Abstract:
BACKGROUND:Amantadine is currently recommended for use in patients of post-traumatic brain injury with unresponsive wakefulness syndrome (UWS). However, the application of amantadine in UWS after cerebral hemorrhage has only been rarely reported. This allows for a further exploration of the role of amantadine in the treatment of UWS resulting from a severe cerebral hemorrhage. METHODS:We observed the changes of seven patients with UWS of intracerebral hemorrhage after taking amantadine. We also carried out a detailed neurological examination of the patient with disorders of consciousness to include or exclude subjects for the study. CRS-R score was used to evaluate the neurological recovery. RESULTS:An improvement in consciousness was observed within 3-6 days after the start of amantadine administration in all seven cases (n = 7/7; 100%). Five patients recovered conscious and left aphasia, hemiplegia and other sequelae, and two patients recovered from UWS to minimally conscious state (MCS). CONCLUSIONS:In this study, amantadine administration showed substantial positive effects on recovery following severe cerebral hemorrhage. We recommend further randomized controlled studies to determine the efficacy of amantadine.
journal_name
Brain Injjournal_title
Brain injuryauthors
Gao Y,Ma L,Liang F,Zhang Y,Yang L,Liu X,Yang Jdoi
10.1080/02699052.2020.1780315subject
Has Abstractpub_date
2020-07-02 00:00:00pages
1084-1088issue
8eissn
0269-9052issn
1362-301Xjournal_volume
34pub_type
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