Rapid response to psychosocial treatment for adolescent depression: a two-year follow-up.

Abstract:

OBJECTIVE:To examine the differential course and treatment outcome of patients who participated in a randomized clinical trial, comparing cognitive, family, and supportive psychotherapies for adolescent major depressive disorder. METHOD:In a sample of 100 depressed adolescents, remission, clinical recovery, recurrence, and functional improvement were examined at the end of acute treatment and at 1- and 2-year follow-up, according to their type of response to treatment. Rapid response was defined as a decline of > or = 50% in the Beck Depression Inventory (BDI) score from pretreatment until the beginning of the second session of psychotherapy, intermediate as a decline of < 50% but > 0%, and initial nonresponse as a BDI score that stayed the same or increased. RESULTS:Rapid responders showed a better outcome at acute treatment, 1-year, and in some measures, 2-year follow-up. For those who had recurrences over time, rapid responders showed a longer period before recurrence. Subjects were most likely to respond rapidly, or not at all, in the supportive cell. CONCLUSIONS:These findings suggest that milder forms of depression may benefit from initial supportive therapy or short trials of more specialized types of psychotherapy. The use of a placebo run-in period might help to "wash out" nonspecific responders.

authors

Renaud J,Brent DA,Baugher M,Birmaher B,Kolko DJ,Bridge J

doi

10.1097/00004583-199811000-00019

subject

Has Abstract

pub_date

1998-11-01 00:00:00

pages

1184-90

issue

11

eissn

0890-8567

issn

1527-5418

pii

S0890-8567(09)66630-2

journal_volume

37

pub_type

临床试验,杂志文章,随机对照试验
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