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Alcohol abuse increases the lipid structural order in human erythrocyte membranes. A steady-state and time-resolved anisotropy study.

Abstract：

:The effect of ethanol abuse on the lipid ordering of the human erythrocyte membranes was studied by steady-state and time-resolved fluorescence anisotropy measurements of DPH and its polar analogue TMA-DPH, which probe different membrane regions. Steady-state anisotropy values with DPH as a probe were slightly but significantly increased (+3%) in erythrocyte membranes from alcoholic patients. A resistance to the ethanol fluidizing effect was evidenced in these membranes with DPH and TMA-DPH. No difference in the probe lifetimes was detected between the control and the alcoholic subjects. In the alcoholic patients as compared to the healthy controls, the residual anisotropy for DPH was significantly increased (+7%) corresponding to an increase in the orientational order parameter of 4%; a decrease of the apparent correlation time value was also observed. Nevertheless, no differences between the two erythrocyte populations were observed with TMA-DPH.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Beaugé F,Gallay J,Stibler H,Borg S

doi

10.1016/0006-2952(88)90062-7

subject

Has Abstract

pub_date

1988-10-15 00:00:00

pages

3823-8

issue

20

eissn

0006-2952

issn

1873-2968

pii

0006-2952(88)90062-7

journal_volume

37

pub_type

杂志文章

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