Abstract：
:In a study of 19 hospitalized chronic schizophrenic patients participating in a manualized skills training program, neuropsychological functioning was found to be an important mediating variable. Executive functioning capacity was positively associated with level of participation in the training groups, and deficits in sustained attention together with negative symptoms correlated negatively with overall program attendance. Neuropsychological functioning should be considered as an important assessment domain when identifying patients with minimal requirements to begin skills training.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
McKee M,Hull JW,Smith TEdoi
10.1016/s0920-9964(96)00090-4subject
Has Abstractpub_date
1997-02-28 00:00:00pages
223-9issue
3eissn
0920-9964issn
1573-2509pii
S0920996496000904journal_volume
23pub_type
杂志文章abstract：INTRODUCTION:Contextual factors representing chronic stressors, such as neighborhood crime characteristics, have been repeatedly linked to compromised mental and physical health, and may contribute to the pathologizing of normative/non-clinical experiences. However, the impact of such structural factors has seldom been...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.11.024
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVE:Deficits in the mediodorsal and anterior nuclei of the thalamus may contribute to the psychopathological symptoms of schizophrenia. These thalamic nuclei have been found to be abnormal in schizophrenia and have close connections with other brain structures implicated in the disorder. We therefore examined sch...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.02.012
更新日期：2005-07-15 00:00:00
abstract：:Antipsychotic pharmacotherapy is the standard of care for the treatment of schizophrenia. Although pharmacotherapy effectively improves some symptoms, others can remain. Pharmacotherapy alone also tends to produce only limited improvement in social functioning and quality of life. Supportive psychosocial therapies hav...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2007.12.468
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVE:Blockade of dopamine D₂ receptors with antipsychotics above 65% is associated with optimal chance of clinical response although recent data suggest a lower threshold for the maintenance treatment of schizophrenia. The objective of this study was to prospectively examine whether such continuous high blockade w...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2015.03.025
更新日期：2015-05-01 00:00:00
abstract：:Epidemiological studies often use age-of-first-admission from psychiatric case registers to estimate age-of-onset in schizophrenia. Retrospective, interview-based methods have shown that there is a delay between onset of symptoms and eventual contact with psychiatric services, and that this delay can vary both among i...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(95)00087-9
更新日期：1996-05-01 00:00:00
abstract：OBJECTIVE:The relationship of religion and schizophrenia is widely acknowledged, but often minimized by practitioners and under investigated by researchers. In striving to help fill this gap, this paper focuses on examining four aims: 1) how research has investigated the association between religiosity and schizophreni...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2010.11.005
更新日期：2011-03-01 00:00:00
abstract：:It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.12.854
更新日期：2006-04-01 00:00:00
abstract：:To investigate relationships between birth season and biological family history in schizophrenia, this study used a sample of schizophrenics that had the advantages of (a) particularly thorough diagnostic assessments of schizophrenics' relatives, including information from direct interviews as well as chart reviews, a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/S0920-9964(99)00162-0
更新日期：2000-08-03 00:00:00
abstract：:Alterations of immune function have been reported in ultra-high risk (UHR) for psychosis patients causing expectations in terms of predictive meaningfulness and benefits of anti-inflammatory agents. According to a RCT in UHR-patients supplementation of omega-3 polyunsaturated fatty acids (PUFA) was effective in reduci...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2017.01.026
更新日期：2017-10-01 00:00:00
abstract：:The number of psychiatric beds has declined considerably in many countries over the past decades. Long-term studies on the impact of these health care changes for the severely mentally ill, however, are still scarce. This epidemiological study investigates the use of inpatient psychiatric services by people with schiz...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.07.006
更新日期：2007-12-01 00:00:00
abstract：:Twenty-five schizophrenic patients diagnosed by DSM-III-R underwent event-related potentials and magnetic resonance imaging scans. Latency and amplitude of P300 waveform were measured using an auditory odd-ball paradigm. Anterior and posterior volumes of the superior temporal gyrus and medial temporal structure were m...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(97)00055-8
更新日期：1997-08-29 00:00:00
abstract：OBJECTIVE:This study sought to evaluate levels of insight and change in insight in subjects with schizophrenia and other major psychiatric disorders. This study also evaluated the relationship of insight to acute psychopathology. METHOD:One-hundred and eighty-seven subjects consecutively admitted to an acute care psyc...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00215-7
更新日期：2000-09-29 00:00:00
abstract：:The occurrence of a microdeletion at 22q11 has long been considered to constitute a risk factor for schizophrenia. Higher rates of 22q11 deletions have been reported in cohorts of patients with schizophrenia. In order to estimate the prevalence of the 22q11 deletion in schizophrenia patients more accurately, a screeni...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.02.008
更新日期：2005-03-01 00:00:00
abstract：OBJECTIVE:Studies in first episode psychosis samples about status of cardiovascular risk factors have shown discordant results. We aimed to determine the 10-year risk of developing coronary heart disease in a sample of first episode psychosis patients referred to an early intervention clinic and compared the same with ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.12.008
