An exploratory study into the role of dynamic contrast-enhanced (DCE) MRI metrics as predictors of response in head and neck cancers.

Abstract:

AIM:To assess the efficacy of dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) in prediction of the response to treatment in patients with head and neck cancers (HNCs). METHODS AND MATERIALS:Twenty-one patients with advanced HNC, suitable for concurrent chemoradiotherapy underwent DCE MRI, for the quantification of blood flow (BF) and volume (BV). All the patients received radical doses of conventionally fractionated radiotherapy up to a dose of 70 Gy along with concurrent weekly cisplatin. RESULTS:The values of BV and BF were higher in complete responders as compared to partial responders at primary as well as nodes. Both BF and BV were found to be significantly higher in patients with high T-stage as compared to patients with lower T-stage. CONCLUSIONS:DCE metrics can be used as a predictor of response to treatment in locally advanced HNCs after validation of these observations in a larger number of patients.

journal_name

Clin Radiol

journal_title

Clinical radiology

authors

Agrawal S,Awasthi R,Singh A,Haris M,Gupta RK,Rathore RK

doi

10.1016/j.crad.2012.03.005

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

e1-5

issue

9

eissn

0009-9260

issn

1365-229X

pii

S0009-9260(12)00125-0

journal_volume

67

pub_type

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