Abstract:
:O6-Alkylguanine-DNA alkyltransferase (AGT) activity was assessed in peripheral blood lymphocytes among 23 mortuary science students before and after 9 weeks in a laboratory course in techniques of embalming. Formaldehyde exposure was established by environmental monitoring. The average air concentration of formaldehyde during embalming was about 1.5 ppm. At the pre-exposure sampling, baseline DNA repair capacity tended to be reduced in subjects who reported a prior history of embalming (p = 0.08). From pre- to post-exposure, 17 subjects decreased in DNA repair capacity, while only 6 increased (p < 0.05). Analysis of variance, including adjustment for age, sex, and smoking status, confirmed these findings. Among the eight subjects who had no embalming experience during the 90 days before study, seven had decreased and one had increased AGT activity during the period of study (p < 0.05). For those with prior embalming experience, 10 subjects decreased in AGT activity, while 5 increased (p < 0.05). Although the major chemical exposure in embalming practice was to formaldehyde, no clear link was established between amount of formaldehyde exposure and AGT activity.
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Hayes RB,Klein S,Suruda A,Schulte P,Boeniger M,Stewart P,Livingston GK,Oesch Fdoi
10.1002/(sici)1097-0274(199703)31:3<361::aid-ajim1subject
Has Abstractpub_date
1997-03-01 00:00:00pages
361-5issue
3eissn
0271-3586issn
1097-0274pii
10.1002/(SICI)1097-0274(199703)31:3<361::AID-AJIM1journal_volume
31pub_type
杂志文章abstract:BACKGROUND:This study examines the prevalence of physician-diagnosed respiratory conditions and mental health symptoms in firefighters and emergency medical service workers up to 9 years after rescue/recovery efforts at the World Trade Center (WTC). METHODS:We analyzed Fire Department of New York (FDNY) physician and ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20993
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Exposure in the dental environment can increase the risk of respiratory disease in dental healthcare workers (HCWs). This study investigated the prevalence of asthma phenotypes in dental HCWs and associated risk factors. METHODS:A cross-sectional study of 454 dental HCWs in five dental institutions in South...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22041
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Noise exposure has long been an occupational health concern and has been an important area of focus of the Occupational Safety and Health Administration (OSHA) since its founding. Nevertheless, it remains unclear what effects OSHA's noise standards have had on employer efforts to reduce risks. Consequently...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.23116
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Lead stabilizers (e.g., lead sulfate, lead stearate) are common additives in plastics used in electrical devices. In 1997, three plastics compounders at one California company were severely lead-poisoned. METHODS:The poisonings were investigated by interviewing the workers, employer, and treating physician ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20123
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:Aspartame (APM) is a well-known intense artificial sweetener used in more than 6,000 products. Among the major users of aspartame are children and women of childbearing age. In previous lifespan experiments conducted on Sprague-Dawley rats we have shown that APM is a carcinogenic agent in multiple sites and ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20896
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Because of reported associations of psychosocial factors and computer related musculoskeletal symptoms, we investigated the effects of a workplace psychosocial factor, reward, in the presence of over-commitment, on trapezius muscle activity and shoulder, head, neck, and torso postures during computer use. M...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22192
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:To compare the type, severity, cause, and cost of work-related injuries between Lebanese and non-Lebanese workers in insured workplaces in Lebanon. METHODS:A total of 4,186 claims and medical reports for 3,748 work-related injuries filed in 1998 at five major insurance companies were reviewed. RESULTS:Non-...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10246
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:The purpose of the study was to evaluate trends in occupational lead exposures throughout U.S. industry after the establishment of the general industry lead standard in 1978 and the construction industry standard in 1993. METHODS:Lead exposure measurements collected by the Occupational Safety and Health Adm...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20008
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Harvesting of blueberries is associated with musculoskeletal injury. This study assessed the effects of several alternative designs of the harvesting rake. METHODS:A community-based work team selected rake design for intervention and pilot tested potential design modifications to the blueberry harvesting ra...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20554
更新日期:2008-04-01 00:00:00
abstract::Asbestos has been widely used in the refinery and petrochemical sector. Mesothelioma has occurred among maintenance employees, and it was hypothesized that mesothelioma is a marker for exposures which might increase lung cancer risk. A death certificate-based case-control study of mesothelioma and lung cancer from 198...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0274(199611)30:5<610::AID-AJIM9
更新日期:1996-11-01 00:00:00
abstract::In conjunction with industrial hygiene surveys, mutagenicity studies were performed for the airborne contaminants in three polyurethane manufacturing plants. Airborne particles were collected on glass-fiber filters with Hi-Vol pumps from different locations in each plant. Gases were collected in multiple-sorbent cartr...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700110410
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Knowledge on intrapulmonary lymph nodes (IPLNs) is still limited. Progress in imaging techniques has enabled easier, more frequent visualization of IPLNs so that a more comprehensive understanding of these nodes is necessary. METHODS:Microscopic slides of lung tissue from 2,337 dust-exposed South African mi...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20436
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:We investigated how night shift duration and sleep problems were jointly associated with disabling low back pain (LBP) among workers in different occupations. METHODS:An online-survey was conducted regarding work schedules, disabling LBP, sleep problems, and other relevant factors in 5,008 workers who were ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22493
更新日期:2015-12-01 00:00:00
