Abstract:
BACKGROUND:p53/p21WAF1/CIP1 and mdm-2 proteins play an important role in cell cycle regulation. The study of the pathogenesis of gastric cancer is important to understand how these tumors progress during their natural history. AIM:To study the relationship between the immunohistochemical expression of p53/p21WAF1/CIP1 and mdm-2 and cell proliferation in gastric cancer. MATERIAL AND METHODS:Fifty one gastrectomy specimens with gastric cancer were studied using immunohistochemistry for p53/p21WAF1/CIP1 and mdm-2. Cell proliferation was determined by immunolabelling with PCNA and Ki67 antigens. Mitosis figures were counted in 10 high power microscopic fields. RESULTS:Patients from whom gastric cancer specimens were obtained had a mean age of 59.3 years. Ki67 and mitosis counting showed the highest correlation index with proliferation indexes studied. No correlation was found between the expression of protein complex p53/p21WAF1/CIP1 and mdm-2 and morphological characteristics of gastric tumors. Mdm-2 protein overexpression was the only marker that showed an independent correlation with cell proliferation. Moreover, mdm-2 positive tumors showed the highest proliferation indexes when p53 was not immunohistochemically over-expressed, as determined by PCNA labelling index. CONCLUSIONS:In gastric cancer, a direct correlation between mdm-2 overexpression and cell proliferation was observed. Moreover, the fact that mdm-2 positive tumors showed the highest cell proliferation when p53 was not overexpressed, entitles us to hypothesize that mdm-2 overexpression could play a major role in gastric carcinogenesis.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Villaseca M,Araya JC,Roa I,Roa JCsubject
Has Abstractpub_date
2000-02-01 00:00:00pages
127-36issue
2eissn
0034-9887issn
0717-6163journal_volume
128pub_type
杂志文章abstract:BACKGROUND:Down syndrome (DS) is associated with higher child mortality especially due to cardiac malformations. AIM:To describe the trend in Chilean infant mortality in DS in the period 1997-2013 as compared to the general population without DS. MATERIAL AND METHODS:Raw data on infant deaths were extracted from the ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872016001100009
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Valsartan is an angiotensin AT1 receptor antagonist. Clinical studies have shown that this is an effective and well tolerated drug. AIM:To compare valsartan with other commonly used antihypertensives in a National multicentric study. MATERIAL AND METHODS:Between 1997 and 1998, a pharmacological surveillanc...
journal_title:Revista medica de Chile
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:The prevalence of pediatric arterial hypertension (AHT) is approximately 1% to 2%. In the last tenyears, mean blood pressure levels (BP) have raised due to obesity and changes in lifestyles. Family history (FH) of AHT is a risk factor to develop AHT in children. AIM:To assess blood pressure, cardiovascular ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872009000100006
更新日期:2009-01-01 00:00:00
abstract::We performed cerebral biopsy in 4 patients with AIDS and evidence of expanding intracerebral lesions. Three patients had cerebral toxoplasmosis and the fourth had Chagas encephalitis. No patient developed complications. We feel that cerebral biopsy is warranted and safe in patients with AIDS and intracerebral lesions ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract:BACKGROUND:Most infectious diseases in template climates have seasonal pattern, that can be influenced by climatic, social and host factors. AIM:To study the seasonal patterns of seven human infectious diseases in Chile. MATERIAL AND METHODS:Series of monthly cases of measles, whooping cough, scarlet fever, meningiti...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00
abstract::A 19 yr-old female patient with the diagnosis of late onset adrenal hyperplasia was treated since age 15 with different glucocorticoid preparations and dosage schedules plus spironolactone. In spite of a very good response in terms of amelioration of their hirsutism she experienced cushingoid manifestations associated...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:Title revalidation of foreign medical graduates to practice medicine in Chile is a complex and expensive process. According to the legislation they are required to approve the Unique National Exam of Medical Knowledge (EUNACOM), which has a theoretical and a practical section. AIM:To demonstrate that a coll...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872018000200232
更新日期:2018-02-01 00:00:00
abstract::Jehovah Witnesses cite religious motives to refuse transfusions of whole blood or its components for themselves and their children, even when life is endangered. An ethical analysis of decision making in health problems is made, giving priority to the alternatives chosen by the patient. One of the elements that turns ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
abstract::In the last years our country has been affected by several outbreaks of infectious diseases such as Cholera and Hanta virus and recently, by pathogens associated to red tide. Chile was able to manage those emergencies using the local health system. The new threat that may emerge and could eventually overcome that capa...
