Abstract:
BACKGROUND:Occupational exposure to vinyl chloride monomer (VCM) has been established as a cause of hepatocellular carcinoma (HCC) and liver angiosarcoma (ASL). However, some controversy remains due to conflicting results on liver cirrhosis, and to evidence on HCC based on few confirmed cases. The aim of the study is to clarify the association between VCM exposure and mortality from liver diseases. METHODS:In a cohort of 1658 workers involved in VCM production and polymerization, Poisson regression was adopted to estimate rate ratios (RR) across categories of VCM exposure for mortality due to ASL (n = 9), HCC (n = 31) confirmed by histological/clinical records, and the combination of deaths from liver cirrhosis and from liver cancer with clinical/histological evidence of cirrhosis (n = 63). RESULTS:Cumulative VCM exposure was associated with study outcomes; RRs in the highest compared to the lowest exposure category were: ASL 91.1 (95%Confidence Interval 16.8-497), HCC 5.52 (2.03-15.0), liver cirrhosis 2.60 (1.19-5.67). CONCLUSIONS:The risk of death from liver cirrhosis, as well as from HCC in the largest available series of confirmed cases, increased with VCM exposure.
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Fedeli U,Girardi P,Gardiman G,Zara D,Scoizzato L,Ballarin MN,Baccini M,Pirastu R,Comba P,Mastrangelo Gdoi
10.1002/ajim.22922subject
Has Abstractpub_date
2019-01-01 00:00:00pages
14-20issue
1eissn
0271-3586issn
1097-0274journal_volume
62pub_type
杂志文章abstract::Certain refining processes were investigated to determine their influence on the dermal carcinogenic activity of petroleum-derived lubricating oil distillates. Specifically, the effects of solvent refining, hydroprocessing, a combination of both processes, and the blending of oils processed using each technique were e...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700050403
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abstract::Organophosphate (OP)-related systemic illnesses reported to the Worker Health and Safety (WH&S) Branch, and restricted OP-related agricultural use data reported to the Information Services Branch at the California Department of Food and Agriculture (CDFA) (now CAL-EPA) during 1984-1988 were used to assess factors asso...
journal_title:American journal of industrial medicine
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journal_title:American journal of industrial medicine
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abstract:BACKGROUND:Construction is a dangerous industry with a large number of small businesses. Because they require minimal resources to deliver, toolbox talks may be an ideal training format for small construction contractors. METHODS:Eight toolbox talks were developed, each with two versions. One version of each toolbox t...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,随机对照试验
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abstract::In 1982, White et al published an assessment of quantitative leukemia risk associated with lifetime occupational exposure to benzene. At about the same time, IARC (1982) published estimates of quantitative cancer risk associated with industrial chemicals. Benzene was one of the two chemicals selected by IARC for its r...
journal_title:American journal of industrial medicine
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journal_title:American journal of industrial medicine
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journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700220312
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journal_title:American journal of industrial medicine
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journal_title:American journal of industrial medicine
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journal_title:American journal of industrial medicine
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journal_title:American journal of industrial medicine
pub_type: 杂志文章
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abstract::Several research projects on work-related respiratory diseases have been conducted in Finland. One of the largest, "Farmers' Occupational Health Programme," was conducted by the Social Insurance Institution of Finland during 1973-1983 in cooperation with Kuopio Regional Institute of Occupational Health and the Nationa...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700180305
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abstract:Background:Little research has addressed the safety environment of child farmworkers. This analysis examines the work safety culture experienced by Latinx child farmworkers in North Carolina. Methods:Survey interviews were conducted in 2017 with 202 Latinx children aged 10 to 17 years employed on North Carolina farms....
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journal_title:American journal of industrial medicine
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doi:10.1002/(sici)1097-0274(199905)35:5<472::aid-ajim4
更新日期:1999-05-01 00:00:00
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journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700220107
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journal_title:American journal of industrial medicine
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journal_title:American journal of industrial medicine
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journal_title:American journal of industrial medicine
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journal_title:American journal of industrial medicine
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:American journal of industrial medicine
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journal_title:American journal of industrial medicine
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journal_title:American journal of industrial medicine
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journal_title:American journal of industrial medicine
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journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
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journal_title:American journal of industrial medicine
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journal_title:American journal of industrial medicine
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