Fear conditioning in adolescents with anxiety disorders: results from a novel experimental paradigm.

Abstract:

OBJECTIVE:Considerable research examines fear conditioning in adult anxiety disorders but few studies examine youths. Adult data suggest that anxiety disorders involve elevated fear but intact differential conditioning. We used a novel paradigm to assess fear conditioning in pediatric anxiety patients. METHOD:Sixteen individuals with anxiety disorders and 38 healthy comparisons viewed two photographs of actresses displaying neutral expressions. One picture served as the conditioned stimulus (CS), paired with a fearful expression and a shrieking scream (CS+), whereas the other picture served as a CS unpaired with the aversive outcome (CS-). Conditioning was indexed by self-reported fear. Subjects participated in two visits involving conditioning and extinction trials. RESULTS:Both groups developed greater fear of the CS+ relative to CS-. Higher fear levels collapsed across each CS characterized anxious relative to healthy subjects, but no significant interaction between group and stimulus type emerged. Fear levels at visit 1 predicted avoidance of visit 2. Fear levels to both CS types showed stability even after extinction. CONCLUSIONS:Consistent with adult data, pediatric anxiety involves higher fear levels following conditioning but not greater differential conditioning. Extending these methods to neuroimaging studies may elucidate neural correlates of fear conditioning. Implications for exposure therapies are discussed.

authors

Lau JYF,Lissek S,Nelson EE,Lee Y,Roberson-Nay R,Poeth K,Jenness J,Ernst M,Grillon C,Pine DS

doi

10.1097/chi.0b01e31815a5f01

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

94-102

issue

1

eissn

0890-8567

issn

1527-5418

pii

S0890-8567(09)62089-X

journal_volume

47

pub_type

杂志文章
  • Office Visits to Monitor Stimulant Medication Safety and Efficacy: Recommended Care.

    abstract::The clinical guidance based on the research article, "Specific Components of Pediatricians' Medication-Related Care Predict Attention-Deficit/Hyperactivity Disorder Improvement," published in the June 2017 issue,1 might be premature. The authors, Epstein et al., suggest that "Physicians do not need to necessarily rely...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 信件

    doi:10.1016/j.jaac.2018.02.015

    authors: Zima BT,Norquist GS,Altchuler SI,Behrens J,Iles-Shih MD,Ng YKW,Schaepper MA

    更新日期:2018-06-01 00:00:00

  • Anxiety, affect, and activity in teenagers: monitoring daily life with electronic diaries.

    abstract:OBJECTIVE:The everyday experiences of a community sample of adolescents differing in anxiety level were compared by means of electronic diaries. METHOD:One hundred fifty-five ninth-grade adolescents completed electronic diaries every 30 minutes for two 4-day intervals, reporting their moods, activities, social setting...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-200206000-00005

    authors: Henker B,Whalen CK,Jamner LD,Delfino RJ

    更新日期:2002-06-01 00:00:00

  • Grandparents, parents, and grandchildren at high risk for depression: a three-generation study.

    abstract:OBJECTIVE:High-risk studies of psychiatric disorders in parents and offspring that include 3 generations are uncommon. Multigenerational studies can be clinically useful as they can provide information for risk prediction from one generation to another for the development of empirically based interventions. Using a hig...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199903000-00016

    authors: Warner V,Weissman MM,Mufson L,Wickramaratne PJ

    更新日期:1999-03-01 00:00:00

  • Safe Thinking and Affect Regulation (STAR): human immunodeficiency virus prevention in alternative/therapeutic schools.

    abstract:OBJECTIVE:To evaluate the effectiveness of Safe Thinking and Affect Regulation (STAR), a 14-session HIV-prevention program for adolescents at alternative/therapeutic schools. Because these youth frequently have difficulties with emotions and cognitions, it was designed to improve sexuality-specific affect management an...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jaac.2011.06.018

    authors: Brown LK,Nugent NR,Houck CD,Lescano CM,Whiteley LB,Barker D,Viau L,Zlotnick C

    更新日期:2011-10-01 00:00:00

  • Methylphenidate and behavior modification in children with ADHD and comorbid ODD or CD: main and incremental effects across settings.

    abstract:OBJECTIVE:Although the combination of methylphenidate (MPH) and behavior modification (BMOD) has been advocated to enhance clinical outcome for children with attention-deficit hyperactivity disorder (ADHD) and comorbid disruptive disorders, few group studies have been conducted. This study evaluates the separate and in...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004583-199905000-00020

    authors: Kolko DJ,Bukstein OG,Barron J

    更新日期:1999-05-01 00:00:00

  • Clomipramine hydrochloride in childhood and adolescent obsessive-compulsive disorder--a multicenter trial.