journal_title:Revista medica de Chile
pub_type: 社论
doi:10.4067/s0034-98872005000900001
更新日期:2005-09-01 00:00:00
abstract::Pancreatic choristoma is the occurrence of normal pancreatic tissue in an abnormal location without any anatomic continuity with the main body of the gland. Although heterotopia is uncommon in the gallbladder and biliary tract, anecdotic cases of gastric mucosa, liver, adrenal gland and pancreas among other tissues ha...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872007001000013
更新日期:2007-10-01 00:00:00
abstract::The author reminds the reform of medical education of 1945 in which he participated as a student. It was approved by the Decree #201 of april 2, introducing Chilean medicine into a new era of modernity. The reform was planned and conducted by professors Hernán Alessandri (1900-1980) and Alejandro Garretón (1900-1980) ...
journal_title:Revista medica de Chile
pub_type: 历史文章,杂志文章
doi:
更新日期:1995-08-01 00:00:00
abstract::Two atypical cases of parvovirus B19 infection occurred consecutively within a family. A 14 year-old patient presented an extended papular-purpuric "gloves and socks" syndrome and two weeks later his mother developed a predominantly unilateral purpuric rash in the limbs with severe malaise. Specific IgM antibodies in ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872008000500011
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:The mucosa distal to the endoscopic mucosal change zone can have easily diagnosed early alterations, in patients with chronic gastroesophageal reflux. AIM:To determine the type of mucosa existent in the zone distal to the squamous-columnar junction in patients with chronic gastroesophageal reflux without in...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::Ultrasound is a sensible and specific method for the diagnosis, study of natural course and follow up of medical treatment of gallstones. Thus it is important to specify the concordance between echographic and pathological findings of the gallbladder. Ninety one patients were subjected to an ultrasound gallbladder exa...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1992-11-01 00:00:00
abstract::Platelet Rich Plasma (PRP) is used in musculoskeletal lesion surgery, including muscle, bone, tendons and ligaments. PRP might accelerate the healing process and the integration of the graft, allowing an earlier return to sports activities of patients. PRP is obtained from autologous blood, which is centrifuged, obtai...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872013001000011
更新日期:2013-10-01 00:00:00
abstract::DSM-5 is a significant factor in promoting the "remedicalization" of psychiatry as the focus of psychiatric knowledge, developed by the evidence-based medicine movement, shifted from the clinically-based biopsychosocial model to a research-based medical model. DSM-5 purposes are 1]clinical: diagnosis, prevention, earl...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872019000400475
更新日期:2019-04-01 00:00:00
abstract::Andrés Bello, a Venezuelan intellectual arrived in Chile in 1829. He had a decisive influence on the development of natural sciences and medical sciences in this country. The first formal teaching program in Medicine appeared in 1833, with few students due to the low social prestige of Medicine at that time. The Facul...
