Total cholesterol, HDL-cholesterol, and risk of nosocomial infection: a prospective study in surgical patients.

Abstract:

OBJECTIVE:To study the relationship between serum high-density lipoprotein cholesterol (HDL-C), total serum cholesterol, and nosocomial infection in patients undergoing general surgery. DESIGN:Prospective cohort study, with an extended follow-up to 1 month after hospital discharge. SETTING:The general surgery service of a tertiary hospital. MAIN OUTCOME MEASURE:Nosocomial infection, mainly surgical-site infection (SSI), urinary tract infection, respiratory tract infection (RTI), and bacteremia. PATIENTS:1,267 surgery patients aged 10 to 92 years. RESULTS:182 subjects acquired 194 nosocomial infections, a cumulative incidence of 14.5%; most (116, 62.3%) were postoperative wound infections. There was an increase in infection risk at low levels of HDL-C, and both low and high total cholesterol levels. After adjusting simultaneously for several confounders, including total cholesterol, low levels of HDL-C (< or = 20 mg/dL) yielded an odds ratio (OR) of 2.2 (95% confidence interval [CI95], 0.6-7.9) for SSI and an OR of 10.3 (CI95, 0.7-151.5) for RTI. Otherwise, no trend was observed between HDL-C levels and infection risk, and no increased risk of nosocomial infection was observed for HDL-C values in the range of 21 to 49 mg/dL. Serum cholesterol showed a U-shaped relationship with nosocomial infection risk. Both low levels (below 102 mg/dL) and high levels (above 290 mg/dL) of total cholesterol were associated with a higher risk of SSI (mainly those caused by gram-negative bacteria) and RTI in comparison with the reference group (139-261 mg/dL). CONCLUSIONS:Serum HDL-C and total cholesterol seem to be associated with the risk of nosocomial infection in surgical patients.

authors

Delgado-Rodríguez M,Medina-Cuadros M,Martínez-Gallego G,Sillero-Arenas M

doi

10.1086/647494

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

9-18

issue

1

eissn

0899-823X

issn

1559-6834

journal_volume

18

pub_type

杂志文章
  • Evidence of delays in transferring patients with methicillin-resistant Staphylococcus aureus or vancomycin-resistant Enterococcus to long-term-care facilities.

    abstract::This retrospective case-control study examined whether there was a difference in length of time awaiting long-term-care placement for patients identified as having methicillin-resistant Staphylococcus aureus or vancomycin-resistant Enterococcus compared to controls. Thirty-nine patients with methicillin-resistant Stap...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/501757

    authors: Bryce EA,Tiffin SM,Isaac-Renton JL,Wright CJ

    更新日期:2000-04-01 00:00:00

  • Surgical site infections following hip and knee arthroplastic surgery: Trends and risk factors of Staphylococcus aureus infections.

    abstract::We investigated surgical site infections (SSIs) following hip and knee arthroplasties to evaluate predictors of SSI. We found a significant increase in deep Staphylococcus aureus (SA) SSIs despite the decreasing overall SSI rate. The risk of deep SA-SSI differed between genders and among age groups and was affected by...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1017/ice.2018.312

    authors: Prattingerová J,Sarvikivi E,Huotari K,Ollgren J,Lyytikäinen O

    更新日期:2019-02-01 00:00:00

  • Factors associated with acquisition of vancomycin-resistant enterococci (VRE) in roommate contacts of patients colonized or infected with VRE in a tertiary care hospital.

    abstract:OBJECTIVE:Most nosocomial acquistion of vancomycin-resistant enterococci (VRE) is due to cross-transmission. We sought to identify risk factors for acquisition of VRE by roommates of patients colonized or infected with VRE. DESIGN:Retrospective cohort study. SETTING:A 472-bed tertiary care teaching hospital. METHODS...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/587187

    authors: Zhou Q,Moore C,Eden S,Tong A,McGeer A,Mount Sinai Hospital Infection Control Team.

