Life threatening diarrhoea ultimately cured by surgery.

Abstract:

:A 30-year-old previously healthy woman was diagnosed as having a vasoactive intestinal polypeptide (VIP)-producing tumour of the pancreas. Her medical history was typical for neuroendocrine gastrointestinal tumours, presenting initially with non-specific symptoms but eventually she developed life-threatening manifestations requiring intensive care due to severe dehydration. She immediately recovered following surgical resection. The patient had elevated serum concentrations of VIP as well as pancreastatin, and post-operatively elevated concentrations of three growth factors, IGF-I, EGF and TGF-alpha, were seen. The importance of the alterations in plasma concentrations of the different peptides for her symptomatology are discussed.

authors

Sjöqvist U,Permert J,Löfberg R,Larsson J,Gadaleanu V,Adrian TE

doi

10.1097/00042737-199811000-00011

subject

Has Abstract

pub_date

1998-11-01 00:00:00

pages

963-7

issue

11

eissn

0954-691X

issn

1473-5687

journal_volume

10

pub_type

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