    abstract::Children and adolescents with obsessive compulsive disorder were studied in an 8-week, multicenter, double-blind, parallel groups trial of clomipramine hydrochloride (CMI) versus placebo. Efficacy assessments included the child version of the Yale-Brown Obsessive Compulsive Scale and the National Institute of Mental H...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00004583-199201000-00008

    authors: DeVeaugh-Geiss J,Moroz G,Biederman J,Cantwell D,Fontaine R,Greist JH,Reichler R,Katz R,Landau P

    更新日期:1992-01-01 00:00:00

  • Predictors of treatment efficacy in a clinical trial of three psychosocial treatments for adolescent depression.

    abstract:OBJECTIVE:To assess the predictors of treatment outcome across treatments, as well as those associated with differential treatment response. METHOD:One hundred seven adolescent outpatients, aged 13 to 18 years, with DSM-III-R major depression were randomly assigned to one of three manual-based, brief (12 to 16 session...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004583-199809000-00010

    authors: Brent DA,Kolko DJ,Birmaher B,Baugher M,Bridge J,Roth C,Holder D

    更新日期:1998-09-01 00:00:00

  • Practice parameter for the assessment and treatment of children and adolescents with anxiety disorders.

    abstract::This revised practice parameter reviews the evidence from research and clinical experience and highlights significant advancements in the assessment and treatment of anxiety disorders since the previous parameter was published. It highlights the importance of early assessment and intervention, gathering information fr...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,实务指引

    doi:10.1097/01.chi.0000246070.23695.06

    authors: Connolly SD,Bernstein GA,Work Group on Quality Issues.

    更新日期:2007-02-01 00:00:00

  • An examination of social typologies in autism.

    abstract::A system proposed by Wing and coworkers for subtyping autistic individuals on the basis of social interaction is examined in 78 autistic, 39 atypical, and 32 nonautistic, developmentally disordered individuals. Clinical ratings and questionnaire data based on the proposed subtypology were employed. Clinicians were abl...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-198901000-00015

    authors: Volkmar FR,Cohen DJ,Bregman JD,Hooks MY,Stevenson JM

    更新日期:1989-01-01 00:00:00

  • Predictors of abstinence: National Institute of Drug Abuse multisite buprenorphine/naloxone treatment trial in opioid-dependent youth.

    abstract:OBJECTIVE:To examine predictors of opioid abstinence in buprenorphine/naloxone (Bup/Nal)-assisted psychosocial treatment for opioid-dependent youth. METHOD:Secondary analyses were performed of data from 152 youth (15-21 years old) randomly assigned to 12 weeks of extended Bup/Nal therapy or up to 2 weeks of Bup/Nal de...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.jaac.2011.07.010

    authors: Subramaniam GA,Warden D,Minhajuddin A,Fishman MJ,Stitzer ML,Adinoff B,Trivedi M,Weiss R,Potter J,Poole SA,Woody GE

    更新日期:2011-11-01 00:00:00

  • Salivary cortisol, personality, and aggressive behavior in adolescent boys: a 5-year longitudinal study.

    abstract:OBJECTIVE:The present investigation tested the hypothesis that low resting salivary cortisol concentration in preadolescent boys would be associated with aggressive behavior later in adolescence. Second, it tested whether personality traits would mediate this relation. METHOD:Resting salivary cortisol concentrations f...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/01.CHI.0000070246.24125.6D

    authors: Shoal GD,Giancola PR,Kirillova GP

    更新日期:2003-09-01 00:00:00

  • Predictors of length of stay of psychiatric adolescent inpatients.

    abstract::This study reviewed 158 consecutive admissions to an inpatient adolescent psychiatric service for factors that determine length of hospitalization. Variables associated with length of stay included diagnostic category and the treatment variables of number and type of psychotropic medications prescribed. Patients with ...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199111000-00019

    authors: Borchardt CM,Garfinkel BD

    更新日期:1991-11-01 00:00:00

  • Medical and nonmedical use of prescription stimulants: results from a national multicohort study.

    abstract:OBJECTIVE:To examine the lifetime prevalence of medical and nonmedical use of prescription stimulants (e.g., Adderall, Concerta, Ritalin, Dexedrine) among high school seniors in the United States, and to assess substance use behaviors (i.e., cigarette smoking, binge drinking, marijuana, and other drug use) based on lif...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2013.09.005

    authors: McCabe SE,West BT

    更新日期:2013-12-01 00:00:00

  • Effects of family history and comorbidity on the neuropsychological performance of children with ADHD: preliminary findings.

