Cost-effectiveness of hepatitis A vaccination in healthcare workers.

Abstract:

OBJECTIVE:To study the cost-effectiveness of vaccination for hepatitis A. SETTING:Hypothetical analysis of students currently enrolled in medical school in the United States. METHOD:A Markov-based model was developed using data from the literature, actual hospital costs, and an annual discount rate of 5%. The incidence rate was based on the lowest annual rate for the US population during the past decade. RESULTS:Over the lifetimes of students currently in medical school, the model estimated that there would be 286 hepatitis A cases with four deaths and 107 lost years of life. With routine vaccination, these numbers would decrease to 17, 0.3, and 6, respectively. The costs per life-year saved and quality adjusted life-year saved were $58,000 and $47,000, respectively. Serologic screening prior to vaccination was less cost-effective than universal vaccination. If the incidence of hepatitis A was underestimated by a factor of 5, the cost per life-year saved would decrease to $5,500. If the incidence of hepatitis was underestimated by a factor of 10, vaccination would result in a net cost savings. CONCLUSION:We conclude that the cost per life-year saved by routine hepatitis A vaccination was similar to many other standard medical modalities. For routine vaccination of medical students to be cost-saving, the incidence rate for hepatitis A must be at least 10 times higher than the rate presently reported for the general population. Serological screening prior to vaccination was not cost-effective.

authors

Smith S,Weber S,Wiblin T,Nettleman M

doi

10.1086/647513

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

688-91

issue

10

eissn

0899-823X

issn

1559-6834

pii

S0195941700000564

journal_volume

18

pub_type

杂志文章
  • One-week versus 2-day ventilator circuit change in neonates with prolonged ventilation: cost-effectiveness and impact on ventilator-associated pneumonia.

    abstract:OBJECTIVE:To investigate the impact of 1-week ventilator circuit change on ventilator-associated pneumonia and its cost-effectiveness compared with a 2-day change. DESIGN:An observational cohort study. SETTING:A tertiary level neonatal intensive care unit in a university-affiliated teaching hospital in Taiwan. Patien...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1017/ice.2014.48

    authors: Chu SM,Yang MC,Hsiao HF,Hsu JF,Lien R,Chiang MC,Fu RH,Huang HR,Hsu KH,Tsai MH

    更新日期:2015-03-01 00:00:00

  • Ventilator-associated pneumonia in a pediatric intensive care unit in Saudi Arabia: a 30-month prospective surveillance.

    abstract:OBJECTIVE:To describe the rate, risk factors, and outcome of ventilator-associated pneumonia (VAP) in pediatric patients. METHODS:This prospective surveillance study of VAP among all patients receiving mechanical ventilation for 48 hours or more admitted to a pediatric intensive care unit (PICU) in Saudi Arabia from M...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/502472

    authors: Almuneef M,Memish ZA,Balkhy HH,Alalem H,Abutaleb A

    更新日期:2004-09-01 00:00:00

  • Excess costs and utilization associated with methicillin resistance for patients with Staphylococcus aureus infection.

    abstract:OBJECTIVE:To determine differences in healthcare costs between cases of methicillin-susceptible Staphylococcus aureus (MSSA) infection and methicillin-resistant S. aureus (MRSA) infection in adults. DESIGN:Retrospective study of all cases of S. aureus infection. SETTING:Department of Veterans Affairs hospital and ass...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/651094

    authors: Filice GA,Nyman JA,Lexau C,Lees CH,Bockstedt LA,Como-Sabetti K,Lesher LJ,Lynfield R

    更新日期:2010-04-01 00:00:00

  • Risk of acquiring extended-spectrum β-lactamase-producing Klebsiella species and Escherichia coli from prior room occupants in the intensive care unit.

    abstract::OBJECTIVE. To quantify the association between admission to an intensive care unit (ICU) room most recently occupied by a patient positive for extended-spectrum β-lactamase (EBSL)-producing gram-negative bacteria and acquisition of infection or colonization with that pathogen. DESIGN. Retrospective cohort study. SETTI...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/670216

    authors: Ajao AO,Johnson JK,Harris AD,Zhan M,McGregor JC,Thom KA,Furuno JP

    更新日期:2013-05-01 00:00:00

  • Age limit does not replace serologic testing for determination of immune status for measles.

    abstract::Adults more than 40 years old are not necessarily immune to measles. A measles outbreak that involved healthcare workers occurred after contact with a 44-year-old patient. Results of a hospital-wide program of mass screening revealed that 117 (4.5%) of 2,600 individuals tested seronegative for measles; 31 (26.1%) of t...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/519928

    authors: Uckay I,Hugonnet S,Kaiser L,Sax H,Pittet D

    更新日期:2007-09-01 00:00:00

  • Handwashing and glove use in a long-term-care facility.