abstract::Formaldehyde is commonly accepted to be an allergen and irritant. However, specifically diagnosed occupational respiratory diseases caused by formaldehyde are relatively rare. Occupational laryngitis was diagnosed in a 47-year-old dairy foreman. He had been exposed for 9 years to formaldehyde emitted from a milk-packi...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-0274(199603)29:3<275::AID-AJIM7
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Previous epidemiological studies investigating modification of organophosphate (OP) neurotoxicity by xenobiotic metabolizing enzymes (XMEs) polymorphisms have produced inconsistent results. METHODS:A cross-sectional study of 301 emerging farmers was conducted. Neurotoxicity testing included forward and back...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22790
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Continuous increase in male incidence of malignant mesothelioma of the pleura (MMP) despite the drop of asbestos production since 1980 in Québec motivated this study aiming to assess when the rates of MMP will decline. METHODS:Age-standardized rates and trends were estimated over the 1984-2007 period by sex...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22442
更新日期:2015-05-01 00:00:00
abstract::A 30 year-old male polyurethane worker was exposed to an accidental spill of 4,4'-methylene-bis-2-chloroaniline (MBOCA) at a plant producing MBOCA-cured plastic products. Exposure to MBOCA is significant in that this compound is a known animal carcinogen and a suspected human carcinogen. The employee was sprayed over ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700180508
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Nickel (Ni) compounds have been classified as carcinogenic to humans. The aim of the study is to evaluate exposures to Ni at workplaces in Italy. METHODS:Data on Ni compounds were collected from an occupational exposure registry. Statistical analysis was carried out for exposure-related variables. The numbe...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22914
更新日期:2018-12-01 00:00:00
abstract::A cohort of 1,117 asbestos insulation workers was established in 1963 and has been prospectively followed since then. Chest X-ray abnormalities detected at the initial medical examination, and interpreted according to the International Labour Office Classification of Radiographs of Pneumoconioses are reported in this ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700100504
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Migrant and seasonal farmworkers are at risk for occupational illnesses from pesticide exposure, and the effectiveness of pesticide safety regulations has not been evaluated. It is important to learn from farmworker safety experiences to develop effective measures to improve agricultural workplace safety. M...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.1042
更新日期:2001-05-01 00:00:00
abstract::Cholinesterase activity measurements for 542 California agricultural pesticide applicators under medical supervision during the first 9 months of 1985 were analyzed. Twenty-six workers, 4.8% of the sample, had cholinesterase values at or below the California threshold values for removal from continued exposure to chol...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700150203
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:The oncogene product EGF-receptor (EGF-R), the tumor suppressor gene product p53, and anti-p53 antibodies are detectable in serum of certain cancer patients. Increased levels of some of these products were reported in lung cancer patients after occupational asbestos exposure, after exposure to polycyclic aro...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,多中心研究
doi:10.1002/(sici)1097-0274(199912)36:6<602::aid-ajim2
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:In this study, we describe the methodology used for historical estimation of exposure to fluoride and to PAH in vertical stud Søderberg (VSS) potrooms at two Norwegian aluminum smelters. The assessment was performed in order to develop exposure data for epidemiological studies of cause-specific mortality and...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199902)35:2<164::aid-ajim8
更新日期:1999-02-01 00:00:00
abstract::The occupational histories of fathers were collected prospectively as part of the Avon Longitudinal Study of Pregnancy and Childhood (ALSPAC), and were used to investigate the association of paternal job title with a baby's birth weight and gestational age. The analysis cohort consisted of 4,795 singleton live-born ba...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199706)31:6<738::aid-ajim1
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:The peripheral nerve conduction velocity (NCV), distribution of nerve conduction velocities (DCV), somatosensory, visual, and brainstem auditory evoked potentials (SEP, VEP, and BAEP, respectively), event-related potential (P300), computerized static posturography with spectral analysis (postural balance), a...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0274(200002)37:2<193::aid-ajim5
更新日期:2000-02-01 00:00:00
abstract::Conventional occupational mortality analysis, using underlying cause of death coding, underestimates the contribution of those chronic diseases which are mentioned on the death certificate but which usually do not appear as underlying cause of death. Proportionate occupational mortality analysis, using all the mention...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700140311
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate the association between dynamic thiol/disulphide homeostasis and occupational exposure to volatile anesthetic gases in operating theater personnel. Decreased blood thiol levels and raised blood disulphide levels serve as biomarkers of oxidative stress. METHODS:We...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22764
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:While assessment of subcontractors' safety performance during project bidding processes are common in commercial construction, the validation of organizational surveys used in these processes is largely absent. METHODS:As part of a larger research project called Assessment of Contractor Safety (ACES), we de...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.23143
更新日期:2020-09-01 00:00:00
abstract::Using injury information from the 1986 Mine Safety and Health Administration database, and demographic information from a 1986 sample survey of the miner population, acute traumatic injury rates for male workers in underground bituminous coal mines were computed by age, current job experience, and total mine work expe...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700230304
更新日期:1993-03-01 00:00:00
abstract::Ethylene oxide was tested in environmental air and in the alveolar air of 10 workers employed in a hospital sterilizer unit at hourly intervals during the work shift. Alveolar ethylene oxide concentrations (Ca) were correlated with environmental concentration (Ci) in all the workers studied (r = 0.89-0.99). The ratio ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700080109
更新日期:1985-01-01 00:00:00