    abstract:OBJECTIVE:Because ADHD is heterogeneous with respect to psychiatric comorbidity, familiality, and learning disabilities, it was hypothesized that such features might influence the severity and pattern of neuropsychological function in ADHD. METHOD:Subjects were 9- to 20-year-old males with DSM-III-R ADHD (n = 65) and ...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199508000-00011

    authors: Seidman LJ,Biederman J,Faraone SV,Milberger S,Norman D,Seiverd K,Benedict K,Guite J,Mick E,Kiely K

    更新日期:1995-08-01 00:00:00

  • Working memory and sleep in 6- to 13-year-old schoolchildren.

    abstract:OBJECTIVE:To study the associations between sleep quality/quantity and performance in auditory/visual working memory tasks of different load levels. METHOD:Sixty schoolchildren aged 6 to 13 years from normal school classes voluntarily participated. Actigraphy measurement was done during a typical school week for 72 co...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004583-200301000-00014

    authors: Steenari MR,Vuontela V,Paavonen EJ,Carlson S,Fjallberg M,Aronen E

    更新日期:2003-01-01 00:00:00

  • The British Child and Adolescent Mental Health Survey 1999: the prevalence of DSM-IV disorders.

    abstract:OBJECTIVE:To describe the prevalence of DSM-IV disorders and comorbidity in a large population-based sample of British children and adolescents. METHOD:Using a one-phase design, 10,438 children were assessed using the Development and Well-Being Assessment (DAWBA), a structured interview with verbatim reports reviewed ...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-200310000-00011

    authors: Ford T,Goodman R,Meltzer H

    更新日期:2003-10-01 00:00:00

  • Parent Training for Preschool ADHD in Routine, Specialist Care: A Randomized Controlled Trial.

    abstract:OBJECTIVE:Parent training is recommended for attention-deficit/hyperactivity disorder (ADHD) in preschool children. Evidence-based interventions are important, but only if they produce better outcomes than usual care. METHOD:The authors conducted a multicenter, 2-arm, parallel-group, randomized controlled trial in rou...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jaac.2018.04.014

    authors: Lange AM,Daley D,Frydenberg M,Houmann T,Kristensen LJ,Rask C,Sonuga-Barke E,Søndergaard-Baden S,Udupi A,Thomsen PH

    更新日期:2018-08-01 00:00:00

  • A multimodal approach to functional dysphagia.

    abstract::Functional dysphagia in children has historically been treated using a cognitive behavioral approach. The case of a 7-year-old boy treated using a successful multimodal approach, including behavioral, family, and play therapy with alprazolam augmentation, is reported. The patient showed minimal response to early inter...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199409000-00012

    authors: Atkins DL,Lundy MS,Pumariega AJ

    更新日期:1994-09-01 00:00:00

  • Prevalence and description of selective mutism in immigrant and native families: a controlled study.

    abstract:OBJECTIVE:To assess the incidence of selective mutism (SM) in West Jerusalem's state preschools and evaluate social anxiety/phobia disposition (SAP), social competence (SC), markers of neurodevelopmental delay/disorder (NDD), mothers' psychological adjustment, and marital conflict in immigrant and native children with ...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-200312000-00012

    authors: Elizur Y,Perednik R

    更新日期:2003-12-01 00:00:00

  • Anxiety, inhibition, and conduct disorder in children: I. Relations to social impairment.

    abstract::Jeffrey A. Gray has proposed a model in which conduct disorder (CD) is viewed as the result of both excessive activity of a behavioral activation system that mediates appetitive and aggressive behavior and deficient activity of a behavioral inhibition system that mediates both anxiety and the inhibition of behavior in...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199103000-00004

    authors: Walker JL,Lahey BB,Russo MF,Frick PJ,Christ MA,McBurnett K,Loeber R,Stouthamer-Loeber M,Green SM

    更新日期:1991-03-01 00:00:00

  • Methylphenidate and thioridazine in the treatment of intellectually subaverage children: effects on cognitive-motor performance.

    abstract::Twenty-seven children (or smaller subgroups depending upon task difficulty and subject ability) with subaverage IQs took part in a double-blind, placebo-controlled, cross-over study of methylphenidate (0.4 mg/kg/day) and thioridazine (1.75 mg/kg/day). The children were tested for IQ performance, breadth of attention, ...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Aman MG,Marks RE,Turbott SH,Wilsher CP,Merry SN

    更新日期:1991-09-01 00:00:00

  • Prevalence of social-emotional and behavioral problems in a community sample of 1- and 2-year-old children.

    abstract:OBJECTIVE:To examine the prevalence of infant-toddler social-emotional and behavioral problems and associations with social-emotional competence, interference in family life, and parental worry. METHOD:The sample consisted of 1- and 2-year-old children (mean [MN] age = 24.8 months) from the baseline survey of a repres...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-200107000-00016

    authors: Briggs-Gowan MJ,Carter AS,Skuban EM,Horwitz SM

    更新日期:2001-07-01 00:00:00

  • Case study: adverse effects of smoking marijuana while receiving tricyclic antidepressants.