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:Activated immune-inflammatory pathways play an important role in the pathophysiology of schizophrenia. Paraoxonase 1 (PON1) activity is inversely associated with inflammatory responses in numerous clinical conditions. The aims of this study were to delineate serum arylesterase PON1 activity in drug-naïve fir...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.06.009
更新日期：2015-08-01 00:00:00
abstract：:The distribution of schizophrenia in families supports the hypothesis of heritable risk factors in schizophrenia, but there is as yet no identification of an inherited neurobiological defect. Human embryonic brain tissue fragments, derived from first trimester abortions, can be transplanted into rat hosts, where they ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(94)90051-5
更新日期：1994-10-01 00:00:00
abstract：BACKGROUND:Alterations in the inhibitory circuitry of the dorsolateral prefrontal cortex (DLPFC) in schizophrenia include reduced expression of the messenger RNA (mRNA) for somatostatin (SST), a neuropeptide present in a subpopulation of gamma-aminobutyric acid (GABA) neurons. Neuropeptide Y (NPY) is expressed in a sub...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.09.014
更新日期：2009-12-01 00:00:00
abstract：:Language disturbance is one of the main diagnostic features in schizophrenia and abnormalities of brain language areas have been consistently found in schizophrenic patients. The main aim of this study was to describe the impairment of micro and macrolinguistic abilities in a group of twenty-nine schizophrenic patient...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.07.011
更新日期：2008-10-01 00:00:00
abstract：:The extent of age-related changes in glutamate and other neurometabolites in the anterior cingulate cortex (ACC) in individuals with schizophrenia remain unclear. Magnetic resonance spectroscopy (MRS) at 7 T, which yields precise measurements of various metabolites and can distinguish glutamate from glutamine, was use...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.02.017
更新日期：2016-04-01 00:00:00
abstract：:The dopamine hypothesis of schizophrenia was formulated 30 years ago and postulates that the symptoms of schizophrenia are related to an increased central dopaminergic neurotransmission. The two fundamental assumptions that underlay the dopamine hypothesis of schizophrenia have received support from brain imaging stud...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(97)00121-7
更新日期：1997-12-19 00:00:00
abstract：:Glutamate transporters facilitate the buffering, clearance and cycling of glutamate and play an important role in maintaining synaptic and extrasynaptic glutamate levels. Alterations in glutamate transporter expression may lead to abnormal glutamate neurotransmission contributing to the pathophysiology of schizophreni...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.12.019
更新日期：2013-03-01 00:00:00
abstract：:Spectral entropy (SE) is a measurement from information theory field that provides an estimation of EEG regularity and may be useful as a summary of its spectral properties. Previous studies using small samples reported a deficit of EEG entropy modulation in schizophrenia during cognitive activity. The present study i...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.08.057
更新日期：2018-05-01 00:00:00
abstract：:Sleep disturbance contributes to impaired procedural learning in schizophrenia, yet little is known about this relationship prior to psychosis onset. Adolescents at ultra high-risk (UHR; N=62) for psychosis completed the Pittsburgh Sleep Quality Index (PSQI) and a procedural learning task (Pursuit Rotor). Increased se...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.03.025
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Many patients recovering from a first psychotic episode will discontinue medication against medical advice, even before a 1-year treatment course is completed. Factors associated with treatment adherence in patients with chronic schizophrenia include beliefs about severity of illness and need for treatment, ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.10.016
更新日期：2006-03-01 00:00:00
abstract：:Schizophrenia and affective disorders are relatively common neuropsychiatric diseases with a complex genetic etiology. A multigenic inheritance with variable influence of unknown environmental factors may be involved. Family studies have demonstrated the existence of both phenotypes in the same kindreds, and in certai...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/s0920-9964(99)00108-5
更新日期：1999-09-29 00:00:00
abstract：:The SELENBP1 gene previously was found to be up-regulated in microarray analysis of both peripheral blood cell and brain tissue samples from schizophrenia patients. Quantitative PCR analysis subsequently corroborated the altered expression of SELENBP1 in schizophrenia brain tissue samples from the Stanley Array Correc...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.06.011
更新日期：2009-09-01 00:00:00
abstract：OBJECTIVE:Following encouraging results in the early detection of psychotic disorders, interest in the early detection of affective, especially bipolar disorders, has recently been renewed. However, the differentiation between affective disorders with and without psychotic features is often missing, although it has bee...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.04.001
更新日期：2012-07-01 00:00:00
abstract：BACKGROUND:Some studies have suggested that antipsychotic-naïve patients with nonaffective psychosis (NAP) have glucose intolerance. AIMS:To conduct a systematic review and meta-analysis of fasting glucose (FG), two hour values in the oral glucose tolerance test (2HG), fasting insulin concentration (INS), and insulin ...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.schres.2016.09.026
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Neurocognitive deficits have been well documented in patients with schizophrenia. Research has shown that a significant proportion of patients with schizophrenia have co-morbid obsessive-compulsive symptoms/disorder (OCS/OCD). However, the impact of OCS/OCD on various neurocognitive domains in patients with ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.05.029
更新日期：2018-11-01 00:00:00
abstract：:There is controversy over whether the incidence rates of schizophrenia and psychotic disorders have changed in recent decades. To detect deviations from trends in incidence, we analysed admission data of patients with an ICD-8/9/10 diagnosis of psychotic disorders in the Canton Zurich / Switzerland, for the period 197...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.06.001
更新日期：2007-09-01 00:00:00
