Dixyrazine for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy.

Abstract:

BACKGROUND:The study assessed the efficacy and safety of dixyrazine, an alternative neuroleptic drug to droperidol, in the prophylaxis of postoperative nausea and vomiting (PONV). METHODS:A total of 197 patients scheduled for laparoscopic cholecystectomy under general anesthesia were randomized to receive either dixyrazine 10 mg or placebo double-blinded at the end of surgery. Scores pertaining to PONV episodes, analgetic supply, rescue medication, adverse events and patient satisfaction were collected over the first 2 h in the PACU and the next 22 h in the ward. RESULTS:The incidence of PONV over the entire 24-h period was reduced from 32% in the placebo group to 13% in the dixyrazine group (P< or =0.004). The incidence of nausea in the first 2 h was reduced from 15% in the placebo group to 4% in the dixyrazine group (P< or =0.02) and from 12% to 5% in the next 22 h. The incidence of emetic episodes was not different between the two groups. Postoperative shivering was significantly less prevalent in the dixyrazine than in the placebo group (2% vs. 13%; P< or =0008), and opioid analgesics were required significantly less often (61% vs. 75%; P< or =0.01). No significant adverse effects were observed. Patient satisfaction was similar in both groups. CONCLUSION:Prophylactic dixyrazine is an effective, safe, and cheap antiemetic drug for laparoscopic cholecystectomy without involving any significant adverse events.

authors

Glaser C,Sitzwohl C,Wallner T,Lerche A,Marhofer P,Schindler I

doi

10.1111/j.1399-6576.2004.00526.x

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

1287-91

issue

10

eissn

0001-5172

issn

1399-6576

pii

AAS526

journal_volume

48

pub_type

临床试验,杂志文章,随机对照试验
  • Effect of hemodiafiltration and sepsis on chemotaxis of granulocytes and the release of IL-8 and IL-10.

    abstract:BACKGROUND:Extracorporeal circulation, such as cardiopulmonary bypass and hemodialysis, has been associated with an activation of the immune system. Continuous veno venous hemodiafiltration (CVVHD) is used in critically ill septic patients. During CVVHD, cytokines are excreted in ultrafiltrate. When the membranes, used...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2002.460203.x

    authors: Toft P,Brix-Christensen V,Baech J,Krog J,Jørgensen HS,Tønnesen E,Petersen TK,Dagnaes-Hansen F

    更新日期:2002-02-01 00:00:00

  • Influence of non-volatile anesthetics on the migration behavior of the human breast cancer cell line MDA-MB-468.

    abstract:BACKGROUND:Anesthetic agents are known to influence functions of the immune system. Anesthetic drugs also support cancer progression by suppressing the activity of immune cells. In breast carcinoma an increase in expression of peripheral-type benzodiazepine receptors (PBR) and the gamma aminobutyl acid (GABA) level has...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2002.460714.x

    authors: Garib V,Niggemann B,Zänker KS,Brandt L,Kubens BS

    更新日期:2002-08-01 00:00:00

  • Metoclopramide reduces the induction dose of propofol.

    abstract:BACKGROUND:Metoclopramide has been shown to reduce the dose of thiopentone required for induction of anaesthesia. When propofol is used, there have been conflicting results with one small study showing a reduction in the anaesthetic dose and one study failing to demonstrate any effect. METHODS:Two groups of 30 patient...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1997.tb04676.x

    authors: Page VJ,Chhipa JH

    更新日期:1997-02-01 00:00:00

  • Bladder function in spinal anaesthesia.

    abstract::Spinal anaesthesia with bupivacaine (22.5 mg) or with a glucose-containing solution of bupivacaine (20 mg) or tetracaine (15 mg) was given to 21 patients allocated randomly to these three groups. A urodynamic study was performed by CO2 cystometry. It consisted of recording of first sensation of bladder filling, sensat...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1985.tb02207.x

    authors: Axelsson K,Möllefors K,Olsson JO,Lingårdh G,Widman B

    更新日期:1985-04-01 00:00:00

  • Repeatability of the acetylene rebreathing method in measuring cardiac output: influence of acetylene concentration.

    abstract::The acetylene rebreathing method is a reliable noninvasive method for estimation of cardiac output. However, the method is not commonly used for clinical purposes. This is due mainly to the fact that acetylene is explosive at concentrations above 2% and that acetylene at concentrations above 0.5% has an unpleasant tas...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1990.tb03102.x

    authors: Wendelboe Nielsen O,Hansen S,Christensen P,Grønlund J

    更新日期:1990-07-01 00:00:00

  • Ultrasound-guided technique allowed early detection of intravascular injection during an infraclavicular brachial plexus block.

