Abstract:
:The conformation of thymosin beta 9 in solution of 40% (v/v) 1,1,1,3,3,3-hexafluoro-2-propanol-d2 in water has been investigated by two-dimensional 1H-nmr spectroscopy. Under this condition thymosin beta 9 adopts an ordered structure. The determination of the conformation of the peptide was based on a set of 304 approximate interproton distance constraints derived from nuclear Overhauser enhancement measurements. The conformation of thymosin beta 9 includes two helical regions from residues 4 to 27 and 32 to 41. The two helices are separated by a poorly defined loop region between amino acids 28 and 31; the N-terminus of thymosin beta 9 shows random-coil structure only.
journal_name
Biopolymersjournal_title
Biopolymersauthors
Stoll R,Voelter W,Holak TAdoi
10.1002/(SICI)1097-0282(199705)41:6<623::AID-BIP3>subject
Has Abstractpub_date
1997-05-01 00:00:00pages
623-34issue
6eissn
0006-3525issn
1097-0282pii
10.1002/(SICI)1097-0282(199705)41:6<623::AID-BIP3>journal_volume
41pub_type
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