Abstract:
:Rats fed 1% paracetamol in the diet failed to grow and a dose-dependent inhibition of growth was observed and found to be independent of hepatoxicity. Addition of 0.5% D- or L-methionine, or L-cysteine to a diet containing 1% paracetamol restored growth. Addition of L-methionine to the drinking water was equally effective. Feeding D-cysteine or sodium sulphate were ineffective. Acute paracetamol toxicity was also prevented by D- as well as by L-methionine. It is concluded that the inhibition of growth was due to depletion of sulphur amino acids in the course of paracetamol metabolism. This was sometimes followed by episodes of liver cell injury. Since the normal human dosage of paracetamol is up to 4 g/day, which is equivalent to 1% of the diet, the possibility of induction of amino acid deficiency by chronic use of paracetamol in normal dosage is raised.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
McLean AE,Armstrong GR,Beales Ddoi
10.1016/0006-2952(89)90048-8subject
Has Abstractpub_date
1989-01-15 00:00:00pages
347-52issue
2eissn
0006-2952issn
1873-2968pii
0006-2952(89)90048-8journal_volume
38pub_type
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