    abstract:OBJECTIVES:To determine glove use and handwashing practices, the factors associated with infection control practices, and the frequency of potential microbial transmission in a long-term-care facility (LTCF). DESIGN:Observational study of 230 staff-resident interactions in an LTCF. We recorded resident characteristics...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/647562

    authors: Thompson BL,Dwyer DM,Ussery XT,Denman S,Vacek P,Schwartz B

    更新日期:1997-02-01 00:00:00

  • Airborne fungal spore monitoring in a protective environment during hospital construction, and correlation with an outbreak of invasive aspergillosis.

    abstract:OBJECTIVE:Evaluate aerobiological monitoring for fungal spores during hospital construction and correlate results with an outbreak of invasive aspergillosis (IA). DESIGN:Prospective air sampling for molds was done using the gravity air-settling plate (GASP) method. SETTING:A university medical center special care uni...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/646916

    authors: Iwen PC,Davis JC,Reed EC,Winfield BA,Hinrichs SH

    更新日期:1994-05-01 00:00:00

  • Epidemiologic and clinical utility of typing systems for differentiating among strains of methicillin-resistant Staphylococcus aureus.

    abstract::Typing systems for differentiating among strains of methicillin-resistant Staphylococcus aureus (MRSA) can be valuable tools for the epidemiologist and the clinician. Specific criteria for evaluating such systems are typeability, reproducibility, and discriminatory power. An ideal typing system also would be rapid, in...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/646234

    authors: Mulligan ME,Arbeit RD

    更新日期:1991-01-01 00:00:00

  • Optimal frequency of changing intravenous administration sets: is it safe to prolong use beyond 72 hours?

    abstract:OBJECTIVE:To determine the safety and cost-effectiveness of replacing the intravenous (IV) tubing sets in hospitalized patients at 4- to 7-day intervals instead of every 72 hours. DESIGN:Prospective, randomized study of infusion-related contamination associated with changing IV tubing sets within 3 days versus within ...

    journal_title:Infection control and hospital epidemiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1086/501879

    authors: Raad I,Hanna HA,Awad A,Alrahwan A,Bivins C,Khan A,Richardson D,Umphrey JL,Whimbey E,Mansour G

    更新日期:2001-03-01 00:00:00

  • Restriction endonuclease analysis of plasmid DNA from methicillin-resistant Staphylococcus aureus: clinical application over a three-year period.

    abstract:OBJECTIVE:To investigate trends in plasmid types of methicillin-resistant Staphylococcus aureus over a 3-year period and determine the clinical impact of plasmid typing. DESIGN:Restriction endonuclease analysis of plasmid DNA (REAP) was used to type 270 clinical isolates. SETTING:A Veterans Affairs Medical Center. R...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/646627

    authors: Trilla A,Nettleman MD,Hollis RJ,Fredrickson M,Wenzel RP,Pfaller MA

    更新日期:1993-01-01 00:00:00

  • Standardized surveillance of hemodialysis vascular access infections: 18-month experience at an outpatient, multifacility hemodialysis center.

    abstract:OBJECTIVE:To develop a standardized surveillance system for monitoring hemodialysis vascular-access infections in order to compare infection rates between outpatient sites and to assess the effectiveness of infection control interventions. DESIGN:Prospective descriptive analysis of incidence infection rates. SETTING:...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/501744

    authors: Stevenson KB,Adcox MJ,Mallea MC,Narasimhan N,Wagnild JP

    更新日期:2000-03-01 00:00:00

  • Evaluation of International Classification of Diseases, Ninth Revision, Clinical Modification Codes for reporting methicillin-resistant Staphylococcus aureus infections at a hospital in Illinois.

    abstract:BACKGROUND:States, including Illinois, have passed legislation mandating the use of International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes for reporting healthcare-associated infections, such as methicillin-resistant Staphylococcus aureus (MRSA). OBJECTIVE:To evaluate the sens...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/651665

    authors: Schaefer MK,Ellingson K,Conover C,Genisca AE,Currie D,Esposito T,Panttila L,Ruestow P,Martin K,Cronin D,Costello M,Sokalski S,Fridkin S,Srinivasan A

    更新日期:2010-05-01 00:00:00

  • Surgical site infections following hip and knee arthroplastic surgery: Trends and risk factors of Staphylococcus aureus infections.

    abstract::We investigated surgical site infections (SSIs) following hip and knee arthroplasties to evaluate predictors of SSI. We found a significant increase in deep Staphylococcus aureus (SA) SSIs despite the decreasing overall SSI rate. The risk of deep SA-SSI differed between genders and among age groups and was affected by...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1017/ice.2018.312

    authors: Prattingerová J,Sarvikivi E,Huotari K,Ollgren J,Lyytikäinen O

    更新日期:2019-02-01 00:00:00

  • The role played by contaminated surfaces in the transmission of nosocomial pathogens.

