Abstract：
OBJECTIVE:High-risk studies of psychiatric disorders in parents and offspring that include 3 generations are uncommon. Multigenerational studies can be clinically useful as they can provide information for risk prediction from one generation to another for the development of empirically based interventions. Using a high-risk design, this study examines the association of grandparent major depressive disorder (MDD) and parent MDD with psychopathology in grandchildren. METHOD:Using Cox proportional hazards in a sample of 90 grandchildren at high and low risk for depression by virtue of their grandparents' and parents' depression status, the authors examined the risk for offspring depression and anxiety. RESULTS:Grandparent and parent MDD were associated with grandchild anxiety (relative risk [RR] = 5.51 and R = 3.09, respectively). Grandchildren with both a depressed parent and grandparent had the highest risk for anxiety. Parental MDD is associated with an increased risk for grandchild disruptive disorder (RR = 10.77). Forty-nine percent of the grandchildren in families in which both the parent and grandparent were depressed had some form of psychopathology. The grandchildren from those families were the most impaired. CONCLUSIONS:Prepubertal-onset anxiety disorder is a risk factor for the later development of clinically significant recurrent MDD across several generations of families at high risk for depression. Parental impaired functioning increases the risk for disruptive disorders. Children in families with multiple generations of depression are at particularly high risk for some form of psychopathology.
journal_name
J Am Acad Child Adolesc Psychiatryauthors
Warner V,Weissman MM,Mufson L,Wickramaratne PJdoi
10.1097/00004583-199903000-00016subject
Has Abstractpub_date
1999-03-01 00:00:00pages
289-96issue
3eissn
0890-8567issn
1527-5418pii
S0890-8567(09)62924-5journal_volume
38pub_type
杂志文章abstract：OBJECTIVE:Most research on irritability and child psychopathology has focused on depressive disorders, bipolar disorder, and/or oppositional defiant disorder (ODD). Less is known about relationships between child anxiety and irritability and moderators of such associations. METHOD:Structural equation modeling (SEM) wa...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章
doi：10.1016/j.jaac.2015.10.007
更新日期：2016-01-01 00:00:00
abstract：:The prevalence of psychiatric disorders, such as major depression and anxiety, is higher in sexual minority individuals (eg, those who identify as gay, lesbian, or bisexual or are unsure of their orientation) than heterosexual individuals.1 Eating disorders and alcohol use also are more common in sexual minority group...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 评论,社论
doi：10.1016/j.jaac.2018.11.006
更新日期：2019-02-01 00:00:00
abstract：OBJECTIVE:To describe the range of depressive symptoms reported by adolescents in a nationally representative U.S. sample and to examine factors associated with persistent depressive symptoms. METHOD:Secondary analysis was done on National Longitudinal Study of Adolescent Health (AddHealth) data from 13,568 adolescent...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章
doi：10.1097/00004583-200202000-00014
更新日期：2002-02-01 00:00:00
abstract：OBJECTIVES:The Collaborative Life Skills (CLS) program is a school-home intervention for students with attention-deficit/hyperactivity disorder (ADHD) symptoms and impairment. CLS integrates school, parent, and student treatments followed by booster sessions during a maintenance period into the subsequent school year. ...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jaac.2018.01.016
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVE:To examine the efficacy of N-acetylcysteine (NAC) for the treatment of pediatric trichotillomania (TTM) in a double-blind, placebo-controlled, add-on study. METHOD:A total of 39 children and adolescents aged 8 to 17 years with pediatric trichotillomania were randomly assigned to receive NAC or matching place...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jaac.2012.12.020
更新日期：2013-03-01 00:00:00
abstract：OBJECTIVE:To examine the feasibility and efficacy of a manual-based cognitive-behavioral therapy (CBT) in reducing depressive symptomatology in adolescents with inflammatory bowel disease (IBD). Primary and Secondary Control Enhancement Therapy-Physical Illness (PASCET-PI) modified for youths with IBD was compared to t...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1097/chi.0b013e3180f6341f
更新日期：2007-10-01 00:00:00
abstract：OBJECTIVE:To determine the prevalence and correlates of psychiatric disorders among preschool children in a primary care pediatric sample. METHOD:In a two-stage design, 3,860 preschool children were screened; 510 received fuller evaluations. RESULTS:For quantitative assessment of disorder (> or = 90th percentile), pr...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章
doi：10.1097/00004583-199602000-00014
更新日期：1996-02-01 00:00:00
