Abstract：
BACKGROUND:The primary aim was to investigate the performance of a National Advisory Committee for Aeronautics based predictive model (NACA-BM) for mortality at 14 days and a reference model using motor GCS (GCS-RM). The secondary aim was to compare the models for impaired consciousness of survivors at 14 days (IC-14; GCS ≤ 13). METHODS:Patients ≥16 years having sustained TBI with an abbreviated injury scale score of head region (HAIS) of >3 were included. Multivariate logistic regression models were used to test models for death and IC-14. The discrimination was assessed using area under the receiver-operating curves (AUROCs); noninferiority margin was -5% between the AUROCs. Calibration was assessed using the Hosmer Lemeshow goodness-of-fit test. RESULTS:Six hundred and seventy seven patients were included. The median age was 54 (IQR 32-71). The mortality rate was 31.6%; 99 of 438 surviving patients (22.6%) had an IC-14. Discrimination of mortality was 0.835 (95%CI 0.803-0.867) for the NACA-BM and 0.839 (0.807-0.872) for the GCS-RM; the difference of the discriminative ability was -0.4% (-2.3% to +1.7%). Calibration was appropriate for the NACA-BM (χ2 8.42; P = 0. 393) and for the GCS-RM (χ2 3.90; P = 0. 866). Discrimination of IC-14 was 0.757 (0.706-0.808) for the NACA-BM and 0.784 (0.734-0.835) for the GCS-RM; the difference of the discriminative ability was -2.5% (-7.8% to +2.6%). Calibration was appropriate for the NACA-BM (χ2 10.61; P = 0.225) and for the GCS-RM (χ2 6.26; P = 0.618). CONCLUSIONS:Prehospital prediction of mortality after TBI was good with both models, and the NACA-BM was not inferior to the GCS-RM. Prediction of IC-14 was moderate in both models.
journal_name
Acta Anaesthesiol Scandjournal_title
Acta anaesthesiologica Scandinavicaauthors
Pannatier M,Delhumeau C,Walder Bdoi
10.1111/aas.13229subject
Has Abstractpub_date
2019-01-01 00:00:00pages
74-85issue
1eissn
0001-5172issn
1399-6576journal_volume
63pub_type
杂志文章abstract：BACKGROUND:The purpose of this study was to investigate whether an initial post-operative lactate level is a predictor of mortality, need for peritoneal dialysis (PD), duration of intubation or length of stay (LOS) in the intensive care unit (ICU) in children undergoing cardiac surgery. METHOD:A retrospective, observa...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1399-6576.2011.02588.x
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Pre-hospital tracheal intubation (TI) is an important but difficult procedure with the potential to produce hypoxaemia. The aim of this study was to determine the incidence of desaturation episodes during out-of-hospital rapid sequence induction (RSI) and TI by the medical team of a German Helicopter Emergen...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章
doi：10.1111/aas.12032
更新日期：2013-02-01 00:00:00
abstract：:Indomethacin has been suggested as a therapeutic tool to manage elevated intracranial pressure in patients with severe head injury and patients undergoing craniotomy for brain tumors. Indomethacin is a non-selective cyclooxygenase inhibitor. Compared to other cyclooxygenase inhibitors indomethacin has unique effects o...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章,评审
doi：10.1111/j.1399-6576.2005.00647.x
更新日期：2005-03-01 00:00:00
abstract：BACKGROUND:Addition of an opioid to low-dose spinal anesthesia with bupivacaine improves the quality and success of anesthesia. However, the intrathecal fentanyl-induced pruritus is as high as 75%. We hypothesized that after administration of 4 or 8 mg of prophylactic IV ondansetron, the incidence of pruritus induced b...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1399-6576.2003.00206.x
更新日期：2003-11-01 00:00:00
abstract：:In vitro tests for the diagnosis of malignant hyperthermia susceptibility were performed in 105 patients and 20 normal controls according to the protocol of the European MH Group. Results of dynamic halothane and caffeine tests (in which muscle bundle length is cyclically changed) were compared to those of static test...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1399-6576.1987.tb02603.x
更新日期：1987-07-01 00:00:00
abstract：BACKGROUND:The effect of alfentanil on intracranial pressure (ICP) in patients with supratentorial cerebral tumors has only been sparsely examined and with somewhat contradictory results. METHODS:Thirty-one patients were anesthetized with propofol and fentanyl. After removal of the bone flap a bolus-dose of alfentanil...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1399-6576.2005.00648.x
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND:Venous gas embolism is a rare but severe event in critically ill patients and the diagnosis should be obtained as soon as possible. Ultrasonography is a sensitive, non-invasive, and bedside means of detection. METHOD:We prospectively estimated the performance of two-dimensional (2D) echocardiography and pul...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章
doi：10.1034/j.1399-6576.1999.430314.x
