INTRODUCTION:Fine-needle aspiration biopsy (FNAB) is the cornerstone of thyroid nodule evaluation. In most cases, FNAB can discriminate between benign and malignant disease. In other cases, it is only indicative of malignancy and the results are considered "suspicious". In Denmark, thyroid FNAB results are categorised ...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-02-01 00:00:00
abstract：INTRODUCTION:Tonsillectomy may be performed by several methods. It is continuously being discussed which method is preferable with regard to postoperative haemorrhage, pain, activity and nutrition. MATERIAL AND METHODS:The present study is a prospective non-randomized study of tonsillectomy. It included 198 patients a...
journal_title：Danish medical journal
pub_type： 临床试验,杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:Heart failure is a complex clinical syndrome and one of the leading causes of morbidity and mortality with a prevalence of 1%-2% of the adult population. The prognosis is poor with a 5-year mortality rate of 50%, which partly can be attributed to the presence of concomitant comorbidity, including neurological and psyc...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2018-04-01 00:00:00
abstract：:Surgeons are increasingly using ultrasonography (US) in their clinical management of patients. However, US is a very user-dependent imaging modality and proper skills of the US operator are needed to ensure quality in patient care. This thesis explores the validity evidence for assessment of competence in abdominal an...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-11-01 00:00:00
abstract：INTRODUCTION:The aim was to illustrate current use of temporary pacing (TP) in Denmark by replicating a questionnaire study from 1986 and to compare the results of the two studies. MATERIAL AND METHODS:The questionnaire was sent to Danish hospitals treating patients with acute myocardial infarction (AMI). To illustrat...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-02-01 00:00:00
abstract：INTRODUCTION:Atrial fibrillation (AF) is a cardiac epidemic. In this study, we aimed to describe the causes of hospital-isation in an AF population over time and to study how different AF treatment strategies affected hospitalization. MATERIAL AND METHODS:This was an observational study in which long-term follow-up da...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:Ischemia-reperfusion injuries occur when the blood supply to an organ or tissue is temporarily cut-off and then restored. Even though the restoration of blood flow is absolutely essential in preventing tissue death, the reperfusion of oxygenated blood to the oxygen-deprived areas may in itself augment the tissue damag...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:Knee and hip OA is the clinical and pathological outcome of a functional and structural failure of the joint, resulting in pain and physical dysfunction. Despite the similarity in clinical presentation the pathogenesis seems to differ. Where knee OA is associated with obesity and trauma, hip OA is associated...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2014-04-01 00:00:00
abstract：INTRODUCTION:Volvulus is an axial twist of any part of the gastrointestinal tract along its mesentery. If it goes unattended, it will cause bowel obstruction and bowel ischaemia with gangrene and perforation. The primary treatment is endoscopic desufflation, but the place for elective surgery is controversial. Volvulus...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-07-01 00:00:00
abstract：INTRODUCTION:Reliable dietary information is crucial for measuring the habitual diet of healthy participants and patients with dyslipidaemia and/or coronary heart disease (CHD). Even so, methods are often complicated and time-consuming for everyone involved. We aimed to validate the new food frequency questionnaire (FF...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2018-11-01 00:00:00
abstract：INTRODUCTION:With the increasing use of cross-sectional imaging, the incidence of non-symptomatic pancreatic cystic neoplasms is increasing. Surgical management of pancreatic cystic neoplasms possess significant risks of perioperative morbidity and mortality. Our aim was to evaluate endoscopic ultrasound (EUS)-guided a...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2020-08-01 00:00:00
abstract：INTRODUCTION:Hemithyroidectomy for benign thyroid disease has traditionally been considered an inpatient procedure due to concerns about post-operative complications, in particular the risk of post-thyroidectomy bleeding (PTB). Hemithyroidectomy in an outpatient setting has not yet been evaluated in a Danish context. T...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2020-09-29 00:00:00
abstract：INTRODUCTION:The aim of the study is to identify how disease management programmes for patients with a chronic disease work. This issue is explored from the patients' perspective. Specifically, we study how transition and coordination are related to the patient's perception of quality of care, with a particular focus o...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2016-03-01 00:00:00
abstract：INTRODUCTION:This study reports our experience with microscopic phonosurgery (PS) of benign lesions of the vocal folds. MATERIAL AND METHODS:During the five-year period from 2003 to 2007, a total of 97 patients had PS for vocal fold polyps (n = 63), vocal fold cysts (n = 17), vocal fold nodules (n = 12) or vocal fold ...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-02-01 00:00:00
abstract：:Excessive health anxiety, still designated as hypochondriasis in ICD-10, refers to worries and anxiety about harbouring serious illness. It is common in both primary and secondary health care with prevalence rates up to 9% and causes great suffering for the individual as well as high health care costs when untreated. ...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:High levels of pro-inflammatory cytokines are present in the gut of patients with inflammatory bowel disease (IBD) and have a crucial role in the dysfunction of mucosal homeostasis. Caudal-related homeobox transcription factor 2 (CDX2) is an essential regulator of intestinal epithelium homeostasis. When expr...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2014-03-01 00:00:00
abstract：INTRODUCTION:An indication of the adequacy of the intra-vascular volume is of importance in critically ill patients. The status of the intravascular volume can be determined from a fluid challenge test. Most tests involve invasive monitoring. An exception is the capnographic measurement of changes in end-tidal (ET) CO2...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2019-09-01 00:00:00
abstract：INTRODUCTION:Establishment of sufficient muscle relaxation is essential in laparoscopic surgery. During laparoscopy, surgeons can experience abdominal contractions in their patients. Deep neuromuscular block (NMB) has the potential to prevent such episodes. In this study, we explored if deep NMB reduces the incidence o...
journal_title：Danish medical journal
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2017-05-01 00:00:00
abstract：:Biological rhythms are essential for the regulation of many life processes. Disturbances of the circadian rhythm are known to affect human health, performance and well-being and the negative consequences are numerous and widespread. Cognitive dysfunction, fatigue, pain, sleep disturbances and mood disorders, such as a...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-09-01 00:00:00
abstract：INTRODUCTION:This prospective cohort study in consecutive shoulder patients sought to determine the minimal, clinically important difference of the Danish version of the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire and to evaluate patient responsiveness to it. The study was undertaken at the Outpatie...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-04-01 00:00:00
abstract：:Sudden Cardiac Death (SCD) in the young (aged 1-35 years), although presumably rare, is always a tragic and devastating event often occurring in apparently healthy persons. Through the last decades, research have been undertaken to estimate the incidence rate and underlying causes of these deaths. However, because aut...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-02-01 00:00:00
abstract：INTRODUCTION:Treatment of infections in neonates with gentamicin is a balance between optimising bactericidal effect and minimising adverse effects. Previously, at the Neonatal Intensive Care Unit (NICU) at Kolding Hospital, Denmark, neonates suspected of having infections were treated daily with gentamicin 5 mg/kg for...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-06-01 00:00:00
abstract：INTRODUCTION:Mechanical restraint and other forms of coercion may be used under certain circumstances at psych-iatric wards. The use of coercion receives considerable focus, yet little is known about its diurnal distribution. We examined the initiation of mechanical restraint, sedative drug administration, physical ret...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-08-01 00:00:00