abstract：OBJECTIVE:Family interventions have been found to be effective in pediatric bipolar disorder (BD). This study examined the moderating effects of parental expressed emotion (EE) on the 2-year symptomatic outcomes of adolescent BD patients assigned to family-focused therapy for adolescents (FFT-A) or a brief psychoeducat...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1097/CHI.0b013e3181a0ab9d
更新日期：2009-06-01 00:00:00
abstract：OBJECTIVES:The primary objective of the study was to assess whether the Availability, Responsiveness and Continuity (ARC) organizational intervention improved youth outcomes in community based mental health programs. The second objective was to assess whether programs with more improved organizational social contexts f...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jaac.2013.02.005
更新日期：2013-05-01 00:00:00
abstract：OBJECTIVE:To examine the differential course and treatment outcome of patients who participated in a randomized clinical trial, comparing cognitive, family, and supportive psychotherapies for adolescent major depressive disorder. METHOD:In a sample of 100 depressed adolescents, remission, clinical recovery, recurrence...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004583-199811000-00019
更新日期：1998-11-01 00:00:00
abstract：:Selected literature is reviewed regarding the question, How may children's self-control skills be developed or improved through training? It is premature to give up on psychosocial methods of training self-control. Self-control is fostered by being in a long-term positive relationship with a dependable person who comm...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章
doi：10.1097/00004583-200201000-00007
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVE:To assess the predictors of treatment outcome across treatments, as well as those associated with differential treatment response. METHOD:One hundred seven adolescent outpatients, aged 13 to 18 years, with DSM-III-R major depression were randomly assigned to one of three manual-based, brief (12 to 16 session...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004583-199809000-00010
更新日期：1998-09-01 00:00:00
abstract：:This study is a clinical extension of two previous epidemiological studies on problem behavior in international adoptees. In depth pictures were obtained by clinical interviews of 132 14-year-old international adoptees and their parents. Children were selected on the basis of previously obtained Child Behavior Checkli...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章
doi：10.1097/00004583-199005000-00014
更新日期：1990-05-01 00:00:00
abstract：OBJECTIVE:Family environmental factors as well as parental attention-deficit/hyperactivity disorder (ADHD) status have shown associations with variability in ADHD. The purpose of the present study was to examine the links among family environment, parental psychiatric diagnosis, and child impairment within a sample of ...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章
doi：10.1097/01.chi.0000192248.61271.c8
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVE:To examine whether first-episode psychosis patients with onset during adolescence (ages 15-18) differ significantly from those with young-adult onset (ages 19-30). METHOD:Consecutive patients presenting with first-episode psychosis (N = 242) were assessed for demographic and illness characteristics such as d...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章
doi：10.1097/01.chi.0000164591.55942.ea
更新日期：2005-08-01 00:00:00
abstract：:Parental anger can have detrimental effects on children and can contribute to physical abuse. Ego-dystonic anger attacks are an underrecognized psychiatric symptom that occurs in associated with depression, with other psychiatric disorders, and in the absence of comorbid disorders. They are characterized by overwhelmi...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章
doi：10.1097/00004583-199710000-00019
更新日期：1997-10-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to examine the co-occurrence of posttraumatic stress disorder (PTSD) and dissociation in a clinical sample of trauma-exposed adolescents by evaluating evidence for the depersonalization/derealization dissociative subtype of PTSD as defined by the DSM-5 and then examining a broade...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章
doi：10.1016/j.jaac.2017.09.425
更新日期：2017-12-01 00:00:00
abstract：:Videotaped interrater reliability was assessed with the K-SADS-III-R on 25 children with a mean age of 10:9. Kappa statistics were computed in syndromes with a frequency rate of at least 20%. The following mean kappas were obtained: major depression = 0.83; overanxious disorder = 0.85; separation anxiety = 0.85; simpl...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章
doi：10.1097/00004583-198909000-00013
更新日期：1989-09-01 00:00:00
abstract：:The authors report an open clinical trial of clomipramine for chronic stereotypic and self-injurious behaviors in 11 consecutive patients with concomitant developmental disorders. Ten patients (91%) had marked decreases in rates of target behaviors. No seizures occurred despite the inclusion of six patients with previ...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 临床试验,杂志文章
