Constitutive expression of mature transforming growth factor beta1 in the liver accelerates hepatocarcinogenesis in transgenic mice.

abstract：:We have investigated the effect of partial hepatectomy (HEP) on tumor growth. MH-134 hepatoma cells, which were inoculated in syngeneic C3H/He mice from 3 to 10 days after HEP, grew with a linear increase in size until 7 days, began to regress, and disappeared 14 days after the inoculation. The survival rate was 100%,...

journal_title：Cancer research

authors： Ono M,Tanaka N,Orita K

更新日期：1986-10-01 00:00:00

abstract：:The ability of a motif of the CYP17 5' untranslated region, created by a polymorphic T to C substitution, to bind to the human transcription factor Sp-1 was investigated. No binding of any of the polymorphic alleles was observed in electromobility shift assay. No other sequence within +1 to +100 of each of the CYP17 a...

journal_title：Cancer research

authors： Nedelcheva Kristensen V,Haraldsen EK,Anderson KB,Lønning PE,Erikstein B,Kåresen R,Gabrielsen OS,Børresen-Dale AL

更新日期：1999-06-15 00:00:00

abstract：:Interleukin 4, a T cell-derived 20-kDa glycoprotein, plays an important role in regulating the immune response of B cells, T cells, and macrophages against infections and malignant cells. For this reason recombinant human interleukin 4 (rhIL-4) has entered early clinical trials in cancer patients. In the present study...

journal_title：Cancer research

authors： Topp MS,Papadimitriou CA,Eitelbach F,Koenigsmann M,Oelmann E,Koehler B,Oberberg D,Reufi B,Stein H,Thiel E

更新日期：1995-05-15 00:00:00

abstract：:A complementary DNA (cDNA) clone (B4) encoding the catalytic subunit of a cAMP-dependent protein kinase (PKAc) was isolated from a lambda gt10 rat brain cDNA library, using a synthetic oligonucleotide probe whose sequence was based on the known amino acid sequence of a bovine cardiac PKAc. Sequence analysis of this cl...

journal_title：Cancer research

authors： Roth JS,Hsieh LL,Peraino C,Weinstein IB

更新日期：1990-03-15 00:00:00

abstract：:A genome-wide computational screen was performed to identify tumor-associated alternative RNA splicing isoforms. A BLAST algorithm was used to compare 11,014 genes from RefSeq with 3,471,822 human expressed sequence tag sequences. The screen identified 26,258 alternative splicing isoforms of which 845 were significant...

journal_title：Cancer research

authors： Wang Z,Lo HS,Yang H,Gere S,Hu Y,Buetow KH,Lee MP

更新日期：2003-02-01 00:00:00

abstract：:Normal, viral transformed and tumor-derived cells grown in tissue culture and representing different species were tested for their ability to produce an extracellular tumor angiogenesis factor (TAF). TAF was assayed by measuring the host-mediated vascular response of the chorioallantoic membrane to TAF preparations. A...

journal_title：Cancer research

authors： Klagsbrun M,Knighton D,Folkman J

更新日期：1976-01-01 00:00:00

abstract：:The NCI Genomic Data Commons (GDC) was launched in 2016 and makes available over 4 petabytes (PB) of cancer genomic and associated clinical data to the research community. This dataset continues to grow and currently includes over 14,500 patients. The GDC is an example of a biomedical data commons, which collocates bi...

journal_title：Cancer research

authors： Wilson S,Fitzsimons M,Ferguson M,Heath A,Jensen M,Miller J,Murphy MW,Porter J,Sahni H,Staudt L,Tang Y,Wang Z,Yu C,Zhang J,Ferretti V,Grossman RL,GDC Project.

更新日期：2017-11-01 00:00:00

abstract：:Sixty % of clones isolated from HeLa cells treated with toxic concentrations of a methylating carcinogen showed increased resistance to the cytotoxicity of N-methyl-N-nitrosourea. D37 values were 6- to 100-fold higher than in the parental cell population. The absence of detectable levels of the repair enzyme O6-methyl...

journal_title：Cancer research

authors： Aquilina G,Hess P,Fiumicino S,Ceccotti S,Bignami M

更新日期：1995-06-15 00:00:00

abstract：:Alternative splicing is an important mechanism for the generation of protein diversity at a post-transcriptional level. Modifications in the splicing patterns of several genes have been shown to contribute to the malignant transformation of different tissue types. In this study, we used the Affymetrix Exon arrays to i...

journal_title：Cancer research

authors： Menghi F,Jacques TS,Barenco M,Schwalbe EC,Clifford SC,Hubank M,Ham J

更新日期：2011-03-15 00:00:00

abstract：:Hyaluronan, a high molecular weight, negatively charged polysaccharide, is a major constituent of the extracellular matrix. High molecular weight hyaluronan is antiangiogenic, but its degradation by hyaluronidase generates proangiogenic breakdown products. Thus, by expression of hyaluronidase, cancer cells can tilt th...