    abstract::The reported incidence of complications after peripheral nerve blocks is generally low and varies from 0% to 5%. The injuries related to brachial plexus block are perhaps more commonly reported, than after peripheral blocks of the lower extremity nerves. Recent reports suggest that expert ultrasound guidance may reduc...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2009.01981.x

    authors: Martínez Navas A,DE LA Tabla González RO

    更新日期:2009-08-01 00:00:00

  • Cell-mediated and humoral immune responses to total hip replacement under spinal or general anaesthesia.

    abstract::Regional anaesthesia has many advantages over general anaesthesia in hip surgery. When the effects of total hip replacement under spinal or general anaesthesia were compared in 22 patients, the only difference between the groups occurred in PHA-induced lymphocyte proliferative responses. In contrast, no differences be...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1990.tb03078.x

    authors: Salo M,Nissilä M

    更新日期:1990-04-01 00:00:00

  • Effect of alfentanil on intracranial pressure during propofol-fentanyl anesthesia for craniotomy. A randomized prospective dose-response study.

    abstract:BACKGROUND:The effect of alfentanil on intracranial pressure (ICP) in patients with supratentorial cerebral tumors has only been sparsely examined and with somewhat contradictory results. METHODS:Thirty-one patients were anesthetized with propofol and fentanyl. After removal of the bone flap a bolus-dose of alfentanil...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2005.00648.x

    authors: Olsen KS,Juul N,Cold GE

    更新日期:2005-04-01 00:00:00

  • A clinical neuropsychological study of the postoperative course after three types of anaesthesia.

    abstract::In a double-blind study, 57 patients were anaesthetized with either Althesin, thiopentone, or fentanyl combined with diazepam for cystoscopies. One and a half and four hours after the administration of anaesthesia, the patients were investigated with an objective neuropsychological method, continuous Reaction Time, an...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-6576.1982.tb01744.x

    authors: Elsass P,Stibolt O,Klauber PV,Christensen SE,Lunding M

    更新日期:1982-04-01 00:00:00

  • Anaesthesia for computerised tomography of the brain in children: a comparison of propofol and thiopentone.

    abstract::Propofol (2,6-di-isopropylphenol) 1.5-2.0 mg/kg i.v. was compared with thiopentone 3.0-4.0 mg/kg i.v. as an induction agent in anaesthesia for computerised tomography (CT) of the brain in children. Both induction agents were combined with diazepam 0.2 mg/kg i.v. Thirty children (ASA physical status I-II) aged 3 to 10 ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1989.tb02884.x

    authors: Valtonen M

    更新日期:1989-02-01 00:00:00

  • The effect of isoflurane on cerebrospinal fluid pressure in patients undergoing neurosurgery.

    abstract::Ten patients with intracerebral tumours (TC) and 13 patients with subarachnoid haemorrhage (SAH) from a ruptured cerebral arterial aneurysm were studied before intracranial surgery, and during a 3-h postoperative period. Cerebrospinal fluid pressure (CSFP) determined by an intraventricular (TC group) or intraspinal (S...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1988.tb02696.x

    authors: Gordon E,Lagerkranser M,Rudehill A,von Holst H

    更新日期:1988-02-01 00:00:00

  • Studies on fluid extravasation related to induced hypothermia during cardiopulmonary bypass in piglets.

    abstract:BACKGROUND:Hypothermia, commonly used for organ protection during cardiopulmonary bypass (CPB), has been associated with changes in plasma volume, hemoconcentration and microvascular fluid shifts. Fluid pathophysiology secondary to hypothermia and the mechanisms behind these changes are still largely unknown. In a rece...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2001.045006720.x

    authors: Heltne JK,Koller ME,Lund T,Farstad M,Rynning SE,Bert JL,Husby P

    更新日期:2001-07-01 00:00:00

  • Pneumoperitoneum--a rare complication of cardiopulmonary resuscitation.

    abstract::Pneumoperitoneum following cardiopulmonary resuscitation (CPR) results from a thoracic air leak (pneumothorax, pneumomediastinum) with escape of the air through diaphragmatic apertures (mostly foramen of Winslow) or primary perforation of the gastrointestinal tract (stomach or esophagus). We report three cases of pneu...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1991.tb03279.x

    authors: Hartoko TJ,Demey HE,Rogiers PE,Decoster HL,Nagler JM,Bossaert LL

    更新日期:1991-04-01 00:00:00

  • Correction of pressure waveforms recorded by fluid-filled catheter recording systems: a new method using a transfer equation.