    abstract::Studies in the 1970s and 1980s suggested that environmental surface contamination played a negligible role in the endemic transmission of healthcare-associated infections. However, recent studies have demonstrated that several major nosocomial pathogens are shed by patients and contaminate hospital surfaces at concent...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章,评审

    doi:10.1086/660363

    authors: Otter JA,Yezli S,French GL

    更新日期:2011-07-01 00:00:00

  • Prospective evaluation of colonization with extended-spectrum beta-lactamase (ESBL)-producing enterobacteriaceae among patients at hospital admission and of subsequent colonization with ESBL-producing enterobacteriaceae among patients during hospitalizati

    abstract:OBJECTIVE:To determine the rates of and risk factors for carriage and acquisition of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae during hospitalization. DESIGN:Cohort study. SETTING:Shaare Zedek Medical Center, a 550-bed teaching hospital. METHODS:During a 5-month period (February 1-June 30,...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/597505

    authors: Friedmann R,Raveh D,Zartzer E,Rudensky B,Broide E,Attias D,Yinnon AM

    更新日期:2009-06-01 00:00:00

  • Antimicrobial cycling: lessons learned from the aminoglycoside experience.

    abstract::Several discrete strategies have been suggested to prevent or reduce microbial resistance to antimicrobials, including optimal use of the agents (also known as good stewardship); control, removal, or restriction of antimicrobials; use of antimicrobials in combination; and rotational or cyclic use of antimicrobials. Th...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章,评审

    doi:10.1086/503168

    authors: Gerding DN

    更新日期:2000-01-01 00:00:00

  • Impact of postdischarge surveillance on the rate of surgical site infection after orthopedic surgery.

    abstract:OBJECTIVE:To evaluate the impact of postdischarge surveillance on surgical site infection (SSI) rates after orthopedic surgery. SETTING:Nine hospitals participating in the Finnish Hospital Infection Program. PATIENTS:All patients who underwent hip or knee arthroplasty or open reduction of a femur fracture during 1999...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/509840

    authors: Huotari K,Lyytikäinen O,Hospital Infection Surveillance Team.

    更新日期:2006-12-01 00:00:00

  • Total cholesterol, HDL-cholesterol, and risk of nosocomial infection: a prospective study in surgical patients.

    abstract:OBJECTIVE:To study the relationship between serum high-density lipoprotein cholesterol (HDL-C), total serum cholesterol, and nosocomial infection in patients undergoing general surgery. DESIGN:Prospective cohort study, with an extended follow-up to 1 month after hospital discharge. SETTING:The general surgery service...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/647494

    authors: Delgado-Rodríguez M,Medina-Cuadros M,Martínez-Gallego G,Sillero-Arenas M

    更新日期:1997-01-01 00:00:00

  • Bactericidal activity of copper and noncopper paints.

    abstract:OBJECTIVE:To screen copper and noncopper paints for their bactericidal effectiveness in rendering surfaces self-disinfecting. DESIGN:Tested paints were applied to glass coverslips, cured, inoculated with test organisms (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Enterococcus faecalis), and dr...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/648361

    authors: Cooney TE

    更新日期:1995-08-01 00:00:00

  • Studies of ventilation efficiency in a protective isolation room by the use of a scale model.

    abstract:OBJECTIVE:To assess the ability of a protective isolation room ventilation system to reduce patient exposure to airborne infectious agents, using a small-scale model that permits cost-effective and unobtrusive study of relevant indices of performance. DESIGN:A one-half scale model of a protective isolation room at the...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/647181

    authors: Marshall JW,Vincent JH,Kuehn TH,Brosseau LM

    更新日期:1996-01-01 00:00:00

  • Delays in the application of outbreak control prophylaxis for influenza A in a nursing home.

    abstract:OBJECTIVE:To identify delayed prophylaxis from a pre-existing database and strategies to improve performance. SETTING:A skilled nursing facility with 14 floors (4 buildings). The "outbreak unit" was a 50- to 60-bed floor. METHODS:We performed surveillance during six seasons using one protocol. Prophylaxis was started...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/501978

    authors: Drinka PJ,Krause P,Nest L,Gravenstein S,Goodman B,Shult P

    更新日期:2002-10-01 00:00:00

  • Multicenter evaluation of computer automated versus traditional surveillance of hospital-acquired bloodstream infections.

    abstract:OBJECTIVE:Central line-associated bloodstream infection (BSI) rates are a key quality metric for comparing hospital quality and safety. Traditional BSI surveillance may be limited by interrater variability. We assessed whether a computer-automated method of central line-associated BSI detection can improve the validity...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1086/678602

    authors: Lin MY,Woeltje KF,Khan YM,Hota B,Doherty JA,Borlawsky TB,Stevenson KB,Fridkin SK,Weinstein RA,Trick WE,Centers for Disease Control and Prevention Epicenter Program.

