Pretreatment with sufentanil reduces myoclonus after etomidate.

Abstract:

BACKGROUND:Myoclonic movements are a common problem during the induction of general anesthesia with etomidate. We investigated the influence of pretreatment with the opioid sufentanil on the incidence of etomidate-induced myoclonus. METHODS:Forty female patients (ASA physical status I-III) were randomly assigned to receive double-blinded either 0.3 micro g kg-1 of sufentanil or placebo 150 s before the induction of sleep with 0.3 mg kg-1 of etomidate. The patients were observed for any myoclonic movement. Grade of dizziness, breathing frequency, non-invasive blood pressure and heart rate were measured during the study period. RESULTS:None of the 20 patients receiving sufentanil had myoclonic movements after the administration of etomidate, whereas 16 patients in the placebo group (80%) experienced such movements (P<0.01). No cases of apnoea before induction of sleep were seen in the sufentanil group. CONCLUSION:Sufentanil 0.3 micro g kg-1 is an effective and safe drug to reduce myoclonus after etomidate without causing any harmful side-effect.

authors

Hueter L,Schwarzkopf K,Simon M,Bredle D,Fritz H

doi

10.1034/j.1399-6576.2003.00081.x

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

482-4

issue

4

eissn

0001-5172

issn

1399-6576

pii

081

journal_volume

47

pub_type

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