    abstract:BACKGROUND:Pressure measuring systems using fluid-filled catheters can result in the recording of distorted pressure waveforms. It results in phase delay, overestimation of systolic and, to a lesser extent, of diastolic pressure. We designed and evaluated a method to correct this pressure waveform distortion using an a...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1998.tb05307.x

    authors: Lambermont B,Gerard P,Detry O,Kolh P,Potty P,D'orio V,Marcelle R

    更新日期:1998-07-01 00:00:00

  • Cognitive function in patients with chronic pain treated with opioids: characteristics and associated factors.

    abstract:BACKGROUND:The paucity of studies regarding cognitive function in patients with chronic pain, and growing evidence regarding the cognitive effects of pain and opioids on cognitive function prompted us to assess cognition via neuropsychological measurement in patients with chronic non-cancer pain treated with opioids. ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2012.02760.x

    authors: Kurita GP,de Mattos Pimenta CA,Braga PE,Frich L,Jørgensen MM,Nielsen PR,Højsted J,Sjøgren P

    更新日期:2012-11-01 00:00:00

  • A new nomogram facilitating adequate haemodilution.

    abstract::When using deliberate haemodilution to a certain haematocrit value (Hct), the appropriate preoperative blood volume of the patient must be determined and matched with the transfusion volume at a certain blood loss. In order to facilitate such calculations a nomogram was constructed, aiming for a final Hct of 33%. Preo...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1986.tb02418.x

    authors: Zetterström H,Wiklund L

    更新日期:1986-05-01 00:00:00

  • Effects of oral clonidine premedication and postoperative i.v. infusion on haemodynamic and adrenergic responses during recovery from anaesthesia.

    abstract::The effects of clonidine, a central alpha 2-adrenoreceptor agonist, on haemodynamic and catecholamine changes were assessed during emergence from anaesthesia, a period which is associated with increased sympathetic nervous discharge, hypertension and tachycardia. According to a double-blind randomized design, 32 patie...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1991.tb03241.x

    authors: Bernard JM,Bourréli B,Homméril JL,Pinaud M

    更新日期:1991-01-01 00:00:00

  • Piritramide and alfentanil display similar respiratory depressant potency.

    abstract:BACKGROUND:The question whether some opioids exert less respiratory depression than others has not been answered conclusively. We applied pharmacokinetic/pharmacodynamic (PKPD) modeling to obtain an estimate of the C50 for the depression of CO2 elimination as a measure of the respiratory depressant potency of alfentani...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1046/j.1399-6576.2003.00251.x

    authors: Bouillon T,Garstka G,Stafforst D,Shafer S,Schwilden H,Hoeft A

    更新日期:2003-11-01 00:00:00

  • Postoperative impact of regular tobacco use, smoking or snuffing, a prospective multi-center study.

    abstract:BACKGROUND:The aim was to study the effects of different tobacco administration routes on pain and post-operative nausea and vomiting (PONV), following three common day surgical procedures: cosmetic breast augmentation (CBA), inguinal hernia repair (IHR) and arthroscopic procedures (AS). We have prospectively investiga...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1399-6576.2009.02140.x

    authors: Brattwall M,Warrén Stomberg M,Rawal N,Segerdahl M,Houltz E,Jakobsson J

    更新日期:2010-03-01 00:00:00

  • Left ventricular ejection and the Heather Index measured by non-invasive methods during postural changes in man.

    abstract::Differences have been found, which are usually 1% or less, between the left ventricular ejection time measured from the external carotid pulse tracing, and from the rate of change of thoracic impedance (dZ/dt) waveform, using either the second heart sound or the X-point of the dZ/dt tracing as the end-point. The Heath...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1976.tb05044.x

    authors: Hill DW,Merrifield AJ

    更新日期:1976-01-01 00:00:00

  • Intrathecal ropivacaine 5 mg/ml for outpatient knee arthroscopy: a comparison with lidocaine 10 mg/ml.

    abstract:PURPOSE:The aim of this prospective, randomised, blind study was to compare the evolution of spinal block produced with 50 mg lidocaine 10 mg/ml and 10 mg ropivacaine 5 mg/ml for outpatient knee arthroscopy. METHODS:Thirty outpatients undergoing knee arthroscopy received 50 mg of lidocaine 10 mg/ml (n=15) or 10 mg of ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2008.01815.x

    authors: Fanelli G,Danelli G,Zasa M,Baciarello M,Di Cianni S,Leone S

    更新日期:2009-01-01 00:00:00

  • DNA and chromosome alterations in lymphocytes of operating room personnel and in patients before and after inhalation anaesthesia.