    更新日期:2008-05-01 00:00:00

  • Absence of association between use of ertapenem and change in antipseudomonal carbapenem susceptibility rates in 25 hospitals.

    abstract:OBJECTIVE:Ertapenem exposure has been reported to select for cross-resistance to other carbapenems in Pseudomonas aeruginosa in vitro. Single-center investigations report conflicting results. We evaluated ertapenem use and antipseudomonal carbapenem susceptibility for 6 years spanning the time of ertapenem adoption at ...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1086/652154

    authors: Eagye KJ,Nicolau DP

    更新日期:2010-05-01 00:00:00

  • Burden of healthcare-associated infections at six tertiary-care hospitals in Saudi Arabia: A point prevalence survey.

    abstract::A point prevalence survey was conducted on May 11, 2017, among inpatients at 6 hospitals in Saudi Arabia. The overall point prevalence was 6.8% (114 of 1,666). The most common types of infections were pneumonia (27.2%), urinary tract infections (20.2%), and bloodstream infections (10.5%). Approximately 19.2% of health...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1017/ice.2018.338

    authors: Alshamrani MM,El-Saed A,Alsaedi A,El Gammal A,Al Nasser W,Nazeer S,Balkhy HH

    更新日期:2019-03-01 00:00:00

  • Mortality rates associated with multidrug-resistant Acinetobacter baumannii infection in surgical intensive care units.

    abstract::A retrospective, propensity-matched cohort study was conducted to determine the mortality rate in patients with healthcare-associated infection (HAI) due to multidrug-resistant (MDR) Acinetobacter baumannii. The 28-day mortality rate for patients with MDR A. baumannii HAI was not significantly different than that for ...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/591456

    authors: Daniels TL,Deppen S,Arbogast PG,Griffin MR,Schaffner W,Talbot TR

    更新日期:2008-11-01 00:00:00

  • Ineffectiveness of handwashing with lotion soap to remove nosocomial bacterial pathogens persisting on fingertips: a major link in their intrahospital spread.

    abstract::The effectiveness of five 30-second handwashes with a non-antiseptic lotion soap to remove nosocomial pathogens (10(8) CFU) applied to fingertips was studied. CFU for all species dropped rapidly after the first handwash; persistence (10 to 15 CFU) was maintained thereafter. Wiping hands with an antiseptic (70% isoprop...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/502388

    authors: Bottone EJ,Cheng M,Hymes S

    更新日期:2004-03-01 00:00:00

  • Variation in definitions and isolation procedures for multidrug-resistant Gram-negative bacteria: a survey of the Society for Healthcare Epidemiology of America Research Network.

    abstract:OBJECTIVE:To assess definitions, experience, and infection control practices for multidrug-resistant gram-negative bacteria (MDR-GNB), including Enterobacteriaceae, Acinetobacter, and Pseudomonas species, in acute care hospitals. DESIGN:Cross-sectional survey. PARTICIPANTS:US and international members of the Society ...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/675600

    authors: Drees M,Pineles L,Harris AD,Morgan DJ

    更新日期:2014-04-01 00:00:00

  • Additional costs for preventing the spread of methicillin-resistant Staphylococcus aureus and a strategy for reducing these costs on a surgical ward.

    abstract:OBJECTIVE:To determine the added costs of hygienic measures (barrier precautions, isolation, and decontamination) required for MRSA carriers in German hospitals and possible strategies for cost reduction. DESIGN:On a septic surgical ward caring for 35% of all MRSA cases in a university hospital (1,182 beds), additiona...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/502274

    authors: Herr CE,Heckrodt TH,Hofmann FA,Schnettler R,Eikmann TF

    更新日期:2003-09-01 00:00:00

  • Blood pressure cuff as a potential vector of pathogenic microorganisms: a prospective study in a teaching hospital.

    abstract:OBJECTIVE:To investigate the potential role of blood pressure (BP) cuffs in the spread of bacterial infections in hospitals. DESIGN:A comprehensive, prospective study quantitatively and qualitatively evaluating the bacterial contamination on BP cuffs of 203 sphygmomanometers in use in 18 hospital units from January th...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/507284

    authors: de Gialluly C,Morange V,de Gialluly E,Loulergue J,van der Mee N,Quentin R