    更新日期:2014-12-01 00:00:00

  • Building and Validating a Computerized Algorithm for Surveillance of Ventilator-Associated Events.

    abstract:OBJECTIVE:To develop an automated method for ventilator-associated condition (VAC) surveillance and to compare its accuracy and efficiency with manual VAC surveillance SETTING:The intensive care units (ICUs) of 4 hospitals METHODS:This study was conducted at Detroit Medical Center, a tertiary care center in metropoli...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1017/ice.2015.127

    authors: Mann T,Ellsworth J,Huda N,Neelakanta A,Chevalier T,Sims KL,Dhar S,Robinson ME,Kaye KS

    更新日期:2015-09-01 00:00:00

  • Methicillin‐resistant Staphylococcus aureus and the media.

    abstract::How the media communicate and how the scientific community influences the media are important factors to consider in the public health response to emerging pathogens, including methicillin-resistant Staphylococcus aureus. Social representation theory suggests that the media link "the threatening" to commonplace "ancho...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/656000

    authors: Perencevich EN,Treise DM

    更新日期:2010-11-01 00:00:00

  • Water Cultures Are More Sensitive Than Swab Cultures for the Detection of Environmental Legionella.

    abstract::Water cultures were significantly more sensitive than concurrently collected swab cultures (n=2,147 each) in detecting Legionella pneumophila within a Veterans Affairs healthcare system. Sensitivity for water versus swab cultures was 90% versus 30% overall, 83% versus 48% during a nosocomial Legionnaires' disease outb...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1017/ice.2017.235

    authors: Decker BK,Harris PL,Toy DL,Muder RR,Sonel AF,Clancy CJ

    更新日期:2018-01-01 00:00:00

  • Frequency of Hand Decontamination of Intraoperative Providers and Reduction of Postoperative Healthcare-Associated Infections: A Randomized Clinical Trial of a Novel Hand Hygiene System.

    abstract::BACKGROUND Healthcare provider hands are an important source of intraoperative bacterial transmission events associated with postoperative infection development. OBJECTIVE To explore the efficacy of a novel hand hygiene improvement system leveraging provider proximity and individual and group performance feedback in r...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/ice.2016.106

    authors: Koff MD,Brown JR,Marshall EJ,O'Malley AJ,Jensen JT,Heard SO,Longtine K,O'Neill M,Longtine J,Houston D,Robison C,Moulton E,Patel HM,Loftus RW

    更新日期:2016-08-01 00:00:00

  • Days of Therapy and Antimicrobial Days: Similarities and Differences Between Consumption Metrics.

    abstract::Benchmarks for antimicrobial consumption measured in antimicrobial days are beginning to emerge. The relationship between the traditional measure of days of therapy and antimicrobial days is unclear. We observed a high intermethod correlation (R2=0.99): antimicrobial days were 1.9-fold lower than days of therapy acros...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1017/ice.2016.109

    authors: Rhodes NJ,Wagner JL,Gilbert EM,Crew PE,Davis SL,Scheetz MH

    更新日期:2016-08-01 00:00:00

  • Comparison of central-line-associated bloodstream infections between central venous catheters lined by combined chlorhexidine and silver sulfadiazine versus silver ionotrophes alone: A before-after-before retrospective study.

    abstract::A before-after-before direct comparison between catheters lined with chlorhexidine and silver sulfadiazine (CHSS) versus silver ionotrophes (SI) with a primary objective of comparison of rate of central-line-associated infection (CLABSI) in three 10-month windows. The CHSS catheters were associated with a lower rate o...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1017/ice.2020.423

    authors: Abouleish YZ,Oldfield EC,Marik PE

    更新日期:2020-09-11 00:00:00

  • 3-Methyl-4-chlorophenol for prion decontamination of medical devices.

    abstract::Disinfectants containing 3-methyl-4-chlorophenol were tested for their capacity to inactivate the infectious agent of scrapie. Coincubation of brain homogenates prepared from terminally ill scrapie-infected hamsters with the disinfectants rendered the prion protein PrP(Sc) sensitive to proteinase K digestion. Inoculat...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/504450

    authors: Riemer C,Bamme T,Mok SW,Baier M

    更新日期:2006-07-01 00:00:00

  • Handrub Consumption Mirrors Hand Hygiene Compliance.

    abstract::We assessed handrub consumption as a surrogate marker for hand hygiene compliance from 2007 to 2014. Handrub consumption varied substantially between departments but correlated in a mixed effects regression model with the number of patient-days and the observed hand hygiene compliance. Handrub consumption may suppleme...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1017/ice.2016.47

    authors: Haubitz S,Atkinson A,Kaspar T,Nydegger D,Eichenberger A,Sommerstein R,Marschall J

    更新日期:2016-06-01 00:00:00