    abstract::Increasingly, children and adolescents are being treated for underlying psychopathology commonly associated with the psychoactive substance use disorders. Despite this apparent increase in using medication, little is known about the interaction of drugs of abuse with the psychotropic medications. The authors describe ...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199701000-00016

    authors: Wilens TE,Biederman J,Spencer TJ

    更新日期:1997-01-01 00:00:00

  • Predicting methylphenidate response in children with ADHD: theoretical, empirical, and conceptual models.

    abstract:OBJECTIVE:To evaluate the theoretical merit and empirical validity of models designed to predict response to methylphenidate (MPH) among children with attention-deficit/hyperactivity disorder (ADHD). METHOD:Seventy-six children with ADHD received each of 4 counterbalanced doses of MPH (5, 10, 15, and 20 mg) in the con...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004583-199904000-00011

    authors: Denney CB,Rapport MD

    更新日期:1999-04-01 00:00:00

  • A Multisite Study of Family Functioning Impairment in Pediatric Obsessive-Compulsive Disorder.

    abstract:OBJECTIVE:Familial aspects of pediatric obsessive-compulsive disorder (OCD), including accommodation and treatment, have received notable and warranted attention. However, individual perspectives of its repercussions on family functioning, including emotional and occupational parental burden, have not been closely exam...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jaac.2016.12.012

    authors: Stewart SE,Hu YP,Leung A,Chan E,Hezel DM,Lin SY,Belschner L,Walsh C,Geller DA,Pauls DL

    更新日期:2017-03-01 00:00:00

  • Editorial: Cognitive-Behavioral Therapy Versus Serotonin Reuptake Inhibitors for Pediatric Obsessive-Compulsive Disorder.

    abstract::How should treatment be initiated for children with obsessive-compulsive disorder (OCD)? This editorial comments on an article by Melin and colleagues,1 published in this issue, from the NordLOTS study, which reports excellent outcomes from cognitive behavior therapy (CBT) for children with OCD. Children continued to ...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 评论,社论

    doi:10.1016/j.jaac.2019.03.015

    authors: Strayhorn J Jr

    更新日期:2020-02-01 00:00:00

  • Secondary prevention of childhood firesetting.

    abstract:OBJECTIVE:The Juvenile Fire Awareness and Intervention Program was established to develop and evaluate an intervention to be offered by fire fighters for children who set fires. METHOD:One hundred thirty-eight children, aged 5 to 16 years, with a history of firesetting participated in a randomized, controlled trial. T...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004583-199410000-00015

    authors: Adler R,Nunn R,Northam E,Lebnan V,Ross R

    更新日期:1994-10-01 00:00:00

  • Mental health need and access to mental health services by youths involved with child welfare: a national survey.

    abstract:OBJECTIVE:This study assessed the relationship between the need for and use of mental health services among a nationally representative sample of children who were investigated by child welfare agencies after reported maltreatment. METHOD:Data were collected at study entry into the National Survey of Child and Adolesc...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/01.chi.0000127590.95585.65

    authors: Burns BJ,Phillips SD,Wagner HR,Barth RP,Kolko DJ,Campbell Y,Landsverk J

    更新日期:2004-08-01 00:00:00

  • Mechanisms of Change in the Prevention of Depression: An Indicated School-Based Prevention Trial at the Transition to High School.

    abstract:OBJECTIVE:Depression represents a major public health concern, and prevalence increases significantly during adolescence. The high school transition may exacerbate the risk of depression for youth with pre-existing vulnerability. The High School Transition Program (HSTP) is a brief, skills-based intervention that has d...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2019.05.031

    authors: Blossom JB,Adrian MC,Stoep AV,McCauley E

    更新日期:2020-04-01 00:00:00

  • Disruptive mood dysregulation disorder and chronic irritability in youth at familial risk for bipolar disorder.

    abstract:OBJECTIVE:Disruptive mood dysregulation disorder (DMDD) is a new diagnosis in the DSM-5. Youth with a family history of bipolar disorder (BD) are at increased risk for BD and non-bipolar psychopathology. No studies to date have examined rates of DMDD among offspring of parents with BD. This study examines the risk for ...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2013.12.026

    authors: Sparks GM,Axelson DA,Yu H,Ha W,Ballester J,Diler RS,Goldstein B,Goldstein T,Hickey MB,Ladouceur CD,Monk K,Sakolsky D,Birmaher B

    更新日期:2014-04-01 00:00:00