journal_title:Revista medica de Chile
pub_type: 传,历史文章,杂志文章
doi:
更新日期:1991-11-01 00:00:00
abstract::Protective immunity against rotavirus infection is directed against antigenic epitopes on the outer capsid proteins VP7 and VP4. The aim of this study was to characterize the VP7 and VP4 antigenic types circulating in different hospital areas of Santiago, Chile, over different time periods. Between April 1993 and Apri...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
abstract::Aiming to correlate the alterations in evoked potentials with the initial clinical manifestations of multiple sclerosis, 29 patients with the disease were studied and 19 were followed for a lapse ranging from 1 to 11 years. Visual evoked potentials were studied in all the patients and 51% were abnormal. Auditory evoke...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:Host genetic predispositions may be important determinants of liver fibrosis in patients with chronic hepatitis C (CHC). The association between Interferon-L 4 (IFNL4) rs12979860 C>T polymorphism and risk of liver fibrosis in CHC is contradictory. AIM:To evaluate the impact of IFNL4 rs12979860 polymorphism ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872018000700823
更新日期:2018-07-01 00:00:00
abstract::Geographical inequalities arising in the death of children under 1 year are studied. Causes regarded as avoidable at the present moment and leading to death are determined and the 27 Regional Chilean Health Services are ranked from best to worse in levels of mortality using cluster analysis. Results show that: 1) t...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1982-04-01 00:00:00
abstract:BACKGROUND:Annually, acute bronchiolitis (AB) occurrence peaks during winter and is probably associated with air pollution. AIM:To relate the number of ambulatory consultations, emergency and hospital admission due to AB with climatic factors and air pollution. PATIENTS AND METHODS:Patients of less than 1 year old wi...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2003-10-01 00:00:00
abstract::ECMO (Extracorporeal Membrane Oxygenation) is an extracorporeal life support system in catastrophic lung failure, shock and cardiopulmonary resuscitation, in different age groups, with multiple physiologic features. When the candidate to be submitted is too unstable to be transported to a hospital with ECMO, cannulati...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872020000300349
更新日期:2020-03-01 00:00:00
abstract::We report a 44 years old male, presenting with an eight months history of right lower quadrant pain, diarrhea and weight loss. Colonoscopy showed a proliferative and ulcerated lesion in the cecum, with necrotic areas. Barium enema showed an extensive irregular stenosis with rigidity of cecum and ascending colon. The e...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:Acute appendicitis is the most common non obstetric surgical emergency during pregnancy. AIM:To asses our experience in the diagnosis and management of acute appendicitis occurring during pregnancy. PATIENTS AND METHODS:Data from all pregnant patients who were subjected to an appendectomy for a suspected a...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872006000200002
更新日期:2006-02-01 00:00:00
abstract::Constrictive Pericarditis (CP) is an unusual disease. Its most common causes are idiopathic or secondary to cardiac surgery. Less frequently it is caused by connective tissue diseases. We report a 30 years old woman hospitalized due to progressive dyspnea, chest pain and signs of right sided heart failure. During her ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872014000800015
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Rates of obesity reach high levels in Chile, with geographic, social and school variations. AIM:To identify factors at two levels associated with excessive weight in school children: child-family characteristics and school-neighborhood. MATERIAL AND METHODS:Using a cross-sectional and multi-step design, se...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872007001200002
更新日期:2007-12-01 00:00:00
abstract::Normal myocardial cells actively uptake the radioisotope Thallium-201 and its myocardial distribution is a reflection of the existent regional coronary artery blood flow at the moment of the examination. Thallium-201 reaches quickly a high intracellular concentration and then leaves myocardial cells in a mean time of ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
abstract::IgG4 disease is a multi-systemic condition involving pancreas, salivary glands and lymph nodes. Less frequently, it causes interstitial nephritis and involves the lungs. We report a 58 years old male with a four years history of hemoptysis and renal dysfunction characterized by hematuria and proteinuria, responsive to...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872017000100018
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:CEA is widely used in the follow up of patients with colorectal carcinoma. AIM:To study the value of preoperative CEA as an independent prognostic factor in colorectal carcinoma. PATIENTS AND METHODS:Analysis of 373 operated patients (204 females, age range 21-92 years) with colorectal carcinoma and a mean...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872004000600005
更新日期:2004-06-01 00:00:00