    更新日期:2006-09-01 00:00:00

  • Issues in the management of resistant bacteria in long-term-care facilities.

    abstract::The prevalence of antibiotic-resistant bacteria in the long-term-care setting and the risk to nursing home residents is still unknown. Few studies have been done in community-based nursing homes, and most have focused on colonization rather than infection rates. Concerns about methicillin-resistant Staphylococcus aure...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章,评审

    doi:10.1086/501637

    authors: Bradley SF

    更新日期:1999-05-01 00:00:00

  • Cluster randomized trial of an antibiotic time-out led by a team-based pharmacist.

    abstract:OBJECTIVE:Antibiotic time-outs (ATOs) have been advocated to improve antibiotic use without dedicated stewardship resources, but their utility is poorly defined. We sought to evaluate the effectiveness of an ATO led by a team-based pharmacist. DESIGN:Cluster randomized controlled trial. SETTING:Six medicine teams at ...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1017/ice.2020.347

    authors: Van Schooneveld TC,Rupp ME,Cavaleiri RJ,Lyden E,Rolek K

    更新日期:2020-11-01 00:00:00

  • An integrated approach to methicillin-resistant Staphylococcus aureus control in a rural, regional-referral healthcare setting.

    abstract:OBJECTIVE:To curtail the prevalence and cross-transmission of methicillin-resistant Staphylococcus aureus (MRSA) in a rural healthcare setting. DESIGN:Before-after, quasi-experimental quality improvement study. SETTING:A regional-referral hospital, 5 affiliated nursing homes, and an outpatient MRSA clinic. INTERVENT...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/650445

    authors: Bowler WA,Bresnahan J,Bradfish A,Fernandez C

    更新日期:2010-03-01 00:00:00

  • Regulation of topical antimicrobials: history, status and future perspective.

    abstract::Antimicrobial agents used as disinfectants and antiseptics are increasing in epidemiologic importance. The regulation of topical antiseptics has ranged from nonexistent, lax and confusing to inclusion in the Food and Drug Administration (FDA) over-the-counter (OTC) review of drug ingredients. This article simplifies t...

    journal_title:Infection control and hospital epidemiology

    pub_type: 历史文章,杂志文章

    doi:10.1086/645935

    authors: Bruch MK,Larson E

    更新日期:1989-11-01 00:00:00

  • Harnessing claims to improve detection of surgical site infections following hysterectomy and colorectal surgery.

    abstract::Surgical site infection (SSI) surveillance is performed using a variety of methods with unclear performance characteristics. We used claims data to identify records for review following hysterectomy and colorectal surgery. Claims-enhanced screening identified SSIs missed by routine surveillance and could be used for t...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/673975

    authors: Letourneau AR,Calderwood MS,Huang SS,Bratzler DW,Ma A,Yokoe DS

    更新日期:2013-12-01 00:00:00

  • Comparative killing kinetics of methicillin-resistant Staphylococcus aureus by bacitracin or mupirocin.

    abstract::The in vitro activities of bacitracin and mupirocin were compared for seven different strains of methicillin-resistant Staphylococcus aureus. Six of seven strains showed bacitracin minimum inhibitory concentrations (MICs) of 0.5 to 1.0 units/mL, and all seven had mupirocin MICs of 0.5 to 2 micrograms/mL. Time-kill stu...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/647270

    authors: Chapnick EK,Gradon JD,Kreiswirth B,Lutwick LI,Schaffer BC,Schiano TD,Levi MH

    更新日期:1996-03-01 00:00:00

  • Unintended consequences of a reflex urine culture order set on appropriate antibiotic use.

