Effects of succinylcholine chloride on the response of fast and slow muscle in the cat.

Abstract:

:Fast and slow muscle fibres differ histochemically, electrophysiologically and pharmacologically. In vivo, the effect of 0.05, 0.075 and 0.1 mg X kg-1 succinylcholine on the response of the indirectly stimulated gastrocnemius (fast) and soleus muscle (slow) to single, train-of-four and tetanic stimuli was studied. There was a significant difference between the response of the two muscles. Maximum twitch suppression occurred 2 min after injection and was more significant in the gastrocnemius than the soleus. The duration of the neuromuscular blockade was 9 min or more in both groups. The train-of-four ratio dropped below 0.7 in the gastrocnemius preparation at all doses and in the soleus when 0.1 mg X kg-1 succinylcholine was used. Sustained tetanus was achieved in both muscles at 5 and 10 min, respectively. There was evidence of fatigue in the soleus muscle at the 5-min observation suggestive of the presence of a phase II block, a phenomenon not observed in the gastrocnemius.

authors

Choi WW,Gergis SD,Sokoll MD

doi

10.1111/j.1399-6576.1984.tb02110.x

subject

Has Abstract

pub_date

1984-10-01 00:00:00

pages

516-20

issue

5

eissn

0001-5172

issn

1399-6576

journal_volume

28

pub_type

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