更新日期：1999-03-01 00:00:00
abstract：:The effect on central haemodynamics of a stepwise increase in airways pressure from spontaneous breathing (SB) to intermittent positive pressure ventilation with a positive end-expiratory pressure (PEEP) of 0, 8, 16 and 24 cmH2O was studied in eight pigs under ketamine anaesthesia. Compared with SB, cardiac output (CO...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1399-6576.1981.tb01701.x
更新日期：1981-12-01 00:00:00
abstract：BACKGROUND:Stimulation of myocardial alpha 1-adrenoceptors has been shown to exert positive inotropic effects through a cyclic AMP-independent mechanism. The purpose of this study was to examine if alpha 1-adrenoceptor stimulation is able to attenuate myocardial depression produced by exposure to halothane, and to test...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1399-6576.1997.tb04812.x
更新日期：1997-08-01 00:00:00
abstract：:Regional anaesthesia has many advantages over general anaesthesia in hip surgery. When the effects of total hip replacement under spinal or general anaesthesia were compared in 22 patients, the only difference between the groups occurred in PHA-induced lymphocyte proliferative responses. In contrast, no differences be...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1399-6576.1990.tb03078.x
更新日期：1990-04-01 00:00:00
abstract：BACKGROUND:Since the cuffed oropharyngeal airway (COPA) has been suggested to cause less pharyngeal trauma than the laryngeal mask airway (LMA), we conducted a prospective, randomised study to compare haemodynamic changes after placing either the COPA or LMA in healthy anaesthetised adults. METHODS:After standard mida...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1034/j.1399-6576.1999.431014.x
更新日期：1999-11-01 00:00:00
abstract：:Heat loss during anesthesia and operation and subsequent hypothermia will increase the postoperative oxygen demand and may endanger patients with restricted cardiopulmonary reserves. Forty patients scheduled for intra-abdominal aortic surgery and 40 patients scheduled for peripheral vascular surgery on the lower limbs...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1399-6576.1984.tb02109.x
更新日期：1984-10-01 00:00:00
abstract：BACKGROUND:Pain after coronary artery bypass surgery persists for several days. A continuous intravenous infusion of an opioid adequately accomplishes good pain control in the intensive care unit, but it is often not suitable on the ordinary ward. Patient-controlled analgesia (PCA) with intermittent injections delivere...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1034/j.1399-6576.2000.440108.x
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Trauma systems have improved outcomes for injured patients, but might be challenging to implement. We assessed the implementation of a trauma system in Norway after recommendations for a national trauma system were published in 2007, with a focus on elements in acute care hospitals. METHODS:All hospitals in...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章
doi：10.1111/aas.12467
更新日期：2015-03-01 00:00:00
abstract：:The effects of surfactant replacement by aerosol inhalation and by bolus instillation were compared in rats with respiratory failure induced by repeated lung lavage. The rats were anesthetized with pentobarbital sodium and mechanically ventilated with 100% oxygen. The PaO2 of control rats not given surfactant (n = 9) ...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1399-6576.1994.tb03842.x
更新日期：1994-01-01 00:00:00
abstract：:This randomized, double-blind and double-dummy study was carried out in order to compare the perioperative sedation after premedication with either brotizolam 0.25-0.50 mg sublingually or diazepam 5-10 mg orally. Sixty-two patients aged 18-60 years scheduled for minor gynaecological surgery in general anaesthesia were...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1399-6576.1992.tb03560.x
更新日期：1992-11-01 00:00:00
abstract：BACKGROUND:It is possible to perform acute normovolemic hemodilution (ANH) in combination with controlled hypotension (CH). In this randomized prospective study, we examined the effect of the combination of ANH and CH on cerebral oxygenation using near-infrared spectroscopy. METHODS:Fifty-six patients undergoing major...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1399-6576.2006.01048.x
更新日期：2006-08-01 00:00:00
abstract：BACKGROUND:Dexmedetomidine is a rather new drug in China. We sought to describe the pharmacokinetics of dexmedetomidine in patients requiring post-operative sedation and ventilation in our surgical intensive care unit. METHODS:Twenty-two patients received post-operative infusions of dexmedetomidine at 6 μg/kg/h for 10...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1399-6576.2010.02392.x
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND:Patients with complex regional pain syndrome (CRPS) are seen and treated by a variety of physicians. The present study aims to describe referral and treatment patterns for CRPS patients in the Netherlands. METHODS:Patients, who were selected (1996-2005) from an electronic general practice (GP) database (Int...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1399-6576.2009.01927.x