    abstract::We evaluated the impact of reflex urine culture screen results on antibiotic initiation. More patients with positive urine screen but negative culture received antibiotics than those with a negative screen (30.5 vs 7.1%). Urine screen results may inappropriately influence antibiotic initiation in patients with a low l...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1017/ice.2020.230

    authors: Klein CN,Elman MR,Townes JM,Lewis JS,McGregor JC

    更新日期:2020-09-01 00:00:00

  • Factors associated with the prevalence of antibiotic use for the treatment of hospital-acquired infections at 393 French hospitals: a regional variation analysis.

    abstract:OBJECTIVE:The present study investigated regional variations in antibiotic use for the treatment of hospital-acquired infections (HAIs) in France by means of a multilevel analysis, to identify targets for quality improvement. METHODS:Data were obtained from the 2001 and 2006 French national point-prevalence surveys of...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/657909

    authors: Amadeo B,Dumartin C,Venier AG,Fourrier-Réglat A,Coignard B,Rogues AM

    更新日期:2011-02-01 00:00:00

  • Role of acid-suppressing medications during a sustained outbreak of Salmonella enteritidis infection in a long-term care facility.

    abstract::During an insidious outbreak of salmonellosis in a long-term care facility, residents who were treated with acid-suppressing medications were 8 times more likely than other residents to develop Salmonella infection. Among vulnerable populations, the risks and benefits of acid-suppressing medications should be consider...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/520736

    authors: Bowen A,Newman A,Estivariz C,Gilbertson N,Archer J,Srinivasan A,Lynch M,Painter J

    更新日期:2007-10-01 00:00:00

  • Evaluation of uncomplicated acute respiratory tract infection management in veterans: A national utilization review.

    abstract:BACKGROUND:Antibiotics are overprescribed for acute respiratory tract infections (ARIs). Guidelines provide criteria to determine which patients should receive antibiotics. We assessed congruence between documentation of ARI diagnostic and treatment practices with guideline recommendations, treatment appropriateness, a...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1017/ice.2019.16

    authors: Bohan JG,Madaras-Kelly K,Pontefract B,Jones M,Neuhauser MM,Bidwell Goetz M,Burk M,Cunningham F,ARI Management Improvement Group.

    更新日期:2019-04-01 00:00:00

  • Airborne fungal spore monitoring in a protective environment during hospital construction, and correlation with an outbreak of invasive aspergillosis.

    abstract:OBJECTIVE:Evaluate aerobiological monitoring for fungal spores during hospital construction and correlate results with an outbreak of invasive aspergillosis (IA). DESIGN:Prospective air sampling for molds was done using the gravity air-settling plate (GASP) method. SETTING:A university medical center special care uni...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/646916

    authors: Iwen PC,Davis JC,Reed EC,Winfield BA,Hinrichs SH

    更新日期:1994-05-01 00:00:00

  • Selective surveillance for nosocomial infections in a Brazilian hospital.

    abstract:OBJECTIVE:To devise a system for surveying the frequency of nosocomial infections in a tertiary care hospital in a developing country. DESIGN:Prospective selective surveillance by nurses of the charts of patients at high risk for nosocomial infections, as identified by a form completed by resident physicians. The sens...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/646715

    authors: Lima NL,Pereira CR,Souza IC,Facanha MC,Lima AA,Guerrant RL,Farr BM

    更新日期:1993-04-01 00:00:00

  • Reduction of Environmental Contamination With Multidrug-Resistant Bacteria by Copper-Alloy Coating of Surfaces in a Highly Endemic Setting.

    abstract::OBJECTIVE To evaluate the efficacy of copper-coating in reducing environmental colonization in an intensive-care unit (ICU) with multidrug-resistant-organism (MDRO) endemicity DESIGN Interventional, comparative crossover trial SETTING The general ICU of Attikon University hospital in Athens, Greece PATIENTS Those admi...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1017/ice.2017.52

    authors: Souli M,Antoniadou A,Katsarolis I,Mavrou I,Paramythiotou E,Papadomichelakis E,Drogari-Apiranthitou M,Panagea T,Giamarellou H,Petrikkos G,Armaganidis A

