Carbamazepine in aggressive children with conduct disorder: a double-blind and placebo-controlled study.

Abstract:

OBJECTIVE:To assess critically the short-term efficacy and safety of carbamazepine in the reduction of aggressiveness in children with diagnosed conduct disorder. METHOD:Subjects were children aged 5 to 12 years who were hospitalized for treatment-resistant aggressiveness and explosiveness and who had diagnosed conduct disorder. The study was double-blind and placebo-controlled, using a parallel-groups design. Following a 2-week placebo baseline period, children who met the aggression criteria were randomly assigned to treatments for 6 weeks; the study ended with a 1-week posttreatment placebo period. Multiple raters rated the children independently, using multiple rating scales under four conditions. The main outcome measures included the Overt Aggression Scale, the Global Clinical Judgments (Consensus) Scale, and the Children's Psychiatric Rating Scale. RESULTS:Twenty-two children, aged 5.33 to 11.7 years, completed the study. Carbamazepine was not superior to placebo at optimal daily doses ranging from 400 to 800 mg, mean 683 mg, at serum levels of 4.98 to 9.1 micrograms/mL. Untoward effects associated with administration of carbamazepine were common. CONCLUSIONS:In this modest sample of children, the superiority of carbamazepine over placebo in reducing aggressive behavior was not demonstrated.

authors

Cueva JE,Overall JE,Small AM,Armenteros JL,Perry R,Campbell M

doi

10.1097/00004583-199604000-00014

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

480-90

issue

4

eissn

0890-8567

issn

1527-5418

pii

S0890-8567(09)63518-8

journal_volume

35

pub_type

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