doi：10.1097/00004583-199211000-00027
更新日期：1992-11-01 00:00:00
abstract：OBJECTIVE:To examine trends in the use of antipsychotic medication in Medicaid-eligible youth from 2008 to 2013 and the factors associated with this use. METHOD:Youth aged 0 to 17 years with at least one claim indicating antipsychotic medication use were identified from the network of a behavioral health managed care ...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章
doi：10.1016/j.jaac.2016.10.005
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVE:To examine the expression of war-related trauma as manifested by DSM-III-R rates of posttraumatic stress disorder (PTSD) and major depressive disorder in two generations of Cambodian refugees living in the western United States. METHOD:A probability sample of 209 Khmer adolescents and one of their parents we...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004583-199509000-00013
更新日期：1995-09-01 00:00:00
abstract：OBJECTIVE:To examine concordance between parent and teacher reports of DSM-IV attention-deficit/hyperactivity disorder (ADHD) and its symptoms. METHOD:Parents and teachers of 74 clinically referred children were interviewed using the ADHD module of the Diagnostic Interview Schedule for Children. Parent-teacher agreeme...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章
doi：10.1097/00004583-200003000-00012
更新日期：2000-03-01 00:00:00
abstract：:We spend approximately a third of our lives sleeping, and many DSM-IV and DSM-5 disorders have sleep problems listed as diagnostic features and are often considered "comorbidities." However, very little is known about the role sleep problems play in the etiology of psychiatric disorders such as attention-deficit/hyper...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 评论,社论
doi：10.1016/j.jaac.2018.10.013
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVE:The 12-month prevalence of DSM-III-R anxiety disorders and intrafamilial stress ratings were determined in 23 children with hemophilia, 37 children with asthma, and 31 healthy children. METHOD:Diagnoses were made using the parent and child versions of the Kiddie Schedule for Affective Disorders and Schizophr...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章
doi：10.1097/00004583-199305000-00011
更新日期：1993-05-01 00:00:00
abstract：:The sudden death of three children receiving the tricyclic antidepressant medication desipramine for behavioral disorders was reported in 1990. We now provide new information about these children and describe a fourth case. Because desipramine is a useful medication for many children, these deaths pose clinical dilemm...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章,评审
doi：10.1097/00004583-199307000-00013
更新日期：1993-07-01 00:00:00
abstract：OBJECTIVE:To investigate whether eye-gaze avoidance, a striking phenotypic feature in fragile X syndrome (FXS), is associated with high levels of "hyperarousal" during social interactions with others. To date, almost all studies in this area have been confounded by inclusion of task demands in addition to social demand...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章
doi：10.1097/CHI.0b013e318195bd15
更新日期：2009-03-01 00:00:00
abstract：:Dysmorphology--in the form of minor physical anomalies--has been frequently reported in children with attention deficit disorder (ADD). The authors report an overrepresentation of minor physical anomalies in both ADD probands and their first-degree relatives. Further, ADD probands who are not dysmorphic have non-ADD r...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章
doi：10.1097/00004583-199003000-00006
更新日期：1990-03-01 00:00:00
abstract：OBJECTIVE:Changes in autism diagnostic criteria found in DSM-5 may affect autism spectrum disorder (ASD) prevalence, research findings, diagnostic processes, and eligibility for clinical and other services. Using our published, total-population Korean prevalence data, we compute DSM-5 ASD and social communication disor...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章
doi：10.1016/j.jaac.2013.12.021
更新日期：2014-05-01 00:00:00
abstract：:This practice parameter describes the epidemiology, clinical picture, differential diagnosis, course, risk factors, and pharmacological and psychotherapy treatments of children and adolescents with major depressive or dysthymic disorders. Side effects of the antidepressants, particularly the risk of suicidal ideation ...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 杂志文章
doi：10.1097/chi.0b013e318145ae1c
更新日期：2007-11-01 00:00:00
abstract：:Twenty-seven children (or smaller subgroups depending upon task difficulty and subject ability) with subaverage IQs took part in a double-blind, placebo-controlled, cross-over study of methylphenidate (0.4 mg/kg/day) and thioridazine (1.75 mg/kg/day). The children were tested for IQ performance, breadth of attention, ...
journal_title：Journal of the American Academy of Child and Adolescent Psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1991-09-01 00:00:00