journal_title：Cancer research

authors： Shiftan L,Israely T,Cohen M,Frydman V,Dafni H,Stern R,Neeman M

更新日期：2005-11-15 00:00:00

abstract：:With normal human skin fibroblasts in culture, a transient decrease in queuine modification of tRNA precedes a phorbol ester tumor promoter-induced 5- to 10-fold increase in saturation density. Subsequently, an increase in the queuine content of cellular tRNA (to levels comparable to those in untreated cultures) prece...

journal_title：Cancer research

authors： Elliott MS,Katze JR,Trewyn RW

更新日期：1984-08-01 00:00:00

abstract：:Seventy-nine esophageal carcinoma patients were studied for genetic abnormalities in the p53 and Rb tumor suppressor genes. Single-strand conformation polymorphism analysis and DNA sequencing were used to detect p53 point mutations, Northern blotting was used to examine abnormal expression of p53 and Rb, and polymeras...

journal_title：Cancer research

authors： Huang Y,Meltzer SJ,Yin J,Tong Y,Chang EH,Srivastava S,McDaniel T,Boynton RF,Zou ZQ

更新日期：1993-04-15 00:00:00

abstract：:Immune system status was characterized in patients with hairy cell leukemia (HCL) with respect to explaining their chronic or recurrent infections with Epstein-Barr virus. Measures of cellular immune responsiveness for a group of 11 HCL patients were, in general, decreased when expressed as the proportion of tested pa...

journal_title：Cancer research

authors： Sairenji T,Sullivan JL,Sakamoto K,Spiro RC,Katayama I,Humphreys RE

更新日期：1985-01-01 00:00:00

abstract：:Traditionally, non-small cell lung cancer (NSCLC) has been evaluated as a unique entity in genotyping studies. However, recent biological data suggest that different NSCLC subtypes, specifically adenocarcinomas (AC) and squamous cell carcinomas (SCC), differentially alter cancer behavior. Several studies have associat...

journal_title：Cancer research

authors： Liu G,Miller DP,Zhou W,Thurston SW,Fan R,Xu LL,Lynch TJ,Wain JC,Su L,Christiani DC

更新日期：2001-12-15 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers largely due to disseminated disease at the time of presentation. Here, we investigated the role and mechanism of action of the metastasis-associated protein anterior gradient 2 (AGR2) in the pathogenesis of pancreatic cancer. AGR2 was induc...

journal_title：Cancer research

authors： Dumartin L,Whiteman HJ,Weeks ME,Hariharan D,Dmitrovic B,Iacobuzio-Donahue CA,Brentnall TA,Bronner MP,Feakins RM,Timms JF,Brennan C,Lemoine NR,Crnogorac-Jurcevic T

更新日期：2011-11-15 00:00:00

abstract：:EWS encodes a ubiquitously expressed RNA binding protein with largely unknown function. In Ewing sarcoma family tumors (EFT), one allele is rearranged with an ETS gene. This is the first description of an EFT with a complete EWS deficiency in the presence of two copies of a rearranged chromosome 22 carrying an interst...

journal_title：Cancer research

authors： Kovar H,Jug G,Hattinger C,Spahn L,Aryee DN,Ambros PF,Zoubek A,Gadner H

更新日期：2001-08-15 00:00:00

abstract：:Structural and functional abnormalities in tumor blood vessels impact the delivery of oxygen and nutrients to solid tumors, resulting in chronic and cycling hypoxia. Although chronically hypoxic regions exhibit treatment resistance, more recently it has been shown that cycling hypoxic regions acquire prosurvival pathw...

journal_title：Cancer research

authors： Matsumoto S,Batra S,Saito K,Yasui H,Choudhuri R,Gadisetti C,Subramanian S,Devasahayam N,Munasinghe JP,Mitchell JB,Krishna MC

更新日期：2011-10-15 00:00:00

abstract：:In vitro analysis of the mitosis from 3-day lymphocyte cultures from two normal males and two normal females treated with bromodeoxyuridine and stained with acridine orange after addition of vincristine during different times demonstrated that vincristine inhibits the progression of the second division. When the secon...

journal_title：Cancer research

authors： Stoll C,Borgaonkar DS,Levy JM

更新日期：1976-08-01 00:00:00

abstract：:Treatment of mice with the immunomodulator pyran copolymer inhibited leukemogenesis produced by Friend leukemia virus (FLV) complex, as evidenced by inhibition of the spleen focus-forming virus and lymphatic leukemia virus, as well as by a significant decrease in splenomegaly. In this report we present data suggesting...

journal_title：Cancer research

authors： Schuller GB,Morahan PS

更新日期：1977-11-01 00:00:00

abstract：:Mouse leukemia (P388) cells were incubated in cell culture medium containing nitrogen mustard [2-chloro-N-(2-chloroethyl)-N-methylethanamine] for 4 h. The nucleophosmin immunoband with a molecular weight of 37,000 (p37; other molecular weights are similarly designated) was observed in both control and nitrogen mustard...

