Cardiorespiratory effects of nalbuphine and morphine premedication in adult cardiac surgical patients.

Abstract:

:Premedication for cardiac surgical patients attempts to achieve relief of anxiety with minimal or no cardiorespiratory changes. Nalbuphine (NUBAIN) and morphine produced similar decreases in respiratory rate (1-3 breaths per min) and PaO2 (averaging 1.34 kPa), and increases in arterial PaCO2 (averaging 0.56 kPa). Cardiovascular changes were not seen with either agent. A similar degree of sedation and relief of anxiety was achieved with both drugs. Side effects were minimal and infrequent. Nalbuphine produces respiratory depression and sedation without cardiovascular changes which is comparable to an equivalent dose of morphine in patients with either valvular or coronary artery disease.

authors

Lake CL,Duckworth EN,DiFazio CA,Magruder MR

doi

10.1111/j.1399-6576.1984.tb02066.x

subject

Has Abstract

pub_date

1984-06-01 00:00:00

pages

305-9

issue

3

eissn

0001-5172

issn

1399-6576

journal_volume

28

pub_type

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