Abstract:
BACKGROUND:Previous epidemiological studies investigating modification of organophosphate (OP) neurotoxicity by xenobiotic metabolizing enzymes (XMEs) polymorphisms have produced inconsistent results. METHODS:A cross-sectional study of 301 emerging farmers was conducted. Neurotoxicity testing included forward and backward recall, digit span, and vibration sensitivity testing. Questionnaire data included demography, potential confounders, and work history of pesticide exposures. Genomic DNA was analyzed from study participants for DNA variants of two glutathione S-transferases (GSTM1 and GSTT1), N-acetyltransferase 2 (NAT2), and Paraoxonase 1 (PON1). RESULTS:There was evidence of OP pesticide neurotoxicity modification by rs1799931 (NAT2), rs662 (PON1), and the null allele of GSTM1 in multivariate analysis. The strongest evidence of modification was observed for rs1799931 (NAT2) on the relationship between pesticide poisoning and impaired vibration sense. CONCLUSIONS:DNA variants of NAT2, PON1, and GSTM1 may modify OP neurotoxicity, and this requires further exploration.
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Glass T,Dalvie MA,Holtman Z,Vorster AA,Ramesar RS,London Ldoi
10.1002/ajim.22790subject
Has Abstractpub_date
2018-01-01 00:00:00pages
11-20issue
1eissn
0271-3586issn
1097-0274journal_volume
61pub_type
杂志文章abstract:BACKGROUND:There are few population-based studies addressing hypersensitivity pneumonitis (HP) in the United States. The National Institute for Occupational Safety and Health (NIOSH) has nationally comprehensive longitudinal mortality data that can contribute to a better understanding of the epidemiology of HP. METHOD...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20405
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:A 5-year longitudinal study examined nonmalignant respiratory effects of wood processing dust exposure. METHODS:Ten study plants, investigator selected from 447 candidate plants, included 1 sawmill-planing-plywood, 1 plywood, 1 milling, 3 cabinet and 4 furniture facilities. Personal dust samples (2363) were...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20594
更新日期:2008-08-01 00:00:00
abstract::The aim of the study was to evaluate the genotoxic risk to medical personnel concurrently exposed to ionizing radiation and antineoplastics, using changes in their lymphocyte cell genome as a bioindicator. The study comprised 12 female nurses employed in the nuclear medicine hospital department and an equal number of ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700270610
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:Many authorities are concerned about the rising use and the potential overuse of opioid pain medications. A study of opioid prevalence and dosage in Ohio's workers' compensation (WC) system was conducted, with comparisons made to opioid use in other WC and non-WC settings. METHODS:Systematic literature revi...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
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更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:In studies in men, risk estimates on occupation and bladder cancer are distorted by about 10% when not adjusting for smoking. We examined the degree to which occupational risk estimates for bladder cancer in women are confounded by smoking, and the degree of residual confounding by inadequate control of this...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,meta分析
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更新日期:1999-07-01 00:00:00
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journal_title:American journal of industrial medicine
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更新日期:2007-04-01 00:00:00
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journal_title:American journal of industrial medicine
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更新日期:2016-12-01 00:00:00
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更新日期:2015-09-01 00:00:00
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更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Dusts containing crystalline silica are generated in mining, construction, glass, granite and concrete production industries. The association between exposure to low levels of concrete dust containing crystalline silica and reduction in lung function, was evaluated in a cross-sectional study. METHODS:The st...
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pub_type: 杂志文章
doi:10.1002/ajim.1080
更新日期:2001-08-01 00:00:00
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doi:10.1002/(sici)1097-0274(199803)33:3<224::aid-ajim3
更新日期:1998-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ajim.22473
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Impairment of olfactory function in humans has been associated with occupational exposure to volatile chemicals. To investigate whether exposure to styrene was associated with olfactory impairment, olfactory function was examined in workers with a minimum of 4 years exposure to styrene in the reinforced-plas...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10102
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Opioid use is rising in the US and may cause special problems in workers compensation cases, including addiction and preventing a return to work after an injury. OBJECTIVE:This study evaluates a physician-level intervention to curb opioid usage. An insurer identified patients with out-of-guideline opioid ut...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22779
更新日期:2017-12-01 00:00:00
abstract::A joint study on effects of formaldehyde exposure in industrial populations by the National Cancer Institute and the Formaldehyde Institute, Inc. (Blair et al. [1986]: J Natl Cancer Inst 76: 1071-1084; Blair and Stewart [1989]: J Occup Med 31: 881, Blair et al. [1990]: Am J Ind Med 17:683-700) reported no significant ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700250413
更新日期:1994-04-01 00:00:00
abstract::The association between lead absorption and objective psychological performance tests in five groups with different levels of lead absorption was studied in the following groups: (1) a control, non-lead-exposed group; (2) cable splicers, (3) cable manufactures, and (4) secondary lead smelter workers. The following per...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700010320
更新日期:1980-01-01 00:00:00
abstract::To investigate the effects of styrene exposure on peripheral, central, and autonomic nervous system functions in man, we measured the distribution of nerve conduction velocities (DCV), short-latency somatosensory evoked potentials (SSEP), and variability in electrocardiographic R-R interval (CVRR) as well as conventio...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700200609
更新日期:1991-01-01 00:00:00
abstract::Multiphasic health testing was provided to 744 rubber workers at a tire manufacturing plant. Sixty-two white males from this population had worked longest in the curing department. Personal exposure to respirable particulates was measured for curing press operators. Outcome on screening tests for curing workers was co...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700020208
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Exposure to microbial agents in the composting industry may cause work related airway inflammation. Nasal lavage (NAL) has been proposed as a noninvasive method to assess such effects in population studies. METHODS:Pre- and post-shift NAL were performed in the workers of a compost plant visited in 1995 (n =...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(200005)37:5<459::aid-ajim2
更新日期:2000-05-01 00:00:00
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journal_title:American journal of industrial medicine
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doi:10.1002/ajim.22922
更新日期:2019-01-01 00:00:00
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更新日期:2003-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ajim.1105
更新日期:2001-09-01 00:00:00
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journal_title:American journal of industrial medicine
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更新日期:1984-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ajim.20251
更新日期:2006-02-01 00:00:00
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更新日期:2020-01-01 00:00:00
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journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22068
更新日期:2012-09-01 00:00:00
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journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700120206
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:The Fogarty International Center (FIC) of the United States National Institutes of Health includes the International Training and Research in Environmental and Occupational Health (ITREOH) Program. The "International Training Program in Environmental Toxicology and Public Health" Center, funded in 2002 is ba...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22044
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Thoroughbred horse farm workers self-report a high frequency of work-related injuries and pain. However, an analysis of Thoroughbred horse farm workers' compensation injury claims is absent from the literature, yet may benefit worker safety. METHODS:We analyzed workers' compensation insurance firm data cont...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
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更新日期:1992-01-01 00:00:00