Abstract:
OBJECTIVE:Neuroleptic-treated pediatric patients with childhood-onset schizophrenia (COS) are at risk for developing extrapyramidal side effects and involuntary movement disorders. A preliminary examination of the incidence of withdrawal dyskinesias (WD), tardive dyskinesia (TD), and extrapyramidal side effects in these patients is presented. METHOD:Thirty-four COS patients (mean age +/- SD, 14.2 +/- 2.1 years) were examined for TD using the Abnormal Involuntary Movements Scale and for extrapyramidal side effects using the Simpson-Angus Neurologic Rating Scale, after a 14- to 28-day drug-free period (n = 33), at week 6 of treatment and 2 to 4 years after completion of the study (n = 14). The mean (+/-SD) number of months of prior neuroleptic exposure for the group was 22.4 (15.0) months. RESULTS:Seventeen (50%) of 34 patients were noted to have either WD or TD at some point during their participation in the studies. The majority of patients experienced WD that were mainly in the orofacial region, transient in nature, and diminished with haloperidol and clozapine. Patients with TD/WD had greater levels of premorbid impairment (p = .02), increased severity of positive symptoms of schizophrenia (p < .01), and a trend toward more months of neuroleptic exposure (p = .10, one-tailed). CONCLUSIONS:A high proportion of COS patients were found to have TD/WD. The majority of these abnormal movements were not severe and generally improved over time. TD/WD in COS appears to be associated with greater premorbid impairment, severity of illness, and duration of neuroleptic exposure. J. Am. Acad.
journal_name
J Am Acad Child Adolesc Psychiatryauthors
Kumra S,Jacobsen LK,Lenane M,Smith A,Lee P,Malanga CJ,Karp BI,Hamburger S,Rapoport JLdoi
10.1097/00004583-199802000-00016subject
Has Abstractpub_date
1998-02-01 00:00:00pages
221-7issue
2eissn
0890-8567issn
1527-5418pii
S0890-8567(09)63884-3journal_volume
37pub_type
临床试验,杂志文章abstract:OBJECTIVE:To examine the differential course and treatment outcome of patients who participated in a randomized clinical trial, comparing cognitive, family, and supportive psychotherapies for adolescent major depressive disorder. METHOD:In a sample of 100 depressed adolescents, remission, clinical recovery, recurrence...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004583-199811000-00019
更新日期:1998-11-01 00:00:00
abstract::Selected literature is reviewed regarding the question, How may children's self-control skills be developed or improved through training? It is premature to give up on psychosocial methods of training self-control. Self-control is fostered by being in a long-term positive relationship with a dependable person who comm...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-200201000-00007
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:To examine whether mental health problems predict incident use of 12 different tobacco products in a nationally representative sample of youth and young adults. METHOD:This study analyzed Wave (W) 1 and W2 data from 10,533 12- to 24-year-old W1 never tobacco users in the Population Assessment of Tobacco and ...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1016/j.jaac.2018.06.029
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:Pediatric anxiety disorders can have a chronic course and are considered gateway disorders to adult psychopathology, but no consistent predictors of long-term outcome have been identified. A single latent symptom dimension that reflects features shared by all mental health disorders, the p factor, is thought ...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1016/j.jaac.2020.08.440
更新日期:2020-09-17 00:00:00
abstract:OBJECTIVE:Studies have suggested a high prevalence of mental health symptoms among youths in the juvenile justice system, with the highest prevalence among girls and whites compared to boys and other races. This multisite, archival study examined whether sex and race differences, when they exist, were consistent across...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,meta分析,多中心研究
doi:10.1097/CHI.0b013e318160d516
更新日期:2008-03-01 00:00:00
abstract::Although narcolepsy is rarely diagnosed before adulthood, symptoms often begin much earlier and can easily mimic psychiatric disorders in children and adolescents. Clinical experience from a pediatric sleep center is reviewed in 16 consecutive cases of polysomnographically proven narcolepsy with onset of symptoms by a...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199407000-00009
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVE:To evaluate whether including children with onset of symptoms between ages 7 and 12 years in the ADHD diagnostic category would: (a) increase the prevalence of the disorder at age 12, and (b) change the clinical and cognitive features, impairment profile, and risk factors for ADHD compared with findings in th...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:This study examined the familial relationship between Gilles de la Tourette's syndrome (GTS) and attention deficit disorder (ADD), learning problems, speech disorders, and stuttering. METHOD:This family study consisted of 338 first degree relatives of 85 GTS probands and 113 controls. All available relatives...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199309000-00025
