Clomipramine hydrochloride in childhood and adolescent obsessive-compulsive disorder--a multicenter trial.

Abstract:

:Children and adolescents with obsessive compulsive disorder were studied in an 8-week, multicenter, double-blind, parallel groups trial of clomipramine hydrochloride (CMI) versus placebo. Efficacy assessments included the child version of the Yale-Brown Obsessive Compulsive Scale and the National Institute of Mental Health Global rating scale. At the end of 8 weeks, CMI-treated patients showed a mean reduction in Yale-Brown Obsessive Compulsive Scale score of 37% compared to 8% in the placebo group. Side effects were typical of tricyclic antidepressants. In a 1-year open label treatment, CMI continued to be effective and well tolerated.

authors

DeVeaugh-Geiss J,Moroz G,Biederman J,Cantwell D,Fontaine R,Greist JH,Reichler R,Katz R,Landau P

doi

10.1097/00004583-199201000-00008

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

45-9

issue

1

eissn

0890-8567

issn

1527-5418

pii

S0890-8567(09)64404-X

journal_volume

31

pub_type

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