    更新日期:2017-07-01 00:00:00

  • Indirect Versus Direct Standardization Methods for Reporting Healthcare-Associated Infections: An Analysis of Central Line-Associated Bloodstream Infections in Maryland.

    abstract::Whether healthcare-associated infection data should be presented using indirect (current CMS/CDC methodology) or direct standardization remains controversial. We applied both methods to central-line-associated bloodstream infection data from 45 acute-care hospitals in Maryland from 2012 to 2014. We found that the 2 me...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1017/ice.2017.120

    authors: O'Hara LM,Masnick M,Leekha S,Jackson SS,Blanco N,Harris AD

    更新日期:2017-08-01 00:00:00

  • Monitoring persistence of coagulase-negative staphylococci in a hematology department using phenotypic and genotypic strategies.

    abstract:OBJECTIVE:To determine persistence of coagulase-negative staphylococci (CNS) on a hematology-oncology ward and to determine the value of phenotypic and genotypic procedures for establishing clonality among CNS isolates. DESIGN:Strains of CNS isolated from bacteremic patients (n = 139) were typed by biochemical reactiv...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:

    authors: van Belkum A,Kluijtmans J,van Leeuwen W,Goessens W,ter Averst E,Wielenga J,Verbrugh H

    更新日期:1996-10-01 00:00:00

  • Susceptibility of Candida auris and Candida albicans to 21 germicides used in healthcare facilities.

    abstract::Candida auris is an emerging fungal pathogen that is often resistant to major classes of antifungal drugs. It is considered a serious global health threat because it can cause severe infections with frequent mortality in more than a dozen countries. It can survive on healthcare environmental surfaces for at least 7 da...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1017/ice.2019.1

    authors: Rutala WA,Kanamori H,Gergen MF,Sickbert-Bennett EE,Weber DJ

    更新日期:2019-03-01 00:00:00

  • Risk factors and costs associated with methicillin-resistant Staphylococcus aureus bloodstream infections.

    abstract:OBJECTIVES:To compare the cost of hospitalization of patients with methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection (BSI) versus patients with methicillin-sensitive S. aureus (MSSA) BSI, controlling for severity of underlying illness; and to identify risk factors associated with MRSA BSI. DESIG...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/502417

    authors: McHugh CG,Riley LW

    更新日期:2004-05-01 00:00:00

  • The effect of high-efficiency particulate air respirator design on occupational health: a pilot study balancing risks in the real world.

    abstract:OBJECTIVES:To quantify specific factors believed to increase healthcare worker (HCW) risk for contaminated sharps injuries (eg, visibility, communication, and range of motion); to quantify the degree to which respirators of various designs impacted those same factors; and to assess HCW opinions about the suitability of...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/647566

    authors: Eck EK,Vannier A

    更新日期:1997-02-01 00:00:00

  • Influenza vaccination and intention to receive the pandemic H1N1 influenza vaccine among healthcare workers of British Columbia, Canada: a cross-sectional study.

    abstract:OBJECTIVE:To assess healthcare workers' attitudes and concerns regarding seasonal and pandemic influenza vaccines in order to improve vaccination campaign communications. DESIGN:Cross-sectional survey. SETTING:All 6 health authorities in British Columbia, Canada. METHODS:An anonymous, self-administered online survey...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/655465

    authors: Kaboli F,Astrakianakis G,Li G,Guzman J,Donovan T,Naus M

    更新日期:2010-10-01 00:00:00

  • Resident Physician Knowledge of Urine Testing and Treatment Over Four Years.

    abstract::We surveyed resident physicians at 2 academic medical centers regarding urinary testing and treatment as they progressed through training. Demographics and self-reported confidence were compared to overall knowledge using clinical vignette-based questions. Overall knowledge was 40% in 2011 and increased to 48%, 55%, a...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1017/ice.2018.34

    authors: Andrews SL,Abbo LM,Johnson JR,Kuskowski MA,Shukla BS,Drekonja DM

    更新日期:2018-05-01 00:00:00