Effect of D- or L-methionine and cysteine on the growth inhibitory effects of feeding 1% paracetamol to rats.

Abstract:

:Rats fed 1% paracetamol in the diet failed to grow and a dose-dependent inhibition of growth was observed and found to be independent of hepatoxicity. Addition of 0.5% D- or L-methionine, or L-cysteine to a diet containing 1% paracetamol restored growth. Addition of L-methionine to the drinking water was equally effective. Feeding D-cysteine or sodium sulphate were ineffective. Acute paracetamol toxicity was also prevented by D- as well as by L-methionine. It is concluded that the inhibition of growth was due to depletion of sulphur amino acids in the course of paracetamol metabolism. This was sometimes followed by episodes of liver cell injury. Since the normal human dosage of paracetamol is up to 4 g/day, which is equivalent to 1% of the diet, the possibility of induction of amino acid deficiency by chronic use of paracetamol in normal dosage is raised.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

McLean AE,Armstrong GR,Beales D

doi

10.1016/0006-2952(89)90048-8

subject

Has Abstract

pub_date

1989-01-15 00:00:00

pages

347-52

issue

2

eissn

0006-2952

issn

1873-2968

pii

0006-2952(89)90048-8

journal_volume

38

pub_type

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