Eltanolone for induction of anaesthesia in the surgical patient. A comparison of dose requirements in young and elderly patients.

Abstract:

BACKGROUND:The relative potency of the steroid anaesthetic agent eltanolone has been compared with respect to induction of anaesthesia in ASA I and II young (18-40 years) and elderly (> 65 years) patients. METHOD:113 temazepam premedicated patients (60 elderly) were evaluated in an open randomised study. They were allocated to receive doses between 0.05 and 0.75 mg/kg given i.v. over 30 s. The first 33 patients formed a pilot phase; the formal study comprised 80 patients. The primary efficacy variable was loss of verbal contact within 120 s and an effect lasting more than 4 min. All patients breathed 100% oxygen throughout the study period. Safety data (heart rate, blood pressure, respiratory apnoea, involuntary movements, hypertonus and other adverse effects) were noted. RESULTS:Anaesthesia was adequately induced in 12/40 elderly and 7/40 young patients. The lowest effective induction dose was 0.2 mg/kg in elderly and 0.3 mg/kg in young patients. This gave a relative potency of 0.28 (95% CI 0.12-0.52; P = 0.0039). The cardiovascular effects associated with induction were small; other side-effects included involuntary movement and hypertonus, and respiratory upsets (apnoea, hiccups and coughing). CONCLUSION:The effective induction dose of eltanolone was significantly lower in the elderly patients; but the drug safety profile was similar in both age groups of patients.

authors

Sear JW

doi

10.1111/j.1399-6576.1997.tb04862.x

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

1175-9

issue

9

eissn

0001-5172

issn

1399-6576

journal_volume

41

pub_type

临床试验,杂志文章,随机对照试验
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