Abstract:
:Valproic acid, a primary anticonvulsant drug, has recently been studied for purported effectiveness in disparate disorders of mood and behaviour. The psychopharmacological treatment of patients with acquired brain injury frequently includes numerous trials of psychotherapeutic drugs such as antipsychotics, benzodiazepines, antidepressants, and lithium, in an effort towards affective and behavioural improvement. In this report we describe and graphically depict the striking efficacy of valproic acid in reducing and improving destructive and aggressive behaviours in five patients with acquired brain injury. In all cases valproic acid was effective after other pharmacological interventions were not. Also, the addition of valproic acid was followed by neurobehavioural improvement rather quickly, often within 1-2 weeks. Advantages of valproic acid, in addition to its possible unique efficacy, include a lower propensity towards sedation and cognitive impairment, and thus a more robust potential for rehabilitation participation. Behaviours associated with affective disorders ranging along the affective spectrum from depression to dysphoric mania may be particularly amenable to valproic acid. The drug may also be beneficial in some cases in which another psychotropic anticonvulsant, carbamazepine, was not.
journal_name
Brain Injjournal_title
Brain injuryauthors
Wroblewski BA,Joseph AB,Kupfer J,Kalliel Kdoi
10.1080/026990597123791subject
Has Abstractpub_date
1997-01-01 00:00:00pages
37-47issue
1eissn
0269-9052issn
1362-301Xjournal_volume
11pub_type
杂志文章相关文献
BRAIN INJURY文献大全abstract:OBJECTIVES:To investigate the relationship between language functions and cognitive and functional outcome and to evaluate the effects of a conventional language rehabilitation programme on aphasic adult patients in the post-acute stage of traumatic brain injury (TBI). DESIGN:Non-concurrent prospective study. Patients...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699050601081844
更新日期:2006-12-01 00:00:00
abstract:PRIMARY OBJECTIVE:To investigate whether assessment method influences the type of post-concussion-like symptoms. METHODS AND PROCEDURES:Participants were 73 Australian undergraduate students (Mage = 24.14, SD = 8.84; 75.3% female) with no history of mild traumatic brain injury (mTBI). Participants reported symptoms ex...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.3109/02699052.2014.915988
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Craniectomy, used to relieve refractory intracranial pressure in traumatic brain injury (TBI), may cause cognitive deficits which could be improved by skull breach repair. This paper studied whether late cranioplasty improves a specific pattern of cognitive functions. DESIGN:A case series of five TBI patient...
journal_title:Brain injury
pub_type: 杂志文章,评审
doi:10.3109/02699052.2013.844857
更新日期:2013-01-01 00:00:00
abstract::This article reviews, analyses and provides commentary on the most recent literature concerning recurrent traumatic brain injury (RTBI) case histories. It is revealed that a significant proportion of TBI sufferers survive and recover most of the functions of daily living. However, relatively little is known about the ...
journal_title:Brain injury
pub_type: 杂志文章,评审
doi:10.3109/02699059209029671
更新日期:1992-05-01 00:00:00
abstract::Objective: To examine the impact of bright white light (BWL) exposure on sleep quality in persons with recent traumatic brain injury (TBI). Design: Randomized, controlled device-sham study Setting: 3 TBI Model System inpatient rehabilitation units Participants: 131 participants (mean 40.9 years, 68% male) Intervention...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699052.2021.1871952
更新日期:2021-01-17 00:00:00
abstract:PRIMARY OBJECTIVE:To document and critically evaluate the likely effectiveness of pharmacological treatments used in a sample of patients with Dysautonomia and to link these findings to previously published literature. RESEARCH DESIGN:Retrospective case control chart review. METHODS AND PROCEDURES:Data were collected...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699050310001645775
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVES:To study depression, anxiety, maladjustment and coping in caregivers of patients in vegetative state (VS) or minimally conscious state (MCS). MATERIALS AND METHODS:Fifty-three caregivers of 43 patients with VS or MCS were assessed using Beck Anxiety Inventory, Beck Depression Inventory, maladjustment scale ...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.3109/02699052.2013.793402
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To investigate the effectiveness of repetitive facilitative exercise (RFE) under surface neuromuscular electrical stimulation (NMES) in patients with post-stroke hemiplegia. METHODS:This randomized, controlled, observer-blinded, pilot trial randomized 27 adults with severe arm impairment [Fugl-Meyer Arm scal...
