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Innovative treatment programs against cancer: II. Nuclear factor-kappaB (NF-kappaB) as a molecular target.

Abstract：

:Nuclear factor-kappaB (NF-kappaB) activity affects cell survival and determines the sensitivity of cancer cells to cytotoxic agents as well as to ionizing radiation. Preventing the protective function of NF-kappaB may result in chemo- and radio-sensitization of cancer cells. Therefore, NF-kappaB has emerged as one of the most promising molecular targets in rational drug design efforts of translational cancer research programs.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Waddick KG,Uckun FM

doi

10.1016/s0006-2952(98)00224-x

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

9-17

issue

1

eissn

0006-2952

issn

1873-2968

pii

S0006-2952(98)00224-X

journal_volume

57

pub_type

杂志文章,评审

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