The wide spectrum of steatohepatitis: a report of four cases and a review of the literature.

Abstract:

:We report on four cases displaying the wide range of aetiological risk factors (presence or absence of family history of dyslipidaemia and cryptogenic cirrhosis, from subnormal body mass index through morbid obesity, from absent through hepatotoxic alcohol consumption), laboratory test results (from subnormal through elevated uric acid and ferritin values), ultrasonographic changes (from normal findings through 'bright liver' with or without attenuation of ultrasound beam and absence/presence of focal lesions), and histological severity of steatohepatitis (fibrosis appearing to be inversely related to the amount of liver fat but zone 3 accentuation of lesions and ballooning being observed in all cases). Cases illustrate the concepts of overlapping aetiologies of steatohepatitis (hepatitis C, diabetes and lipodystrophy); the relationships between cryptogenic cirrhosis, familial cirrhosis, non-alcoholic fatty liver disease and hepatocellular carcinoma; familial hypobetalipoproteinaemia as an aetiology of steatohepatitis; and alcoholic liver disease in the obese. These issues, which are worthy of future investigation, are reviewed.

authors

Lonardo A,Bagni A,Tarugi P,Loria P

doi

10.1097/00042737-200410000-00015

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

1043-50

issue

10

eissn

0954-691X

issn

1473-5687

pii

00042737-200410000-00015

journal_volume

16

pub_type

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