journal_title:Brain injury
pub_type: 杂志文章,随机对照试验
doi:10.3109/02699052.2013.860472
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To identify literature which discusses the barriers and enablers of eHealth technology and which evaluates its role in facilitating interdisciplinary team work for the care of people with a traumatic brain injury (TBI). DESIGN:Systematic review. DATA SOURCES:Studies were identified by searching CINAHL, Emba...
journal_title:Brain injury
pub_type: 杂志文章,评审
doi:10.1080/02699052.2017.1387932
更新日期:2017-01-01 00:00:00
abstract::This study describes the rehabilitation length of stay (LOS), discharge destination and discharge functional status of 149 patients admitted with traumatic brain injury (TBI) to an Australian hospital over a 5-year period. Hospital charts of patients admitted between 1993-1998 were reviewed. Average LOS over the 5-yea...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699050010013923
更新日期:2001-07-01 00:00:00
abstract::In a simulated functional task involving comprehension of a spoken passage, the performance of 20 traumatically brain-injured and 14 non-brain-injured control patients was compared under conditions which included the presence and absence of competing vocal stimuli. The subjects heard 10 target paragraphs which were ap...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.3109/02699058809150937
更新日期:1988-04-01 00:00:00
abstract:BACKGROUND:Introduced in the 1980s, the neurofunctional approach (NFA) is one of the few interventions designed primarily for clients with severe deficits following traumatic brain injury (TBI). Specifically the NFA was intended for those individuals who were limited in their ability to solve novel problems or generali...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.3109/02699052.2014.946449
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:To determine what is the use of time and physical activity in people undertaking inpatient rehabilitation in a specialised brain injury unit. To determine participants' level of independence related to the use of time and physical activity. METHODS:Design: Cross-sectional observation study. PARTICIPANTS:Fo...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699052.2018.1463454
更新日期:2018-01-01 00:00:00
abstract:STUDY OBJECTIVE:Duration of post-traumatic amnesia (PTA) is an important index of severity of head injury. Retrospective assessment of PTA duration is arguably unreliable. Existing objective measures of PTA duration are designed for use over a 24-hour timeframe and, therefore, are not useful for assessing PTA following...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699050310001646152
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVES:Although much is known about discourse impairment, little is known about discourse recovery after severe traumatic brain injury (TBI). This paper explores discourse recovery across the critical first year, controlling for pre-injury, injury and post-injury variables. DESIGN AND METHODS:An inception cohort c...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699052.2018.1539246
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To study the effects on the hemiplegic upper limb of repetitive facilitation exercises (RFEs) using a novel facilitation technique, in which the patient's intention to move the hemiplegic upper limb or finger was followed by realization of the movement using multiple sensory stimulations. METHODS:Twenty-thre...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.3109/02699052.2010.506855
更新日期:2010-01-01 00:00:00
abstract::This paper is a sequel to that of McMillan (1997) and describes further assessment of an extremely severely head injured patient. A combination of direct observations, structured interviews with staff, simple cognitive tests and questions with yes/no answers were used to assess communication and cognitive function in ...
journal_title:Brain injury
pub_type: 评论,杂志文章
doi:10.1080/026990598122043
更新日期:1998-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In work with chronic stroke patients the authors observed that patients frequently appear sleepy and often comment on their poor sleep. Sleep difficulties are frequently reported and indeed clinically recognized in the acute phase post-stroke, but little is known about the sleep and daytime sleep...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699050802189727
更新日期:2008-07-01 00:00:00
abstract::Over the past three or four decades two treatment technologies have been evolving in parallel, recently to some extent merging. The first of these technologies is behaviour analysis, with its emphasis on identification and manipulation of variables external to the individual as controlling agents. The second is neurol...