更新日期：2009-07-01 00:00:00
abstract：:When using deliberate haemodilution to a certain haematocrit value (Hct), the appropriate preoperative blood volume of the patient must be determined and matched with the transfusion volume at a certain blood loss. In order to facilitate such calculations a nomogram was constructed, aiming for a final Hct of 33%. Preo...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1399-6576.1986.tb02418.x
更新日期：1986-05-01 00:00:00
abstract：:It can be shown that the assumption of an arbitrary value for VDphys/VT during IPPV can lead to unacceptable degrees of hypo- or hyperventilation. We investigated 33 adult patients scheduled for major non-thoracic surgery, to see if any simple tests could be used to predict VDphys/VT during anaesthesia/IPPV. Fifteen w...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1399-6576.1981.tb01606.x
更新日期：1981-02-01 00:00:00
abstract：BACKGROUND:Ethyl pyruvate has been shown to possess anti-inflammatory and free radical scavenging properties. However, the haemodynamic effects of ethyl pyruvate have not been studied in detail. We investigated the systemic, regional and microcirculatory haemodynamic and metabolic effects of resuscitation with Ringer's...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1399-6576.2006.01140.x
更新日期：2006-11-01 00:00:00
abstract：BACKGROUND:Our objective was to compare the recovery characteristics of sevoflurane and halothane for short day-case anaesthesia in a specifically limited age group of children 1-3 yr. METHODS:Eighty unpremedicated children undergoing day-case adenoidectomy were randomly assigned to receive inhalational induction with...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1034/j.1399-6576.2000.440118.x
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Neuromuscular monitoring using the corrugator supercilii muscle is associated with a number of challenges. The aim of this study was to assess reversal of a rocuronium-induced neuromuscular blockade with sugammadex according to monitoring either using the corrugator supercilii muscle or the adductor pollicis...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章,随机对照试验
doi：10.1111/aas.12549
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Appropriate utilization of vancomycin is important to attain therapeutic targets while avoiding clinical failure and the development of antimicrobial resistance. Our aim was to observe the use of vancomycin in an intensive care population, with the main focus on achievement of therapeutic serum concentration...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章
doi：10.1111/aas.12897
更新日期：2017-07-01 00:00:00
abstract：:Pneumoperitoneum following cardiopulmonary resuscitation (CPR) results from a thoracic air leak (pneumothorax, pneumomediastinum) with escape of the air through diaphragmatic apertures (mostly foramen of Winslow) or primary perforation of the gastrointestinal tract (stomach or esophagus). We report three cases of pneu...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1399-6576.1991.tb03279.x
更新日期：1991-04-01 00:00:00
abstract：BACKGROUND:High-dose fentanyl anesthesia is reported to attenuate the metabolic and endocrinal responses to surgery. Interleukin-1 (IL-1) is one of the key mediators in the immunoneuroendocrine system, and may be involved in the stress responses to surgery. We studied whether high-dose fentanyl may influence the IL-1 b...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1399-6576.1996.tb04411.x
更新日期：1996-02-01 00:00:00
abstract：BACKGROUND:Data are scarce on the withdrawal of life-sustaining therapies and limitation of care orders (LCOs) during physician-staffed Helicopter Emergency Medical Service (HEMS) missions. We investigated LCOs and the quality of information available when physicians made treatment decisions in pre-hospital care. METH...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章
doi：10.1111/aas.13649
更新日期：2020-09-01 00:00:00
abstract：:The effects of addition of 1 ml of lignocaine (10 mg) or isotonic saline to 19 ml of the emulsified preparation of propofol (Diprivan) were studied in a randomised, double-blind trial in 80 patients. The incidence and severity of pain on injection of propofol were significantly reduced by the addition of lignocaine (P...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1399-6576.1988.tb02774.x
更新日期：1988-08-01 00:00:00
abstract：:Cardiac complications are the major cause of perioperative and late mortality and morbidity in patients undergoing elective major vascular surgery. This review focuses on the pathophysiology of perioperative complications, risk assessment and risk reduction strategies, all related to cardiovascular disease. Patients w...
journal_title：Acta anaesthesiologica Scandinavica
pub_type： 杂志文章,评审
doi：10.1034/j.1399-6576.2003.00149.x
更新日期：2003-07-01 00:00:00
