MR differentiation of phaeochromocytoma from other adrenal lesions based on qualitative analysis of T2 relaxation times.

Abstract:

AIM:To determine the diagnostic accuracy of MR imaging in differentiating phaeochromocytoma from other adrenal lesions. MATERIALS AND METHODS:Sixty-seven adrenal masses (65 patients) including 17 phaeochromocytomas were imaged using T2-weighted pulse sequences on 0.6 T and 1.5 T GE MR units. The adrenal lesions were qualitatively assessed by three observers and divided into three categories (benign adenomas, malignant lesions and phaeochromocytomas) based on lesion signal intensity relative to liver and cerebrospinal fluid. RESULTS:Eleven phaeochromocytomas (65%) were correctly identified while the remaining six (35%) were misclassified, five as malignant lesions and one as a benign adenoma, because of atypical low signal intensity on T2-weighted MR images. Conversely, six non-phaeochromocytomas (three benign adenomas, two adrenal carcinomas and one metastasis) were wrongly classified as phaeochromocytomas because of very high lesion signal intensity. The sensitivity of MR imaging for diagnosing phaeochromocytoma was 64.7%, specificity 88.0%, positive predictive value 64.7% and negative predictive value 88.0%. CONCLUSION:There is considerable overlap between the MR appearance of phaeochromocytoma and other adrenal lesions. A phaeochromocytoma cannot be excluded on the basis of a lack of high signal intensity on T2-weighted MR imaging.

journal_name

Clin Radiol

journal_title

Clinical radiology

authors

Varghese JC,Hahn PF,Papanicolaou N,Mayo-Smith WW,Gaa JA,Lee MJ

doi

10.1016/s0009-9260(97)80252-8

subject

Has Abstract

pub_date

1997-08-01 00:00:00

pages

603-6

issue

8

eissn

0009-9260

issn

1365-229X

pii

S0009-9260(97)80252-8

journal_volume

52

pub_type

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