journal_title:Brain injury
pub_type: 杂志文章,评审
doi:10.3109/02699059509008213
更新日期:1995-08-01 00:00:00
abstract::This paper describes a conceptual model for treatment of the externalizing behavioural sequelae to an acquired brain injury and discusses relevant research. Use of the model by practitioners should lead to sophisticated and minimally intrusive intervention. In the model, there are two different categories of approache...
journal_title:Brain injury
pub_type: 杂志文章,评审
doi:10.1080/026990599121232
更新日期:1999-09-01 00:00:00
abstract::Background: The Convergence Insufficiency Symptom Survey (CISS) is being utilized as an assessment measure following concussion despite minimal research. This study explored the sensitivity and specificity of the CISS in identifying receded near point of convergence (NPC) post-concussion. Methods: Prospective study of...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699052.2019.1658131
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Amantadine is currently recommended for use in patients of post-traumatic brain injury with unresponsive wakefulness syndrome (UWS). However, the application of amantadine in UWS after cerebral hemorrhage has only been rarely reported. This allows for a further exploration of the role of amantadine in the tr...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699052.2020.1780315
更新日期:2020-07-02 00:00:00
abstract::We report a patient who exhibited Gerstmann's syndrome in association with a chronic subdural haematoma. A 71-year-old right-handed woman presented with mild right arm and leg weakness that began 2 weeks prior to admission. Neurological examination on admission revealed a mild right hemiparesis. Neuropsychological exa...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/026990598122250
更新日期:1998-08-01 00:00:00
abstract::The purpose of this article is to review relevant literature on the effect of mild traumatic brain injury (mTBI) and blast injury on the vestibular system. Dizziness and imbalance are common sequelae associated with mTBI, and in some individuals, these symptoms may last for six months or longer. In war-related injurie...
journal_title:Brain injury
pub_type: 杂志文章,评审
doi:10.1080/02699052.2017.1288928
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To estimate the national 30-day re-admission rate after traumatic brain injury (TBI) in insured patients under age 65 and to examine factors that predict re-admission. METHODS:This study reviewed data on patients hospitalized with a primary diagnosis of TBI in the MarketScan® database from 2010-2012. Patient...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699052.2016.1199898
更新日期:2016-01-01 00:00:00
abstract:PRIMARY OBJECTIVE:To explore the epidemiology of patients in a Vegetative State (VS) and Minimally Conscious State (MCS) that are cared for in long-term care facilities in Austria. The study was inspired by increasing evidence that the cognitive abilities of minimal behavioural patients with disorders of consciousness ...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.3109/02699052.2011.577047
更新日期:2011-01-01 00:00:00
abstract:PRIMARY OBJECTIVE:This paper examined the use of an atypical neuroleptic medication, risperidone, in reducing the excessive motor activity of an adolescent with an anoxic brain injury following cardiac arrest from a lightning strike. Lower extremity restlessness caused the patient to develop skin breakdown and interfer...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/0269905021000013192
更新日期:2003-03-01 00:00:00
abstract::The current study evaluated under double-blind placebo-controlled conditions, the safety and efficacy of 400 mg pramiracetam sulphate TID in treating memory and other cognitive problems of males who have sustained brain injuries. The results of the study indicate that subject performance in measures of memory, especia...
journal_title:Brain injury
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/02699059109008110
更新日期:1991-10-01 00:00:00
abstract::During the past decade the usage of dopaminergic agonists for the brain-injured population has become a more common treatment option during both the acute and subacute phases of recovery. We attempted to use Sinemet to address the functional limitations of a 74-year-old woman who was 7 months status post-traumatic bra...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.3109/02699059509008208
更新日期:1995-07-01 00:00:00
abstract:PRIMARY OBJECTIVE:To study the effect of flavonoids isolated from aerial parts of Scutellaria baicalensis Georgi (SSF) on cerebral damage induced by okadaic acid (OA) in rats. METHODS AND PROCEDURES:OA was microinjected into the right lateral ventricle of male rats at a dose of 200 ng kg(-1) twice with a 3-day interva...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.3109/02699052.2015.1042053
更新日期:2015-01-01 00:00:00