更新日期:1993-09-01 00:00:00
abstract::It is heartening to see that our rapid systematic review1 is stimulating others to highlight the needs of particular subsets of vulnerable children and adolescents. We found evidence that loneliness in children and adolescents is associated with increased depression and anxiety symptoms both cross-sectionally and long...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 评论,信件
doi:10.1016/j.jaac.2020.08.437
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:This article first summarizes key research findings from the Pittsburgh Youth Study from 1987 to the present, and focuses on delinquency in 1,517 young men who have been followed up from late childhood into their 20s. Second, the article addresses how indicators of self-control prospectively predict later off...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.jaac.2012.08.019
更新日期:2012-11-01 00:00:00
abstract::The comorbidity of depression and anxiety is a major global health problem. A 2015 report examining response patterns of 74,000 adults across 27 World Mental Health surveys in 24 countries showed a very high comorbidity between a diagnosis of lifetime DSM-IV1 major depressive disorder and a diagnosis of any anxiety di...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 评论,社论
doi:10.1016/j.jaac.2019.01.003
更新日期:2019-03-01 00:00:00
abstract::Few studies have followed young people with autism spectrum disorder (shortened to "autism" herein) over time, and all previous longitudinal studies have used clinical or center-based samples,1,2 leaving considerable uncertainty about the course of autism in the general population. In this issue, Simonoff and colleagu...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 社论
doi:10.1016/j.jaac.2020.06.011
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To test whether attention problems in children are continuously distributed or categorically discrete, the authors performed latent class analyses (LCA) of items from the Attention Problems scale of the Child Behavior Checklist (CBCL) using data from the clinical and nonclinical samples used in the derivation...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199908000-00014
更新日期:1999-08-01 00:00:00
abstract:OBJECTIVE:To examine the prevalence of encopresis/enuresis, relationship between maternal hostility and encopresis, parent-child concordance of reporting encopresis/enuresis, and familial aggregation of enuresis in subjects with a prepubertal and early adolescent bipolar-I disorder phenotype (PEA-BP), attention-deficit...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 临床试验,杂志文章
doi:10.1097/01.chi.0000172554.26349.dd
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:A substantial body of literature has established the positive effect of breastfeeding on child developmental outcomes. There is increasing consensus that breastfed children have higher IQs after accounting for key variables, including maternal education, IQ, and socioeconomic status. Cross-sectional investiga...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1016/j.jaac.2016.02.009
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To conduct a systematic review and meta-analysis and estimate the economic costs attributable to child and adolescent bullying victimization in Australia. METHOD:The costs of bullying victimization were measured from a societal perspective that accounted for costs associated with health care, education resou...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1016/j.jaac.2020.05.010
更新日期:2020-06-30 00:00:00
abstract:OBJECTIVE:A callous-unemotional (CU) subtype of conduct disorder (CD) has been proposed as an addition to the fifth edition of the Diagnostic and Statistic Manual of Mental Disorders (DSM-5). This study tested the hypothesis that young girls with the CU subtype of CD would exhibit more severe antisocial behavior and le...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1016/j.jaac.2011.10.005
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To examine associations between the Massachusetts Youth Screening Instrument-Second Version (MAYSI-2) and Diagnostic Interview Schedule for Children-Present State Voice Version (DISC-IV) and the extent to which they overlap in identifying youths with mental health concerns. METHOD:Among 325 New Jersey and So...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-200405000-00017
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:To evaluate systematically the longitudinal course of conduct disorder (CD) in a sample of youths with attention-deficit hyperactivity disorder (ADHD) to determine the effects of a persistent course on outcome. METHOD:One hundred forty children with ADHD and their nuclear families were assessed at baseline a...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-200103000-00008
