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Protection against tetanus toxin in mice nasally immunized with recombinant Lactococcus lactis expressing tetanus toxin fragment C.

Abstract：

:Mice inoculated intranasally (i.n.) with a recombinant strain of live Lactococcus lactis expressing tetanus toxin fragment C (TTFC), produced both serum and secretory antibodies to TTFC. Killed bacteria which had accumulated TTFC intracellularly in vitro also elicited protective serum antibody responses. There was no requirement for either colonization or invasion of the mucosa. In addition secretory antibody responses in the lung and nasal tissues were elicited after i.n. inoculation in the presence of an adjuvant.

journal_name

Vaccine

journal_title

Vaccine

authors

Norton PM,Wells JM,Brown HW,Macpherson AM,Le Page RW

doi

10.1016/s0264-410x(96)00241-1

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

616-9

issue

6-7

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(96)00241-1

journal_volume

15

pub_type

杂志文章

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