    abstract::In order to evaluate the possible genotoxic effects of inhalation anaesthetics, the frequency of sister chromatid exchanges and chromosome aberrations was studied in peripheral lymphocytes of control subjects, operating room personnel and patients before and after inhalation anaesthesia during orthopaedic operations. ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1982.tb01814.x

    authors: Holmberg K,Lambert B,Lindsten J,Söderhäll S

    更新日期:1982-10-01 00:00:00

  • Perineural meperidine blocks nerve conduction in a dose-related manner: a randomized double-blind study.

    abstract:BACKGROUND:Meperidine has been shown to exhibit a sensory block in peripheral nerves. However, its motor blockade ability is controversial. The aim of this study was to investigate, electroneurographically, the ability of meperidine to inhibit conduction in both sensory and motor fibres in the ulnar nerve. MATERIALS A...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2009.01953.x

    authors: Oztürk E,Beyazova M,Kaya K,Meray J,Zinnuroglu M,Tarhan B

    更新日期:2009-07-01 00:00:00

  • Procalcitonin and neopterin as indicators of infection in critically ill patients.

    abstract:BACKGROUND:: In critically ill patients, severe infection and systemic inflammation due to non-infectious causes produce very similar clinical presentations, and traditional infection markers do not always differentiate these two conditions. Both procalcitonin and neopterin have been suggested to aid in the early diagn...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1034/j.1399-6576.2002.460412.x

    authors: Ruokonen E,Ilkka L,Niskanen M,Takala J

    更新日期:2002-04-01 00:00:00

  • Comparison of a propofol target-controlled infusion and inhalational sevoflurane for fibreoptic intubation under spontaneous ventilation.

    abstract:BACKGROUND:A propofol target-controlled infusion (TCI) is often proposed for the management of difficult airway intubation and fibreoptic intubation under anaesthesia and spontaneous ventilation. No data are available about sevoflurane. The aim of the present study was to compare propofol and sevoflurane as hypnotics d...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2006.01186.x

    authors: Bonnin M,Therre P,Albuisson E,Beaujard H,Barthelemy I,Mondie JM,Bazin JE

    更新日期:2007-01-01 00:00:00

  • Trends in practice and safety measures of epidural analgesia: Report of a national survey.

    abstract:BACKGROUND:The clinical use of epidural analgesia has changed over past decades. Minimally invasive surgery and emergence of alternative analgesic techniques have led to an overall decline in its use. In addition, there is increasing awareness of the patient-specific risks for complications such as spinal haematoma and...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.13219

    authors: Bos EME,Schut ME,de Quelerij M,Kalkman CJ,Hollmann MW,Lirk P

    更新日期:2018-11-01 00:00:00

  • An observational study of community-acquired severe sepsis comparing intensive care and non-intensive care patients.

    abstract:BACKGROUND:Most studies of sepsis are from intensive care units (ICUs). We aimed to investigate community-acquired severe sepsis in a broader population, in order to compare patients treated in or outside an ICU . METHODS:We performed a 1-year prospective observational study with enrollment of patients from three unit...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.12848

    authors: Nygård ST,Skrede S,Langeland N,Flaatten HK

    更新日期:2017-02-01 00:00:00

  • Quantitative EEG analysis as a supplement to the clinical coma scale RLS85.

    abstract:BACKGROUND:The aim of the study was to investigate the correlation between EEG indicators and clinical scores based on the RLS85 (Reaction Level Scale 85) in comatose patients. The results of a simple visual assessment of the EEG, using an arbitrary scale with typical EEG patterns, were compared with those obtained by ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1996.tb04540.x

    authors: Matousek M,Takeuchi E,Starmark JE,Stalhammar D

    更新日期:1996-08-01 00:00:00

  • Peroperative depth of anaesthesia may influence postoperative opioid requirements.

    abstract:BACKGROUND:Studies on monitoring the depth of anaesthesia have shown that with the use of these monitors the peroperative consumption of anaesthetics can be reduced. Studies have also indicated that the peroperative depth of anaesthesia may affect the postoperative course. The purpose of this study was to evaluate a po...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-6576.2005.00598.x

    authors: Henneberg SW,Rosenborg D,Weber Jensen E,Ahn P,Burgdorff B,Thomsen LL

    更新日期:2005-03-01 00:00:00

  • Who is responsible for operating room management and how do we measure how well we do it?

    abstract:BACKGROUND:Managing the surgical process in the operating suite - often the most expensive unit in the hospital - is vital, yet challenging. While sensible management can improve efficiency, unclear managerial structures can hinder the optimal use of resources. Despite that, no previous data exists as to how the operat...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2007.01368.x

    authors: Marjamaa RA,Kirvelä OA

    更新日期:2007-08-01 00:00:00