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVE:Considerable research examines fear conditioning in adult anxiety disorders but few studies examine youths. Adult data suggest that anxiety disorders involve elevated fear but intact differential conditioning. We used a novel paradigm to assess fear conditioning in pediatric anxiety patients. METHOD:Sixteen ...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/chi.0b01e31815a5f01
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To investigate whether eye-gaze avoidance, a striking phenotypic feature in fragile X syndrome (FXS), is associated with high levels of "hyperarousal" during social interactions with others. To date, almost all studies in this area have been confounded by inclusion of task demands in addition to social demand...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/CHI.0b013e318195bd15
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:Clinical research depends on the participation of representative samples. At the 2001 Annual Meeting of the American Academy of Child and Adolescent Psychiatry, the Workgroup on Research conducted a research forum with the purpose of improving recruitment and retention of children and adolescents in research ...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type:
doi:10.1097/01.chi.0000129222.89433.3d
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVE:Previous studies have reported reduced cortical thickness and surface area and altered gyrification in frontal and temporal regions in adolescents with conduct disorder (CD). Although there is evidence that the clinical phenotype of CD differs between males and females, no studies have examined whether such s...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jaac.2017.05.015
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:The course of obsessive-compulsive disorder (OCD) in childhood and adolescence was analyzed. METHOD:Twenty-three (88%) of 26 children and adolescents with OCD, all referred to a county child psychiatric clinic as inpatients or outpatients, were longitudinally evaluated every 6 months for obsessive-compulsive...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199511000-00009
更新日期:1995-11-01 00:00:00
abstract:OBJECTIVE:An alternative set of criteria for posttraumatic stress disorder (PTSD) for preschool children was analyzed for validity. METHOD:Sixty-two traumatized children and 63 healthy controls, aged 20 months through 6 years, were assessed. The traumatic experiences included motor vehicle collisions, accidental injur...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/01.CHI.0000046822.95464.14
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:To examine the expression of war-related trauma as manifested by DSM-III-R rates of posttraumatic stress disorder (PTSD) and major depressive disorder in two generations of Cambodian refugees living in the western United States. METHOD:A probability sample of 209 Khmer adolescents and one of their parents we...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004583-199509000-00013
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:To report results from a long-term prospective study of safety of haloperidol treatment and prevalence of haloperidol-related dyskinesias. METHOD:Subjects were children with autism requiring pharmacotherapy for target symptoms. After baseline assessments, children received haloperidol treatment; responders r...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199706000-00022
更新日期:1997-06-01 00:00:00
abstract::Japanese society strongly influences the mode of presentation of child mental health problems, both in terms of protective factors and pressures inherent in Japanese child-rearing practices. Recent changes in society associated with Japan's rapid economic development are affecting the mental health of children and fam...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,评审
doi:10.1097/00004583-198907000-00003
更新日期:1989-07-01 00:00:00
abstract:OBJECTIVE:To compare clinical characteristics of hospitalized adolescents who (1) have recently made their first suicide attempt, (2) have recently made a second or subsequent attempt, (3) have made previous but no recent attempts, or (4) have never made an attempt. METHOD:Semistructured psychiatric diagnostic intervi...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199605000-00018
更新日期:1996-05-01 00:00:00
abstract::Children's reactions to parental quarrels were investigated in a general population sample of children between 9 and 12 years old. One hundred and thirty-nine families participated in the study. Approximately half the children were living in disharmonious families and half were in harmonious families. Mothers and chil...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-198903000-00006
更新日期:1989-03-01 00:00:00