journal_title：Cancer research

authors： Chan PK

更新日期：1989-06-15 00:00:00

abstract：:N-Hydroxyarylamides are metabolically activated to nucleic acid-binding species by the action of N,O-acyltransferase (AT). The substrate specificity of these enzymes in rat, guinea pig, monkey, baboon, pig, and human liver has been examined by measuring the AT-mediated nucleic acid binding of the N-formyl, N-acetyl, a...

journal_title：Cancer research

authors： Beland FA,Allaben WT,Evans FE

更新日期：1980-03-01 00:00:00

abstract：:17beta-Hydroxysteroid dehydrogenase type 12 (17beta-HSD12) has been shown to be involved in elongation of very long chain fatty acid (VLCFA) as well as in biosynthesis of estradiol (E2). 17beta-HSD12 expression was also reported in breast carcinomas but its functions have remained unknown. In this study, we examined t...

journal_title：Cancer research

authors： Nagasaki S,Suzuki T,Miki Y,Akahira J,Kitada K,Ishida T,Handa H,Ohuchi N,Sasano H

更新日期：2009-02-15 00:00:00

abstract：:B7-H3, a surface immunomodulatory glycoprotein, inhibits natural killer cells and T cells. The monoclonal antibody (mAb) 8H9 is specific for 4Ig-B7-H3, the long and principal form of B7-H3. Early results from radioimmunotherapy using 8H9 have shown promise in patients with metastatic solid tumors to the central nervou...

journal_title：Cancer research

authors： Xu H,Cheung IY,Guo HF,Cheung NK

更新日期：2009-08-01 00:00:00

abstract：:Replicating adenoviruses (Ads) are designed to replicate in and destroy cancer cells, generating viral progeny that spread within the tumor. To address the importance of the primary cellular receptor for Ads, the coxsackievirus and Ad receptor (CAR), in permitting intratumoral spread of a replicating Ad, we have used ...

journal_title：Cancer research

authors： Douglas JT,Kim M,Sumerel LA,Carey DE,Curiel DT

更新日期：2001-02-01 00:00:00

abstract：:We have constructed a DNA plasmid encoding the full length complementary DNA for human carcinoembryonic antigen (CEA) driven by the cytomegalovirus early promoter/enhancer (plasmid DNA encoding human CEA) and demonstrated that this plasmid can function as a polynucleotide vaccine. This polynucleotide vaccine induced h...

journal_title：Cancer research

authors： Conry RM,LoBuglio AF,Kantor J,Schlom J,Loechel F,Moore SE,Sumerel LA,Barlow DL,Abrams S,Curiel DT

更新日期：1994-03-01 00:00:00

abstract：:Amyloid fibrils from two cases of cancer-associated, systemic amyloidosis with renal cell carcinoma and mesothelioma as the respective underlying disorders were studied. The immunochemical studies suggested strongly that amyloid A comprised a principal fibril component in both cases of cancer-associated amyloidosis. T...

journal_title：Cancer research

authors： Husby G,Marhaug G,Sletten K

更新日期：1982-04-01 00:00:00

abstract：:The growth of a panel of eight different human glioblastoma cell lines was examined in a human tumor cloning assay in agar, a tritiated thymidine uptake assay, and by counting cell numbers, in cultures performed in the absence or presence of increasing concentrations (1 to 100 ng/ml) of recombinant human stem cell fac...

journal_title：Cancer research

authors： Berdel WE,de Vos S,Maurer J,Oberberg D,von Marschall Z,Schroeder JK,Li J,Ludwig WD,Kreuser ED,Thiel E

更新日期：1992-06-15 00:00:00

abstract：:The ability of the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), to induce chemotaxis in three different populations of mouse peritoneal macrophages was studied. TPA in the range of 10(-9) to 10(-7) M produced a dose- and time-related increase in chemotaxis in resident, thioglycollate-elicited, and divin...

journal_title：Cancer research

authors： Laskin DL,Laskin JD,Weinstein IB,Carchman RA

更新日期：1981-05-01 00:00:00

abstract：:Bombesin (BBN), a 14 amino acid peptide, is an analogue of human gastrin-releasing peptide (GRP) that binds to GRP receptors (GRPrs) with high affinity and specificity. The GRPr is overexpressed on a variety of human cancer cells, including prostate, breast, lung, and pancreatic cancers. The specific aim of this study...

journal_title：Cancer research

authors： Smith CJ,Sieckman GL,Owen NK,Hayes DL,Mazuru DG,Kannan R,Volkert WA,Hoffman TJ

更新日期：2003-07-15 00:00:00

abstract：:Eleven patients with advanced breast cancer and four with astrocytoma were treated with plasma perfused over columns containing staphylococcal Protein A (SPA). Doses of 5 to 20 mg of SPA were bound to collodion charcoal particles, and this treatment resulted in partial remissions in one patient with astrocytoma and in...

journal_title：Cancer research

authors： Bertram JH,Grunberg SM,Shulman I,Apuzzo ML,Boquiren D,Kunkel L,Hengst JC,Nelson J,Waugh WJ,Plotkin D

更新日期：1985-09-01 00:00:00